The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Infectious diarrhea: Cellular and molecular mechanisms
Open accessAbstract
Diarrhea caused by enteric infections is a major factor in morbidity and mortality worldwide. An estimated 2-4 billion episodes of infectious diarrhea occur each year and are especially prevalent in infants. This review highlights the cellular and molecular mechanisms underlying diarrhea associated with the three classes of infectious agents, i.e., bacteria, viruses and parasites. Several bacterial pathogens have been chosen as model organisms, including Vibrio cholerae as a classical example of secretory diarrhea, Clostridium difficile and Shigella species as agents of inflammatory diarrhea and selected strains of pathogenic Escherichia coli (E. coli) to discuss the recent advances in alteration of epithelial ion absorption. Many of the recent studies addressing epithelial ion transport and barrier function have been carried out using viruses and parasites. Here, we focus on the rapidly developing field of viral diarrhea including rotavirus, norovirus and astrovirus infections. Finally we discuss Giardia lamblia and Entamoeba histolytica as examples of parasitic diarrhea. Parasites have a greater complexity than the other pathogens and are capable of creating molecules similar to those produced by the host, such as serotonin and PGE(2). The underlying mechanisms of infectious diarrhea discussed include alterations in ion transport and tight junctions as well as the virulence factors, which alter these processes either through direct effects or indirectly through inflammation and neurotransmitters.
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Cites
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Can probiotics modulate human disease by impacting intestinal barrier function?
Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114516004037 · Cited by 499
“Many pathogens influence barrier permeability through production of toxins that disrupt TJ and/or cause increased secretion or decreased absorption of fluids and electrolytes((52,53)).”
BackgroundDehydration: Physiology, Assessment, and Performance Effects
Cheuvront, S. N., & Kenefick, R. W. (2014) · Comprehensive Physiology · doi:10.1002/cphy.c130017 · Cited by 461
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Transient Osmotic Perturbation Causes Long-Term Alteration to the Gut Microbiota
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Gut Microbiota and Diarrhea: An Updated Review
Li, Y., Xia, S., Jiang, X., Feng, C., Gong, S., Ma, J., Fang, Z., Yin, J., & Yin, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625210 · Cited by 219
Metadata
- Authors
- Hodges, K., & Gill, R.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2010-01
- Volume
- 1
- Issue
- 1
- Pages
- 4-21
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- OpenAlex
- W1997981215
- Cited by
- 281
- References
- 117
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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