The DOI matches its Crossref record; 72 of the 72 references it cites were found in a registry or an index.
miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer
Open accessAbstract
Tumor growth results in hypoxia. Understanding the mechanisms of gene expression reprogramming under hypoxia may provide important clues to cancer pathogenesis. We studied miRNA genes that are regulated by hypoxia in ovarian cancer cell lines by TaqMan miRNA assay containing 157 mature miRNAs. MiR-210 was the most prominent miRNA consistently stimulated under hypoxic conditions. We provide evidence for the involvement of the HIF signaling pathway in miR-210 regulation. Biocomputational analysis and in vitro assays demonstrated that e2f transcription factor 3 (e2f3), a key protein in cell cycle, is regulated by miR-210. E2F3 was further confirmed to be downregulated at the protein level upon induction of miR-210. Importantly, we found remarkably high frequency of miR-210 gene copy deletions in ovarian cancer patients (64%, n = 114) and that gene copy number correlates with miR-210 expression levels. Taken together, our results indicate that miR-210 plays a crucial role in tumor onset as a key regulator of the hypoxia response and provide evidence for a link between hypoxia and the regulation of cell cycle.
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Cites
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Cited by
Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Wouters, B. G., & Koritzinsky, M. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2501 · Cited by 894
Chan, S. Y., Zhang, Y.-Y., Hemann, C., Mahoney, C. E., Zweier, J. L., & Loscalzo, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.08.015 · Cited by 702
“The cellcycle regulator E2F3 (Giannakakis et al., 2008), the receptor tyrosine kinase ligand ephrin A3 (Fasanaro et al., 2008), and the DNA repair protein RAD52 (Crosby et al., 2009) have been studied as targets for repression by miR-210; however, the complete functions of this miRNA have yet to be delineated.”
Hypoxia-Modified Cancer Cell Metabolism
Al Tameemi, W., Dale, T. P., Al-Jumaily, R. M. K., & Forsyth, N. R. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00004 · Cited by 503
MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease
Hu, S., Huang, M., Li, Z., Jia, F., Ghosh, Z., Lijkwan, M. A., Fasanaro, P., Sun, N., Wang, X., Martelli, F., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.928424 · Cited by 462
Metadata
- Authors
- Giannakakis, A., Sandaltzopoulos, R., Greshock, J., Liang, S., Huang, J., Hasegawa, K., Li, C., O'Brien-Jenkins, A., Katsaros, D., Weber, B. L., Simon, C., Coukos, G., & Zhang, L.
- Venue
- Cancer Biology & Therapy
- Publisher
- Informa UK Limited
- Published
- 2008-02-04
- Volume
- 7
- Issue
- 2
- Pages
- 255-264
- ISSN
- 1538-4047 (ISSN-L)
- 1555-8576
- OpenAlex
- W2041748697
- Cited by
- 344
- References
- 72
- FWCI
- 8.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Giannakakis, A., Sandaltzopoulos, R., Greshock, J., Liang, S., Huang, J., Hasegawa, K., Li, C., O'Brien-Jenkins, A., Katsaros, D., Weber, B. L., Simon, C., Coukos, G., & Zhang, L. (2008). miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancer. Cancer Biology & Therapy. https://doi.org/10.4161/cbt.7.2.5297
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