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p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects
Open accessAbstract
Suppression of macroautophagy, due to mutations or through processes linked to aging, results in the accumulation of cytoplasmic substrates that are normally eliminated by the pathway. This is a significant problem in long-lived cells like neurons, where pathway defects can result in the accumulation of aggregates containing ubiquitinated proteins. The p62/Ref(2)P family of proteins is involved in the autophagic clearance of cytoplasmic protein bodies or sequestosomes. These unique structures are closely associated with protein inclusions containing ubiquitin as well as key components of the autophagy pathway. In this study we show that detergent fractionation followed by western blot analysis of insoluble ubiquitinated proteins (IUP), mammalian p62 and its Drosophila homologue, Ref(2)P can be used to quantitatively assess the activity level of aggregate clearance (aggrephagy) in complex tissues. Using this technique we show that genetic or age-dependent changes that modify the long-term enhancement or suppression of aggrephagy can be identified. Moreover, using the Drosophila model system this method can be used to establish autophagy-dependent protein clearance profiles that are occurring under a wide range of physiological conditions including developmental, fasting and altered metabolic pathways. This technique can also be used to examine proteopathies that are associated with human disorders such as frontotemporal dementia, Huntington and Alzheimer disease. Our findings indicate that measuring IUP profiles together with an assessment of p62/Ref(2)P proteins can be used as a screening or diagnostic tool to characterize genetic and age-dependent factors that alter the long-term function of autophagy and the clearance of protein aggregates occurring within complex tissues and cells.
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“Indeed, p62 is present in neuronal inclusions of individuals with Alzheimer’s disease and other neurodegenerative diseases11”
From Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice (2018) · cites this paper as [11]
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Metadata
- Authors
- Bartlett, B. J., Isakson, P., Lewerenz, J., Sanchez, H., Kotzebue, R. W., Cumming, R. C., Harris, G. L., Nezis, I. P., Schubert, D. R., Simonsen, A., & Finley, K. D.
- Affiliations
- San Diego State University (US)
- University of Oslo (NO)
- Salk Institute for Biological Studies (US)
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2011-06
- Volume
- 7
- Issue
- 6
- Pages
- 572-583
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- PMC
- PMC3127048
- OpenAlex
- W2014829450
- Cited by
- 215
- References
- 74
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 13 · 2023: 15 · 2022: 15 · 2021: 17 · 2020: 13 · 2019: 13 · 2018: 15 · 2017: 12 · 2016: 22 · 2015: 17 · 2014: 18 · 2013: 11 · 2012: 12
- FWCI
- 9.84
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Autophagy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Scholarship@Western (Western University) (submittedVersion)
- Funders
- National Institute on Aging (R21AG030187, R01AG033283, R44AG033427, R43AG033427, R01AG039628)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Keywords
- p62, neuronal aging, aggrephagy, protein aggregate clearance, ubiquitinated proteins, autophagy defects, Drosophila, frontotemporal dementia, Huntington's disease, Alzheimer's disease, proteinopathies
- MeSH terms
- Sequestosome-1 Protein, Alzheimer Disease, Animals, Autophagy, Cytoplasm, Detergents, DNA-Binding Proteins, Drosophila melanogaster, Humans, Models, Biological, Models, Genetic, Mutation, Neurons, Nuclear Proteins, Time Factors, Gene Expression Regulation, Developmental, Drosophila Proteins, Animals, Genetically Modified, Microscopy, Electron, Transmission, Adaptor Proteins, Signal Transducing
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