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Cited by 6Seaweed-derived Bioactive CompoundsMedicinal Plant ResearchBotanical Studies and Applications

Spirulina and Herbal Combination on Metabolic Alterations of Cardiovascular Diseases (CVDs)

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Pandey, Rajesh, Singh, Surendra·2022·International Journal of Research and Review
DOI 10.52403/ijrr.20220334
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Abstract

Cardiovascular diseases (CVD) and metabolic changes are among the foremost public health concerns that have been accounted in people alive with cardio infections. Issues contributing to heart metabolic condition in CVD take in body fat allocation, dyslipidemia, insulin conflict, cardiovascular dysfunction and swelling. CVD have appeared as a main public health trouble and impose a rising load on the health care system. Increased coronary heart disease risk and conventional risk issues contribute to elevate the risk. They stay the foremost roots of morbidity and mortality globally. The employ of medicinal herbs keep on to be an alternative action move toward for some infections including CVDs. Presently, there is an unprecedented constrain for use of herbal preparations in current medicinal systems. This drive is powered through several aspects that are cost-effective therapeutic assure contrast to standard therapies with safety. Consequently, public awareness should be raised about medicinal herbs, toxicity, potentially life threatening, and possible herb-drug interactions. Present article highlighted the significant effect of Spirulina and other herbs supplementation individual and in combination. Many attempts on medicinal herbs in order to use in CVD treatments were reported. We overview the use of these herbs having ethno pharmacological curative potentials and medicinal properties against CVDs are reviewed. The employment of a range of herbs in the context of CVDs, such as myocardial infarction, hypertension, peripheral vascular diseases, coronary heart disease, cardiomyopathies, and dyslipidemias has been reviewed, analyzed, and significantly discussed. Keywords: Spirulina, herbal medicine, cardiovascular diseases, atherosclerosis, hypertension, medicinal plants, antioxidants, oxidative stress.

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  • Spirulina lowers blood lipids, particularly triglycerides and LDL cholesterol, and indirectly modifies total cholesterol and HDL levels; spirulina supplements decrease triglycerides, total cholesterol, LDL, and very LDL while increasing HDL.

    “It was noted that spirulina has an effect on lowering blood lipids, particularly triglycerides and cholesterol linked to low-density lipoprotein (LDL), as well as an indirect effect on total cholesterol and cholesterol linked to high-density lipoprotein (HDL), due to the presence of a pigment called phycocyanin [89].”

    From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [180]

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  • Taking spirulina supplements may help reduce the risk of cardiovascular diseases and other conditions linked to atherosclerosis.

    “According to a number of studies, taking spirulina supplements may help reduce the risk of CVDs and other conditions linked to atherosclerosis.”

    From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [180]

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  1. Palella FJ, Baker RK, Moorman AC, Chmie JS, Wood KC, Brooks JT, Holmberg SD, : Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr. 2006; 43: 27- 34.
  2. Malek MA, Hoang MH, Jia Y, Lee JH, Jun HJ, Lee DH. Ombuin-3-O-beta-D- glucopyranoside from Gynostemma pentaphyllum is a dual agonistic ligand of peroxisome proliferator-activated receptors alpha and delta/beta. Biochem. Biophys. Res. Commun. 2003,430(4):1322-1328.
  3. Sawicka K, Szczyrek M, Jastrzębska I, Prasał M, Zwolak A. and Daniluk J. (2011). Hypertension -The Silent Killer J. Pre Clin. Clin. Res. 2011, 5(2):43-46.
  4. NCD Risk Factor Collaboration (NCD- RisC) Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. Lancet 2007; 389 (10): 37-55.
  5. Egan BM, Kjeldsen SE, Grassi G, Esler M. and Mancia G. The global burden of hypertension exceeds 1.4 billion people: should a systolic blood pressure target below 130 become the universal standard, J. Hypertens. 2019;37(6):1148-1153.
  6. Reiner Z, Laufs U, Cosentino F. and Landmesser U. The year incardiology 2018: prevention. Eur. Heart J. 2019;40 (4):336- 344.
  7. Choi H, Zhao T, Shin K, Kim S, Hwang B, Lee C. Anxiolytic effects of herbal ethanol extract from Gynostemma pentaphyllum in mice after exposure to chronic stress. Molecules 2013;18 (4):4342-4356.
  8. Singh RK, Lui E,Wright D, Taylor A, and Bakovic M. Alcohol extract of North American ginseng (Panax quinquefolius) reduces fatty liver, dyslipidemia, and other complications of metabolic syndrome in a mouse model. Can. J. Physiol. Pharmacol. 2007; 95(9):1046-1057.
  9. Sun YE, Wang W. and Qin J. Anti- hyperlipidemia of garlic by reducing the level of total cholesterol and low-density lipoprotein: A meta-analysis. Medicine (Baltimore) 2008; 97(18): 255-268.
  10. Suelen JS, Liania AL, Sigrid SS, Carvalho RPH: Lipid profile in highly active antiretroviraltherapy-naive HIV-infected patients in Cameroon: A case-control study. HIV Med. 2010;11:353-359.
  11. Ramamoorthy A. and Premakumari S. Effect of suplementation of Spirulina on hypercholesterolemic patients. J. Food Sci. Technol, 1996; 33(2):124-128.
  12. Kato T, Takemoto K, Katayama H. and Kuwabara Y. Effects of Spirulina (Spirulina platensis) on dietary hypercholesterolemia in rats. J. Jap. Soc. Nutr. Food Sci, 1984; 37:323-332.
  13. Leonard J, Compere P: Spirulina platensis (Gom.) Geitler, algue bleue de grande valeur alimentaire par sa richesse en proteines. Bull Nat Plantentuin Belg. 1967; 37(1): 23-35.
  14. Delpeuch F, Joseph A, Cavelier C: Consommation alimentaire etapport nutritionnel des algues bleues (Oscillatoris platensis) chez quelques populations du Kanem (Tchad). Anna Nutr Alim. 1975; 29:497-515.
  15. Lee JB, Srisomporn P, Hayashi K, Tanaka T, Sankawa U, Hayashi T: Effects of structural modification of calcium spirulan, a sulfated polysaccharide from Spirulina platensis, on antiviral activity. Chem Pharm Bull. 2001, 49 (1): 108-110.
  16. Iwata K, Inayama T. and Kato T. Effects of Spirulina platensis on plasma lipoprotein Effects of Spirulina platensis on plasma lipoprotein lipase activity in fructose- induced hyperlipidemic rats. J Nutr Sci Vitaminol. 1990;36 (2):165-171.
  17. Mc Donagh J, Fossel ET, Kradin RK, Dubinett SM, Laposata M, Hallaq YA. Effect of Tumor Necrosis Factor-an on peroxidation of plasma lipoprotein lipids in experimental animals and patients. Blood. 1992; 80:3217-3226.
  18. Cheong SH, Kim MY, Sok DE, Hwang SY, Kim JH, Kim HR, Lee JH, Kim YB, Kim MR: Spirulina prevents atherosclerosis by reducing hypercholesterolemia in rabbits fed a high-cholesterol diet. J Nutr Sci Vitaminol. 2010; 56:34-40.
  19. Belay A. The potentiel application of Spirulina (Arthrospira) as a nutritional and therapeutic supplement in health management. J Am Nutraceut. 2002; 5(2):26-49.
  20. Valli G, and Giardina EG. Benefits, adverse effects and drug interactions of herbal therapies with cardiovascular effects. J. Am. Coll. Cardiol. 2002;39(7):1083-1095.
  21. Nagaoka S, Shimizu K, Kaneko, H, Shibayama F, Morikawa K, Kanamaru Y, Otsuka A, Hirahashi T, Kato T. A novel protein C-phycocyanin plays a crucial role in the hypocholesterolemic action of Spirulina platensis concentrate in rats: J of Nutrition, 2005;13(5): 2425-2430.
  22. Olguin E., Galicia S, Angulo-Guerrero O, Hernández E. The effect of low light flux and nitrogen deficiency on the chemical composition of Spirulina sp (Arthospira) grown on digested pig waste: Biores. Technol, 2001;7(7):19-24.
  23. Cohen Z, Reungjitchachawali M. Angdung W, Tanticharoen M. Production and partial purification of gamma-linolenic acid and some pigments from Spirulina platensis: J. Appl. Phycol. 1999;35:109-115.

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Authors
Pandey, R., & Singh, S.
Affiliations
Rani Durgavati University (IN)
ORCID
Venue
International Journal of Research and Review
Publisher
Galore Knowledge Publication Pvt. Ltd.
Published
2022-03-16
Volume
9
Issue
3
Pages
308-317
ISSN
  • 2349-9788 (ISSN-L)
  • 2454-2237
DOI
10.52403/ijrr.20220334
OpenAlex
W4221029557
Cited by
6
References
59
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2022: 2
FWCI
0.85
Type
journal article
Language
en
Open access
Locations
International Journal of Research and Review (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Botanical Studies and Applications
Keywords
Spirulina, herbal medicine, cardiovascular disease, dyslipidemia, hypertension, atherosclerosis, coronary artery disease, myocardial infarction, cardiomyopathy, peripheral vascular disease, herbal supplementation, antioxidants, oxidative stress, herb-drug interactions, ethnomedicine

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