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Aging: ROS or TOR
Abstract
It is widely believed that aging is caused by the accumulation of random molecular damage due to reactive oxygen species (ROS). Here I discuss evidence for and against the ROS theory. Remarkably, even supporting evidence has an alternative explanation, consistent with the model that aging is driven by the TOR (target of rapamycin) signaling pathway.
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“In addition, several of the pathologies associated with aging, such as atherosclerosis and inflammation, involve uncontrolled cellular overgrowth or hyperactivity (Blagosklonny, 2008).”
From The Hallmarks of Aging (2013) · cites this paper as Blagosklonny, 2008
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Self-citationVazquez-Martin, A., Oliveras-Ferraros, C., & Menendez, J. A. (2009) · Cell Cycle · doi:10.4161/cc.8.1.7499 · Cited by 250
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The role of mitochondria in mTOR‐regulated longevity
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Metadata
- Authors
- Blagosklonny, M. V.
- Venue
- Cell Cycle
- Publisher
- Informa UK Limited
- Published
- 2008-11
- Volume
- 7
- Issue
- 21
- Pages
- 3344-3354
- ISSN
- 1538-4101
- 1551-4005
- Cited by
- 332
- References
- 0
- Language
- en
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