The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer
Open accessAbstract
Epithelial-mesenchymal transition (EMT) is an essential developmental program that becomes reactivated in adult tissues to promote the progression of cancer. EMT has been largely studied by examining the beginning epithelial state or the ending mesenchymal state without studying the intermediate stages. Recent studies using trophoblast stem (TS) cells paused in EMT have defined the molecular and epigenetic mechanisms responsible for modulating the intermediate "metastable" stages of EMT. Targeted inactivation of MAP3K4, knockdown of CBP, or overexpression of SNAI1 in TS cells induced similar metastable phenotypes. These TS cells exhibited epigenetic changes in the histone acetylation landscape that cause loss of epithelial maintenance while preserving self-renewal and multipotency. A similar phenotype was found in claudin-low breast cancer cells with properties of EMT and stemness. This intersection between EMT and stemness in TS cells and claudin-low metastatic breast cancer demonstrates the usefulness of developmental EMT systems to understand EMT in cancer.
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Cites
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Zeisberg, M., & Neilson, E. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36183 · Cited by 2,299 · cited 1×
“1).(4,10) Developmental EMTs constitute the first EMT subtype and include implantation, gastrulation and neural crest formation.”
BackgroundThe snail superfamily of zinc-finger transcription factors
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Cited by
Nieto, M. A., Huang, R. Y.-J., Jackson, R. A., & Thiery, J. P. (2016) · Cell · doi:10.1016/j.cell.2016.06.028 · Cited by 4,492
Tan, T. Z., Miow, Q. H., Miki, Y., Noda, T., Mori, S., Huang, R. Y., & Thiery, J. P. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201404208 · Cited by 792
Epithelial-mesenchymal transition in tissue repair and fibrosis
Stone, R. C., Pastar, I., Ojeh, N., Chen, V., Liu, S., Garzon, K. I., & Tomic-Canic, M. (2016) · Cell and Tissue Research · doi:10.1007/s00441-016-2464-0 · Cited by 572
Zhang, J., Tian, X.-J., Zhang, H., Teng, Y., Li, R., Bai, F., Elankumaran, S., & Xing, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005304 · Cited by 462
Repair Schwann cell update: Adaptive reprogramming, EMT, and stemness in regenerating nerves
Jessen, K. R., & Arthur‐Farraj, P. (2019) · Glia · doi:10.1002/glia.23532 · Cited by 353
Metadata
- Authors
- Jordan, N. V., Johnson, G. L., & Abell, A. N.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2011-09
- Volume
- 10
- Issue
- 17
- Pages
- 2865-2873
- ISSN
- 1538-4101 (ISSN-L)
- 1551-4005
- OpenAlex
- W2002654154
- Cited by
- 220
- References
- 7
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
