The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
Open accessAbstract
Both anabolism and catabolism of the amino acids released by starvation-induced autophagy are essential for cell survival, but their actual metabolic contributions in adult animals are poorly understood. Herein, we report that, in mice, liver autophagy makes a significant contribution to the maintenance of blood glucose by converting amino acids to glucose via gluconeogenesis. Under a synchronous fasting-initiation regimen, autophagy was induced concomitantly with a fall in plasma insulin in the presence of stable glucagon levels, resulting in a robust amino acid release. In liver-specific autophagy (Atg7)-deficient mice, no amino acid release occurred and blood glucose levels continued to decrease in contrast to those of wild-type mice. Administration of serine (30 mg/animal) exerted a comparable effect, raising the blood glucose levels in both control wild-type and mutant mice under starvation. Thus, the absence of the amino acids that were released by autophagic proteolysis is a major reason for a decrease in blood glucose. Autophagic amino acid release in control wild-type livers was significantly suppressed by the prior administration of glucose, which elicited a prompt increase in plasma insulin levels. This indicates that insulin plays a dominant role over glucagon in controlling liver autophagy. These results are the first to show that liver-specific autophagy plays a role in blood glucose regulation.
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Metadata
- Authors
- Ezaki, J., Matsumoto, N., Takeda-Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., Iwata, J., Tanida, I., Furuya, N., Zheng, D.-M., Tada, N., Tanaka, K., Kominami, E., & Ueno, T.
- Venue
- Autophagy
- Publisher
- Informa UK Limited
- Published
- 2011-07
- Volume
- 7
- Issue
- 7
- Pages
- 727-736
- ISSN
- 1554-8627 (ISSN-L)
- 1554-8635
- OpenAlex
- W2078253583
- Cited by
- 281
- References
- 12
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
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