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Bifidobacterium infantis35624 modulates host inflammatory processes beyond the gut
Open accessAbstract
Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert beneficial immunoregulatory effects by mimicking commensal-immune interactions; however, the value of these effects in patients with non-gastrointestinal inflammatory conditions remains unclear. In this study, we assessed the impact of oral administration of B. infantis 35624, for 6‒8 weeks on inflammatory biomarker and plasma cytokine levels in patients with ulcerative colitis (UC) (n = 22), chronic fatigue syndrome (CFS) (n = 48) and psoriasis (n = 26) in three separate randomized, double-blind, placebo-controlled interventions. Additionally, the effect of B. infantis 35624 on immunological biomarkers in healthy subjects (n = 22) was assessed. At baseline, both gastrointestinal (UC) and non-gastrointestinal (CFS and psoriasis) patients had significantly increased plasma levels of C-reactive protein (CRP) and the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) compared with healthy volunteers. B. infantis 35624 feeding resulted in reduced plasma CRP levels in all three inflammatory disorders compared with placebo. Interestingly, plasma TNF-α was reduced in CFS and psoriasis while IL-6 was reduced in UC and CFS. Furthermore, in healthy subjects, LPS-stimulated TNF-α and IL-6 secretion by peripheral blood mononuclear cells (PBMCs) was significantly reduced in the B. infantis 35624-treated groups compared with placebo following eight weeks of feeding. These results demonstrate the ability of this microbe to reduce systemic pro-inflammatory biomarkers in both gastrointestinal and non-gastrointestinal conditions. In conclusion, these data show that the immunomodulatory effects of the microbiota in humans are not limited to the mucosal immune system but extend to the systemic immune system.
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“the immune modulation effect of B. infantis 35624 was extended to systemic level since it was effective in reducing inflammatory biomarkers in patients with non-gastrointestinal inflammatory processes, such as chronic fatigue syndrome and psoriasis [144]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [144]
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“The studies carried out with the strain 35624 show that it was effective in reducing the proinflammatory state of patients with IBD [142,143] , as well as with UC [144]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [144]
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The gut microbiome as a major regulator of the gut-skin axis
Salem, I., Ramser, A., Isham, N., & Ghannoum, M. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01459 · Cited by 707
“In a separate placebocontrolled study of psoriasis patients, Bifidobacterium infantis 35624 supplementation led to significantly reduced plasma levels of TNF-α in the probiotic-treated group (Table 2) (Groeger et al., 2013).”
Background
Metadata
- Authors
- Groeger, D., O’Mahony, L., Murphy, E. F., Bourke, J. F., Dinan, T. G., Kiely, B., Shanahan, F., & Quigley, E. M. M.
- Affiliations
- Alimentary Health (Ireland) (IE)
- University of Zurich (CH)
- South Infirmary Victoria University Hospital (IE)
- University College Cork (IE)
- Corresponding author
- Quigley, Eamonn M.M.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2013-07-12
- Volume
- 4
- Issue
- 4
- Pages
- 325-339
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC3744517
- OpenAlex
- W2056812430
- Cited by
- 448
- References
- 57
- Citations by year
- 2026: 16 · 2025: 52 · 2024: 54 · 2023: 52 · 2022: 56 · 2021: 40 · 2020: 29 · 2019: 36 · 2018: 28 · 2017: 30 · 2016: 16 · 2015: 21 · 2014: 15 · 2013: 3
- FWCI
- 27.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut Microbes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- probiotics, immunomodulation, ulcerative colitis, chronic fatigue syndrome, psoriasis, systemic inflammation, C-reactive protein, TNF-α, interleukin-6, peripheral blood mononuclear cells, gut microbiota
- MeSH terms
- Administration, Oral, Adolescent, Adult, Aged, Bifidobacterium, C-Reactive Protein, Colitis, Ulcerative, Double-Blind Method, Female, Humans, Immunosuppression Therapy, Male, Middle Aged, Placebos, Psoriasis, Fatigue Syndrome, Chronic, Cytokines, Treatment Outcome, Probiotics, Gastrointestinal Tract, Young Adult
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