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The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

Farzaei, Mohammad H, Bahramsoltani, Roodabeh, Abdollahi, Mohammad, Rahimi, Roja·2016·Journal of Neurogastroenterology and Motility

DOI 10.5056/jnm16001

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Functional Bowel Disorders
Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856
Global Prevalence of and Risk Factors for Irritable Bowel Syndrome: A Meta-analysis
Lovell, R. M., & Ford, A. C. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.029 · Cited by 2,155
Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles
O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448
Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1‐like immunoreactivity, in the central nervous system of the rat and human
Mezey, É., Tóth, Z. E., Cortright, D. N., Arzubi, M. K., Krause, J. E., Elde, R., Guo, A., Blumberg, P. M., & Szallasi, A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3655 · Cited by 850
The efficacy of probiotics in the treatment of irritable bowel syndrome: a systematic review
Moayyedi, P., Ford, A. C., Talley, N. J., Cremonini, F., Foxx-Orenstein, A. E., Brandt, L. J., & Quigley, E. M. M. (2010) · Gut · doi:10.1136/gut.2008.167270 · Cited by 728
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526
Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine
Saha, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i22.6759 · Cited by 500
Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome
Gwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415
Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis
Villani, A., Lemire, M., Thabane, M., Belisle, A., Geneau, G., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., Franchimont, D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.049 · Cited by 244 · cited 16×
“More preclinical and clinical investigations are needed to provide efficacious and targeted medicines for the management of VH. (J Neurogastroenterol Motil 2016;22:558-574) Key Words Hyperalgesia; Irritable bowel syndrome; Pain perception; Pain, visceral; Visceral hypersensitivity Received: January 8, 2016 Revised: Ma…”
BackgroundInfluential
Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome
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Ohara, T. E., & Hsiao, E. Y. (2025) · Nature Reviews Microbiology · doi:10.1038/s41579-024-01136-9 · Cited by 147
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New psychological therapies for irritable bowel syndrome: Mindfulness, acceptance and commitment therapy (ACT)
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“Several pathogenic factors responsible for IBS have been proposed, such as genetic and environmental factors (4), abnormal gut motility (5), visceral hypersensitivity (6), post-infectious inflammatory mechanisms (7), psychological morbidity, physical, emotional and sexual abuse (8), bacterial overgrowth (9) and change…”
Background
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5

Authors: Farzaei, M. H., Bahramsoltani, R., Abdollahi, M., & Rahimi, R.
Affiliations: Pharmaceutical Sciences Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
Department of Traditional Pharmacy, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
Venue: Journal of Neurogastroenterology and Motility
Publisher: The Korean Society of Neurogastroenterology and Motility
Published: 2016-10-30
Volume: 22
Issue: 4
Pages: 558-574
ISSN: 2093-0879
2093-0887
DOI: 10.5056/jnm16001
Cited by: 197
References: 17
Language: en

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The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

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