Improving estimation of cardiac vagal tone during spontaneous breathing using a paced breathing calibration
Open accessAbstract
Respiratory sinus arrhythmia (RSA) is a commonly employed non-invasive measure of cardiac vagal control. It has been demonstrated that respiratory parameters such as tidal volume and respiratory frequency can change RSA without altering tonic vagal activity. Thus, within-individual comparisons of cardiac vagal control across different behavioral tasks might benefit from an adjustment for respiratory confounds. We tested an adjustment method using transfer function analysis and paced breathing at 3 different respiratory frequencies as the basis for regressing out respiratory related RSA changes in a task where breathing was not controlled. Electrocardiogram and calibrated respiration were recorded with the LifeShirt system from 15 young adult participants. Time series of RR intervals and lung volume change were computed and the respiration-to-RR-interval transfer-function magnitude (RSA-TF, in ms/liter) estimated. Mean (SD) of RSA-TF was 142 (68) at 9 breaths/min, 78 (52) at 13.5 breaths/min, 57 (43) at 18 breaths/min, and 121 (56) during baseline, with a respiratory frequency of 12.5 (3.8) breaths/min. At baseline, measured and predicted RSA-TF values (mean 94 +/- 82) differed significantly and correlated only moderately (r = 0.67). Factors contributing to a less than perfect correlation included slightly elevated subjective anxiety levels and hyperventilation during paced breathing, both of which may have affected cardiac vagal tone. This study demonstrates a novel procedure…
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When assessing HRV in situ, the predictive value of HRV is increased when controlling for respiration and physical activity.
“When assessing HRV in situ, the predictive value of HRV is increased when controlling for respiration and physical activity (Wilhelm et al., 2004).”
From Heart Rate Variability and Cardiac Vagal Tone in Psychophysiological Research – Recommendations for Experiment Planning, Data Analysis, and Data Reporting (2017) · cites this paper as Wilhelm et al., 2004
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Cochrane, M. (2018) · UVic’s Research and Learning Repository (University of Victoria)
- Authors
- Wilhelm, F. H., Grossman, P., & Coyle, M. A.
- Affiliations
- University of Basel (CH)
- Venue
- Instrument Society of America
- Publisher
- Instrument Society of America
- Published
- 2004
- Volume
- 40
- Pages
- 317-24
- OpenAlex
- W2258745636
- Cited by
- 62
- References
- 21
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 4 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- edoc (University of Basel)
- PubMed
- Funders
- National Institute on Aging (P01AG018784)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Physical Sciences › Engineering › Biomedical Engineering › Non-Invasive Vital Sign Monitoring
- Keywords
- cardiac vagal tone, respiratory sinus arrhythmia, transfer function analysis, respiratory rate, tidal volume, RR interval, anxiety, hyperventilation, cardiac vagal control
- MeSH terms
- Adult, Algorithms, Calibration, Diagnosis, Computer-Assisted, Electrocardiography, Female, Heart, Heart Rate, Humans, Respiration, Sensitivity and Specificity, Sinoatrial Node, Vagus Nerve, Reproducibility of Results, Respiratory Mechanics, Artifacts, Monitoring, Ambulatory
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