The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Pannexin channels are not gap junction hemichannels
Open accessAbstract
Pannexins, a class of membrane channels, bear significant sequence homology with the invertebrate gap junction proteins, innexins and more distant similarities in their membrane topologies and pharmacological sensitivities with the gap junction proteins, connexins. However, the functional role for the pannexin oligomers, or pannexons, is different from connexin oligomers, the connexons. Many pannexin publications have used the term "hemichannels" to describe pannexin oligomers while others use the term "channels" instead. This has led to confusion within the literature about the function of pannexins that promotes the idea that pannexons serve as gap junction hemichannels and thus have an assembly and functional state as gap junctional intercellular channels. Here we present the case that unlike the connexin gap junction intercellular channels, so far, pannexin oligomers have repeatedly been shown to be channels that are functional in single membranes, but not as intercellular channel in appositional membranes. Hence, they should be referred to as channels and not hemichannels. Thus, we advocate that in the absence of firm evidence that pannexins form gap junctions, the use of the term "hemichannel" be discontinued within the pannexin literature.
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Cites
Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor
Pelegrin, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,431
Pannexin 1 channels mediate ‘find-me’ signal release and membrane permeability during apoptosis
Chekeni, F. B., Elliott, M. R., Sandilos, J. K., Walk, S. F., Kinchen, J. M., Lazarowski, E. R., Armstrong, A. J., Penuela, S., Laird, D. W., Salvesen, G. S., et al. (2010) · Nature · doi:10.1038/nature09413 · Cited by 1,120
Self-citationPannexin membrane channels are mechanosensitive conduits for ATP
Bao, L., Locovei, S., & Dahl, G. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.07.009 · Cited by 802
Self-citationPannexins, a family of gap junction proteins expressed in brain
Bruzzone, R., Hormuzdi, S. G., Barbe, M. T., Herb, A., & Monyer, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2233464100 · Cited by 774
Structure of the connexin 26 gap junction channel at 3.5 Å resolution
Maeda, S., Nakagawa, S., Suga, M., Yamashita, E., Oshima, A., Fujiyoshi, Y., & Tsukihara, T. (2009) · Nature · doi:10.1038/nature07869 · Cited by 725
A ubiquitous family of putative gap junction molecules
Panchina, Y., Kelmanson, I., Matz, M., Lukyanov, K., Usman, N., & Lukyanov, S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00576-5 · Cited by 562
Ischemia Opens Neuronal Gap Junction Hemichannels
Thompson, R. J., Zhou, N., & MacVicar, B. A. (2006) · Science · doi:10.1126/science.1126241 · Cited by 560
Self-citationThe role of pannexin 1 hemichannels in ATP release and cell–cell communication in mouse taste buds
Huang, Y.-J., Maruyama, Y., Dvoryanchikov, G., Pereira, E., Chaudhari, N., & Roper, S. D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611280104 · Cited by 532
Pannexin 1 in erythrocytes: Function without a gap
Locovei, S., Bao, L., & Dahl, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601037103 · Cited by 508
Self-citationThe mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins
Baranova, A., Ivanov, D., Petrash, N., Pestova, A., Skoblov, M., Kelmanson, I., Shagin, D., Nazarenko, S., Geraymovych, E., Litvin, O., et al. (2004) · Genomics · doi:10.1016/j.ygeno.2003.09.025 · Cited by 491
Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Osteocytes: master orchestrators of bone
Schaffler, M. B., Cheung, W.-Y., Majeska, R., & Kennedy, O. (2014) · Calcified Tissue International · doi:10.1007/s00223-013-9790-y · Cited by 514
The biochemistry and function of pannexin channels
Penuela, S., Gehi, R., & Laird, D. W. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2012.01.017 · Cited by 386
Self-citationSandilos, J. K., Chiu, Y.-H., Chekeni, F. B., Armstrong, A. J., Walk, S. F., Ravichandran, K. S., & Bayliss, D. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.323378 · Cited by 302
Mechanisms of ATP Release by Inflammatory Cells
Dosch, M., Gerber, J., Jebbawi, F., & Beldi, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041222 · Cited by 283
Metadata
- Authors
- Sosinsky, G. E., Boassa, D., Dermietzel, R., Duffy, H. S., Laird, D. W., MacVicar, B., Naus, C. C., Penuela, S., Scemes, E., Spray, D. C., Thompson, R. J., Zhao, H.-B., & Dahl, G.
- Venue
- Channels
- Publisher
- Informa UK Limited
- Published
- 2011-05
- Volume
- 5
- Issue
- 3
- Pages
- 193-197
- ISSN
- 1933-6950 (ISSN-L)
- 1933-6969
- OpenAlex
- W2032216837
- Cited by
- 349
- References
- 34
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Pannexin channels are not gap junction hemichannels. https://app.cochat.ai/papers/10.4161/chan.5.3.15765
- The paper
- Sosinsky, G. E., Boassa, D., Dermietzel, R., Duffy, H. S., Laird, D. W., MacVicar, B., Naus, C. C., Penuela, S., Scemes, E., Spray, D. C., Thompson, R. J., Zhao, H.-B., & Dahl, G. (2011). Pannexin channels are not gap junction hemichannels. Channels. https://doi.org/10.4161/chan.5.3.15765
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