Infection, inflammation, and the irritable bowel syndrome

Spiller, R.; Garsed, K.

doi:10.1016/j.dld.2009.07.007

Cited by 122Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

Infection, inflammation, and the irritable bowel syndrome

Open access

Spiller, R., Garsed, K.·2009·Digestive and Liver Disease

DOI 10.1016/j.dld.2009.07.007

Open this paper in CoChat — free account Open PDF

Abstract

Gastrointestinal infection is ubiquitous worldwide though the pattern of infection varies widely. Poor hygiene and lack of piped water is associated with a high incidence of childhood infection, both viral and bacterial. However in developed countries bacterial infection is commoner in young adults. Studies of bacterial infections in developed countries suggest 75% of adults fully recover, however around 25% have long lasting changes in bowel habit and a smaller number develop the irritable bowel syndrome (IBS). Whether the incidence is similar in developing countries is unknown. Post-infective IBS (PI-IBS) shares many features with unselected IBS but by having a defined onset allows better definition of risk factors. These are in order of importance: severity of initial illness, smoking, female gender and adverse psychological factors. Symptoms may last many years for reasons which are unclear. They are likely to include genetic factors controlling the immune response, alterations in serotonin signaling, low grade mucosal inflammation maintained by psychological stressors and alterations in gut microbiota. As yet there are no proven specific treatments, though 5HT(3) receptor antagonists, anti-inflammatory agents and probiotics are all logical treatments which should be examined in large well-designed randomised placebo controlled trials.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.dld.2009.07.007

Cites

93 of 93 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Clinical studies show that up to 20% of IBS is preceded by an enteric infection, which produces a profound alteration of the host microbiota.
“Clinical studies show that up to 20% of IBS is preceded by an enteric infection, which produces a profound alteration of the host microbiota [52] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [52]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475 · see citing works
Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria
Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works
Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.06.010 · Cited by 1,310 · see citing works
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works
Self-citation
Activation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833 · see citing works
Childhood functional gastrointestinal disorders
Weber, A. M., Hyman, P. E., Cucchiara, S., Fleisher, D. R., Hyams, J. S., Milla, P. J., & Staiano, A. (1999) · Gut · doi:10.1136/gut.45.2008.ii60 · Cited by 815 · see citing works
Study of infectious intestinal disease in England: rates in the community, presenting to general practice, and reported to national surveillance
Wheeler, J. G., Sethi, D., Cowden, J. M., Wall, P. G., Rodrigues, L. C., Tompkins, D. S., Hudson, M. J., & Roderick, P. J. (1999) · BMJ · doi:10.1136/bmj.318.7190.1046 · Cited by 794 · see citing works
Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783 · see citing works
The magnitude of the global problem of diarrhoeal disease: a ten-year update.
Bern, C., Martines, J., Zoysa, I. D., & Glass, R. I. (1992) · Europe PMC (PubMed Central) · Cited by 773 · see citing works
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works
Immune Activation in Patients With Irritable Bowel Syndrome
Liebregts, T., Adam, B., Bredack, C., Röth, A., Heinzel, S., Lester, S., Downie–Doyle, S., Smith, E., Drew, P., Talley, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.046 · Cited by 660 · see citing works
Epidemiology of colonic symptoms and the irritable bowel syndrome
Talley, N. J., Zinsmeister, A. R., van Dyke, C., & Melton, L. J. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90717-y · Cited by 648 · see citing works
Hypothalamic-Pituitary-Gut Axis Dysregulation in Irritable Bowel Syndrome: Plasma Cytokines as a Potential Biomarker?
Dinan, T. G., Quigley, E. M. M., Ahmed, S. M. M., Scully, P., O’Brien, S., O’Mahony, L., O’Mahony, S., Shanahan, F., & Keeling, P. W. N. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.033 · Cited by 636 · see citing works
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · see citing works
Prevalence of gastrointestinal symptoms six months after bacterial gastroenteritis and risk factors for development of the irritable bowel syndrome: postal survey of patients
Neal, K. R., Hebden, J., & Spiller, R. (1997) · BMJ · doi:10.1136/bmj.314.7083.779 · Cited by 586 · see citing works
Self-citation
Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583 · see citing works
Self-citation
Human Campylobacteriosis in Developing Countries1
Coker, A. O., Isokpehi, R. D., Thomas, B. N., Amisu, K. O., & Obi, C. L. (2002) · Emerging infectious diseases · doi:10.3201/eid0803.010233 · Cited by 531 · see citing works
Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain
Akbar, A., Yiangou, Y., Facer, P., Walters, J. R. F., Anand, P., & Ghosh, S. (2008) · Gut · doi:10.1136/gut.2007.138982 · Cited by 526 · see citing works
Host-Mediated Inflammation Disrupts the Intestinal Microbiota and Promotes the Overgrowth of Enterobacteriaceae
Lupp, C., Robertson, M. L., Wickham, M. E., Sekirov, I., Champion, O. L., Gaynor, E. C., & Finlay, B. B. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.08.002 · Cited by 501 · see citing works
Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes
Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476 · see citing works
Self-citation
Systematic review and meta-analysis: the incidence and prognosis of post-infectious irritable bowel syndrome
THABANE, M., KOTTACHCHI, D. T., & MARSHALL, J. K. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03399.x · Cited by 466 · see citing works
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Gwee, K., Read, N. W., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., & Walters, S. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90341-4 · Cited by 466 · see citing works
Epidemiologic and Clinical Features ofCampylobacter jejuniInfections
Blaser, M. J. (1997) · The Journal of Infectious Diseases · doi:10.1086/513780 · Cited by 453 · see citing works
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Ka, G., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., Walters, S., & Read, N. W. (1996) · African journal of medical practice · Cited by 429 · see citing works
Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome
Gwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415 · see citing works
Dyspepsia and Irritable Bowel Syndrome After a Salmonella Gastroenteritis Outbreak: One-Year Follow-up Cohort Study
Mearin, F., Pérez-Oliveras, M., Juan, A. P., Vinyet, J., Ibañez, A., Coderch, J., & Perona, M. C. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.04.012 · Cited by 406 · see citing works
Diarrhoea in children: an interface between developing and developed countries
Thapar, N., & Sanderson, I. R. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15599-2 · Cited by 406 · see citing works
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387 · see citing works
Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery
Marshall, J. K., Thabane, M. E., Garg, A. X., Clark, W. F., Salvadori, M. I., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.053 · Cited by 370 · see citing works
Distinctive Clinical, Psychological, and Histological Features of Postinfective Irritable Bowel Syndrome
Dunlop, S. P., Jenkins, D., & Spiller, R. C. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07542.x · Cited by 359 · see citing works
Self-citation
Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
Dunlop, S. P., Coleman, N. S., Blackshaw, E., Perkins, A. C., Singh, G., Marsden, C. A., & Spiller, R. E. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00726-8 · Cited by 355 · see citing works
Self-citation
Terminal ileal mucosal mast cells in irritable bowel syndrome
Weston, A. P., Biddle, W. L., Bhatia, P. S., & Miner, P. B. (1993) · Digestive Diseases and Sciences · doi:10.1007/bf01303164 · Cited by 338 · see citing works
Irritable bowel syndrome—post salmonella infection
McKendrick, M. W., & Read, N. W. (1994) · Journal of Infection · doi:10.1016/s0163-4453(94)94871-2 · Cited by 320 · see citing works
Detection by PCR of eight groups of enteric pathogens in 4,627 faecal samples: re-examination of the English case-control Infectious Intestinal Disease Study (1993–1996)
Amar, C., East, C., Gray, J., Iturriza‐Gómara, M., Maclure, E. A., & McLauchlin, J. (2007) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-007-0290-8 · Cited by 318 · see citing works
Prevalence of gastrointestinal symptoms in a multiracial Asian population, with particular reference to reflux-type symptoms
Ho, K. Y., Kang, J. Y., & Seow, A. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.00526.x · Cited by 318 · see citing works
Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity
Gecse, K., Róka, R., Ferrier, L., Leveque, M., Eutamene, H., Cartier, C., Ait-Belgnaoui, A., Rosztóczy, A., Izbéki, F., Fioramonti, J., et al. (2008) · Gut · doi:10.1136/gut.2007.140210 · Cited by 314 · see citing works
Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat
Santos, J., Yang, P.-C., Söderholm, J. D., Benjamin, M., & Perdue, M. H. (2001) · Gut · doi:10.1136/gut.48.5.630 · Cited by 313 · see citing works
Sex-related differences in IBS patients: central processing of visceral stimuli
Naliboff, B. D., Berman, S. M., Chang, L., Derbyshire, S. W. G., Suyenobu, B. Y., Vogt, B. A., Mandelkern, M. A., & Mayer, E. A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00400-1 · Cited by 291 · see citing works
A millennium update on pediatric diarrheal illness in the developing world.
O’Ryan, M., Prado, V., & Pickering, L. K. (2005) · Seminars in Pediatric Infectious Diseases · doi:10.1053/j.spid.2005.12.008 · Cited by 283 · see citing works
Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?: Table 1
Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273 · see citing works
Campylobacter jejuni Cytolethal Distending Toxin Causes a G 2 -Phase Cell Cycle Block
Whitehouse, C. A., Balbo, P., Pesci, E. C., et al. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1934-1940.1998 · Cited by 266 · see citing works
Definitions of fiber
Trowell, H. C. (1974) · The Lancet · Cited by 259 · see citing works
Overlap of gastrointestional symptom complexes in a US community
Locke, G., Zinsmeister, A., Fett, S., Melton, L., & Talley, N. (2005) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2004.00581.x · Cited by 254 · see citing works
Postinfectious Irritable Bowel Syndrome After a Food-Borne Outbreak of Acute Gastroenteritis Attributed to a Viral Pathogen
Marshall, J. K., Thabane, M., Borgaonkar, M. R., & James, C. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.11.025 · Cited by 241 · see citing works
Efficacy of alosetron in irritable bowel syndrome: a meta‐analysis of randomized controlled trials
Cremonini, F., Delgado‐Aros, S., & Camilleri, M. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00389.x · Cited by 219 · see citing works
Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
Berčík, P., Wang, L., Verdu, E. F., Mao, Y., Blennerhassett, P. A., Khan, W. I., Kean, I. R. L., Tougas, G. H., & Collins, S. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.006 · Cited by 218 · see citing works
Role of Tumor Necrosis Factor-alpha and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome
van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works
Smoking in relation to anxiety and depression: evidence from a large population survey: the HUNT study
Mykletun, A., Overland, S., Aarø, L. E., Liabø, H.-M., & Stewart, R. (2008) · European Psychiatry · doi:10.1016/j.eurpsy.2007.10.005 · Cited by 213 · see citing works
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00719.x · Cited by 205 · see citing works
Self-citation
Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force.
Ghoshal, U. C., Abraham, P., Bhatt, C. B., Choudhuri, G., Bhatia, S. J., Shenoy, K. T., Banka, N. H., Bose, K. S. C., Bohidar, N. P., Chakravartty, K., et al. (2008) · PubMed · Cited by 191 · see citing works
The Prevalence, Symptom Characteristics, and Impact of Irritable Bowel Syndrome in an Asian Urban Community
Gwee, K.-A., Wee, S., Wong, M.-L., & J C Png, D. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.04161.x · Cited by 190 · see citing works
Role of infection in irritable bowel syndrome
Spiller, R. C. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1925-8 · Cited by 187 · see citing works
Self-citation
Psychosocial risk markers for new onset irritable bowel syndrome – Results of a large prospective population-based study
Nicholl, B. I., Halder, S. L. S., Macfarlane, G. J., Thompson, D. G., O’Brien, S. J., Musleh, M., & McBeth, J. (2007) · Pain · doi:10.1016/j.pain.2007.08.029 · Cited by 182 · see citing works
Randomized, double‐blind, placebo‐controlled trial of prednisolone in post‐infectious irritable bowel syndrome
Dunlop, S., Jenkins, D., Neal, K. R., Næsdal, J., Borgaonker, M., Collins, S. M., & Spiller, R. E. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01640.x · Cited by 178 · see citing works
Self-citation
Post-Infectious Functional Gastrointestinal Disorders in Children
Saps, M., Pensabene, L., di Martino, L., Staiano, A., Wechsler, J. B., Zheng, X., & Lorenzo, C. D. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.11.042 · Cited by 177 · see citing works
Antibiotics increase functional abdominal symptoms
Maxwell, P., Rink, E., Kumar, D., & Mendall, M. A. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05428.x · Cited by 176 · see citing works
Structural and functional changes of the duodenum in human norovirus infection
Troeger, H., Loddenkemper, C., Schneider, T., Schreier, E., Epple, H.-J., Zeitz, M., Fromm, M., & Schulzke, J.-D. (2008) · Gut · doi:10.1136/gut.2008.160150 · Cited by 175 · see citing works
The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors
Lee, K. J., Kim, Y. B., Kim, J. H., Kwon, H. C., Kim, D. K., & Cho, S. W. (2008) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2008.05574.x · Cited by 171 · see citing works
The cognitive behavioural model of irritable bowel syndrome: a prospective investigation of patients with gastroenteritis
Spence, M. J., & Moss-Morris, R. E. (2007) · Gut · doi:10.1136/gut.2006.108811 · Cited by 161 · see citing works
Post‐infectious irritable bowel syndrome in patients with Shigella infection
Ji, S.-W., Park, H., LEE, D., Song, Y. G., Choi, J., & LEE, S. (2005) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2005.03574.x · Cited by 158 · see citing works
Antibiotic use, childhood affluence and irritable bowel syndrome (IBS)
Mendall, M. A., & Kumar, D. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199801000-00011 · Cited by 155 · see citing works
Relationship ofCampylobacterToxigenicity In Vitro to the Development of Postinfectious Irritable Bowel Syndrome
Thornley, J. P., Jenkins, D., Neal, K., Wright, T., Brough, J., & Spiller, R. C. (2001) · The Journal of Infectious Diseases · doi:10.1086/322845 · Cited by 144 · see citing works
Self-citation
COHORT STUDY OF INTESTINAL INFECTION WITH CAMPYLOBACTER IN MEXICAN CHILDREN
Calva, J. J. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91297-4 · Cited by 138 · see citing works
A demographic survey of campylobacter, salmonella and shigella infections in England: A Public Health Laboratory Service Survey
Skirrow, M. B. (1987) · Epidemiology and Infection · doi:10.1017/s0950268800066504 · Cited by 129 · see citing works
Modeling and reinforcement of the sick role during childhood predicts adult illness behavior.
Whitehead, W. E., Crowell, M. D., Heller, B., Robinson, J. C., Schuster, M., & Horn, S. R. G.-V. (1994) · Psychosomatic Medicine · doi:10.1097/00006842-199411000-00010 · Cited by 128 · see citing works
Maladaptive Intestinal Epithelial Responses to Life Stress May Predispose Healthy Women to Gut Mucosal Inflammation
Alonso, C., Guilarte, M., Vicario, M., Ramos, L., Ramadan, Z., Antolín, M., Martínez, C., Rezzi, S., Saperas, E., Kochhar, S., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.036 · Cited by 128 · see citing works
To “Lump” or to “Split” the Functional Somatic Syndromes: Can Infectious and Emotional Risk Factors Differentiate Between the Onset of Chronic Fatigue Syndrome and Irritable Bowel Syndrome?
Moss-Morris, R. E., & Spence, M. J. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221384.07521.05 · Cited by 128 · see citing works
A population‐based epidemiologic study of irritable bowel syndrome in South China: stratified randomized study by cluster sampling
Xiong, L. S., Chen, M. H., Chen, H. X., Xu, A., Wang, W. A., & Hu, P. J. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.01939.x · Cited by 127 · see citing works
Characteristics of patients with irritable bowel syndrome recruited from three sources: implications for clinical trials
Longstreth, G. F., Hawkey, C. J., Mayer, E. A., Jones, R. H., Naesdal, J., Wilson, I. K., Peacock, R. A., & Wiklund, I. K. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.01010.x · Cited by 124 · see citing works
Is Traveler's Diarrhea a Significant Risk Factor for the Development of Irritable Bowel Syndrome? A Prospective Study
Stermer, E., Lubezky, A., Potasman, I., Paster, E., & Lavy, A. (2006) · Clinical Infectious Diseases · doi:10.1086/507540 · Cited by 120 · see citing works
Comparative Effects of Moxifloxacin and Clarithromycin on the Normal Intestinal Microflora
Edlund, G. B. C. (2000) · Scandinavian Journal of Infectious Diseases · doi:10.1080/00365540050164272 · Cited by 106 · see citing works
Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea‐predominant irritable bowel syndrome
Park, J. H., Rhee, P., Kim, G., Lee, J. H., Kim, Y., Kim, J. J., Rhee, J. C., & Song, S. Y. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00771.x · Cited by 89 · see citing works
Increased visceral sensitivity in Giardia‐induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3‐antagonist ondansetron
Dizdar, V., Gilja, O. H., & Hausken, T. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.00988.x · Cited by 89 · see citing works
Afferent hypersensitivity in a mouse model of post‐inflammatory gut dysfunction: role of altered serotonin metabolism
Keating, C. D., Beyak, M. J., Foley, S., Singh, G., Marsden, C. A., Spiller, R. E., & Grundy, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156984 · Cited by 88 · see citing works
Self-citation
Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon
O’Hara, J. R., Skinn, A. C., MacNaughton, W. K., Sherman, P. M., & Sharkey, K. A. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00657.x · Cited by 82 · see citing works
Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments
Motomura, Y., Ghia, J., Wang, H., Akiho, H., El–Sharkawy, R. T., Collins, M., Wan, Y., McLaughlin, J. T., & Khan, W. I. (2008) · Gut · doi:10.1136/gut.2007.129296 · Cited by 80 · see citing works
Age-related decline in rectal mucosal lymphocytes and mast cells
Dunlop, S. P., Jenkins, D., & Spiller, R. E. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200410000-00010 · Cited by 73 · see citing works
Self-citation
Campylobacter Immunity and Quantitative Excretion Rates in Thai Children
Taylor, D. N., Perlman, D., Echeverria, P. D., et al. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/168.3.754 · Cited by 73 · see citing works
Prevalence of irritable bowel syndrome in Shahrekord, Iran.
Hoseini-Asl, M. K., & Amra, B. (2004) · PubMed · Cited by 64 · see citing works
Acute Infective Colitis Caused by Endemic Pathogens in Western Europe: Endoscopic Features
Rutgeerts, P., Geboes, K., Ponette, E., et al. (1982) · Endoscopy · doi:10.1055/s-2007-1021624 · Cited by 61 · see citing works
Epidemiology of noninfective intestinal diseases in various ethnic groups in South Africa.
Walker, A. R. P., & Segal, I. (1979) · PubMed · Cited by 60 · see citing works
Factors associated with the development of post-infectious functional gastrointestinal diseases: does smoking play a role?
Parry, S. D., Barton, J. R., & Welfare, M. (2005) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200510000-00010 · Cited by 58 · see citing works
Irritable Bowel Syndrome in Persons Who Acquired Trichinellosis
Soytürk, M., Akpınar, H., Gürler, O., Pozio, E., Sarı, İ., Akar, S., Akarsu, M., Bırlık, M., Önen, F., & Akkoç, N. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01084.x · Cited by 57 · see citing works
Role of antibiotic therapy on long‐term germ excretion in faeces and digestive symptoms after Salmonella infection
Barbara, Stanghellini, Berti‐Ceroni, Giorgio, D., Salvioli, Corradi, Cremon, & Corinaldesi (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00818.x · Cited by 55 · see citing works
Structured surveillance of infectious intestinal disease in pre-school children in the community: ‘The Nappy Study’
Iturriza‐Gómara, M., Elliot, A. J., Dockery, C., Fleming, D., & GRAY, J. J. (2008) · Epidemiology and Infection · doi:10.1017/s0950268808001556 · Cited by 53 · see citing works
Important Bacterial Gastrointestinal Pathogens in Children: A Pathogenesis Perspective
Amieva, M. R. (2005) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2005.03.002 · Cited by 43 · see citing works
Campylobacter jejuni as a Cause of Traveler's Diarrhea: Clinical Features and Antimicrobial Susceptibility
Gallardo, F., Gascón, J., Ruiz, J., Corachan, M., de Anta, M. T. J., & Vilà, J. (1998) · Journal of Travel Medicine · doi:10.1111/j.1708-8305.1998.tb00451.x · Cited by 40 · see citing works
Effect of Age on the Gastrointestinal-Associated Mucosal Immune Response of Humans
Beharka, A. A., de Paiva, S. A. R., Leka, L. S., Ribaya‐Mercado, J. D., Russell, R. M., & Meydani, S. N. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.5.b218 · Cited by 36 · see citing works
Ecological Study on the Intestinal Bacterial Flora of Patients with Diarrhea
Tazume, S., Ozawa, A., Yamamoto, T., Takahashi, Y., Takeshi, K., Saidi, S. M., Ichoroh, C. G., & Waiyaki, P. G. (1993) · Clinical Infectious Diseases · doi:10.1093/clinids/16.supplement_2.s77 · Cited by 35 · see citing works
Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis
Simpson, J. A., Sundler, F., Humes, D. J., et al. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2007.01037.x · Cited by 33 · see citing works
Physicochemical characteristics and flora of diarrhoeal and recovery faeces in children with acute gastroenteritis in Kenya
Fujita, K., Kaku, M., Yanagase, Y., Ezaki, T., Furuse, K., Ozawa, A., Saidi, S. M., Sang, W. K., & Waiyaki, P. G. (1990) · Annals of Tropical Paediatrics · doi:10.1080/02724936.1990.11747455 · Cited by 26 · see citing works
Campylobacter jejuniisolations from Mexican and Swedish patients, with repeated symptomatic and/or asymptomatic diarrhoea episodes
Sjögren, E., Ruiz-Palacios, G. M., & KAIJSER, B. (1989) · Epidemiology and Infection · doi:10.1017/s0950268800029678 · Cited by 15 · see citing works
T1394 Mesalazine Treatment for Intestinal Immune Activation in Patient with Irritable Bowel Syndrome: A Randomized Controlled Pilot Trial
Barbara, G., Cremon, C., Gargano, L., et al. (2008) · Gastroenterology · doi:10.1016/s0016-5085(08)62548-2 · Cited by 9 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Coker AO, Isokpehi RD, Thomas BN, et al. Human campylobacteriosis in devel- oping countries. Emerg Infect Dis 2002;8:237-44.
Whitehouse CA, Balbo PB, Pesci EC, et al. Campylobacter jejuni cyto- lethal distending toxin causes a G2-phase cell cycle block. Infect Immun 1998;66:1934-40.

Sorted by citations

5-Hydroxytryptamine (serotonin) in the gastrointestinal tract
Gershon, M. D. (2013) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e32835bc703 · Cited by 617 · see citing works
Disease burden of foodborne pathogens in the Netherlands, 2009
Havelaar, A. H., Haagsma, J. A., Mangen, M.-J. J., Kemmeren, J. M., Verhoef, L. P. B., Vijgen, S. M. C., Wilson, M., Friesema, I. H. M., Kortbeek, L. M., van Duynhoven, Y. T. H. P., et al. (2012) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2012.03.029 · Cited by 380 · see citing works
Meta-analysis: Lactobacillus rhamnosus GG for abdominal pain-related functional gastrointestinal disorders in childhood: Meta-analysis: Lactobacillus GG and abdominal pain-related functional disorders
Horvath, A., Dziechciarz, P., & Szajewska, H. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04665.x · Cited by 201 · see citing works
Recent developments in the pathophysiology of irritable bowel syndrome
El-Salhy, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i25.7621 · Cited by 111 · see citing works
Visceral hypersensitivity in endometriosis: a new target for treatment?
Issa, B., Onon, T. S., Agrawal, A., Shekhar, C., Morris, J., Hamdy, S., & Whorwell, P. J. (2012) · Gut · doi:10.1136/gutjnl-2011-300306 · Cited by 90 · see citing works
Dietary therapies for functional bowel symptoms: Recent advances, challenges, and future directions
Tuck, C. J., & Vanner, S. J. (2018) · Neurogastroenterology & Motility · doi:10.1111/nmo.13238 · Cited by 52 · see citing works

Irritable Bowel Syndrome
Owyang, C. (2008) · Textbook of Gastroenterology · doi:10.1002/9781444303254.ch60 · Cited by 8 · see citing works
Stability of irritable bowel syndrome using a Rome II‐based classification
WILLIAMS, R. E., BLACK, C. L., KIM, H. ‐., Andrews, E. B., Mangel, A. W., Buda, J. J., & Cook, S. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.02723.x · Cited by 38 · see citing works
Prevalence of Irritable Bowel Syndrome in Chronic Fatigue
Gomborone, J., Gorard, D., Dewsnap, P., Libby, G., & Farthing, M. (1996) · Journal of the Royal College of Physicians of London · doi:10.1016/s0035-8819(25)00303-4 · Cited by 58 · see citing works
Irritable Bowel Syndrome
Ford, A. C., Moayyedi, P., & Talley, N. J. (2010) · Wiley eBooks · doi:10.1002/9781444314403.ch21 · Cited by 1 · see citing works
Irritable Bowel Syndrome and Relationship Between Emotional Factors Probe
Wang, J. (2011) · Journal of Practical Traditional Chinese Internal Medicine · Cited by 1 · see citing works

Authors: Spiller, R., & Garsed, K.
Affiliations: Nottingham University Hospitals NHS Trust (GB)
NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
Corresponding author: Spiller, R.
ORCID: Spiller, R.
Venue: Digestive and Liver Disease
Publisher: Elsevier BV
Published: 2009-12
Volume: 41
Issue: 12
Pages: 844-849
ISSN: 1590-8658 (ISSN-L)
DOI: 10.1016/j.dld.2009.07.007
OpenAlex: W2003617540
Cited by: 122
References: 93
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 5 · 2018: 5 · 2017: 6 · 2016: 7 · 2015: 9 · 2014: 15 · 2013: 12 · 2012: 10
FWCI: 2.13
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Digestive and Liver Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Keywords: irritable bowel syndrome, gastrointestinal infections, bacterial infection, viral infection, pediatric infection, altered bowel habits, mucosal inflammation, serotonin signaling, gut microbiota, psychological stress, smoking, female sex, immune response genetics, 5-HT3 receptor antagonists, probiotics, anti-inflammatory agents
MeSH terms: Age Factors, Developing Countries, Gastroenteritis, Humans, Inflammation, Life Style, Risk Factors, Sex Factors, Incidence, Developed Countries, Gastrointestinal Tract, Irritable Bowel Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Infection, inflammation, and the irritable bowel syndrome

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks