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Bifidobacterium infantis35624 modulates host inflammatory processes beyond the gut
Open accessAbstract
Certain therapeutic microbes, including Bifidobacteria infantis (B. infantis) 35624 exert beneficial immunoregulatory effects by mimicking commensal-immune interactions; however, the value of these effects in patients with non-gastrointestinal inflammatory conditions remains unclear. In this study, we assessed the impact of oral administration of B. infantis 35624, for 6‒8 weeks on inflammatory biomarker and plasma cytokine levels in patients with ulcerative colitis (UC) (n = 22), chronic fatigue syndrome (CFS) (n = 48) and psoriasis (n = 26) in three separate randomized, double-blind, placebo-controlled interventions. Additionally, the effect of B. infantis 35624 on immunological biomarkers in healthy subjects (n = 22) was assessed. At baseline, both gastrointestinal (UC) and non-gastrointestinal (CFS and psoriasis) patients had significantly increased plasma levels of C-reactive protein (CRP) and the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) compared with healthy volunteers. B. infantis 35624 feeding resulted in reduced plasma CRP levels in all three inflammatory disorders compared with placebo. Interestingly, plasma TNF-α was reduced in CFS and psoriasis while IL-6 was reduced in UC and CFS. Furthermore, in healthy subjects, LPS-stimulated TNF-α and IL-6 secretion by peripheral blood mononuclear cells (PBMCs) was significantly reduced in the B. infantis 35624-treated groups compared with placebo following eight weeks of feeding. These results demonstrate the ability of this microbe to reduce systemic pro-inflammatory biomarkers in both gastrointestinal and non-gastrointestinal conditions. In conclusion, these data show that the immunomodulatory effects of the microbiota in humans are not limited to the mucosal immune system but extend to the systemic immune system.
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“the immune modulation effect of B. infantis 35624 was extended to systemic level since it was effective in reducing inflammatory biomarkers in patients with non-gastrointestinal inflammatory processes, such as chronic fatigue syndrome and psoriasis [144]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [144]
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“The studies carried out with the strain 35624 show that it was effective in reducing the proinflammatory state of patients with IBD [142,143] , as well as with UC [144]”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [144]
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“It can regulate host’s immune responses [17], relieve allergic symptoms [18], and treat inflammatory diseases [19].”
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“2015 [48] 60/Inactive ≥18 UCDAI Probiotic vs. control a Bio-Three Placebo * Petersen et al. 2014 [49] 50/Active ≥18 CAI Probiotic vs. control a Mutaflor Placebo Groeger et al. 2013 [50] 22/Active ≥18 Not assessed Probiotic vs. control B. infantis 35624 b Placebo Outcomes considered in this systematic review were the e…”
Human Microbiome: Composition and Role in Inflammatory Skin Diseases
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Probiotics: A potential immunomodulator in COVID-19 infection management
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“[54] Groeger D , O’Mahony L , Murphy EF , Bourke JF , Dinan TG , et al.”
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Metabolite and Microbiome Interplay in Cancer Immunotherapy
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“Changes to the microbiome have been associated with various inflammatory diseases, such as atopic dermatitis (2) and psoriasis (3) as well as chronic lung diseases [chronic obstructive pulmonary disease (COPD) and cystic fibrosis], which are associated with the state of the lung microbiome (4).”
BackgroundMechanisms of microbe-immune system dialogue within the skin
Lunjani, N., Ahearn-Ford, S., Dube, F. S., Hlela, C., & O’Mahony, L. (2021) · Genes and Immunity · doi:10.1038/s41435-021-00133-9 · Cited by 114
“Other recent studies have shown potentially beneficial effects of oral probiotics in plaque psoriasis [87, 88], adult AD [89], hand dermatitis [90], papulopustular rosacea, seborrhoeic dermatitis [86] and dandruff [91].”
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Altmann, F., Kosma, P., O’Callaghan, A. A., Leahy, S. C., Bottacini, F., Molloy, E. M., Plattner, S., Schiavi, E., Gleinser, M., Groeger, D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162983 · Cited by 97
“Administration of this bacterium to humans increases Foxp3+ lymphocytes in peripheral blood, enhances IL-10 secretion ex vivo, and reduces the level of circulating proinflammatory biomarkers in a wide range of patient groups and healthy volunteers [16, 17].”
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Lunjani, N., Hlela, C., & O’Mahony, L. (2019) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0000000000000542 · Cited by 93
“Little has been reported on the clinical effects of probiotic treatment in patients with psoriasis, but administration of a Bifidobacterium longum strain to adults with psoriasis resulted in reduced circulating levels of C-reactive protein, tumor necrosis factor, and IL17 [55].”
BackgroundSelf-citationEmerging role of gut microbiota in autoimmune diseases
Wang, X., Yuan, W., Yang, C., Wang, Z., Zhang, J., Xu, D., Sun, X., & Sun, W. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1365554 · Cited by 104
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“[19] Groeger D, O’Mahony L, Murphy EF, et al.”
Transforming Psoriasis Care: Probiotics and Prebiotics as Novel Therapeutic Approaches
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“showed that Bifidobacteria infantis supplementation reduced the proinflammatory status by reducing LPS-stimulated TNF-α and IL-6 levels in healthy participants [47].”
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“In the sera and colonic tissues of UC patients, the levels of IL1β, IL-6 and TNF-α were significantly higher than those of normal subjects, while down-regulation of them could prevent UC (Galli et al., 2011; Roberts-Thomson et al., 2011; Groeger et al., 2013).”
BackgroundThe Defect in Regulatory T Cells in Psoriasis and Therapeutic Approaches
Kanda, N., Hoashi, T., & Saeki, H. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10173880 · Cited by 85
“Oral administration of B. infantis 35624 in patients with psoriasis reduced plasma levels of TNF-α and CRP [76].”
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How do probiotics and prebiotics function at distant sites?
Reid, G., Abrahamsson, T., Bailey, M. T., Bindels, L. B., Bubnov, R. V., Ganguli, K. A., Martoni, C., O’Neill, C. A., Savignac, H. M., Stanton, C., et al. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0222 · Cited by 84
Balancing reactive oxygen species generation by rebooting gut microbiota
Singh, V., Ahlawat, S., Mohan, H., Gill, S. S., & Sharma, K. K. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15504 · Cited by 85
“…and superoxide radical (O2 •−) Reduces the production of pro- inflammatory cytokines; epithelial cell renewal Villéger et al. (2018); Feng et al. (2015); Groeger et al. (2013) Lactobacillus Yes IBD Upregulates antioxidant factors (e.g. SOD1, SOD2, GPX2) Reduces the production of pro- inflammatory…”
BackgroundInflammatory proteins are altered in chronic fatigue syndrome—A systematic review and meta-analysis
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Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model
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“…for their immunomodulatory effects especially on Th17 and in the amelioration of inflammatory process (de Vrese et al., 2005; Wang et al., 2011; Groeger et al., 2013; Jungersen et al., 2014; King et al., 2014; Han et al., 2016; Schiavi et al., 2016; Bozkurt et al., 2019; Bozkurt and Kara,…”
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“infantis 35624 is able to reduce proinflammatory biomarkers in a systemic inflammatory disorder [24]; however, future studies should incorporate clinical grading and assessments.”
BackgroundProbiotics: Protecting Our Health from the Gut
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The growth potential for dairy probiotics
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“This is supportedbystudies showing thatprobiotic food can enhancemucosal immunity to better eradicate the common cold virus and relieve its effect on fever, rhinorrhoea, and cough incidence (Groeger et al., 2013; Leyer, Li, Mubasher, Reifer, & Ouwehand, 2009).”
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“infantis for the treatment of ulcerative colitis and psoriasis, it was found to lead to a reduction in the C reactive protein (CRP) levels [72].”
BackgroundThe role of the microbiome in psoriasis: moving from disease description to treatment selection?
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Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches
Štofilová, J., Kvaková, M., Kamlárová, A., Hijová, E., Bertková, I., & Guľašová, Z. (2022) · Biomedicines · doi:10.3390/biomedicines10092236 · Cited by 78
Metadata
- Authors
- Groeger, D., O’Mahony, L., Murphy, E. F., Bourke, J. F., Dinan, T. G., Kiely, B., Shanahan, F., & Quigley, E. M. M.
- Affiliations
- Alimentary Health (Ireland) (IE)
- University of Zurich (CH)
- South Infirmary Victoria University Hospital (IE)
- University College Cork (IE)
- Corresponding author
- Quigley, Eamonn M.M.
- Venue
- Gut Microbes
- Publisher
- Informa UK Limited
- Published
- 2013-07-12
- Volume
- 4
- Issue
- 4
- Pages
- 325-339
- ISSN
- 1949-0976 (ISSN-L)
- 1949-0984
- PMC
- PMC3744517
- OpenAlex
- W2056812430
- Cited by
- 448
- References
- 57
- Citations by year
- 2026: 16 · 2025: 52 · 2024: 54 · 2023: 52 · 2022: 56 · 2021: 40 · 2020: 29 · 2019: 36 · 2018: 28 · 2017: 30 · 2016: 16 · 2015: 21 · 2014: 15 · 2013: 3
- FWCI
- 27.31
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Gut Microbes (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- probiotics, immunomodulation, ulcerative colitis, chronic fatigue syndrome, psoriasis, systemic inflammation, C-reactive protein, TNF-α, interleukin-6, peripheral blood mononuclear cells, gut microbiota
- MeSH terms
- Administration, Oral, Adolescent, Adult, Aged, Bifidobacterium, C-Reactive Protein, Colitis, Ulcerative, Double-Blind Method, Female, Humans, Immunosuppression Therapy, Male, Middle Aged, Placebos, Psoriasis, Fatigue Syndrome, Chronic, Cytokines, Treatment Outcome, Probiotics, Gastrointestinal Tract, Young Adult
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