CoChat
Sign Up
Cited by 259

The DOI matches its Crossref record.

Aging, stem cells and tissue regeneration: lessons from muscle.

Conboy, Irina M., Rando, Thomas A.·2005·Cell Cycle
DOI 10.4161/cc.4.3.1518
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.4161/cc.4.3.1518

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In heterochronic parabiosis studies, young animals often experienced premature aging of their respective tissues.

    “and often the young animals experienced premature aging of their respective tissues [1, 3, 4, 6–8].”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [6]

    The Lessons from Muscle section reports that an aged systemic milieu appeared to inhibit regeneration in young tissues during heterochronic parabiosis, with effects varying by tissue. It does not establish that young animals experienced premature tissue aging or that this often occurred. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The general conclusion of heterochronic parabiosis studies was that old partners had better health and/or repair of cartilage, muscle, liver, brain, spinal cord, kidneys, bone, skin, etc.

    “The general conclusion of these studies was that the old partners had better health and/or repair of cartilage, muscle, liver, brain, spinal cord, kidneys, bone, skin, etc.”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [6]

    In “Lessons from Muscle” (page unavailable), the paper reports markedly improved regeneration of aged muscle in old mice paired with young mice, and enhanced liver progenitor-cell proliferation. It does not report improved overall health or repair of cartilage, brain, spinal cord, kidneys, bone, or skin in the old partners; its suggestion that effects may extend beyond muscle is not evidence for those specific tissues. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Old human serum strongly reduced myogenic cell proliferation.

    “As demonstrated in Figure 2, old human serum strongly reduced myogenic cell proliferation (which is consistent with the effects of the old mouse serum [1, 2, 6, 7, 13]).”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [6]

    The citation is attached to the comparison with old mouse serum, not to the citing authors’ Figure 2 result for human serum. In “Lessons from Muscle” (page unavailable), the source says the aged systemic milieu appeared to inhibit regeneration in young tissues, but it does not report that old mouse serum strongly reduced myogenic cell proliferation. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Heterochronic blood sharing rejuvenates old tissues.

    “Heterochronic blood sharing rejuvenates old tissues”

    From Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin (2020) · cites this paper as [6]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 27

  1. Sohal RS, Mockett RJ, Orr WC. Mechanisms of aging: An appraisal of the oxidative stress hypothesis. Free Radic Biol Med 2002; 33:575-86.
  2. Ames BN. Delaying the mitochondrial decay of aging. Ann NY Acad Sci 2004; 1019:406-11.
  3. Thomas DR. Age-related changes in wound healing. Drugs Aging 2001; 18:607-20.
  4. Edelberg JM, Reed MJ. Aging and angiogenesis. Front Biosci 2003; 8:s1199-209.
  5. Franklin RJ, Zhao C, Sim FJ. Ageing and CNS remyelination. Neuroreport 2002; 13:923-8.
  6. Young HE, Duplaa C, Romero-Ramos M, Chesselet MF, Vourc'h P, Yost MJ, Ericson K, Terracio L, Asahara T, Masuda H, Tamura-Ninomiya S, Detmer K, Bray RA, Steele TA, Hixson D, el-Kalay M, Tobin BW, Russ RD, Horst MN, Floyd JA, Henson NL, Hawkins KC, Groom J, Parikh A, Blake L, Bland LJ, Thompson AJ, Kirincich A, Moreau C, Hudson J, Bowyer FP 3rd, Lin TJ, Black AC Jr.. Adult reserve stem cells and their poten- tial for tissue engineering. Cell Biochem Biophys 2004; 40:1-80.
  7. Morrison SJ, Wandycz AM, Akashi K, Globerson A, Weissman IL. The aging of hematopoietic stem cells. Nat Med 1996; 2:1011-6.
  8. Martin K, Potten CS, Roberts SA, Kirkwood TB. Altered stem cell regeneration in irradi- ated intestinal crypts of senescent mice. J Cell Sci 1998; 111:2297-303.
  9. Conboy IM, Conboy MJ, Smythe GM, Rando TA. Notch-mediated restoration of regen- erative potential to aged muscle. Science 2003; 302:1575-7.
  10. Capogrossi MC. Cardiac stem cells fail with aging: A new mechanism for the age-depen- dent decline in cardiac function. Circ Res 2004; 94:411-3.
  11. Kuhn HG, Dickinson-Anson H, Gage FH. Neurogenesis in the dentate gyrus of the adult rat: Age-related decrease of neuronal progenitor proliferation. J Neurosci 1996; 16:2027-33.
  12. Grounds MD. Age-associated changes in the response of skeletal muscle cells to exercise and regeneration. Ann NY Acad Sci 1998; 854:78-91.
  13. Zammit PS, Heslop L, Hudon V, Rosenblatt JD, Tajbakhsh S, Buckingham ME, Beauchamp JR, Partridge TA. Kinetics of myoblast proliferation show that resident satel- lite cells are competent to fully regenerate skeletal muscle fibers. Exp Cell Res 2002; 281:39-49.
  14. Zammit PS, Golding JP, Nagata Y, Hudon V, Partridge TA, Beauchamp JR. Muscle satel- lite cells adopt divergent fates: A mechanism for self-renewal? J Cell Biol 2004; 166:347-57.
  15. Beauchamp JR, Heslop L, Yu DS, Tajbakhsh S, Kelly RG, Wernig A, Buckingham ME, Partridge TA, Zammit PS. Expression of CD34 and Myf5 defines the majority of quiescent adult skeletal muscle satellite cells. J Cell Biol 2000; 151:1221-34.
  16. Seale P, Sabourin LA, Girgis-Gabardo A, Mansouri A, Gruss P, Rudnicki MA. Pax7 is required for the specification of myogenic satellite cells. Cell 2000; 102:777-86.
  17. Cornelison DD, Filla MS, Stanley HM, Rapraeger AC, Olwin BB. Syndecan-3 and syn- decan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Dev Biol 2001; 239:79-94.
  18. Sherwood RI, Christensen JL, Conboy IM, Conboy MJ, Rando TA, Weissman IL, Wagers AJ. Isolation of adult mouse myogenic progenitors: Functional heterogeneity of cells with- in and engrafting skeletal muscle. Cell 2004; 119:543-54.
  19. Schultz E, Lipton BH. Skeletal muscle satellite cells: Changes in proliferation potential as a function of age. Mech Ageing Dev 1982; 20:377-83.
  20. Bockhold KJ, Rosenblatt JD, Partridge TA. Aging normal and dystrophic mouse muscle: Analysis of myogenicity in cultures of living single fibers. Muscle Nerve 1998; 21:173-83.
  21. Renault V, Thornell LE, Eriksson PO, Butler-Browne G, Mouly V, Thorne LE. Regenerative potential of human skeletal muscle during aging. Aging Cell 2002; 1:132-9.
  22. Gibson MC, Schultz E. Age-related differences in absolute numbers of skeletal muscle satellite cells. Muscle Nerve 1983; 6:574-80.
  23. Charge SB, Rudnicki MA. Cellular and molecular regulation of muscle regeneration. Physiol Rev 2004; 84:209-38.
  24. Conboy IM, Rando TA. The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev Cell 2002; 3:397-409.
  25. Zacks SI, Sheff MF. Age-related impeded regeneration of mouse minced anterior tibial muscle. Muscle Nerve 1982; 5:152-61.
  26. Carlson BM, Faulkner JA. Muscle transplantation between young and old rats: Age of host determines recovery. Am J Physiol 1989; 256:C1262-6.
  27. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a youthful systemic environment. Nature 2005; 433: 760-4.

Cited by

Sorted by citations

Metadata

Authors
Conboy, I. M., & Rando, T. A.
Venue
Cell Cycle
Publisher
Informa UK Limited
Published
2005-02
Volume
4
Issue
3
Pages
407-410
ISSN
  • 1538-4101
  • 1551-4005
DOI
10.4161/cc.4.3.1518
Cited by
259
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review