Cited by 56Genetics, Aging, and Longevity in Model OrganismsMitochondrial Function and PathologyAutophagy in Disease and Therapy

The role of mitochondria in mTOR‐regulated longevity

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Wei, Yuehua, Zhang, Yan‐Jie, Cai, Ying, Xu, Mang‐Hua·2015·Biological Reviews

Abstract

Several unbiased genome-wide RNA interference (RNAi) screens have pointed to mitochondrial metabolism as the major factor for lifespan regulation. However, conflicting data remain to be clarified concerning the mitochondrial free radical theory of aging (MFRTA). Recently, mTOR (mechanistic target of rapamycin) has been proposed to be the central regulator of aging although how mTOR modulates lifespan is poorly understood. Interestingly, mTOR has been shown to regulate many aspects of mitochondrial function, such as mitochondrial biogenesis, apoptosis, mitophagy and mitochondrial hormesis (mitohormesis) including the retrograde response and mitochondrial unfolded protein response (mito-UPR). Here we discuss the data linking mitochondrial metabolism to mTOR regulation of lifespan, suggesting that hormetic effects may be key to explaining some controversial results regarding the MFRTA. We also discuss the possibility that dysfunction of mitochondrial adaptive responses rather than free radicals per se contributes to the aging process.

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Authors
Wei, Y., Zhang, Y., Cai, Y., & Xu, M.
Affiliations
  • Shanghai Jiao Tong University (CN)
  • No.3 People's Hospital School of Medicine, Shanghai Jiao Tong University 280 Mohe Road Shanghai 201900 China
Corresponding author
Wei, Yuehua
Venue
Biological Reviews
Publisher
Wiley
Published
2014-03-28
Volume
90
Issue
1
Pages
167-181
ISSN
  • 0006-3231 (ISSN-L)
  • 1464-7931
  • 1469-185X
OpenAlex
W1525028956
Cited by
56
References
195
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 12 · 2022: 6 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 1
FWCI
0.49
Type
journal article
Language
en
Open access
Locations
  • Biological reviews/Biological reviews of the Cambridge Philosophical Society (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81200248)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mTOR, longevity, lifespan regulation, mitochondrial metabolism, mitochondrial biogenesis, mitophagy, mitochondrial unfolded protein response, retrograde response, apoptosis, aging
MeSH terms
Animals, Gene Expression Regulation, Longevity, Mitochondria, TOR Serine-Threonine Kinases

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