The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The involvement of the JAK-STAT signaling pathway in chronic inflammatory skin disease atopic dermatitis
Open accessAbstract
Atopic dermatitis (AD), a common chronic inflammatory skin disease, is characterized by inflammatory cell skin infiltration. The JAK-STAT pathway has been shown to play an essential role in the dysregulation of immune responses in AD, including the exaggeration of Th2 cell response, the activation of eosinophils, the maturation of B cells, and the suppression of regulatory T cells (Tregs). In addition, the JAK-STAT pathway, activated by IL-4, also plays a critical role in the pathogenesis of AD by upregulating epidermal chemokines, pro-inflammatroy cytokines, and pro-angiogenic factors as well as by downregulating antimicrobial peptides (AMPs) and factors responsible for skin barrier function. In this review, we will highlight the recent advances in our understanding of the JAK-STAT pathway in the pathogenesis of AD.
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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
Shimoda, K., van Deursent, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A. A., et al. (1996) · Nature · doi:10.1038/380630a0 · Cited by 1,278
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Ehret, G. B., Reichenbach, P., Schindler, U., Horvath, C. M., Fritz, S., Nabholz, M., & Bucher, P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m001748200 · Cited by 369
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O'Shea, J. J., Lahesmaa, R., Vahedi, G., Laurence, A., & Kanno, Y. (2011) · Nature Reviews Immunology · doi:10.1038/nri2958 · Cited by 295
Th2 Cytokines Act on S100/A11 to Downregulate Keratinocyte Differentiation
Howell, M. D., Fairchild, H. R., Kim, B. E., Bin, L., Boguniewicz, M., Redzic, J. S., Hansen, K. C., & Leung, D. Y. M. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.74 · Cited by 224
Mechanism of HBD-3 deficiency in atopic dermatitis
Howell, M. D., Boguniewicz, M., Pastore, S., Novak, N., Bieber, T., Girolomoni, G., & Leung, D. Y. M. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.08.008 · Cited by 208
Interleukin-10 Downregulates Anti-Microbial Peptide Expression in Atopic Dermatitis
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Cited by
Simpson, E. L., Sinclair, R., Forman, S., Wollenberg, A., Aschoff, R., Cork, M., Bieber, T., Thyssen, J. P., Yosipovitch, G., Flohr, C., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30732-7 · Cited by 522
Topical tofacitinib for atopic dermatitis: a phase II a randomized trial
Bissonnette, R., Papp, K. A., Poulin, Y., Gooderham, M., Raman, M., Mallbris, L., Wang, C., Purohit, V., Mamolo, C., Papacharalambous, J., et al. (2016) · British Journal of Dermatology · doi:10.1111/bjd.14871 · Cited by 420
JAK inhibitors in the treatment of atopic dermatitis
Chovatiya, R., & Paller, A. S. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.08.009 · Cited by 398
Guttman-Yassky, E., Thaçi, D., Pangan, A. L., Hong, H. C.-H., Papp, K. A., Reich, K., Beck, L. A., Mohamed, M.-E. F., Othman, A. A., Anderson, J. K., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.11.025 · Cited by 369
Environmental risk factors and their role in the management of atopic dermatitis
Kantor, R., & Silverberg, J. I. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1212660 · Cited by 365
Metadata
- Authors
- Bao, L., Zhang, H., & Chan, L. S.
- Venue
- JAK-STAT
- Publisher
- Informa UK Limited
- Published
- 2013-07-15
- Volume
- 2
- Issue
- 3
- Pages
- e24137
- ISSN
- 2162-3988 (ISSN-L)
- 2162-3996
- OpenAlex
- W1982385791
- Cited by
- 320
- References
- 8
- FWCI
- 8.12
- Type
- journal article
- Language
- en
- Open access
- bronze
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