Can probiotics modulate human disease by impacting intestinal barrier function?
Open accessAbstract
Intestinal barrier integrity is a prerequisite for homeostasis of mucosal function, which is balanced to maximise absorptive capacity, while maintaining efficient defensive reactions against chemical and microbial challenges. Evidence is mounting that disruption of epithelial barrier integrity is one of the major aetiological factors associated with several gastrointestinal diseases, including infection by pathogens, obesity and diabetes, necrotising enterocolitis, irritable bowel syndrome and inflammatory bowel disease. The notion that specific probiotic bacterial strains can affect barrier integrity fuelled research in which in vitro cell lines, animal models and clinical trials are used to assess whether probiotics can revert the diseased state back to homeostasis and health. This review catalogues and categorises the lines of evidence available in literature for the role of probiotics in epithelial integrity and, consequently, their beneficial effect for the reduction of gastrointestinal disease symptoms.
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Probiotics can strengthen the intestinal barrier, regulate mucosal immune function, and produce metabolites beneficial to the host to maintain health.
“There is substantial evidence that probiotics can strengthen the intestinal barrier, regulate mucosal immune function, and produce metabolites beneficial to the host to maintain health, as illustrated in Figure 1 [22,23].”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [22]
A variety of studies suggest that probiotics are able to improve mucosal barrier function.
“a variety of studies do suggest that probiotics are able to improve mucosal barrier function (Bron et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Bron et al., 2017
Probiotics are able to support the intestinal barrier, which may dampen the increased inflammatory tone seen in aging and enhance the immune response to viral infections and vaccinations.
“There is compelling evidence that probiotics are able to support the intestinal barrier (Bron et al., 2017), which may act to dampen the increased inflammatory tone seen in aging and enhance the immune response to viral infections and vaccinations.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Bron et al., 2017
The gastrointestinal microbiome is thought to be a key player in inflammaging because it is essential for proper maintenance of the intestinal barrier through mechanisms such as production of short-chain fatty acids and tryptophan metabolites.
“The GI microbiome is thought to be a key player in this process as it is essential for the proper maintenance of the intestinal barrier through various mechanisms, e.g., production of SCFA (Bron et al., 2017) as well as tryptophan metabolites (Rothhammer and Quintana, 2019).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Bron et al., 2017
Probiotics may improve mucosal barrier function, limiting viral particles crossing and maintaining barrier during viral disease.
“Similar as the endogenous microbiota, probiotics may improve mucosal barrier function, limiting the ability of viral particles to cross this physical barrier and maintain this barrier during viral disease (Bron et al., 2017).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Bron et al., 2017
Numerous pre-clinical studies have shown that oral probiotics are capable of positively influencing gut barrier function and systemic immunity, and thus in pneumonia may enhance the host's ability to suppress and clear reproducing lung pathogens.
“Numerous pre-clinical studies have shown that oral probiotics are capable of positively influencing gut barrier function and systemic immunity, and thus, in the case of pneumonia, may enhance the host’s ability to suppress and clear reproducing lung pathogens as they emerge (Bron et al., 2017) (Forsythe, 2014).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Bron et al., 2017
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“These observations are in agreement with the reduction of metabolic endotoxaemia, gut barrier dysfunction and inflammatory disorders that could be achieved in mice by prebiotic supplementation, which restored the bifidobacterial abundance in the intestinal microbiota((76,83,93,94)).”
ResultEmerging molecular insights into the interaction between probiotics and the host intestinal mucosa
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“In addition to the resident microbiota, various bacteria transiently pass through the intestine as a consequence of ingestion – for example in fermented food products, or as supplements containing probiotics((3,4)).”
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“This is of particular interest in the light of the significant differences that have been reported for the intestinal microbiota composition when comparing IBS patients and healthy controls in both adult((172)) and children((192))”
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“E-cadherin homotypic interactions that help maintain junctional integrity((13)).”
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“difficile-associated disease, which has been successful even after the failure of multiple courses of antibiotics((220,221)).”
BackgroundFate, activity, and impact of ingested bacteria within the human gut microbiota
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“infants and, although cases of sepsis due to probiotic administration have been occasionally described in preterm((167)) and immunocompromised patients((168)), these cases remain rare.”
BackgroundFADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
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“A soluble factor from Bifidobacterium infantis also increases occludin and ZO-1 in epithelial cells in vitro and ameliorates colitis in IL-10 knock-out mice((214,215)).”
BackgroundEpithelial crosstalk at the microbiota–mucosal interface
Wells, J. M., Rossi, O., Meijerink, M., & van Baarlen, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000092107 · Cited by 574 · cited 1× · see citing works
“More recently, the concept of indirect pathogen antagonism arose by the recognition that microbial colonisation can stimulate innate and adaptive immune responses in the intestinal mucosa((11,62)).”
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Updated Meta-analysis of Probiotics for Preventing Necrotizing Enterocolitis in Preterm Neonates
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Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
Prasad, S. B., Mingrino, R., Kaukinen, K., Hayes, K. L., Powell, R. M., MacDonald, T. T., & Collins, J. E. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700316 · Cited by 493 · cited 1× · see citing works
“Cytokine IL-13 induces up-regulation of claudin 2, changing ion transport across the epithelium((198)).”
BackgroundMennigen, R. B., Nolte, K., Rijcken, E. J. M., Utech, M., Loeffler, B., Senninger, N. J., & Bruewer, M. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90534.2008 · Cited by 484 · see citing works
Gareau, M. G., Jury, J., MacQueen, G., Sherman, P. M., & Perdue, M. H. (2007) · Gut · doi:10.1136/gut.2006.117176 · Cited by 472 · cited 1× · see citing works
“Barrier integrity improvements measured in these models include a decreased permeability to small solutes((153)), macromolecules and endotoxin((157)).”
BackgroundWehkamp, J., Harder, J., Wehkamp, K., Meissner, B. W.-V., Schlee, M., Enders, C., Sonnenborn, U., Nuding, S., Bengmark, S., Fellermann, K., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.10.5750-5758.2004 · Cited by 471 · see citing works
Bifidobacterium longum with Fructo-Oligosaccharides in Patients with Non Alcoholic Steatohepatitis
Malaguarnera, M., Vacante, M., Antic, T., Giordano, M., Chisari, G., Acquaviva, R., Mastrojeni, S., Malaguarnera, G., Mistretta, A., Volti, G. L., et al. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1887-4 · Cited by 456 · see citing works
Pastorelli, L., Salvo, C. D., Mercado, J. R., Vecchi, M. L., & Pizarro, T. T. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00280 · Cited by 434 · cited 1× · see citing works
“In active IBD, mucosal inflammation is accompanied by impaired barrier function((195)).”
BackgroundCarroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01891.x · Cited by 425 · see citing works
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Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition
Delzenne, N. M., & Cani, P. D. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145146 · Cited by 409 · see citing works
Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy
Borody, T. J., Warren, E. F., Leis, S., Surace, R., & Ashman, O. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200307000-00012 · Cited by 388 · cited 1× · see citing works
“Indeed, recent studies on UC((222)) and the metabolic syndrome((223)) indicated that gut microbiota infusion improved remission period length or insulin resistance, respec-”
BackgroundInterplay between obesity and associated metabolic disorders: New insights into the gut microbiota
Cani, P. D., & Delzenne, N. M. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.016 · Cited by 377 · cited 1× · see citing works
“Among the reduced abundance bacterial groups were the bifidobacteria((87)), which”
BackgroundYan, F., Cao, H., Cover, T. L., Washington, M. K., Shi, Y., Liu, L., Chaturvedi, R., Peek, R. M., Wilson, K. T., & Polk, D. B. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44031 · Cited by 376 · cited 1× · see citing works
“rhamnosus GG, which prevents cytokine-induced epithelial barrier dysfunction by signalling through the epidermal growth factor receptor((209)).”
BackgroundIsolauri, E., Majamaa, H., Arvola, T., Rantala, I. S., Virtanen, E., & Arvilommi, H. S. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)91059-q · Cited by 374 · see citing works
Epidemiology and health care seeking in the functional GI disorders: a population-based study
Koloski, N. A., Talley, N. J., & Boyce, P. M. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05783.x · Cited by 371 · see citing works
Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome
Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 366 · see citing works
The gut microbiome as therapeutic target
Cani, P. D., & Delzenne, N. M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.012 · Cited by 349 · see citing works
The intestinal epithelial barrier in the control of homeostasis and immunity
Rescigno, M. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.04.003 · Cited by 346 · cited 1× · see citing works
“The endogenous microbiota play a key role in establishing mucosal barrier function development in infancy, but also in maintenance of this function during later life((216)).”
BackgroundRole of Toll-like Receptors in Spontaneous Commensal-Dependent Colitis
Rakoff-Nahoum, S., Hao, L., & Medzhitov, R. M. (2006) · Immunity · doi:10.1016/j.immuni.2006.06.010 · Cited by 343 · see citing works
The impact of probiotics and prebiotics on the immune system
Klaenhammer, T. R., Kleerebezem, M., Kopp, M., & Rescigno, M. (2012) · Nature reviews. Immunology · doi:10.1038/nri3312 · Cited by 335 · cited 2× · see citing works
“In diverse Bacteroides species, a type VI secretion system (T6SS) mediates cell-contact-dependent mechanisms of inter-bacterial antagonism via the export antibacterial proteins((228)).”
BackgroundRosenfeldt, V., Benfeldt, E., Valerius, N. H., Pærregaard, A., & Michaelsen, K. F. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.068 · Cited by 326 · cited 1× · see citing works
“Notably, both positive((144,226)) and negative((26,227)) impacts of probiotic consumption on barrier function have been reported, suggesting that a balanced view is required to evaluate their capacity to modulate intestinal barrier function in humans, particularly when severely compromised”
BackgroundLiu, A. Y. ‐., Destoumieux‐Garzón, D., Wong, A. V., Park, C. H., Valore, E. V., Liu, L., & Ganz, T. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01651.x · Cited by 324 · see citing works
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
An, H. M., Park, S. Y., Lee, D. K., Kim, J. R., Cha, M. K., Lee, S. W., Lim, H. T., Kim, K. J., & Ha, N. J. (2011) · Lipids in Health and Disease · doi:10.1186/1476-511x-10-116 · Cited by 320 · see citing works
RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis
Takahashi, N., Vereecke, L., Bertrand, M. J. M., Duprez, L., Berger, S. B., Divert, T., Gonçalves, A., Sze, M., Gilbert, B., Kourula, S., et al. (2014) · Nature · doi:10.1038/nature13706 · Cited by 318 · see citing works
Pretzer, G., Snel, J., Molenaar, D., Wiersma, A., Bron, P. A., Lambert, J., de Vos, W. M., van der Meer, R., Smits, M. A., & Kleerebezem, M. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.17.6128-6136.2005 · Cited by 316 · see citing works
Self-citationLuoto, R., Kalliomäki, M. A., Laitinen, K., & Isolauri, E. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.50 · Cited by 315 · cited 1× · see citing works
“rhamnosus GG reduces excessive weight gain during the first years of life in children((113)), thereby suggesting that perinatal intervention may”
BackgroundManzoni, P., Mostert, M., Leonessa, M., Priolo, C., Farina, D., Monetti, C., Latino, M. A., & Gomirato, G. (2006) · Clinical Infectious Diseases · doi:10.1086/504324 · Cited by 305 · see citing works
Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus
Collado, M. C., Meriluoto, J., & Salminen, S. (2007) · Letters in Applied Microbiology · doi:10.1111/j.1472-765x.2007.02212.x · Cited by 303 · cited 1× · see citing works
“Intriguingly, this Bifidobacterium strain was also shown to competitively exclude the binding of pathogenic bacteria to the mucosa((118)) and improve TJ integrity((119)) in vitro, again pointing towards enhanced intestinal barrier function as the compensatory mode of action.”
BackgroundDupont, A. W., Richards, Jelinek, K. A., Krill, J. T., Rahimi, E. F., & Ghouri, Y. A. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s27530 · Cited by 303 · see citing works
Aronsson, L., Huang, Y., Parini, P., Korach-André, M., Håkansson, J., Gustafsson, J.-Å., Pettersson, S., Arulampalam, V., & Rafter, J. J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013087 · Cited by 298 · cited 1× · see citing works
“plantarum 14 supplementation was shown to reduce the mean adipocyte size((106)) and Lactobacillus paracasei F19 could induce a reduction of total fat mass and plasma TAG possibly via a mechanism involving angiopoietin-like factor 4((107)).”
BackgroundA systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome
Hoveyda, N., Heneghan, C., Mahtani, K. R., Perera, R., Roberts, N., & Glasziou, P. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-15 · Cited by 297 · see citing works
Gossum, A. V., Dewit, O., Louis, E. J., Hertogh, G., Baert, F., Fontaine, F., Devos, M., Enslen, M., Paintin, M., & Franchimont, D. P. (2006) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20063 · Cited by 296 · see citing works
Hase, K., Eckmann, L., Leopard, J. D., Varki, N. M., & Kagnoff, M. F. (2002) · Infection and Immunity · doi:10.1128/iai.70.2.953-963.2002 · Cited by 294 · cited 1× · see citing works
“However, some studies reported no change in production of defensins by commensal colonisation of the gut((66,67)), which may be due to differences in the regulatory control of certain AMP.”
BackgroundAdlerberth, I., Ahrne, S., Johansson, M. L., Molin, G., Hanson, L. A., & Wold, A. E. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.7.2244-2251.1996 · Cited by 293 · cited 1× · see citing works
“Probiotics have been shown to inhibit the colonisation of pathogens through competition for common receptors of adhesion((48)).”
BackgroundEmulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation
Laugerette, F., Vors, C., Géloën, A., Chauvin, M., Soulage, C. O., Lambert-Porcheron, S., Peretti, N., Alligier, M., Burcelin, R., Laville, M., et al. (2010) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.11.011 · Cited by 291 · cited 1× · see citing works
“A high fat content in the diet and changes in barrier function are considered to be important factors in endotoxaemia((80,81)).”
BackgroundHodges, K., & Gill, R. K. (2010) · Gut Microbes · doi:10.4161/gmic.1.1.11036 · Cited by 278 · cited 1× · see citing works
“Many pathogens influence barrier permeability through production of toxins that disrupt TJ and/or cause increased secretion or decreased absorption of fluids and electrolytes((52,53)).”
BackgroundAsahara, T., Shimizu, K., Nomoto, K., Hamabata, T., Ozawa, A., & Takeda, Y. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2240-2247.2004 · Cited by 277 · cited 1× · see citing works
“coli (EHEC) 0157:H7 strains in vitro, as well as in vivo in a mouse infection model((54)).”
BackgroundCleusix, V., Lacroix, C., Vollenweider, S., Duboux, M., & Blay, G. L. (2007) · BMC Microbiology · doi:10.1186/1471-2180-7-101 · Cited by 271 · cited 1× · see citing works
“For example, Lactobacillus reuteri can produce reuterin, a secondary metabolite with broadspectrum antimicrobial activity that can modulate the microbiota composition, as well as directly inhibit enteric pathogens((44)).”
BackgroundTop-down systems biology modeling of host metabotype-microbiome associations in obese rodents.
Waldram, A., Holmes, E., Wang, Y.-L., Rantalainen, M., Wilson, I., Tuohy, K., McCartney, A., Gibson, G., & Nicholson, J. (2009) · Journal of Proteome Research · doi:10.1021/pr8009885 · Cited by 269 · see citing works
Caplan, M. S., Miller–Catchpole, R., Kaup, S. M., Russell, T., Lickerman, M. J., Amer, M. D., Xiao, Y., & Thomson, R. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70450-6 · Cited by 269 · see citing works
Saccharomyces boulardii protease inhibits Clostridium difficile toxin A effects in the rat ileum
Castagliuolo, I., LaMont, J. T., Nikulásson, S. Þ., & Pothoulakis, C. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5225-5232.1996 · Cited by 263 · cited 1× · see citing works
“A more specific mechanism has been proposed for probiotic yeast Saccharomyces boulardii that secretes a protease that can degrade Toxin A that is produced by Clostridium difficile((56)).”
BackgroundRegulation of Homeostasis and Inflammation in the Intestine
MacDonald, T. T., Monteleone, I., Fantini, M. C., & Monteleone, G. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.047 · Cited by 262 · cited 1× · see citing works
“There is rather strong evidence that the immune response in CD is directed against the indigenous microbiota, but in UC the role of the microbiota is more contentious((194)).”
BackgroundAidy, S. E., van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D. J., Hooiveld, G. J. E. J., Levenez, F., Dore, J. M., Dekker, J. P., Samsom, J. N., Nieuwenhuis, E. E. S., et al. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.32 · Cited by 249 · cited 1× · see citing works
“Indeed, colonisation of germ-free mice and the expansion of bacteria after weaning caused an increased regenerating family member 3 (Reg3) production((64,65)).”
BackgroundSteed, H., Macfarlane, G. T., Blackett, K. L., Bahrami, B., Reynolds, N., Walsh, S., Cummings, J. H., & Macfarlane, S. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04417.x · Cited by 247 · cited 1× · see citing works
“Synbiotic therapies combine probiotics with prebiotics, and although an initial synbiotic study did not report any benefit in post-operative occurrence of CD((203)), a more recent study reported a slight but significant enhancement of the induction of remission of active CD((204)).”
BackgroundUnderstanding the Susceptibility of the Premature Infant to Necrotizing Enterocolitis (NEC)
Hunter, C. J., Upperman, J. S., Ford, H. R., & Niklas, V. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e31815ed64c · Cited by 246 · see citing works
Sherman, P. M., Johnson-Henry, K. C., Yeung, H. P., Ngo, P. S. C., Goulet, J., & Tompkins, T. A. (2005) · Infection and Immunity · doi:10.1128/iai.73.8.5183-5188.2005 · Cited by 246 · cited 3× · see citing works
“Lactobacillus acidophilus LB((57)) and Lactobacillus helveticus R0052((58)) have been shown to antagonise the cytoskeleton rearrangements caused by EPEC in vitro.”
BackgroundGastrointestinal development and meeting the nutritional needs of premature infants
Neu, J. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.629s · Cited by 246 · see citing works
Everard, A., Geurts, L., Caesar, R., Hul, M. V., Matamoros, S., Duparc, T., Denis, R., Cochez, P. M., Pierard, F., Castel, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms6648 · Cited by 237 · cited 1× · see citing works
“epithelium can enhance the production of inducible antimicrobials such as epithelial β-defensins and members of the antimicrobial C-type lectins in the gut((63)).”
THE ROLE OF THE INTESTINAL BARRIER IN THE PATHOGENESIS OF NECROTIZING ENTEROCOLITIS
Anand, R., Leaphart, C. L., Mollen, K. P., & Hackam, D. J. (2007) · Shock · doi:10.1097/01.shk.0000239774.02904.65 · Cited by 234 · see citing works
Kadooka, Y., Sato, M., Ogawa, A., Miyoshi, M., Uenishi, H., Ogawa, H., Ikuyama, K., Kagoshima, M., & Tsuchida, T. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513001037 · Cited by 232 · cited 1× · see citing works
“gasseri SBT2055 for 12 weeks reduced fat-mass gain, body weight, waist:hip ratio in overweight subjects compared with placebo((110)), an effect recently confirmed by the authors((111)).”
BackgroundMohan, R., Koebnick, C., Schildt, J., Schmidt, S., Mueller, M. J., Possner, M., Radke, M. H., & Blaut, M. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00767-06 · Cited by 231 · cited 1× · see citing works
“clostridia and enterobacteria((145))), which may be related to accompanying increased faecal SCFA levels and lower faecal pH((150)).”
BackgroundMATTE, H. O., Rodriguez, O., & CASTRO, E. A. (1955) · PubMed · Cited by 231 · see citing works
Indrio, F., Riezzo, G., Raimondi, F., Bisceglia, M., Cavallo, L., & Francavilla, R. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.11.005 · Cited by 222 · see citing works
Altenhoefer, A., Oswald, S., Sonnenborn, U., Enders, C., Schulze, J., Hacker, J., & Oelschlaeger, T. A. (2004) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00368-7 · Cited by 221 · cited 1× · see citing works
“of an unidentified factor rather than competition for receptors((51)).”
BackgroundClarke, G. A., Cryan, J. F., Dinan, T. G., & Quigley, E. M. M. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04965.x · Cited by 217 · cited 1× · see citing works
“Particularly, lactic acid bacteria have been selected as promising probiotic candidates in the treatment of IBS((191)).”
BackgroundRougé, C., Piloquet, H., Butel, M., Berger, B. W., Rochat, F., Ferraris, L., Robert, C. D., Legrand, A., de la Cochetière, M.-F., Nguyen, J., et al. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26919 · Cited by 216 · see citing works
Laval, L., Martín, R., Natividad, J. M., Chain, F., Miquel, S., de Maredsous, C. D., Capronnier, S., Sokol, H., Verdu, E. F., Vlieg, J. E. T. V. H., et al. (2014) · Gut Microbes · doi:10.4161/19490976.2014.990784 · Cited by 215 · cited 1× · see citing works
“Mostly, in vitro and ex vivo cell culture((181,182)), as well as animal models such as mice and rats((184,185)), have been used in which epithelial barrier integrity is experimentally disrupted before the”
BackgroundNaito, E., Yoshida, Y., Makino, K., KOUNOSHI, Y., Kunihiro, S., Takahashi, R., Matsuzaki, T., Miyazaki, K., & Ishikawa, F. (2010) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2010.04922.x · Cited by 213 · cited 1× · see citing works
“barrier function and glucose regulation can be elicited by mechanisms that are independent of body weight and fat mass development((109)).”
BackgroundThe effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants
Stratiki, Z., Costalos, C., Sevastiadou, S., Kastanidou, O., Skouroliakou, M., Giakoumatou, A., & Petrohilou, V. (2007) · Early Human Development · doi:10.1016/j.earlhumdev.2006.12.002 · Cited by 208 · cited 2× · see citing works
“an increased relative abundance of faecal bifidobacteria((144)).”
BackgroundHuman-derived probiotic Lactobacillus reuteri strains differentially reduce intestinal inflammation
Liu, Y., Fatheree, N. Y., Mangalat, N., & Rhoads, J. M. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00124.2010 · Cited by 207 · cited 1× · see citing works
“lated both intestinal inflammation and barrier outcomes((148,158,165)).”
Smirnova, M. G., Guo, L., Birchall, J. P., & Pearson, J. P. (2003) · Cellular Immunology · doi:10.1016/s0008-8749(03)00059-5 · Cited by 206 · cited 2× · see citing works
“Analogously, lipopolysaccharide (LPS) can stimulate expression and secretion of MUC5AC and MUC5B(75), and thereby enhance mucus barrier function(75).”
BackgroundBifidobacterium bifidum improves intestinal integrity in a rat model of necrotizing enterocolitis
Khailova, L. S., Dvorak, K., Arganbright, K. M., Halpern, M. D., Kinouchi, T., Yajima, M., & Dvořák, B. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00141.2009 · Cited by 199 · cited 3× · see citing works
“Probiotics were also shown to enhance enterocyte proliferation and migration((148)), to reduce apoptosis and promote epithelial cytoprotective responses((160,162,163)), to improve the expression of the enterocyte injury markers intestinal-type and liver-type fatty-acidbinding proteins (I-FABP and L-FABP)((164)), to re…”
BackgroundGriffiths, E. A., Duffy, L. C., Schanbacher, F. L., Qiao, H., Dryja, D., Leavens, A., Rossman, J., Rich, G. A., DiRienzo, D. B., & Ogra, P. L. O. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000026302.92898.ae · Cited by 197 · see citing works
The Role of Bifidobacteria in Gut Barrier Function After Thermal Injury in Rats
Wang, Z., Xiao, G., Yao, Y.-M., Guo, S., Lu, K., & Sheng, Z. (2006) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/01.ta.0000196574.70614.27 · Cited by 193 · see citing works
Mihatsch, W., Braegger, C., Decsi, T., Kolaček, S., Lanzinger, H., Mayer, B., Moreno, L. A., Pohlandt, F., Puntis, J. W. L., Shamir, R., et al. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.09.004 · Cited by 193 · cited 1× · see citing works
“small trials that use different probiotic strains((126,127)).”
Loonen, L. M. P., Stolte, E. H., Jaklofsky, M., Meijerink, M., Dekker, J. P., van Baarlen, P., & Wells, J. M. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.109 · Cited by 189 · cited 1× · see citing works
“In the small intestine, the mucus layer is thinner, but bacteria are rarely seen in contact with the epithelium((8)), the exception being segmented filamentous bacteria in mice that have an atypical and intimate association with enterocytes((50)).”
BackgroundEnteral feeding of premature infants with Saccharomyces boulardii
Costalos, C., Skouteri, V., Gounaris, A., Sevastiadou, S., Triandafilidou, A., Ekonomidou, C., Kontaxaki, F., & Petrochilou, V. (2003) · Early Human Development · doi:10.1016/s0378-3782(03)00090-2 · Cited by 185 · see citing works
Romeo, M. G., Romeo, D. M., Trovato, L., Oliveri, S. M., Palermo, F., Cota, F., & Betta, P. (2010) · Journal of Perinatology · doi:10.1038/jp.2010.57 · Cited by 183 · see citing works
Probiotics in the management of irritable bowel syndrome and inflammatory bowel disease
Whelan, K., & Quigley, E. M. M. (2013) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835d7bba · Cited by 183 · cited 1× · see citing works
“Taken together, the use of probiotics as a therapy for active CD or for maintenance of disease remission has been disappointing, which has also been concluded in various recent reviews((205,206)).”
BackgroundLactobacillus plantarum 299v Inhibits Escherichia coli-Induced Intestinal Permeability
Mangell, P., Nejdfors, P., Wang, M., Ahrné, S., Weström, B. R., Thorlacius, H., & Jeppsson, B. W. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1017947531536 · Cited by 181 · see citing works
Liu, Y., Fatheree, N. Y., Mangalat, N., & Rhoads, J. M. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00266.2011 · Cited by 181 · cited 3× · see citing works
“lated both intestinal inflammation and barrier outcomes((148,158,165)).”
BackgroundAhl, D., Liu, H., Schreiber, O., Roos, S., Phillipson, M., & Holm, L. (2016) · Acta Physiologica · doi:10.1111/apha.12695 · Cited by 181 · see citing works
A prospective randomised trial of probiotics in critically ill patients
MCNAUGHT, C., WOODCOCK, N., ANDERSON, A., & MACFIE, J. (2005) · Clinical Nutrition · doi:10.1016/j.clnu.2004.08.008 · Cited by 179 · cited 2× · see citing works
“Bacteria can compete with enteric pathogens by competition for carbohydrates depending on the diet((227)).”
BackgroundFailure of Synbiotic 2000 to Prevent Postoperative Recurrence of Crohn’s Disease
Chermesh, I., Tamir, A., Reshef, R., Chowers, Y., Suissa, A., Katz, D., Gelber, M., Halpern, Z., Bengmark, S., & Eliakim, R. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9549-7 · Cited by 178 · cited 1× · see citing works
“Synbiotic therapies combine probiotics with prebiotics, and although an initial synbiotic study did not report any benefit in post-operative occurrence of CD((203)), a more recent study reported a slight but significant enhancement of the induction of remission of active CD((204)).”
BackgroundTanaka, H., Takechi, M., Kiyonari, H., Shioi, G., Tamura, A., & Tsukita, S. (2015) · Gut · doi:10.1136/gutjnl-2014-308419 · Cited by 175 · see citing works
Yun, S., Park, H. O., & Kang, J. H. (2009) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2009.04350.x · Cited by 174 · cited 1× · see citing works
“development in overweight rats((104,105)), whereas in high-fatdiet-induced obese mouse models L.”
BackgroundŠrůtková, D., Schwarzer, M., Hudcovic, T., Zakostelska, Z. J., Dráb, V., Španová, A., Rittich, B., Kozáková, H., & Schabussová, I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134050 · Cited by 172 · see citing works
Yan, F., Liu, L., Dempsey, P. J., Tsai, Y.-H., Raines, E. W., Wilson, C. L., Cao, H., Cao, Z., Liu, L., & Polk, D. B. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.492397 · Cited by 171 · cited 1× · see citing works
“A soluble factor from Bifidobacterium infantis also increases occludin and ZO-1 in epithelial cells in vitro and ameliorates colitis in IL-10 knock-out mice((214,215)).”
BackgroundThe effects of butyrate enemas on visceral perception in healthy volunteers
Vanhoutvin, S. A. L. W., Troost, F. J., Kilkens, T. O. C., Lindsey, P. J., Hamer, H. M., Jonkers, D. M. A. E., Venema, K., & Brummer, R. ‐. M. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01324.x · Cited by 171 · cited 1× · see citing works
“The role of butyrate is especially interesting in this perspective, because it has been shown to alleviate the perception of afferent visceral signalling and, as a consequence, could improve IBS symptoms((193)).”
BackgroundUnderwood, M. A., Salzman, N. H., Bennett, S. H., Barman, M., Mills, D. A., Marcobal, A. M., Tancredi, D. J., Bevins, C. L., & Sherman, M. P. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31818de195 · Cited by 169 · see citing works
Gotteland, M., Cruchet, S., & Verbeke, S. M. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00898.x · Cited by 168 · cited 5× · see citing works
“For example, Gotteland et al.((26)) evaluated the impact of consumption of Lactobacillus rhamnosus GG in healthy human volunteers upon epithelial barrier challenge by treatment with the nonsteroidal anti-inflammatory drug indomethacin.”
BackgroundInfluentialNovel opportunities for next-generation probiotics targeting metabolic syndrome
Cani, P. D., & Van Hul, M. (2015) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.006 · Cited by 167 · cited 2× · see citing works
“In many of these studies, diet-induced obesity models were used to induce metabolic dysfunction in the animal models to subsequently address the possible health beneficial role of probiotic supplementation((103)).”
BackgroundMethodMohan, R., Koebnick, C., Schildt, J., Mueller, M., Radke, M., & Blaut, M. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318181b7fa · Cited by 165 · cited 1× · see citing works
“Notably, this study also reported decreased calprotectin (marker for intestinal inflammation) and increased serum IgA levels in faecal samples((146)), supporting the proposed impact of this probiotic on barrier function either directly or via the decreased relative abundance of pathogenic bacterial groups.”
BackgroundSundin, J., Rangel, I., Fuentes, S., Heikamp‐de Jong, I., Hultgren‐Hörnquist, E., de Vos, W. M., & Brummer, R. J. (2015) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13055 · Cited by 164 · cited 1× · see citing works
“Separate analysis of the faecal and mucosaassociated microbiome in IBS revealed specific patterns and correlates with mucosal lymphocyte phenotypes((176)).”
BackgroundSelf-citation<i>Lactobacillus plantarum</i> strain No. 14 reduces adipocyte size in mice fed high-fat diet
Takemura, N., Okubo, T., & Sonoyama, K. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009377 · Cited by 163 · cited 1× · see citing works
“plantarum 14 supplementation was shown to reduce the mean adipocyte size((106)) and Lactobacillus paracasei F19 could induce a reduction of total fat mass and plasma TAG possibly via a mechanism involving angiopoietin-like factor 4((107)).”
BackgroundThe gut microbiota manages host metabolism
Cani, P. D. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.240 · Cited by 160 · cited 1× · see citing works
“In addition to the resident microbiota, various bacteria transiently pass through the intestine as a consequence of ingestion – for example in fermented food products, or as supplements containing probiotics((3,4)).”
BackgroundCarey, C. M., Kostrzynska, M., Ojha, S., & Thompson, S. (2008) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2008.01.014 · Cited by 157 · cited 1× · see citing works
“EHEC in vitro by fifteen different probiotics, depending on their capacity to produce organic acids((55)).”
BackgroundDelivery strategies to enhance oral vaccination against enteric infections
Davitt, C. J. H., & Lavelle, E. C. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.007 · Cited by 156 · cited 1× · see citing works
“As an alternative, attenuated pathogenic bacteria, which were developed as oral vaccines, have been used for experimental challenge studies in humans((27)).”
BackgroundSiggers, R. H., Siggers, J., Boyé, M., Thymann, T., Mølbak, L., Leser, T. D., Jensen, B. B., & Sangild, P. T. (2008) · Journal of Nutrition · doi:10.1093/jn/138.8.1437 · Cited by 156 · see citing works
Ζουμποπούλου, Γ., Foligné, B., Christodoulou, K., Grangette, C., Pot, B., & Tsakalidou, E. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2007.10.013 · Cited by 155 · see citing works
Increased gut permeability in Crohn’s disease: is TNF the link?
Gibson, P. R. (2004) · Gut · doi:10.1136/gut.2004.047092 · Cited by 152 · see citing works
Moal, V. L.-L., Amsellem, R., Servin, A. L., & Coconnier, M.-H. (2002) · Gut · doi:10.1136/gut.50.6.803 · Cited by 152 · cited 1× · see citing works
“Lactobacillus acidophilus LB((57)) and Lactobacillus helveticus R0052((58)) have been shown to antagonise the cytoskeleton rearrangements caused by EPEC in vitro.”
BackgroundSilva, S. D., Masselot, C. R., Ait-Belgnaoui, A., Mancuso, A., Mercade, M., Salvador–Cartier, C., Gillet, M., Ferrier, L., Loubière, P., Dague, É., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00290.2013 · Cited by 147 · cited 1× · see citing works
“Mostly, in vitro and ex vivo cell culture((181,182)), as well as animal models such as mice and rats((184,185)), have been used in which epithelial barrier integrity is experimentally disrupted before the”
BackgroundParassol, N., Freitas, M., Thoreux, K., Dalmasso, G., Bourdet‐Sicard, R., & Rampal, P. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.09.013 · Cited by 146 · cited 1× · see citing works
“plantarum 299v((59,60)) and Lactobacillus casei DN-114 001((61))”
Jung, S.-P., Lee, K.-M., Kang, J.-H., Yun, S.-I., Park, H.-O., Moon, Y., & Kim, J.-Y. (2013) · Korean Journal of Family Medicine · doi:10.4082/kjfm.2013.34.2.80 · Cited by 140 · cited 2× · see citing works
“Jung et al.(112) have shown that the ingestion of Lactobacillus gasseri BNR17, a strain showing beneficial effects in rodents, reduced weight and waist and hip circumference after 12 weeks of treatment.”
BackgroundGerm-free and Colonized Mice Generate the Same Products from Enteric Prodefensins
Pütsep, K., Axelsson, L.-G., Boman, A., Midtvedt, T., Normark, S. J., Boman, H. G., & Andersson, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007816200 · Cited by 140 · cited 1× · see citing works
“However, some studies reported no change in production of defensins by commensal colonisation of the gut((66,67)), which may be due to differences in the regulatory control of certain AMP.”
BackgroundNew Concepts of Microbial Translocation in the Neonatal Intestine: Mechanisms and Prevention
Sherman, M. P. (2010) · Clinics in Perinatology · doi:10.1016/j.clp.2010.05.006 · Cited by 136 · see citing works
Good, M. L., Sodhi, C. P., Ozolek, J. A., Buck, R. H., Goehring, K. C., Thomas, D. L., Vikram, A., Bibby, K. J., Morowitz, M. J., Firek, B., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00452.2013 · Cited by 135 · cited 2× · see citing works
“Moreover, in these models, the mucosal expression of various factors involved in barrier function regulation and maintenance could be normalised by probiotic supplementation, including TLR4(158) and TLR9(159), mucin and trefoil factor (TFF)(160) and antimicrobial protein and peptides(161).”
BackgroundKang, J.-H., Yun, S.-I., & Park, H.-O. (2010) · The Journal of Microbiology · doi:10.1007/s12275-010-0363-8 · Cited by 135 · cited 1× · see citing works
“development in overweight rats((104,105)), whereas in high-fatdiet-induced obese mouse models L.”
BackgroundIntestinal, segmented, filamentous bacteria
Klaasen, H. L. B. M., Koopman, J. P., Poelma, F. G. J., & Beynen, A. C. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb04986.x · Cited by 132 · cited 1× · see citing works
“In the small intestine, the mucus layer is thinner, but bacteria are rarely seen in contact with the epithelium((8)), the exception being segmented filamentous bacteria in mice that have an atypical and intimate association with enterocytes((50)).”
BackgroundSzajewska, H., Wanke-Rytt, M., & Patro-Gołąb, B. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04837.x · Cited by 131 · cited 1× · see citing works
“diarrhoea in children((33,34)), although with a variable outcome.”
BackgroundEffects of Oral Lactobacillus GG on Enteric Microflora in Low-Birth-Weight Neonates
Agarwal, R. K., Sharma, N., Chaudhry, R., Deorari, A. K., Paul, V. K., Gewolb, I. H., & Panigrahi, P. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200303000-00019 · Cited by 129 · see citing works
Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells
Paolillo, R., Carratelli, C. R., Sorrentino, S., Mazzola, N., & Rizzo, A. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.07.008 · Cited by 125 · see citing works
Whelan, K. (2011) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32834b8082 · Cited by 120 · see citing works
Sherman, M. P., Bennett, S. H., Hwang, F. F. Y., & Yu, C. (2004) · BioMetals · doi:10.1023/b:biom.0000027706.51112.62 · Cited by 120 · see citing works
Amelioration of the Effects ofCitrobacter rodentiumInfection in Mice by Pretreatment with Probiotics
Johnson‐Henry, K. C., Nadjafi, M., Avitzur, Y., Mitchell, D. J., Ngan, B., Galindo‐Mata, E., Jones, N. L., & Sherman, P. M. (2005) · The Journal of Infectious Diseases · doi:10.1086/430318 · Cited by 120 · see citing works
Gut Microbiota and the Pathogenesis of Insulin Resistance
Delzenne, N. M., & Cani, P. D. (2011) · Current Diabetes Reports · doi:10.1007/s11892-011-0191-1 · Cited by 118 · see citing works
Lin, P. W., Nasr, T. R., Berardinelli, A., Kumar, A., & Neish, A. S. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e3181827c0f · Cited by 112 · cited 1× · see citing works
“Probiotics were also shown to enhance enterocyte proliferation and migration((148)), to reduce apoptosis and promote epithelial cytoprotective responses((160,162,163)), to improve the expression of the enterocyte injury markers intestinal-type and liver-type fatty-acidbinding proteins (I-FABP and L-FABP)((164)), to re…”
BackgroundChen, J. J., Wang, R., Li, X., & Wang, R. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010399 · Cited by 112 · cited 1× · see citing works
“longum supplementation via increased expression of intestinal REG-family proteins((116)).”
BackgroundProbiotics for the Treatment of Inflammatory Bowel Disease
Veerappan, G. R., Betteridge, J. D., & Young, P. E. (2012) · Current Gastroenterology Reports · doi:10.1007/s11894-012-0265-5 · Cited by 111 · see citing works
Putaala, H., Salusjärvi, T., Nordström, M., Saarinen, M., Ouwehand, A. C., Hansen, E. B., & Rautonen, N. (2008) · Research in Microbiology · doi:10.1016/j.resmic.2008.08.002 · Cited by 111 · cited 1× · see citing works
“Intriguingly, this Bifidobacterium strain was also shown to competitively exclude the binding of pathogenic bacteria to the mucosa((118)) and improve TJ integrity((119)) in vitro, again pointing towards enhanced intestinal barrier function as the compensatory mode of action.”
BackgroundPachikian, B. D., Neyrinck, A. M., Deldicque, L., Backer, F. C. D., Catry, É., Dewulf, E. M., Sohet, F. M., Bindels, L. B., Everard, A., Francaux, M., et al. (2010) · Journal of Nutrition · doi:10.3945/jn.109.117374 · Cited by 111 · cited 1× · see citing works
“These observations are in agreement with the reduction of metabolic endotoxaemia, gut barrier dysfunction and inflammatory disorders that could be achieved in mice by prebiotic supplementation, which restored the bifidobacterial abundance in the intestinal microbiota((76,83,93,94)).”
ResultProbiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine
Preidis, G. A., Saulnier, D. M. A., Blutt, S. E., Mistretta, T., Riehle, K. P., Major, A. M., Venable, S. F., Finegold, M. J., Petrosino, J. F., Conner, M. E., et al. (2012) · The FASEB Journal · doi:10.1096/fj.10-177980 · Cited by 107 · cited 2× · see citing works
“lated both intestinal inflammation and barrier outcomes((148,158,165)).”
BackgroundIntestinal microbiota in pathophysiology and management of irritable bowel syndrome.
(2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8886 · Cited by 106 · see citing works
Agostini, S., Goubern, M., Tondereau, V., Salvador–Cartier, C., Bézirard, V., Lévèque, M., Keränen, H., Théodorou, V., Bourdu-Naturel, S., Goupil-Feuillerat, N., et al. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01865.x · Cited by 106 · cited 1× · see citing works
“Mostly, in vitro and ex vivo cell culture((181,182)), as well as animal models such as mice and rats((184,185)), have been used in which epithelial barrier integrity is experimentally disrupted before the”
BackgroundWang, H., Gong, J., Wang, W., Long, Y., Fu, X., Fu, Y., Qian, W., & Hou, X. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090153 · Cited by 105 · see citing works
Interferon-γ Regulation of Intestinal Epithelial Permeability
Beaurepaire, C., Smyth, D. R., & McKay, D. M. (2009) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2008.0057 · Cited by 102 · cited 1× · see citing works
“Pro-inflammatory cytokines such as interferonγ((196)) and TNF-α make the epithelium leaky((197)).”
BackgroundBiancheri, P., Sabatino, A. D., Corazza, G. R., & MacDonald, T. T. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1390-z · Cited by 99 · cited 1× · see citing works
“Matrix metalloproteinases such as matrix metallopeptidase (MMP)-12 made by activated macrophages and MMP-3 made by activated myofibroblasts degrade the epithelial basement membrane and disrupt epithelial cell adhesion leading to anoikis((199)).”
BackgroundMichail, S., & Abernathy, F. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200209000-00021 · Cited by 96 · cited 1× · see citing works
“plantarum 299v((59,60)) and Lactobacillus casei DN-114 001((61))”
(2014) · PubMed Central · doi:10.3748/wjg.v20.i27.8859 · Cited by 95 · see citing works
Refinement of a Human Challenge Model for Evaluation of Enterotoxigenic Escherichia coli Vaccines
Harro, C. D., Chakraborty, S., Feller, A. J., DeNearing, B., Cage, A., Ram, M., Lundgren, A., Svennerholm, A., Bourgeois, A. L., Walker, R. I., et al. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.05194-11 · Cited by 95 · cited 1× · see citing works
“offering a model system for controlled enteric pathogen challenge studies in human individuals((28,29)).”
BackgroundMenéndez, A., Willing, B. P., Montero, M., Wlodarska, M., So, C. C., Bhinder, G., Vallance, B. A., & Finlay, B. B. (2012) · Journal of Innate Immunity · doi:10.1159/000341630 · Cited by 92 · see citing works
Risk factors of development of gut-derived bacterial translocation in thermally injured rats
Zhong-tang, W. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i11.1619 · Cited by 90 · see citing works
Li, S., Huang, X.-L., Sui, J., Chen, S., Xie, Y., Deng, Y., Wang, J., Xie, L., Li, T., He, Y., et al. (2013) · European Journal of Pediatrics · doi:10.1007/s00431-013-2220-3 · Cited by 89 · cited 1× · see citing works
“Several studies have evaluated the potential of probiotics in eradication therapy of Helicobacter pylori((32)) and the prevention of rotavirus-caused”
BackgroundArora, T., Anastasovska, J., Gibson, G. R., Tuohy, K. M., Sharma, R. K., Bell, J. D., & Frost, G. S. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114511006957 · Cited by 88 · cited 1× · see citing works
“acidophilus NCDC supplementation in diet-induced obese mice did not induce any significant changes in body fat composition and/or liver and muscle fat content((108)).”
BackgroundDiet during Rotavirus Enteritis Affects Jejunal Permeability to Macromolecules in Suckling Rats
Isolauri, E., Kaila, M., Arvola, T., Majamaa, H., Rantala, I. S., Virtanen, E., & Arvilommi, H. S. (1993) · Pediatric Research · doi:10.1203/00006450-199306000-00002 · Cited by 85 · see citing works
Effect of commensals and probiotics on visceral sensitivity and pain in irritable bowel syndrome
Theodorou, V., Ait-Belgnaoui, A., Agostini, S., & Eutamene, H. (2014) · Gut Microbes · doi:10.4161/gmic.29796 · Cited by 83 · see citing works
Bovee-Oudenhoven, I. M. J., Lettink-Wissink, M. L. G., van Doesburg, W., Witteman, B. J. M., & van der Meer, R. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00884-9 · Cited by 83 · cited 1× · see citing works
“offering a model system for controlled enteric pathogen challenge studies in human individuals((28,29)).”
BackgroundColonization Resistance: Battle of the Bugs or Ménage à Trois with the Host?
Spees, A. M., Lopez, C. A., Kingsbury, D. D., Winter, S., & Bäumler, A. J. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003730 · Cited by 77 · cited 1× · see citing works
“The presence of commensal bacteria can inhibit the efficacy of enteropathogens via ‘colonisation resistance’, which encompasses a variety of molecular mechanisms involving microbe–microbe and/or microbe–host interactions((42,43)).”
BackgroundAngelakis, E., Bastelica, D., Amara, A. B., Filali, A. E., Dutour, A., Mège, J., Alessi, M., & Raoult, D. (2011) · Microbial Pathogenesis · doi:10.1016/j.micpath.2011.10.004 · Cited by 76 · cited 1× · see citing works
“However, a recent study showed that in 3-weekold mice the high-dosage supplementation with Lactobacillus ingluviei (4× 10(10) CFU) led to increased overall weight gain, as well as total liver weight, while not affecting fat mass despite increased transcription levels of the lipogenic markers (PPARγ and sterol regulato…”
BackgroundMultispecies probiotic protects gut barrier function in experimental models
Vivinus-Nébot, M. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6832 · Cited by 72 · cited 1× · see citing works
“Mostly, in vitro and ex vivo cell culture((181,182)), as well as animal models such as mice and rats((184,185)), have been used in which epithelial barrier integrity is experimentally disrupted before the”
BackgroundToumi, R., Abdelouhab, K., Rafa, H., Soufli, I., Raissi-Kerboua, D., Djeraba, Z., & Touil-Boukoffa, C. (2013) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2013.790413 · Cited by 68 · see citing works
Emami, C. N., Petrosyan, M., Giuliani, S., Williams, M., Hunter, C. J., Prasadarao, N. V., & Ford, H. R. (2009) · Surgical Infections · doi:10.1089/sur.2009.054 · Cited by 66 · see citing works
The role of epithelial tight junctions involved in pathogen infections
Lu, R., Yang, W., & Hu, Y.-J. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3543-5 · Cited by 65 · cited 1× · see citing works
“Many pathogens influence barrier permeability through production of toxins that disrupt TJ and/or cause increased secretion or decreased absorption of fluids and electrolytes((52,53)).”
BackgroundEvaluation of probiotic treatment in a neonatal animal model
Lee, D. J., Drongowski, R. A., Coran, A. G., & Harmon, C. M. (2000) · Pediatric Surgery International · doi:10.1007/s003830050736 · Cited by 64 · cited 1× · see citing works
“clostridia and enterobacteria((145))), which may be related to accompanying increased faecal SCFA levels and lower faecal pH((150)).”
Background
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Mucus barrier, mucins and gut microbiota: the expected slimy partners?
Paone, P., & Cani, P. D. (2020) · Gut · doi:10.1136/gutjnl-2020-322260 · Cited by 1,602 · see citing works
Human gut microbiota/microbiome in health and diseases: a review
Gomaa, E. Z. (2020) · Antonie van Leeuwenhoek · doi:10.1007/s10482-020-01474-7 · Cited by 1,294 · see citing works
Regulation of the intestinal barrier by nutrients: The role of tight junctions
Suzuki, T. (2020) · Animal Science Journal · doi:10.1111/asj.13357 · Cited by 754 · see citing works
“These aspects are not extensively discussed in the current review as they have been recently reviewed elsewhere (Bron et al., 2017; Hiippala et al., 2018).”
BackgroundFermented foods in a global age: east meets West
Tamang, J. P., Cotter, P. D., Endo, A., Han, N. S., Kort, R., Liu, S. Q., Mayo, B., Westerik, N., & Hutkins, R. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12520 · Cited by 719 · see citing works
Li, P., Wang, H., Guo, L., Gou, X., Chen, G., Lin, D., Fan, D., Guo, X., & Liu, Z. (2022) · BMC Medicine · doi:10.1186/s12916-022-02657-x · Cited by 577 · see citing works
“Although the present study did not find a causal effect of bacteria, which were previously reported to impair the intestinal barrier in PE, some probiotics such as Bifidobacterium have been reported to stimulate the expression of Mucins 3 in intestinal epithelial cells [67] and restore mucus growth [68], thereby maint…”
ResultNutrition, immunity and COVID-19
Calder, P. C. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000085 · Cited by 587 · see citing works
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity
Wang, X., Zhang, P., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26196076 · Cited by 529 · see citing works
“There is substantial evidence that probiotics can strengthen the intestinal barrier, regulate mucosal immune function, and produce metabolites beneficial to the host to maintain health, as illustrated in Figure 1 [22,23].”
BackgroundHow Probiotics Affect the Microbiota
Wieërs, G., Belkhir, L., Enaud, R., Leclercq, S., de Foy, J.-M. P., Dequenne, I., de Timary, P., & Cani, P. D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00454 · Cited by 544 · see citing works
“Several dozens of specific strains of Lactobacillus or Bifidobacterium have been studied in various protocols and models (for review Cani and Van Hul, 2015; Bron et al., 2017; Borgeraas et al., 2018; Hiippala et al., 2018).”
BackgroundThe role of the microbiome for human health: From basic science to clinical applications
Mohajeri, M. H., Brummer, R. J. M., Rastall, R. A., Weersma, R. K., Harmsen, H. J. M., Faas, M., & Eggersdorfer, M. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1703-4 · Cited by 440 · see citing works
“The potential of probiotic bacteria to improve intestinal barrier function is discussed extensively in a recent review [49].”
BackgroundThe progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Probiotics and the microbiota-gut-brain axis: Focus on psychiatry
Mörkl, S., Butler, M. I., Holl, A., Cryan, J. F., & Dinan, T. G. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00313-5 · Cited by 337 · see citing works
The Gut-Brain Axis: Influence of Microbiota on Mood and Mental Health.
Appleton, J. (2018) · Europe PMC (PubMed Central) · Cited by 337 · see citing works
Intestinal dysbiosis and probiotic applications in autoimmune diseases
de Oliveira, G. L. V., Leite, A. Z., Higuchi, B. S., Gonzaga, M. I., & Mariano, V. S. (2017) · Immunology · doi:10.1111/imm.12765 · Cited by 320 · see citing works
How do intestinal probiotics restore the intestinal barrier?
Gou, H.-Z., Zhang, Y.-L., Ren, L., Li, Z.-J., & Zhang, L. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.929346 · Cited by 326 · see citing works
Flavonoids, Dairy Foods, and Cardiovascular and Metabolic Health
Mozaffarian, D., & Wu, J. H. Y. (2018) · Circulation Research · doi:10.1161/circresaha.117.309008 · Cited by 305 · see citing works
“systemic circulation), a putative contributor to obesity-related diseases.(189) Probiotics also seem to influence host microbiota”
BackgroundGao, J., Li, Y., Wan, Y., Hu, T., Liu, L., Yang, S., Gong, Z., Zeng, Q., Wei, Y., Yang, W., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00477 · Cited by 298 · see citing works
“…of a number of intestinal-related diseases, including irritable bowel syndrome, inflammatory bowel disease, acute liver failure and extra-intestinal infectious diseases (Martín et al., 2016; Xiong et al., 2016; Bron et al., 2017; Vancamelbeke and Vermeire, 2017; Assimakopoulos et al., 2018).”
BackgroundProbiotics in Medicine: A Long Debate
Stavropoulou, E., & Bezirtzoglou, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02192 · Cited by 295 · see citing works
Ni, Y., Yang, X., Zheng, L., Wang, Z., Wu, L., Jiang, J., Yang, T., Ma, L., & Fu, Z. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900603 · Cited by 255 · see citing works
Shared mechanisms among probiotic taxa: implications for general probiotic claims
Sanders, M. E., Benson, A. K., Lebeer, S., Merenstein, D. J., & Klaenhammer, T. R. (2017) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2017.09.007 · Cited by 254 · see citing works
“Positively impacting intestinal barrier function is a major probiotic mechanism [47].”
BackgroundThe critical role of gut microbiota in obesity
Cheng, Z., Zhang, L., Yang, L., & Chu, H. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1025706 · Cited by 233 · see citing works
“Moreover, the spectacular success of FMT in Clostridium difficile infections treatment indicates that FMT is emerging as a potential therapeutic candidate for multiple diseases associated with gut dysbiosis, such as chronic constipation, irritable bowel syndrome and ulcerative colitis (107).”
BackgroundProbiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants
Sharif, S., Meader, N., Oddie, S., Rojas, M. X., & McGuire, W. L. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005496.pub5 · Cited by 223 · see citing works
Gut Microbiota and Diarrhea: An Updated Review
Li, Y., Xia, S., Jiang, X., Feng, C., Gong, S., Ma, J., Fang, Z., Yin, J., & Yin, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.625210 · Cited by 219 · see citing works
“Probiotics have been widely reported to treat pathogens-caused diarrhea by maintaining or improving the balance of gut microbiota and the mechanisms may be associated with the inhibitory effect on the colonization of harmful bacteria by competing for nutrients and producing antibacterial compounds (Bron et al., 2017).”
BackgroundCui, Y., Wang, Q., Chang, R., Zhou, X., & Xu, C. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b00080 · Cited by 217 · see citing works
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 217 · see citing works
Molecular mechanisms of probiotic prevention of antibiotic-associated diarrhea
Mekonnen, S. A., Merenstein, D. J., Fraser, C. M., & Marco, M. L. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.01.005 · Cited by 198 · see citing works
“Currently, specific compounds responsible for probiotic-induced changes to epithelial barrier function are largely unknown [52].”
BackgroundProtective Microbiota: From Localized to Long-Reaching Co-Immunity
Chiu, L., Bazin, T., Truchetet, M., Schaeverbeke, T., Delhaès, L., & Pradeu, T. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01678 · Cited by 192 · see citing works
Probiotics: Versatile Bioactive Components in Promoting Human Health
Sharifi‐Rad, J., Rodrigues, C. F., Stojanović-Radić, Z. Z., Dimitrijević, M., Aleksić, A., Neffe‐Skocińska, K., Zielińska, D., Kołożyn‐Krajewska, D., Salehi, B., Prabu, S. M., et al. (2020) · Medicina · doi:10.3390/medicina56090433 · Cited by 191 · see citing works
The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics
Camara-Lemarroy, C. R., Metz, L. M., Meddings, J. B., Sharkey, K. A., & Yong, V. W. (2018) · Brain · doi:10.1093/brain/awy131 · Cited by 188 · see citing works
“Probiotics have emerged as an interesting option in regulating intestinal barrier function, fuelled by research in both in vitro and in vivo models that show that some microbiota can stabilize the intestinal barrier (Bron et al., 2017).”
BackgroundGut microbiota and diabetes: From correlation to causality and mechanism
Li, W., Stirling, K., Yang, J., & Zhang, L. (2020) · World Journal of Diabetes · doi:10.4239/wjd.v11.i7.293 · Cited by 187 · see citing works
Schoultz, I., & Keita, Å. V. (2019) · Cells · doi:10.3390/cells8020193 · Cited by 187 · see citing works
“Probiotics have been proposed to have an impact on the intestinal barrier directly, by limiting the colonization of pathogenic bacteria as well as indirectly by interacting with innate immune cells, leading to the production of IL-22 and the initiation of specific mucin genes [147].”
BackgroundThe Role of Intestinal Mucosal Barrier in Autoimmune Disease: A Potential Target
An, J., Liu, Y., Wang, Y., Fan, R., Hu, X., Zhang, F., Yang, J., & Chen, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.871713 · Cited by 191 · see citing works
“There is increasing evidence that the intestinal microbiome plays a key role in regulating and supporting the intestinal mucosa barrier (10, 39).”
BackgroundSchepper, J. D., Collins, F. L., Rios-Arce, N. D., Raehtz, S., Schaefer, L., Gardinier, J. D., Britton, R. A., Parameswaran, N., & McCabe, L. R. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3635 · Cited by 182 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
“Numerous pre-clinical studies have shown that oral probiotics are capable of positively influencing gut barrier function and systemic immunity, and thus, in the case of pneumonia, may enhance the host’s ability to suppress and clear reproducing lung pathogens as they emerge (Bron et al., 2017) (Forsythe, 2014).”
BackgroundInfluentialProbiotics and necrotizing enterocolitis
Patel, R. M., & Underwood, M. A. (2017) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2017.11.008 · Cited by 170 · see citing works
“There are a number of mechanisms of probiotic action in the gut, which include: 1) upregulation of cytoprotective genes (24); 2) downregulation of pro-inflammatory gene expression (25–28); 3) production of butyrate and other short chain fatty acids that nourish colonocytes and lower the pH and oxygen tension within th…”
BackgroundTargeted Delivery of Probiotics: Perspectives on Research and Commercialization
Yoha, K. S., Nida, S., Dutta, S., Moses, J. A., & Anandharamakrishnan, C. (2021) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-021-09791-7 · Cited by 170 · see citing works
Impact of probiotics and prebiotics on food texture
Guimarães, J. T., Balthazar, C. F., Silva, R., Rocha, R. S., da Graça, J. S., Esmerino, E. A., Silva, M. C., Sant’Ana, A. S., Duarte, M. C. K. H., Freitas, M. Q., et al. (2019) · Current Opinion in Food Science · doi:10.1016/j.cofs.2019.12.002 · Cited by 165 · see citing works
Oral nanomedicine for modulating immunity, intestinal barrier functions, and gut microbiome
Lee, Y., Kamada, N., & Moon, J. J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114021 · Cited by 168 · see citing works
“Moreover, some commensal microbial species, such as Lactobacillus spp [83,84], Bifidobacterium longum [85], Lactobacillus reuteri [86], and Akkermansia muciniphila [87–92], promote the mucin production and increase the mucus layer thickness.”
BackgroundXu, H., Zhang, Y., Wang, P., Zhang, J., Chen, H., Zhang, L., Du, X., Zhao, C., Wu, D., Liu, F., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.03.024 · Cited by 163 · see citing works
Chu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 159 · see citing works
“Thus, probiotics could be used as adjuvant therapy to treat immune-mediated diseases [162, 163].”
BackgroundIntestinal epithelial barrier functions in ageing
Branca, J. J. V., Gulisano, M., & Nicoletti, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100938 · Cited by 157 · see citing works
Hungin, A. P. S., Mitchell, C. R., Whorwell, P., Mulligan, C., Cole, O., Agréus, L., Fracasso, P., Lionis, C., Mendive, J., Philippart de Foy, J. ‐., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14539 · Cited by 154 · see citing works
“microorganisms, inhibition of pathogen adhesion, production of anti-microbial substances and modulation of the immune system.(4-6) Studies in several animal models have indicated positive therapeutic results for probiotics in a range of conditions, such as asthma,(7) obesity,(8,9) diabetes mellitus,(10) hypertension,(…”
Yao, M., Li, B., Ye, H., Huang, W., Luo, Q., Xiao, H., McClements, D. J., & Li, L. (2018) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2018.05.024 · Cited by 151 · see citing works
“Probiotics have been used as treatments for various diseases due to their ability to promote a healthier gut microbiota (Bron et al., 2017).”
BackgroundWang, Y., Xie, Q., Zhang, Y., Ma, W., Ning, K., Xiang, J., Cui, J., & Xiang, H. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10259-6 · Cited by 144 · see citing works
Dunleavy, K. A., Raffals, L. E., & Camilleri, M. (2023) · Digestive Diseases and Sciences · doi:10.1007/s10620-023-08122-w · Cited by 132 · see citing works
Brugman, S., Ikeda‐Ohtsubo, W., Braber, S., Folkerts, G., Pieterse, C. M. J., & Bakker, P. A. H. M. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00080 · Cited by 127 · see citing works
“, via increasing mucosal immunity, regulating Thelper cell responses, and release of cytokines) (160, 162, 169, 170).”
BackgroundThe influence of antibiotics and dietary components on gut microbiota
Dudek-Wicher, R. K., Junka, A., & Bartoszewicz, M. (2018) · Gastroenterology Review · doi:10.5114/pg.2018.76005 · Cited by 126 · see citing works
“The gut microbiota contributes to the structural development of the gut mucosa and can also modulate mucosal glycosylation patterns that are microbial attachment sites both at the cell surface and subcellular levels [8, 13, 14].”
BackgroundLimosilactobacillus reuteri in Health and Disease
Abuqwider, J., Altamimi, M., & Mauriello, G. (2022) · Microorganisms · doi:10.3390/microorganisms10030522 · Cited by 124 · see citing works
Chong, H.-X., Yusoff, N. A. A., Hor, Y.-Y., Lew, L.-C., Jaafar, M. H., Choi, S. B., Yusoff, M. S. B., Wahid, N. A., Abdullah, M. F. I. L. B., Zakaria, N., et al. (2019) · Journal of Dairy Science · doi:10.3168/jds.2018-16103 · Cited by 121 · see citing works
Human Intestinal Barrier: Effects of Stressors, Diet, Prebiotics, and Probiotics
Camilleri, M. (2021) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000308 · Cited by 121 · see citing works
“The ability of probiotics to alter intestinal barrier and microbiome has been recently reviewed (46) and is summarized in this study.”
BackgroundInfluentialDeng, H., Yang, S., Zhang, Y., Qian, K., Zhang, Z., Liu, Y., Wang, Y., Bai, Y., Fan, H., Zhao, X., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02976 · Cited by 121 · see citing works
Probiotics: A Promising Candidate for Management of Colorectal Cancer
Tripathy, A., Dash, J., Kancharla, S., Kolli, P., Mahajan, D., Senapati, S., & Jena, M. K. (2021) · Cancers · doi:10.3390/cancers13133178 · Cited by 118 · see citing works
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice
Mendes, M. C. S., Paulino, D. S., Brambilla, S. R., Camargo, J. A., Persinoti, G. F., & Carvalheira, J. B. C. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i18.1995 · Cited by 116 · see citing works
Qiu, K., Li, C., Wang, J., Qi, G., Gao, J. L., Zhang, H., & Wu, S. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.786878 · Cited by 116 · see citing works
“Gut commensals, referred to as probiotics, were discovered to reinforce intestinal health by impacting the intestinal barrier function (39, 40).”
BackgroundBajić, S. S., Đokić, J., Dinić, M., Veljović, K., Golić, N., Mihajlović, S., & Tolinački, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00527 · Cited by 109 · see citing works
Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism
Din, A. U., Hassan, A., Zhu, Y. S., Zhang, K., Wang, Y., Li, T., Wang, Y., & Wang, G. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108353 · Cited by 109 · see citing works
Zhou, L., & Xiao, X. (2017) · Bioscience Reports · doi:10.1042/bsr20171234 · Cited by 107 · see citing works
Bai, Y., Huang, F., Zhang, R., Dong, L., Jia, X., Liu, L., Yi, Y., & Zhang, M. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115475 · Cited by 106 · see citing works
Wang, G., Huang, S., Cai, S., Yu, H., Wang, Y., Zeng, X., & Qiao, S. (2020) · Nutrients · doi:10.3390/nu12082298 · Cited by 107 · see citing works
Duchon, J. M., Barbian, M. E., & Denning, P. W. (2021) · Clinics in Perinatology · doi:10.1016/j.clp.2021.03.002 · Cited by 106 · see citing works
The Role of Mucosal Immunity in the Pathogenesis of Necrotizing Enterocolitis
Hodzic, Z., Bolock, A. M., & Good, M. L. (2017) · Frontiers in Pediatrics · doi:10.3389/fped.2017.00040 · Cited by 104 · see citing works
“Moreover, there are several mechanisms by which probiotics can prevent the development of NEC (187).”
BackgroundRoyal Jelly: Biological Action and Health Benefits
Oršolić, N., & Jembrek, M. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116023 · Cited by 103 · see citing works
Song, X., Wang, M., Dong, L., Zhu, H., & Wang, J. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006899 · Cited by 101 · see citing works
Costa, R. J. S., Gaskell, S. K., McCubbin, A. J., & Snipe, R. M. J. (2019) · Temperature · doi:10.1080/23328940.2019.1597676 · Cited by 101 · see citing works
“infection and inflammation) [164], it is suggested that probiotic supplementation may also ameliorate exercise-associated gastrointestinal perturbations.”
BackgroundAluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers
Hao, W., Hao, C., Wu, C., Xu, Y., & Jin, C. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.132556 · Cited by 101 · see citing works
Wang, Y., Guo, Y., Chen, H., Wei, H., & Wan, C. (2018) · Canadian Journal of Microbiology · doi:10.1139/cjm-2017-0716 · Cited by 99 · see citing works
Receptor-targeted engineered probiotics mitigate lethal Listeria infection
Drolia, R., Amalaradjou, M. A. R., Ryan, V., Tenguria, S., Liu, D., Bai, X., Xu, L., Singh, A. K., Cox, A. D., Bernal-Crespo, V., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-20200-5 · Cited by 100 · see citing works
Role of prebiotics in enhancing the function of next-generation probiotics in gut microbiota
Fei, Y., Chen, Z., Han, S., Zhang, S., Zhang, T., Lu, Y., Berglund, B., Xiao, H., Li, L., & Yao, M. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1958744 · Cited by 103 · see citing works
“For example, butyrate, being a primary substrate for intestinal epithelial cells, increases intestinal mucus production, stimulates the proliferation of colonocytes and strengthens tight junctions by reducing bacterial translocation (Bron et al. 2017; Lewis et al. 2010; Wilson andWhelan 2017).”
BackgroundMicrobiota and Probiotics in Health and HIV Infection
D’Angelo, C., Reale, M., & Costantini, E. (2017) · Nutrients · doi:10.3390/nu9060615 · Cited by 97 · see citing works
Engineering Diagnostic and Therapeutic Gut Bacteria
Landry, B. P., & Tabor, J. J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.bad-0020-2017 · Cited by 95 · see citing works
“These microbes have been used to treat Clostridium infection (7); in fl amma-tory diseases such as obesity, diabetes, and in fl ammatory bowel disease (8); and neurological conditions such as anxiety, depression, and autism spectrum disorder (6), among other pathologies.”
Singh, A., Vishwakarma, V., & Singhal, B. (2018) · Advances in Bioscience and Biotechnology · doi:10.4236/abb.2018.94012 · Cited by 95 · see citing works
Probiotics in microbiome ecological balance providing a therapeutic window against cancer
Sehrawat, N., Yadav, M. K., Singh, M. P., Kumar, V., Sharma, V., & Sharma, A. K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.009 · Cited by 95 · see citing works
Hu, J. P., Chen, L., Zheng, W., Shi, M. Y., Liu, L., Xie, C., Wang, X., Niu, Y., Hou, Q., Xu, X., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00897 · Cited by 94 · see citing works
“Growing evidences have revealed that probiotics (benign commensals) facilitated the intestinal epithelial barrier function maintenance in mammals (Bron et al., 2011, 2017; Wan et al., 2016).”
BackgroundSales, K. M., & Reimer, R. A. (2022) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2022.09.002 · Cited by 97 · see citing works
“This reduces the translocation of bacteria and endotoxins from the intestinal lumen into systemic circulation, thus reducing inflammation and improving immunity.(78) As a result, it is possible the Lactobacillus and Bifidobacterium interventions indirectly improved endurance exercise capacity by enhancing intestinal b…”
BackgroundHan, C., Xiao, Y., Liu, E., Su, Z., Meng, X., & Liu, B. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.07.247 · Cited by 93 · see citing works
Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants
Sharif, S., Meader, N., Oddie, S., Rojas, M. X., & McGuire, W. L. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005496.pub6 · Cited by 112 · see citing works
The ameliorative effect of Lactobacillus plantarum -12 on DSS-induced murine colitis
Sun, M., Liu, Y., Song, Y., Gao, Y., Zhao, F., Luo, Y., Qian, F., Mu, G., & Tuo, Y. (2020) · Food & Function · doi:10.1039/d0fo00007h · Cited by 92 · see citing works
The Potential Effects of Probiotics and ω-3 Fatty Acids on Chronic Low-Grade Inflammation
Hutchinson, A. N., Tingö, L., & Brummer, R. J. (2020) · Nutrients · doi:10.3390/nu12082402 · Cited by 90 · see citing works
Zhao, T.-S., Xie, L., Cai, S., Xu, J., Zhou, H., Tang, L., Yang, C., Fang, S., Li, M., & Tian, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.717636 · Cited by 88 · see citing works
“A study reported that the beneficial bacteria regulated the composition of gut microbiota by competing for nutrients or producing metabolites, and affected the colonization of intestinal pathogens (Bron et al., 2017; Pickard et al., 2017).”
BackgroundChen, T., Shen, M., Yu, Q., Chen, Y., Wen, H., Lu, H., Chen, D., & Xie, J. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133768 · Cited by 87 · see citing works
Advances in Probiotic Regulation of Bone and Mineral Metabolism
McCabe, L. R., & Parameswaran, N. (2018) · Calcified Tissue International · doi:10.1007/s00223-018-0403-7 · Cited by 85 · see citing works
Obesity and Multiple Sclerosis—A Multifaceted Association
Schreiner, T. G., & Genes, T.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10122689 · Cited by 82 · see citing works
“We should also mention early research related to probiotic treatment and fecal microbial transplantation that modifies the intestinal microbiota ecosystem and could be useful in MS, although currently without significant therapeutic impact (Bron et al., 2017) [70].”
BackgroundFilippis, A. D., Ullah, H., Baldi, A., Dacrema, M., Esposito, C., Garzarella, E. U., Santarcangelo, C., Tantipongpiradet, A., & Daglia, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144929 · Cited by 85 · see citing works
“Probiotics can provide a number of benefits to the host beyond nutrition, such as enhancing intestinal epithelial integrity, regulating immunity of the GI mucosa, protecting gut barrier disruption, and inhibiting the growth and/or activity of pathogenic microbes in the GI [70,71,99].”
BackgroundRomán, E., Nieto, J. C., Gely, C., Vidal, S., Pozuelo, M., Poca, M., Juárez, C., Guarner, C., Manichanh, C., & Soriano, G. (2019) · Hepatology Communications · doi:10.1002/hep4.1325 · Cited by 80 · see citing works
“Nevertheless, we would like to point out that the results from the biomarkers used in the present study that could suggest an improvement in the intestinal barrier after probiotic treatment are consistent with previous data.(23,38-45) As future research, a study with a larger number of patients and with a longer treat…”
ResultEffect of Non-Nutritive Sweeteners on the Gut Microbiota
Conz, A., Salmona, M., & Diomede, L. (2023) · Nutrients · doi:10.3390/nu15081869 · Cited by 80 · see citing works
“They are also a crucial energy source for intestinal epithelial cells, reinforcing the mucosal barrier [28,29].”
BackgroundGarcía-Castillo, V., Komatsu, R., Clua, P., Indo, Y., Takagi, M., Salva, S., Islam, M. A., Alvarez, S., Takahashi, H., García, A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01376 · Cited by 79 · see citing works
“Experimental models have demonstrated that immunobiotics can attenuate the severity of infections caused by several gastrointestinal pathogens including Helicobacter pylori, Citrobacter rodentium, Listeria monocytogenes, and Salmonella typhimurium (16).”
BackgroundInteractions of probiotics and prebiotics with the gut microbiota
Ballan, R., Battistini, C., Xavier-Santos, D., & Saad, S. M. I. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.03.008 · Cited by 81 · see citing works
“leading to the activation of NF-κB and production of cytokines such as TNF-α, which results in increased insulin resistance due to an IRS-1 phosphorylation in serine.(142,143) Interestingly, some scientists have attempted to”
BackgroundDeng, H., Yang, S., Zhang, Y., Qian, K., Zhang, Z., Liu, Y., Wang, Y., Bai, Y., Fan, H., Zhao, X., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00601 · Cited by 79 · see citing works
Soluble Fiber and Insoluble Fiber Regulate Colonic Microbiota and Barrier Function in a Piglet Model
Chen, T., Chen, D., Tian, G., Zheng, P., Mao, X., Yu, J., He, J., Huang, Z., Luo, Y., Luo, J., et al. (2019) · BioMed Research International · doi:10.1155/2019/7809171 · Cited by 78 · see citing works
Jiang, H., Zhang, Y., Xu, D., & Wang, Q. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23650 · Cited by 76 · see citing works
Ferro, M., Charneca, S., Dourado, E., Guerreiro, C. S., & Fonseca, J. E. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.711788 · Cited by 75 · see citing works
“Examples include the adherent Lactobacillus spp, which can stimulate MUC3 expression in human intestinal epithelial cells and MUC2 production and secretion (Sicard et al., 2017; Bron et al., 2017), and Lactobacillus reuteri (L.”
BackgroundKing, S., Tancredi, D. J., Lenoir‐Wijnkoop, I., Gould, K. M., Vann, H., Connors, G., Sanders, M. E., Linder, J. A., Shane, A. L., & Merenstein, D. (2018) · European Journal of Public Health · doi:10.1093/eurpub/cky185 · Cited by 76 · see citing works
Kleerebezem, M., Binda, S., Bron, P. A., Gross, G., Hill, C., Vlieg, J. E. V. H., Lebeer, S., Satokari, R. M., & Ouwehand, A. C. (2018) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2018.09.007 · Cited by 73 · see citing works
“Finally, most of the AAD associated pathogens disturb the intestinal barrier, an effect that could be compensated by probiotic stimulation of barrier integrity and/or repair [36,37].”
BackgroundElazzazy, A. M., Baeshen, M. N., Alasmi, K. M., Alqurashi, S. I., Desouky, S. E., & Khattab, S. M. R. (2025) · Microorganisms · doi:10.3390/microorganisms13030566 · Cited by 77 · see citing works
“Unlike probiotics, postbiotics do not rely on live microorganisms, making them more stable and easier to incorporate into health interventions.”
Is there a relationship between intestinal microbiota, dietary compounds, and obesity?
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Probiotics in Gut-Bone Signaling
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Spotlight on the Compositional Quality of Probiotic Formulations Marketed Worldwide
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- Authors
- Bron, P. A., Kleerebezem, M., Brummer, R.-J., Cani, P. D., Mercenier, A., MacDonald, T. T., Garcia-Ródenas, C. L., & Wells, J. M.
- Affiliations
- Nederlands Instituut Voor Zuivel Oonderzoek (NL)
- Wageningen University & Research (NL)
- Örebro University (SE)
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Nestlé (Switzerland) (CH)
- Queen Mary University of London (GB)
- Corresponding author
- Bron, Peter A.
- ORCID
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-01-14
- Volume
- 117
- Issue
- 1
- Pages
- 93-107
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC5297585
- OpenAlex
- W2573938105
- Cited by
- 499
- References
- 232
- Citations by year
- 2026: 54 · 2025: 47 · 2024: 55 · 2023: 52 · 2022: 64 · 2021: 67 · 2020: 54 · 2019: 43 · 2018: 42 · 2017: 19 · 2016: 1
- FWCI
- 4.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- British Journal Of Nutrition (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc-nd)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by-nc-nd)
- Funders
- Fonds De La Recherche Scientifique - FNRS (WELBIO-CR-2012S-02R)
- Walloon excellence in life sciences and biotechnology
- FP7 Ideas: European Research Council (336452)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, intestinal barrier function, epithelial barrier integrity, mucosal homeostasis, gastrointestinal diseases, irritable bowel syndrome, inflammatory bowel disease, necrotizing enterocolitis, obesity, diabetes mellitus, pathogen infection
- MeSH terms
- Animals, Humans, Intestinal Diseases, Intestines, Probiotics
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