The DOI matches its Crossref record; 85 of the 85 references it cites were found in a registry or an index.
Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy
Abstract
INTRODUCTION: Human umbilical cord mesenchymal stem cells (HUC-MSCs) are one of the typical adult stem cells; they have superiorities including low immunogenicity, non-invasive harvest procedure, easy expansion in vitro, and ethical access compared with stem cells from other sources. Therefore, HUC-MSCs are a promising candidate for cell-based therapy. AREAS COVERED: Here we reviewed the development of stem cell-based therapy, the manufacturing and banking process of HUC-MSCs, the emerging clinical studies in the field of cancer, central nervous system diseases, liver diseases and graft-versus-host disease, the potential therapeutic mechanisms, as well as challenges of HUC-MSCs in clinical translation. EXPERT OPINION: HUC-MSCs seem to be an optimal choice for stem cell-based therapy. However, before the cells translate from basic to clinical research, some problems still remain to be solved: i) building regulatory guidelines as well as an efficient and safe manufacturing procedure; ii) establishing donor's genetic testing and long-term closely monitoring system; iii) conducting further clinical trials to determine the optimum and standard dosage, time, route, frequency and many other technical issues of HUC-MSCs transplantation.
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Stem cell-derived exosomes: emerging therapeutic opportunities for wound healing
Zhou, C., Zhang, B., Yang, Y., Jiang, Q., Li, T., Gong, J., Tang, H., & Zhang, Q. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03345-0 · Cited by 341
Self-citationTreatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
Shu, L., Niu, C., Li, R., Huang, T., Wang, Y., Huang, M., Ji, N., Zheng, Y., Chen, X., Shi, L., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01875-5 · Cited by 303
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297
Self-citationXin, L., Lin, X., Pan, Y., Zheng, X., Shi, L., Zhang, Y., Ma, L., Gao, C., & Zhang, S. (2019) · Acta Biomaterialia · doi:10.1016/j.actbio.2019.05.012 · Cited by 201
Metadata
- Authors
- Li, T., Xia, M., Gao, Y., Chen, Y., & Xu, Y.
- Venue
- Expert Opinion on Biological Therapy
- Publisher
- Informa UK Limited
- Published
- 2015-06-12
- Volume
- 15
- Issue
- 9
- Pages
- 1293-1306
- ISSN
- 1471-2598 (ISSN-L)
- 1744-7682
- OpenAlex
- W2097452330
- Cited by
- 263
- References
- 85
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, T., Xia, M., Gao, Y., Chen, Y., & Xu, Y. (2015). Human umbilical cord mesenchymal stem cells: an overview of their potential in cell-based therapy. Expert Opinion on Biological Therapy. https://doi.org/10.1517/14712598.2015.1051528
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