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Insulin resistance and Alzheimer's disease
Open accessAbstract
Emerging data demonstrate pivotal roles for brain insulin resistance and insulin deficiency as mediators of cognitive impairment and neurodegeneration, particularly Alzheimer's disease (AD). Insulin and insulin-like growth factors (IGFs) regulate neuronal survival, energy metabolism, and plasticity, which are required for learning and memory. Hence, endogenous brain-specific impairments in insulin and IGF signaling account for the majority of AD-associated abnormalities. However, a second major mechanism of cognitive impairment has been linked to obesity and Type 2 diabetes (T2DM). Human and experimental animal studies revealed that neurodegeneration associated with peripheral insulin resistance is likely effectuated via a liver-brain axis whereby toxic lipids, including ceramides, cross the blood brain barrier and cause brain insulin resistance, oxidative stress, neuro-inflammation, and cell death. In essence, there are dual mechanisms of brain insulin resistance leading to AD-type neurodegeneration: one mediated by endogenous, CNS factors; and the other, peripheral insulin resistance with excess cytotoxic ceramide production.
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“Alterations in the insulin signaling pathway have also been suggested as potential contributors to cognitive dysfunction because of the pivotal role of this hormone in modulating brain structure and function.[12][13][14]”
In the citing paper
“It is becoming clear that the obesity-induced toxic internal environment does not spare the brain ([24](#B24), [46](#B46), [48](#B48), [52](#B52), [59](#B59), [95](#B95), [121](#B121), [127](#B127), [177](#B177), [182](#B182), [198](#B198)).”
From Food reward, hyperphagia, and obesity (2011) · cites this paper as [46]
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“Recent evidence suggests that insulin resistance, a hallmark of diabetes, develops in Alzheimer’s brains (, 2000; Craft et al., 1999; de la Monte, 2009; Moroz et al., 2008; Pedersen and Flynn, 2004; Razay and Wilcock, 1994; Watson and Craft, 2003).”
From The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease (2011) · cites this paper as de la Monte, 2009
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Cites
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
Szkudelski, T. (2001) · Physiological Research · doi:10.33549/physiolres.930111 · Cited by 2,881
Regulation of neuronal survival by the serine-threonine protein kinase Akt
Dudek, H., Datta, S. R., Franke, T. F., Birnbaum, M. J., Yao, R., Cooper, G. M., Segal, R. A., Kaplan, D. R., & Greenberg, M. E. (1997) · Science · doi:10.1126/science.275.5300.661 · Cited by 2,436
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
Ullrich, A., Bell, J. R., Chen, E. Y., Herrera, R., Petruzzelli, L., Dull, T. J., Gray, A., Coussens, L. M., Liao, Y.-C., Tsubokawa, M., et al. (1985) · Nature · doi:10.1038/313756a0 · Cited by 2,251
GSK-3: tricks of the trade for a multi-tasking kinase
Doble, B. W., & Woodgett, J. R. (2003) · Journal of Cell Science · doi:10.1242/jcs.00384 · Cited by 2,084
Steen, E., Terry, B. M., J. Rivera, E., Cannon, J. L., Neely, T. R., Tavares, R., Xu, X. J., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer's Disease · doi:10.3233/jad-2005-7107 · Cited by 1,703
Alzheimer’s disease is type 3 diabetes—Evidence reviewed
de la Monte, S. M., & Wands, J. R. (2008) · Journal of Diabetes Science and Technology · doi:10.1177/193229680800200619 · Cited by 1,158
Ceramides in insulin resistance and lipotoxicity
Summers, S. A. (2005) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.11.002 · Cited by 866
Intranasal insulin improves cognition and modulates β-amyloid in early AD
Reger, M. A., Watson, G. S., Green, P. S., Wilkinson, C. W., Baker, L. D., Cholerton, B., Fishel, M. A., Plymate, S. R., Breitner, J. C. S., DeGroodt, W., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000265401.62434.36 · Cited by 830
Rivera, E. J., Goldin, A., Fulmer, N., Tavares, R., Wands, J. R., & de la Monte, S. M. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2005-8304 · Cited by 723 · cited 15×
“In addition, inhibition of insulin/IGF-1 signaling blocks the Wnt pathway (24), which negatively regulates GSK-3β via a PI3K/Akt-independent mechanism.”
BackgroundInfluentialHolland, W. L., & Summers, S. A. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0025 · Cited by 604
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Talbot, K., Wang, H.-Y., Kazi, H., Han, L.-Y., Bakshi, K. P., Stucky, A., Fuino, R. L., Kawaguchi, K. R., Samoyedny, A. J., Wilson, R. S., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59903 · Cited by 1,871
Bomfim, T. R., Forny‐Germano, L., Sathler, L. B., Brito‐Moreira, J., Houzel, J., Decker, H., Silverman, M. A., Kazi, H., Melo, H. M., McClean, P. L., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci57256 · Cited by 849
Chen, Z., & Zhong, C. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.004 · Cited by 698
Brain fuel metabolism, aging, and Alzheimer’s disease
Cunnane, S. C., Nugent, S., Roy, M., Courchesne‐Loyer, A., Croteau, É., Tremblay, S., Castellano, A., Pifferi, F., Bocti, C., Paquet, N., et al. (2010) · Nutrition · doi:10.1016/j.nut.2010.07.021 · Cited by 633
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Mehran, A. E., Templeman, N. M., Brigidi, G. S., Lim, G. E., Chu, K.-Y., Hu, X., Botezelli, J. D., Asadi, A., Hoffman, B. G., Kieffer, T. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.10.019 · Cited by 498
Enduring consequences of maternal obesity for brain inflammation and behavior of offspring
Bilbo, S. D., & Tsang, V. (2010) · The FASEB Journal · doi:10.1096/fj.09-144014 · Cited by 489
The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer’s disease
Ferreira, S. T., & Klein, W. L. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.003 · Cited by 442
Willette, A. A., Bendlin, B. B., Starks, E. J., Birdsill, A. C., Johnson, S. C., Christian, B. T., Okonkwo, O. C., La Rue, A., Hermann, B. P., Koscik, R. L., et al. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0613 · Cited by 418
Butterfield, D. A., Di Domenico, F., & Barone, E. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.010 · Cited by 402
Insulin and Insulin Resistance in Alzheimer’s Disease
Sędzikowska, A., & Szablewski, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189987 · Cited by 414
Kim, B., & Feldman, E. L. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2015.3 · Cited by 372
Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease
Frisardi, V., Solfrizzi, V., Seripa, D., Capurso, C. A., Santamato, A., Sancarlo, D., Vendemiale, G., Pilotto, A., & Panza, F. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.007 · Cited by 365
de la Monte, S. M. (2017) · Drugs · doi:10.1007/s40265-016-0674-0 · Cited by 331
Michailidis, M., Moraitou, D., Tata, D. A., Kalinderi, K., Papamitsou, T., & Papaliagkas, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052687 · Cited by 330
Insulin resistance in the nervous system
Kim, B., & Feldman, E. L. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.12.004 · Cited by 321
Arnold, S. E., Lucki, I., Brookshire, B. R., Carlson, G. C., Browne, C. A., Kazi, H., Bang, S., Choi, B., Chen, Y., McMullen, M. F., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.011 · Cited by 320
Desideri, G., Kwik-Uribe, C., Grassi, D., Necozione, S., Ghiadoni, L., Mastroiacovo, D., Raffaele, A., Ferri, L., Bocale, R., Lechiara, M. C., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193060 · Cited by 311
Astrocytes as Key Regulators of Brain Energy Metabolism: New Therapeutic Perspectives
Béard, E., Lengacher, S., Dias, S., Magistretti, P. J., & Finsterwald, C. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.825816 · Cited by 326
High fat diet induces brain insulin resistance and cognitive impairment in mice
Kothari, V. M., Luo, Y., Tornabene, T., O’Neill, A. M., Greene, M. W., Geetha, T., & Babu, J. R. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.10.006 · Cited by 290
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Berthoud, H.-R., Lenard, N. R., & Shin, A. C. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00028.2011 · Cited by 275
Choi, J. S., Islam, M. N., Ali, M. Y., Kim, E. J., Kim, Y., & Jung, H. A. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.11.020 · Cited by 271
ER stress and UPR in Alzheimer’s disease: mechanisms, pathogenesis, treatments
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Human conditions of insulin-like growth factor-I (IGF-I) deficiency
Puche, J. E., & Castilla‐Cortázar, I. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-224 · Cited by 280
The Emerging Link between O-GlcNAc and Alzheimer Disease
Zhu, Y., Shan, X., Yuzwa, S. A., & Vocadlo, D. J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.r114.601351 · Cited by 267
Salcedo, I., Tweedie, D., Li, Y., & Greig, N. H. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01971.x · Cited by 272
Yuzwa, S. A., & Vocadlo, D. J. (2014) · Chemical Society Reviews · doi:10.1039/c4cs00038b · Cited by 249
High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity
Liu, Z., Patil, I., Jiang, T., Sancheti, H., Walsh, J. P., Stiles, B. L., Yin, F., & Cadenas, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128274 · Cited by 250
McNay, E. C., & Recknagel, A. K. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.08.005 · Cited by 233
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Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects
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Cerebral blood flow in Alzheimer’s disease
Roher, A. E., Debbins, Malek‐Ahmadi, M. H., Pipe, Maze, Belden, Maarouf, Hunter, Kokjohn, Walker, et al. (2012) · Vascular Health and Risk Management · doi:10.2147/vhrm.s34874 · Cited by 198
Multifactorial Hypothesis and Multi-Targets for Alzheimer’s Disease
Gong, C., Liu, F., & Iqbal, K. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179921 · Cited by 188
Chornenkyy, Y., Wang, W., Wei, A. L., & Nelson, P. T. (2018) · Brain Pathology · doi:10.1111/bpa.12655 · Cited by 189
Driver, J. A. (2014) · Biogerontology · doi:10.1007/s10522-014-9523-2 · Cited by 184
Barone, E., Domenico, F. D., Marzia Perluigi, A., & Butterfield, D. A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.006 · Cited by 182
Voss, M. W., Carr, L. J., Clark, R., & Weng, T. (2014) · Mental health and physical activity · doi:10.1016/j.mhpa.2014.01.001 · Cited by 164
Dorenkott, M. R., Griffin, L. E., Goodrich, K. M., Thompson‐Witrick, K. A., Fundaro, G., Ye, L., Stevens, J. R., Ali, M. M., O’Keefe, S. F., Hulver, M. W., et al. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf500333y · Cited by 153
Fusco, S., Ripoli, C., Podda, M. V., Ranieri, S. C., Leone, L., Toietta, G., McBurney, M. W., Schütz, G., Riccio, A., Grassi, C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109237109 · Cited by 148
Developmental programming of brain and behavior by perinatal diet: focus on inflammatory mechanisms
Bolton, J. L., & Bilbo, S. D. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/jbolton · Cited by 149
Chan, K., Lam, K. S. L., Cheng, O.-Y., Kwan, J., Ho, P. W., Cheng, K. K. Y., Chung, S. K., Ho, J. W.-M., Guo, V. Y., & Xu, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052354 · Cited by 143
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Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Salminen, A., Kaarniranta, K., Haapasalo, A., Hiltunen, M., Soininen, H., & Alafuzoff, I. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.11.005 · Cited by 153
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Lu, J. L., Wu, D.-M., Zheng, Z.-H., Zheng, Y., Hu, B., & Zhang, Z.-F. (2011) · Brain · doi:10.1093/brain/awq376 · Cited by 135
Rosales‐Corral, S., Tan, D., Manchester, L. C., & Reiter, R. J. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/985845 · Cited by 134
Mullins, R. J., Mustapić, M., Goetzl, E. J., & Kapogiannis, D. (2017) · Human Brain Mapping · doi:10.1002/hbm.23494 · Cited by 131
Felice, F. G. D., & Lourenco, M. V. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00094 · Cited by 122
Akhtar, M. W., Sanz‐Blasco, S., Dolatabadi, N., Parker, J., Chon, K., Lee, M. S., Soussou, W., McKercher, S. R., Ambasudhan, R., Nakamura, T., et al. (2016) · Nature Communications · doi:10.1038/ncomms10242 · Cited by 122
Di Domenico, F., Barone, E., Perluigi, M., & Butterfield, D. A. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6759 · Cited by 114
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Novel insights for the treatment of Alzheimer's disease
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Singh, M. K., Shin, Y., Han, S., Ha, J., Tiwari, P. K., Kim, S. S., & Kang, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105483 · Cited by 111
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Song, Z., Xu, Y., Deng, W., Zhang, L., Zhu, H., Yü, P., Qu, Y., Zhao, W., Han, Y., & Qin, C. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00079 · Cited by 103
Vascular and metabolic dysfunction in Alzheimer’s disease: a review
Murray, I. V. J., Proza, J. F., Sohrabji, F., & Lawler, J. M. (2011) · Experimental Biology and Medicine · doi:10.1258/ebm.2011.010355 · Cited by 104
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Pani, G. (2015) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.03.004 · Cited by 103
Western diets induce blood-brain barrier leakage and alter spatial strategies in rats.
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Vejražková, D., Včelák, J., Vaňková, M., Lukášová, P., Bradnová, O., Hálková, T., Kancheva, R. L., & Bendlová, B. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.11.007 · Cited by 102
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Gratas-Delamarche, A., Derbré, F., Vincent, S., & Cillard, J. (2014) · Free Radical Research · doi:10.3109/10715762.2013.847528 · Cited by 99
The diabetic brain and cognition
Riederer, P., Korczyn, A. D., Ali, S. S., Bajenaru, O. A., Choi, M. S., Chopp, M., Dobrota, V. Đ., Grünblatt, E., Jellinger, K. A., Kamal, M. A., et al. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1763-2 · Cited by 98
Alzheimer’s disease and type 2 diabetes mellitus: Pathophysiologic and pharmacotherapeutics links
Rojas, M., Chávez-Castillo, M., Bautista, J., Ortega, Á., Nava, M., Salazar, J. J., Díaz-Camargo, E. A., Medina, O., Rojas, J., & Bermúdez, V. (2021) · World Journal of Diabetes · doi:10.4239/wjd.v12.i6.745 · Cited by 98
Lipid metabolism and neuroinflammation in Alzheimer’s disease: a role for liver X receptors
Kang, J., & Rivest, S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1049 · Cited by 94
Shpakov, A. O., Derkach, K. V., & Berstein, L. M. (2015) · Future Science OA · doi:10.4155/fso.15.23 · Cited by 93
Biana: a software framework for compiling biological interactions and analyzing networks
Garcı́a-Garcı́a, J., Güney, E., Aragüés, R., Planas-Iglesias, J., & Oliva, B. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-56 · Cited by 91
Kellar, D., Lockhart, S. N., Aisen, P. S. S., Raman, R., Rissman, R. A., Brewer, J. B., & Craft, S. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2021.14 · Cited by 92
Yin, Q., Ma, Y., Yan, H., Hou, X., Chen, J., Shen, C., Sun, M., Shang, Y., Dong, S., Zeng, Z., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.07.020 · Cited by 90
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Piao, Y., Kim, H. G., Oh, M. S., & Pak, Y. K. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.007 · Cited by 81
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Candeias, E., Duarte, A. I., Carvalho, C., Correia, S. C., Cardoso, S., Santos, R. X., Plácido, A. I., Perry, G. L., & Moreira, P. I. (2012) · IUBMB Life · doi:10.1002/iub.1098 · Cited by 85
Datusalia, A. K., & Sharma, S. S. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8632-x · Cited by 81
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Son, S. M., Song, H., Byun, J., Park, K. S., Jang, H. C., Park, Y. J., & Mook‐Jung, I. (2012) · Diabetes · doi:10.2337/db11-1735 · Cited by 81
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Metadata
- Authors
- De La Monte, S. M.
- Venue
- BMB Reports
- Published
- 2009-08-31
- Volume
- 42
- Issue
- 8
- Pages
- 475-481
- ISSN
- 1976-6696 (ISSN-L)
- PMC
- PMC4600067
- OpenAlex
- W1963640549
- Cited by
- 392
- References
- 57
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 17 · 2023: 23 · 2022: 29 · 2021: 22 · 2020: 22 · 2019: 21 · 2018: 20 · 2017: 24 · 2016: 25 · 2015: 36 · 2014: 24 · 2013: 23 · 2012: 39
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMB Reports (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5r01aa011431-26)
- National Institute on Alcohol Abuse and Alcoholism (R01-AA011431, AA-12908, K24AA016126, AA-16126, AA11431, R56AA011431, R01AA012908, R37AA011431)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- brain insulin resistance, Alzheimer's disease, insulin-like growth factor, cognitive impairment, neurodegeneration, type 2 diabetes, obesity, liver-brain axis, ceramide, blood-brain barrier, oxidative stress, neuroinflammation, neuronal cell death, insulin signaling
- MeSH terms
- Alzheimer Disease, Animals, Brain, Humans, Insulin Resistance, Models, Biological, Somatomedins, Amyloid beta-Protein Precursor
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