The DOI matches its Crossref record; 136 of the 136 references it cites were found in a registry or an index.
Candida albicans pathogenicity mechanisms
Open accessAbstract
The polymorphic fungus Candida albicans is a member of the normal human microbiome. In most individuals, C. albicans resides as a lifelong, harmless commensal. Under certain circumstances, however, C. albicans can cause infections that range from superficial infections of the skin to life-threatening systemic infections. Several factors and activities have been identified which contribute to the pathogenic potential of this fungus. Among them are molecules which mediate adhesion to and invasion into host cells, the secretion of hydrolases, the yeast-to-hypha transition, contact sensing and thigmotropism, biofilm formation, phenotypic switching and a range of fitness attributes. Our understanding of when and how these mechanisms and factors contribute to infection has significantly increased during the last years. In addition, novel virulence mechanisms have recently been discovered. In this review we present an update on our current understanding of the pathogenicity mechanisms of this important human pathogen.
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“The link between mitochondrial respiration and pathogenicity in C. albicans is well established, and the capability of adapting cellular metabolism to different stress conditions is an important aspect of this connection (Mayer et al. 2013; Sun et al. 2019; Liu et al. 2023).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Mayer et al. 2013
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“The link between mitochondrial respiration and pathogenicity in C. albicans is well established, and the capability of adapting cellular metabolism to different stress conditions is an important aspect of this connection (Mayer et al. 2013; Sun et al. 2019; Liu et al. 2023).”
From Mitochondrial retrograde control of transcription evolves with respiratory stress, metabolic adaptation, and virulence in budding yeasts (2026) · cites this paper as Mayer et al. 2013
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“Besides this, lipase activity has been detected and shown to be involved in the pathogenicity of yeasts such as Candida, Cryptococcus, or Malassezia species (Mayer et al. 2013; Park et al. 2013; Sommer et al. 2016).”
From Biocontrol yeasts: mechanisms and applications (2019) · cites this paper as Mayer et al. 2013
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Cited by
Sorted by citations
The wound microbiota: microbial mechanisms of impaired wound healing and infection
Uberoi, A., McCready-Vangi, A. R., & Grice, E. A. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01035-z · Cited by 963
Antifungal Drug Resistance: Molecular Mechanisms in Candida albicans and Beyond
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Candida albicans—The Virulence Factors and Clinical Manifestations of Infection
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“The transition from yeast to the hyphal form is a transition into a pathogenic form [22,23].”
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Metadata
- Authors
- Mayer, F. L., Wilson, D., & Hube, B.
- Affiliations
- Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) (DE)
- Jena University Hospital (DE)
- Corresponding author
- Hube, Bernhard
- Venue
- Virulence
- Publisher
- Informa UK Limited
- Published
- 2013-02-15
- Volume
- 4
- Issue
- 2
- Pages
- 119-128
- ISSN
- 2150-5594 (ISSN-L)
- 2150-5608
- PMC
- PMC3654610
- OpenAlex
- W2144035662
- Semantic Scholar
- ea82d70b2925d03c8aa23ad612a18cdb8c6906ed
- Cited by
- 1,848
- References
- 136
- Citations by year
- 2026: 99 · 2025: 162 · 2024: 163 · 2023: 180 · 2022: 195 · 2021: 189 · 2020: 164 · 2019: 156 · 2018: 150 · 2017: 119 · 2016: 97 · 2015: 84 · 2014: 57 · 2013: 30
- FWCI
- 11.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Virulence (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (01EO1002)
- Bundesministerium für Bildung und Forschung (01EO1002)
- International Leibniz Research School for Microbial and Biomolecular Interactions
- Leibniz-Gemeinschaft
- Center for Sepsis Control and Care (BMBF 01EO1002, 01EO1002)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, fungal pathogenicity, virulence factors, host cell invasion, yeast-to-hypha transition, tactile sensing, thigmotropism, biofilm formation, phenotypic switching, commensal to pathogen transition, systemic candidiasis, superficial fungal infections
- MeSH terms
- Candida albicans, Candidiasis, Humans, Virulence Factors
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