Spirulina platensis effects on the levels of total cholesterol, HDL and triacylglycerols in rabbits fed with a hypercholesterolemic diet
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In this work, hypercholesterolemia was induced in rabbits by feeding them a high cholesterol diet (CD, 350 mg/d) and the effects of supplementing this diet with 0.5 g/d Spirulina platensis was evaluated by measuring the levels of serum total-cholesterol (TC), triacylglycerols (TAG) and high-density lipoprotein (HDL-cholesterol) at the start of the experiment and after 30 d and 60 d. It was found that the levels of serum cholesterol decreased from 1,054±101 mg.dL-1 in the rabbits fed a CD without S. platensis to 516±163 mg.dL-1 to those fed with a high cholesterol diet supplemented with S. platensis (significant at p <0.0001). The addition of Spirulina to the cholesterolemic diet did not cause significative decrease on the levels of triacylglycerols in the animals. The levels of serum high-density lipoprotein (HDL-cholesterol) was 73±31 mg.dL-1 for rabbits fed a CD without S. platensis as compared to 91.0±15.7 mg.dL-1 in those fed a CD supplemented with S. platensis (significant at p=0.1533).
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Spirulina contains natural antioxidants such as phenolic compounds, γ-linolenic acid, and phycocyanin, which prevent hypercholesterolemia and its negative consequences.
“According to the findings of the study, this is because spirulina contains natural antioxidants such as phenolic compounds, γ-linolenic acid, and phycocyanin, all of which work to prevent hypercholesterolemia and the negative consequences of the condition.”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [176]
The Introduction (page unavailable) identifies phenolics, γ-linolenic acid and phycocyanin as Spirulina components and says antioxidant compounds are thought to account for its therapeutic properties, including treatment of hypercholesterolemia and atherosclerosis. The claim overstates that tentative explanation as an established mechanism by which each component prevents the condition and its consequences. (LLM, conf=0.86)
Experimental — accuracy not yet measuredIn hypercholesterolemic rabbits, an increase in HDL in the blood was associated with a decrease in total cholesterol, with no discernible change in triglycerides.
“An increase in the level of HDL in the blood was shown to be associated with a decrease in the levels of total cholesterol found in the blood, but there was no discernible change in the levels of triglycerides found in the blood.”
From Trends and Technological Advancements in the Possible Food Applications of Spirulina and Their Health Benefits: A Review. (2022) · cites this paper as [176]
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- Authors
- Colla, L. M., Muccillo-Baisch, A. L., & Costa, J. A. V.
- Affiliations
- Universidade de Passo Fundo (BR)
- Departamento de Ciências Fisiológicas
- Universidade Federal do Rio Grande (BR)
- Venue
- Brazilian Archives of Biology and Technology
- Publisher
- FapUNIFESP (SciELO)
- Published
- 2008-04
- Volume
- 51
- Issue
- 2
- Pages
- 405-411
- ISSN
- 1516-8913 (ISSN-L)
- OpenAlex
- W2168728779
- Cited by
- 116
- References
- 34
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 10 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 15 · 2019: 5 · 2018: 6 · 2017: 6 · 2016: 8 · 2015: 14 · 2014: 5 · 2013: 2 · 2012: 3
- FWCI
- 5.54
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- Brazilian Archives of Biology and Technology (publishedVersion, cc-by-nc)
- Americanae (AECID Library) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Americanae (AECID Library) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Surgery › Natural Products and Biological Research
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Keywords
- Spirulina platensis, hypercholesterolemia, high-cholesterol diet, total cholesterol, HDL cholesterol, triglycerides, serum lipids, dietary supplementation, rabbits
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