BCL-6 Overexpression as a predictor for endometriosis in patients undergoing in vitro fertilization
Open accessAbstract
OBJECTIVE: To evaluate the positive predictive value (PPV) of endometrial BCL-6 overexpression as a noninvasive screening test endometriosis in patients undergoing in vitro fertilization (IVF). METHODS: Retrospective cohort study at a university-affiliated private practice. Inclusion criteria were reproductive age females currently undergoing IVF with a diagnosis of unexplained infertility or unexplained recurrent pregnancy loss. Those with endometrial BCL-6 overexpression underwent laparoscopic surgery with an indication for treatment of suspected endometriosis. The primary outcome was the PPV of endometrial BCL-6 testing to surgically diagnose endometriosis. Statistical analysis was performed using SPSS v.25.0. RESULTS: Seventy-five patients met inclusion criteria for our study. The PPV of BCL-6 testing for endometriosis was 96%. Of those patients without endometriosis, 100% had other inflammatory pelvic pathologies, which were diagnosed and treated at the time of laparoscopy. CONCLUSIONS: Endometrial BCL-6 overexpression has a high PPV for diagnosing endometriosis and can help identify a patient population that may require surgical treatment before embryo transfer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A positive ReceptivaDx test indicates possible progesterone resistance or BCL6 overexpression, commonly associated with endometriosis-related infertility.
“A subset of patients was referred following a positive ReceptivaDx test, indicating possible progesterone resistance or BCL6 overexpression, commonly associated with endometriosis-related infertility [14].”
From Selective Appendectomy in Patients Undergoing Minimally Invasive Surgery for Endometriosis: A Retrospective Cohort Study (2025) · cites this paper as [14]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Clinical diagnosis of endometriosis: a call to action
Agarwal, S. K., Chapron, C., Giudice, L. C., Laufer, M. R., Leyland, N., Missmer, S. A., Singh, S. S., & Taylor, H. S. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2018.12.039 · Cited by 843 · see citing works
Self-citationBulletti, C., Coccia, M. E., Battistoni, S., & Borini, A. (2010) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-010-9436-1 · Cited by 776 · see citing works
Burney, R. O., Talbi, S., Hamilton, A. E., Vo, K. C., Nyegaard, M., Nezhat, C. R., Lessey, B. A., & Giudice, L. C. (2007) · Endocrinology · doi:10.1210/en.2006-1692 · Cited by 735 · see citing works
Self-citationMacer, M. L., & Taylor, H. S. (2012) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2012.10.002 · Cited by 681 · see citing works
Endometriosis and infertility: a committee opinion
(2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.05.031 · Cited by 633 · see citing works
Mack, M. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.010 · Cited by 516 · see citing works
What exactly is endometrial receptivity?
Lessey, B. A., & Young, S. L. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.02.009 · Cited by 440 · see citing works
Endometriosis‐associated infertility: aspects of pathophysiological mechanisms and treatment options
Tanbo, T., & Fedorcsak, P. (2017) · Acta Obstetricia et Gynecologica Scandinavica · doi:10.1111/aogs.13082 · Cited by 432 · see citing works
Lessey, B. A., & Kim, J. J. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.05.031 · Cited by 286 · see citing works
Uterine polyps, adenomyosis, leiomyomas, and endometrial receptivity
Munro, M. G. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.02.008 · Cited by 248 · see citing works
Time to redefine endometriosis including its pro-fibrotic nature
Vigano, P., Candiani, M., Monno, A., Giacomini, E., Vercellini, P., & Somigliana, E. (2018) · Human Reproduction · doi:10.1093/humrep/dex354 · Cited by 235 · see citing works
Donnez, J., Lousse, J., Jadoul, P., Donnez, O., & Squifflet, J. P. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2009.02.065 · Cited by 218 · see citing works
Bowel endometriosis: Diagnosis and management
Nezhat, C., Li, A., Falik, R., Copeland, D., Razavi, G., Shakib, A., Mihailide, C., Bamford, H., DiFrancesco, L., Tazuke, S., et al. (2018) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.09.023 · Cited by 205 · see citing works
Self-citationEvidence-based treatments for couples with unexplained infertility: a guideline
Penzias, A., Bendikson, K. A., Falcone, T., Hansen, K., Hill, M., Jindal, S., Mersereau, J., Racowsky, C., Rebar, R., Steiner, A. Z., et al. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.10.014 · Cited by 198 · see citing works
Thoracic Endometriosis Syndrome: A Review of Diagnosis and Management
Nezhat, C., Lindheim, S. R., Backhus, L., Vu, M., Vang, N., Nezhat, A., & Nezhat, C. (2019) · JSLS : Journal of the Society of Laparoendoscopic Surgeons · doi:10.4293/jsls.2019.00029 · Cited by 189 · see citing works
Self-citationImmune-inflammation gene signatures in endometriosis patients
Ahn, S. H., Khalaj, K., Young, S. L., Lessey, B. A., Koti, M., & Tayade, C. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.07.005 · Cited by 187 · see citing works
Endometriosis: ancient disease, ancient treatments
NEZHAT, C. R., Nezhat, F. R., & NEZHAT, C. H. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.08.001 · Cited by 177 · see citing works
Self-citationLittman, E. D., Giudice, L. C., Lathi, R. B., Berker, B., Milki, A. A., & NEZHAT, C. R. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.02.059 · Cited by 162 · see citing works
Self-citationImplications of immune dysfunction on endometriosis associated infertility
Miller, J., Ahn, S., Monsanto, S. P., Khalaj, K., Koti, M., & Tayade, C. (2016) · OncoTarget · doi:10.18632/oncotarget.12577 · Cited by 157 · see citing works
Nezhat, F. R., NEZHAT, C. R., Allan, C. J., METZGER, D. A., & Sears, D. L. (1992) · PubMed · Cited by 137 · see citing works
Self-citationVEERASWAMY, A., LEWIS, M., MANN, A., KOTIKELA, S., HAJHOSSEINI, B., & NEZHAT, C. (2010) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0b013e3181e0ea6e · Cited by 132 · see citing works
Self-citationEutopic endometrium in women with endometriosis: ground zero for the study of implantation defects
Lessey, B., Lebovic, D., & Taylor, R. (2013) · Seminars in Reproductive Medicine · doi:10.1055/s-0032-1333476 · Cited by 113 · see citing works
Endometrial BCL6 Overexpression in Eutopic Endometrium of Women With Endometriosis
Evans-Hoeker, E. A., Lessey, B. A., Jeong, J. W., Savaris, R. F., Palomino, W. A., Yuan, L., Schammel, D. P., & Young, S. L. (2016) · Reproductive Sciences · doi:10.1177/1933719116649711 · Cited by 113 · see citing works
Pathophysiology and management of urinary tract endometriosis
Nezhat, C., Falik, R., McKinney, S., & King, L. P. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.58 · Cited by 113 · see citing works
Self-citationGeorgiou, E. X., Melo, P., Baker, P. E., Sallam, H. N., Arici, A., Garcia-Velasco, J. A., Abou-Setta, A. M., Becker, C., & Granne, I. E. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013240.pub2 · Cited by 113 · see citing works
Endometrial BCL6 testing for the prediction of in vitro fertilization outcomes: a cohort study
Almquist, L. D., Likes, C. E., Stone, B., Brown, K. R., Savaris, R., Forstein, D. A., Miller, P. B., & Lessey, B. A. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2017.09.017 · Cited by 88 · see citing works
Chronic Inflammation May Enhance Leiomyoma Development by the Involvement of Progenitor Cells
Orciani, M., Caffarini, M., Biagini, A., Lucarini, G., Carpini, G. D., Berretta, A., Primio, R. D., & Ciavattini, A. (2018) · Stem Cells International · doi:10.1155/2018/1716246 · Cited by 80 · see citing works
Optimal Management of Endometriosis and Pain
NEZHAT, C. R., Vang, N., Tanaka, P. P., & NEZHAT, C. H. (2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003461 · Cited by 78 · see citing works
Self-citationStrong Association Between Endometriosis and Symptomatic Leiomyomas
Nezhat, C., Li, A., Abed, S., Balassiano, E., Soliemannjad, R., Nezhat, A., Nezhat, C. H., & Nezhat, F. (2016) · JSLS : Journal of the Society of Laparoendoscopic Surgeons · doi:10.4293/jsls.2016.00053 · Cited by 75 · see citing works
Self-citationThe Role of Tumor Necrosis Factor α in the Biology of Uterine Fibroids and the Related Symptoms
Ciebiera, M., Włodarczyk, M., Zgliczyńska, M., Łukaszuk, K., Męczekalski, B., Kobierzycki, C., Łoziński, T., & Jakiel, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123869 · Cited by 67 · see citing works
Soriano, D., Adler, I., Bouaziz, J., Zolti, M., Eisenberg, V. H., Goldenberg, M., Seidman, D. S., & Elizur, S. E. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.06.003 · Cited by 62 · see citing works
The Link Between Endometriosis and Ovarian Cancer
Nezhat, F. R., Pejovic, T., Reis, F. M., & Guo, S.-W. (2014) · International Journal of Gynecological Cancer · doi:10.1097/igc.0000000000000100 · Cited by 58 · see citing works
Likes, C. E., Cooper, L. J., Efird, J. L., Forstein, D. A., Miller, P. B. W., Savaris, R. F., & Lessey, B. A. (2019) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-018-1388-x · Cited by 48 · see citing works
Evans, M. B., Stentz, N. C., Richter, K. S., Schexnayder, B., Connell, M. T., Healy, M. W., Devine, K., Widra, E. A., Stillman, R. J., DeCherney, A. H., et al. (2020) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003795 · Cited by 32 · see citing works
Classification of endometriosis:Improving the classification of endometriotic ovarian cysts
NEZHAT, C. R., Nezhat, F. R., NEZHAT, C. R., & Seidman, D. S. (1994) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a138423 · Cited by 30 · see citing works
Self-citationGerbie, A. B., & Merrill, J. A. (1988) · Clinical Obstetrics & Gynecology · doi:10.1097/00003081-198812000-00004 · Cited by 29 · see citing works
Endometriosis doubles odds for miscarriage in patients undergoing IVF or ICSI
Pallacks, C., Hirchenhain, J., Krüssel, J.-S., Fehm, T. N., & Fehr, D. (2017) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2017.04.008 · Cited by 17 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [31]Falik RC Li A Farrimound F Razavi GM Nezhat C Nezhat F. Endometriomas: classification and surgical management. OBG Management. 2017; 29: 39– 43.
Cited by
Sorted by citations
Nezhat, C., Najmi, Z., Mirzaie, M., Harding, Q., Pennington, Z., Amirlatifi, N., Khaloghli, R., Zarroug, D., & Sokol, E. R. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14207277 · Cited by 1 · see citing works
“A subset of patients was referred following a positive ReceptivaDx test, indicating possible progesterone resistance or BCL6 overexpression, commonly associated with endometriosis-related infertility [14].”
Self-citation
- Authors
- Nezhat, C., Rambhatla, A., Miranda-Silva, C., Asiaii, A., Nguyen, K., Eyvazzadeh, A., Tazuke, S., Agarwal, S., Jun, S., Nezhat, A., & Roman, R. A.
- Affiliations
- University of California, San Francisco (US)
- Stanford Medicine (US)
- Unidade Local de Saúde de Coimbra (PT)
- Center for Special Minimally Invasive and Robotic Surgery (US)
- Colorado Center for Reproductive Medicine (US)
- Corresponding author
- Nezhat, Camran
- Venue
- JSLS : Journal of the Society of Laparoscopic & Robotic Surgeons
- Published
- 2020
- Volume
- 24
- Issue
- 4
- Pages
- e2020.00064
- ISSN
- 1086-8089 (ISSN-L)
- 1938-3797
- PMC
- PMC7757768
- OpenAlex
- W3119641241
- Cited by
- 34
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 12 · 2023: 5 · 2022: 8
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc-nd
- Locations
- JSLS Journal of the Society of Laparoscopic & Robotic Surgeons (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, in vitro fertilization, endometrial biopsy, positive predictive value, endometriosis screening, unexplained infertility, recurrent pregnancy loss, diagnostic laparoscopy, embryo transfer
- MeSH terms
- Adult, Endometriosis, Female, Fertilization in Vitro, Humans, Infertility, Female, Middle Aged, Laparoscopy, Pregnancy, Retrospective Studies, Biomarkers, Pregnancy Rate, Proto-Oncogene Proteins c-bcl-6
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
