The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.
Mesenchymal stem cells: Emerging mechanisms of immunomodulation and therapy
Open accessAbstract
Mesenchymal stem cells (MSCs) are a pleiotropic population of cells that are self-renewing and capable of differentiating into canonical cells of the mesenchyme, including adipocytes, chondrocytes, and osteocytes. They employ multi-faceted approaches to maintain bone marrow niche homeostasis and promote wound healing during injury. Biomedical research has long sought to exploit their pleiotropic properties as a basis for cell therapy for a variety of diseases and to facilitate hematopoietic stem cell establishment and stromal reconstruction in bone marrow transplantation. Early results demonstrated their usage as safe, and there was little host response to these cells. The discovery of their immunosuppressive functions ushered in a new interest in MSCs as a promising therapeutic tool to suppress inflammation and down-regulate pathogenic immune responses in graft-versus-host and autoimmune diseases such as multiple sclerosis, autoimmune diabetes, and rheumatoid arthritis. MSCs produce a large number of soluble and membrane-bound factors, some of which inhibit immune responses. However, the full range of MSC-mediated immune-modulation remains incompletely understood, as emerging reports also reveal that MSCs can adopt an immunogenic phenotype, stimulate immune cells, and yield seemingly contradictory results in experimental animal models of inflammatory disease. The present review describes the large body of literature that has been accumulated on the fascinating biology of MSCs and their complex effects on immune responses.
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Cites
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Cited by
Perets, N., Betzer, O., Shapira, R., Brenstein, S., Angel, A., Sadan, T., Ashery, U., Popovtzer, R., & Offen, D. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b04148 · Cited by 382
Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?
Oryan, A., Kamali, A., Moshiri, A., & Baghaban Eslaminejad, M. (2017) · Cells Tissues Organs · doi:10.1159/000469704 · Cited by 353
Luz-Crawford, P., Djouad, F., Toupet, K., Bony, C., Franquesa, M., Hoogduijn, M. J., Jorgensen, C., & Noël, D. (2016) · Stem Cells · doi:10.1002/stem.2254 · Cited by 274
Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy
Li, T., Xia, M., Gao, Y., Chen, Y., & Xu, Y. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1051528 · Cited by 263
Maumus, M., Rozier, P., Boulestreau, J., Jorgensen, C., & Noël, D. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00997 · Cited by 203
Metadata
- Authors
- Glenn, J. D.
- Venue
- World Journal of Stem Cells
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2014
- Volume
- 6
- Issue
- 5
- Pages
- 526
- ISSN
- 1948-0210 (ISSN-L)
- OpenAlex
- W2170589477
- Cited by
- 406
- References
- 89
- FWCI
- 21.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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