Disease model organism for Parkinson disease: Drosophila melanogaster
Open accessAbstract
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20 genes, such as SNCA, parkin, PTEN-induced kinase1 (pink1), leucine-rich repeat kinase 2 (LRRK2), ATP13A2, MAPT, VPS35, and DJ-1, whereas the environmental factors consist of oxidative stress-induced toxins such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), rotenone, and paraquat. The analyses of their functions and mechanisms have provided important insights into the disease process, which has demonstrated that these factors cause oxidative damage and mitochondrial dysfunction. The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. In this review, we have focused on the fly model organism to summarize recent progress, including pathogenesis, neuroprotective compounds, and newer approaches. [BMB Reports 2019; 52(4): 250-258].
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Drosophila melanogaster under hypergravity conditions, there is a significant reduction of dopaminergic neurons compared with the control group, in a similar way to human Parkinson's disease.
“Another study that used Drosophila melanogaster showed a significant reduction of dopaminergic neurons, compared with the control group, under hypergravity conditions in a similar way to human’s Parkinson’s disease (PD)98.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [98]
The Introduction and the section on dopaminergic neurons describe neuronal loss in Drosophila models of Parkinson’s disease. The paper does not report a hypergravity experiment, a control-group comparison, or a statistically significant reduction under those conditions; it is a review, not the study described. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
Polymeropoulos, M. H., Lavedan, C., Leroy, E., Ide, S. E., Dehejia, A., Dutra, A., Pike, B., Root, H., Rubenstein, J., Boyer, R., et al. (1997) · Science · doi:10.1126/science.276.5321.2045 · Cited by 8,240 · see citing works
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Kitada, T., Asakawa, S., Hattori, N., Matsumine, H., Yamamura, Y., Minoshima, S., Yokochi, M., Mizuno, Y., & Shimizu, N. (1998) · Nature · doi:10.1038/33416 · Cited by 5,227 · see citing works
α-Synuclein Locus Triplication Causes Parkinson's Disease
Singleton, A. B., Farrer, M., Johnson, J., Singleton, A., Hague, S., Kachergus, J., Hulihan, M., Peuralinna, T., Dutra, A., Nussbaum, R., et al. (2003) · Science · doi:10.1126/science.1090278 · Cited by 4,383 · see citing works
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
Betarbet, R., Sherer, T., Mackenzie, G., Garcia-Osuna, M., Panov, A., & Greenamyre, J. (2000) · Nature Neuroscience · doi:10.1038/81834 · Cited by 3,797 · see citing works
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598 · see citing works
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>
Valente, E. M., Abou-Sleiman, P. M., Caputo, V., Muqit, M. M. K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A. R., Healy, D. G., et al. (2004) · Science · doi:10.1126/science.1096284 · Cited by 3,481 · see citing works
Mutations in LRRK2 Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology
Zimprich, A. A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M. J., Lincoln, S., Kachergus, J. M., Hulihan, M., Uitti, R. J., Calne, D. B., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.005 · Cited by 3,024 · see citing works
A Drosophila model of Parkinson's disease
Feany, M., & Bender, W. (2000) · Nature · doi:10.1038/35006074 · Cited by 2,145 · see citing works
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788 · see citing works
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705 · see citing works
Neuropathology of Parkinson's Disease
Forno, L. (1996) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199603000-00001 · Cited by 1,556 · see citing works
Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works
Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208 · see citing works
Mitochondrial pathology and apoptotic muscle degeneration in <i>Drosophila parkin</i> mutants
Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203 · see citing works
Devi, L., Raghavendran, V., Prabhu, B. M., Avadhani, N. G., & Anandatheerthavarada, H. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710012200 · Cited by 1,087 · see citing works
Mechanism of Toxicity in Rotenone Models of Parkinson's Disease
Sherer, T., Betarbet, R. S., Testa, C. M., Seo, B. B., Richardson, J. R., Kim, J. H., Miller, G. W., Yagi, T., Matsuno‐Yagi, A., & Greenamyre, J. T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-34-10756.2003 · Cited by 1,073 · see citing works
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Zimprich, A. A., Benet‐Pagès, A., Struhal, W., Graf, E., Eck, S. H., Offman, M. N., Haubenberger, D., Spielberger, S., Schulte, E. C., Lichtner, P., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.06.008 · Cited by 885 · see citing works
Expanding insights of mitochondrial dysfunction in Parkinson's disease
Abou-Sleiman, P. M., Muqit, M. M. K., & Wood, N. W. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1868 · Cited by 869 · see citing works
Mitochondria and neuronal activity
Kann, O., & Kovács, R. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00222.2006 · Cited by 847 · see citing works
Lee, M. K., Stirling, W., Xu, Y., Xu, X., Qui, D., Mandir, A. S., Dawson, T. M., Copeland, N. G., Jenkins, N. A., & Price, D. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132197599 · Cited by 824 · see citing works
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
Schober, A. (2004) · Cell and Tissue Research · doi:10.1007/s00441-004-0938-y · Cited by 803 · see citing works
Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.-W., Yang, L., Beal, M. F., Vogel, H., & Lu, B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602493103 · Cited by 798 · see citing works
Inflammation as a causative factor in the aetiology of Parkinson's disease
Whitton, P. S. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707167 · Cited by 625 · see citing works
Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
Li, Y., Liu, W., Oo, T. F., Wang, L., Tang, Y. L., Jackson-Lewis, V. R., Zhou, C., Geghman, K. D., Bogdanov, M. B., Przedborski, S., et al. (2009) · Nature Neuroscience · doi:10.1038/nn.2349 · Cited by 533 · see citing works
Mosharov, E. V., Larsen, K. E., Kanter, E., Phillips, K. A., Wilson, K., Schmitz, Y., Krantz, D. E., Kobayashi, K., Edwards, R. H., & Sulzer, D. L. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.033 · Cited by 530 · see citing works
Dehay, B., Bourdenx, M., Gorry, P., Przedborski, S., Vila, M., Hunot, S., Singleton, A., Olanow, C. W., Merchant, K., Bézard, E., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00006-x · Cited by 530 · see citing works
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk
MacLeod, D. A., Rhinn, H., Kuwahara, T., Zolin, A., Paolo, G. D., McCabe, B. D., Marder, K. S., Honig, L. S., Clark, L. N., Small, S. A., et al. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.033 · Cited by 519 · see citing works
Ludtmann, M. H. R., Angelova, P. R., Horrocks, M. H., Choi, M. L., Rodrigues, M., Baev, A. Y., Berezhnov, A. V., Yao, Z., Little, D., Banushi, B., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04422-2 · Cited by 513 · see citing works
Parkinson’s disease: animal models and dopaminergic cell vulnerability
Blesa, J., & Przedborski, S. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00155 · Cited by 483 · see citing works
A Guide to Neurotoxic Animal Models of Parkinson's Disease
Tieu, K. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009316 · Cited by 483 · see citing works
Parkinson's--Divergent Causes, Convergent Mechanisms
Greenamyre, J. T., & Hastings, T. G. (2004) · Science · doi:10.1126/science.1098966 · Cited by 453 · see citing works
Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases
Trushina, E. V., & McMurray, C. T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.056 · Cited by 440 · see citing works
Animal models of Parkinson’s disease
Blandini, F., & Armentero, M. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08491.x · Cited by 428 · see citing works
DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism
Bonifati, V., Rizzu, P., Squitieri, F., Krieger, E., Vanacore, N., Swieten, J. C. V., Brice, A., van Duijn, C. M., Oostra, B. A., Meco, G., et al. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0108-0 · Cited by 427 · see citing works
Drosophila as a Model for Human Neurodegenerative Disease
Bilen, J., & Bonini, N. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095804 · Cited by 420 · see citing works
Zhang, L., Shimoji, M., Thomas, B., Moore, D. J., Yu, S.-W., Marupudi, N. I., Torp, R., Torgner, I. A., Ottersen, O. P., Dawson, T. M., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi211 · Cited by 418 · see citing works
Martins, L. M., Morrison, A., Klupsch, K., Fedele, V., Moisoi, N., Teismann, P., Abuin, A., Grau, E., Geppert, M., Livi, G. P., et al. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.22.9848-9862.2004 · Cited by 395 · see citing works
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
Kim, Y. S., Park, J., Kim, S., Song, S., Kwon, S., Lee, S., Kitada, T., Kim, J., & Chung, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.104 · Cited by 389 · see citing works
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
Irrcher, I., Aleyasin, H., Seifert, E. L., Hewitt, S. J., Chhabra, S., Phillips, M., Lutz, A. K., Rousseaux, M. W. C., Bevilacqua, L., Jahani‐Asl, A., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq288 · Cited by 386 · see citing works
Vitamin K 2 Is a Mitochondrial Electron Carrier That Rescues Pink1 Deficiency
Vos, M. H., Esposito, G., Edirisinghe, J. N., Vilain, S., Haddad, D., Slabbaert, J. R., Meensel, S. V., Schaap, O., Strooper, B. D., Meganathan, R., et al. (2012) · Science · doi:10.1126/science.1218632 · Cited by 364 · see citing works
Meulener, M. C., Whitworth, A. J., Armstrong‐Gold, C. E., Rizzu, P., Heutink, P., Wes, P. D., Pallanck, L. J., & Bonini, N. M. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.064 · Cited by 354 · see citing works
The Parkinson's disease–linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Burchell, V., Nelson, D. E., Sánchez-Martínez, Á., Delgado-Camprubi, M., Ivatt, R. M., Pogson, J. H., Randle, S. J., Wray, S., Lewis, P. A., Houlden, H., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3489 · Cited by 334 · see citing works
Mutation in theSYNJ1Gene Associated with Autosomal Recessive, Early-Onset Parkinsonism
Quadri, M., Fang, M., Picillo, M., Olgiati, S., Breedveld, G. J., Graafland, J., Wu, B., Xu, F., Erro, R., Amboni, M., et al. (2013) · Human Mutation · doi:10.1002/humu.22373 · Cited by 320 · see citing works
Schulze, K. L., Broadie, K., Perin, M. S., & Bellen, H. J. (1995) · Cell · doi:10.1016/0092-8674(95)90414-x · Cited by 318 · see citing works
Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
Chartier‐Harlin, M., Dächsel, J. C., Vilariño‐Güell, C., Lincoln, S., Leprêtre, F., Hulihan, M., Kachergus, J. M., Milnerwood, A. J., Tapia, L., Song, M.-S., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2011.08.009 · Cited by 298 · see citing works
Davis, M. Y., Trinh, K., Thomas, R. E., Yu, S., Germanos, A. A., Whitley, B. N., Sardi, S. P., Montine, T. J., & Pallanck, L. J. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005944 · Cited by 294 · see citing works
Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity
Usenovic, M., Tresse, E., Mazzulli, J. R., Taylor, J. P., & Krainc, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5575-11.2012 · Cited by 291 · see citing works
A Drosophila model for LRRK2 -linked parkinsonism
Liu, Z., Wang, X., Yu, Y., Li, X., Wang, T., Jiang, H., Ren, Q., Jiao, Y., Sawa, A., Moran, T. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708452105 · Cited by 279 · see citing works
Tang, F., Liu, W., Hu, J.-X., Erion, J., Ye, J., Mei, L., & Xiong, W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.08.001 · Cited by 274 · see citing works
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
Cha, G., Kim, S., Park, J., Lee, E., Kim, M., Lee, S. B., Kim, J., Chung, J., & Cho, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500346102 · Cited by 261 · see citing works
Deficiency of parkin and PINK1 impairs age-dependent mitophagy in Drosophila
Cornelissen, T., Vilain, S., Vints, K., Gounko, N., Verstreken, P., & Vandenberghe, W. (2018) · eLife · doi:10.7554/elife.35878 · Cited by 239 · see citing works
Lee, K., Huh, S., Lee, S., Wu, Z., Kim, A., Kang, H., & Lu, B. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721136115 · Cited by 233 · see citing works
Meulener, M. C., Xu, K., Thomson, L., Ischiropoulos, H., & Bonini, N. M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601891103 · Cited by 230 · see citing works
Perier, C., Bové, J., Wu, D., Dehay, B., Choi, D., Jackson-Lewis, V. R., Rathke‐Hartlieb, S., Bouillet, P., Strasser, A., Schulz, J. B., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609874104 · Cited by 229 · see citing works
Mizuno, Y., Sone, N., & Saitoh, T. (1987) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1987.tb05737.x · Cited by 222 · see citing works
Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction
Park, J., Kim, S. Y., Cha, G., Lee, S. B., Kim, S., & Chung, J. (2005) · Gene · doi:10.1016/j.gene.2005.06.040 · Cited by 211 · see citing works
DJ-1 binds to mitochondrial complex I and maintains its activity
Hayashi, T., Ishimori, C., Takahashi-Niki, K., Taira, T., Kim, Y.-C., Maita, H., Maita, C., Ariga, H., & Iguchi‐Ariga, S. M. M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.10.025 · Cited by 199 · see citing works
Miura, E., Hasegawa, T., Konno, M., Suzuki, M., Sugeno, N., Fujikake, N., Geisler, S., Tabuchi, M., Oshima, R., Kikuchi, A., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.07.014 · Cited by 195 · see citing works
Roles of Drosophila DJ-1 in Survival of Dopaminergic Neurons and Oxidative Stress
Menzies, F. M., Yenisetti, S. C., & Min, K. (2005) · Current Biology · doi:10.1016/j.cub.2005.07.036 · Cited by 191 · see citing works
DNAJC6 is responsible for juvenile parkinsonism with phenotypic variability
Köroğlu, Ç., Baysal-Kıraç, L., Çetinkaya, M., Karasoy, H., & Tolun, A. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.11.006 · Cited by 190 · see citing works
Cellular processes associated with LRRK 2 function and dysfunction
Wallings, R. L., Manzoni, C., & Bandopadhyay, R. (2015) · FEBS Journal · doi:10.1111/febs.13305 · Cited by 179 · see citing works
Lu, X., Fleming, S. M., Meurers, B. H., Ackerson, L. C., Mortazavi, F., Lo, V., Hernandez, D., Sulzer, D., Jackson, G. R., Maidment, N. T., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5351-08.2009 · Cited by 177 · see citing works
Endocytosis and clathrin-uncoating defects at synapses of auxilin knockout mice
Yim, Y.-I., Sun, T., Wu, L., Raimondi, A., Camilli, P. V. D., Eisenberg, E., & Greene, L. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000738107 · Cited by 150 · see citing works
Pan, P.-Y., Li, X., Wang, J., Powell, J., Wang, Q., Zhang, Y., Chen, Z., Wicinski, B. A., Hof, P. R., Ryan, T. A., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0964-17.2017 · Cited by 147 · see citing works
Srivastava, P., & Panda, D. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.06004.x · Cited by 140 · see citing works
Abolaji, A. O., Adedara, A. O., Adie, M. A., Vicente-Crespo, M., & Farombi, E. O. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.114 · Cited by 125 · see citing works
Genetics of Parkinson's disease
Gasser, T. (2001) · Journal of Neurology · doi:10.1007/s004150170066 · Cited by 124 · see citing works
Trinh, K., Andrews, L. A., Krause, J., Hanak, T. J., Lee, D., Gelb, M. H., & Pallanck, L. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4777-09.2010 · Cited by 112 · see citing works
Genetics of Parkinson's disease.
Gasser, T. (2004) · Europe PMC (PubMed Central) · Cited by 111 · see citing works
Heo, J. Y., Park, J. H., Kim, S. J., Seo, K. S., Han, J., Lee, S. H., Kim, J., Park, J., Park, S. K., Lim, K., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032629 · Cited by 102 · see citing works
Abnormal α-Synuclein Interactions with Rab Proteins in α-Synuclein A30P Transgenic Mice
Dalfó, E., Gómez‐Isla, T., Rosa, J. L., Bodelón, M. N., Tejedor, M. C., Barrachina, M., Ambrosio, S., & Ferrer, I. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.4.302 · Cited by 98 · see citing works
Suzuki, M., Fujikake, N., Takeuchi, T., Kohyama‐Koganeya, A., Nakajima, K., Hirabayashi, Y., Wada, K., & Nagai, Y. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv372 · Cited by 97 · see citing works
Impairment of PARK14-dependent Ca2+ signalling is a novel determinant of Parkinson’s disease
Zhou, Q., Yen, A., Rymarczyk, G., Asai, H., Trengrove, C., Aziz, N. M., Kirber, M. T., Mostoslavsky, G., Ikezu, T., Wolozin, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms10332 · Cited by 96 · see citing works
Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin
Tain, L. S., Chowdhury, R. B., Tao, R., Plun‐Favreau, H., Moisoi, N., Martins, L. M., Downward, J., Whitworth, A. J., & Tapon, N. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.23 · Cited by 91 · see citing works
Norris, K. L., Hao, R., Chen, L., Lai, C.-H., Kapur, M., Shaughnessy, P. J., Chou, D., Yan, J., Taylor, J. P., Engelender, S., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.634063 · Cited by 87 · see citing works
Rousseaux, M. W. C., Marcogliese, P. C., Qu, D., Hewitt, S. J., Seang, S., Kim, R. H., Slack, R. S., Schlossmacher, M. G., Lagace, D. C., Mak, T. W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205102109 · Cited by 86 · see citing works
S-nitrosylation of UCHL1 induces its structural instability and promotes α-synuclein aggregation
Kumar, R., Jangir, D. K., Verma, G., Shekhar, S., Hanpude, P., Kumar, S., Kumari, R., Singh, N., Bhavesh, N. S., Jana, N. R., et al. (2017) · Scientific Reports · doi:10.1038/srep44558 · Cited by 82 · see citing works
Giovannone, B., Tsiaras, W. G., de la Monte, S. M., Kłysik, J., Lautier, C., Karashchuk, G., Goldwurm, S., & Smith, R. J. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp430 · Cited by 78 · see citing works
Li, S., He, Y., Ou, J., Zhao, Y., Li, R., Cheng, J., Lin, C., & Ho, M. S.-C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.005 · Cited by 76 · see citing works
A New Evolutionary Paradigm for the Parkinson Disease Gene DJ-1
Lucas‐Lledó, J. I., & Marı́n, I. (2006) · Molecular Biology and Evolution · doi:10.1093/molbev/msl186 · Cited by 68 · see citing works
Vingill, S., Brockelt, D., Lancelin, C., Tatenhorst, L., Dontcheva, G., Preisinger, C., Schwedhelm‐Domeyer, N., Joseph, S., Mitkovski, M., Goebbels, S., et al. (2016) · The EMBO Journal · doi:10.15252/embj.201593585 · Cited by 67 · see citing works
Moisoi, N., Fedele, V., Edwards, J., & Martins, L. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.10.009 · Cited by 65 · see citing works
Karuppagounder, S. S., Xiong, Y., Lee, Y., Lawless, M. C., Kim, D., Nordquist, E., Martin, I., Ge, P., Brahmachari, S., Jhaldiyal, A., et al. (2016) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2016.01.007 · Cited by 53 · see citing works
Self-citationChiu, C., Yeh, T., Lu, C.-S., Huang, Y.-C., Cheng, Y., Huang, Y., Weng, Y.-H., Liu, Y.-C., Lai, S., Chen, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.20893 · Cited by 53 · see citing works
Kim, M., Semple, I. A., Kim, B. Y., Kiers, A., Nam, S., Park, H., Park, H., Ro, S., Kim, J.-S., Juhász, G., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1063766 · Cited by 48 · see citing works
Zinc supplement greatly improves the condition of parkin mutant Drosophila
Saini, N., & Schaffner, W. (2010) · Biological Chemistry · doi:10.1515/bc.2010.052 · Cited by 48 · see citing works
Characterization of early-onset motor deficits in the Pink1−/− mouse model of Parkinson disease
Kelm‐Nelson, C. A., Brauer, A. F. L., Barth, K. J., Lake, J. M., Sinnen, M. L. K., Stehula, F. J., Muslu, C. S., Marongiu, R., Kaplitt, M. G., & Ciucci, M. R. (2017) · Brain Research · doi:10.1016/j.brainres.2017.12.002 · Cited by 46 · see citing works
Piperine ameliorates SCA17 neuropathology by reducing ER stress
Guo, J., Cui, Y., Liu, Q., Yang, Y., Li, Y., Weng, L., Tang, B., Jin, P., Li, X., Yang, S., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0236-x · Cited by 44 · see citing works
Pareek, G., Thomas, R. E., & Pallanck, L. J. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0365-8 · Cited by 42 · see citing works
Khair, S. B. A., Dhanushkodi, N. R., Ardah, M. T., Chen, W., Yang, Y., & Haque, M. E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00081 · Cited by 41 · see citing works
Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson’s Disease
Tran, H., Dang, S., Nguyễn, T. T., Huynh, M. A., Đào, L. M., Kamei, K., Yamaguchi, M., & Thảo, Đ. T. P. (2018) · Scientific Reports · doi:10.1038/s41598-018-22804-w · Cited by 31 · see citing works
Olfactory Deficits in an Alpha-Synuclein Fly Model of Parkinson’s Disease
Chen, A. Y., Xia, S., Wilburn, P., & Tully, T. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097758 · Cited by 27 · see citing works
Mena, M. A., Casarejos, M. J., Solano, R. M., & de Yébenes, J. G. (2009) · PubMed · Cited by 26 · see citing works
Payami, H., & Factor, S. A. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0237-y · Cited by 16 · see citing works
Poudel, S., & Lee, Y. (2018) · Europe PMC (PubMed Central) · doi:10.14348/molcells.2018.0014 · Cited by 16 · see citing works
Self-citationThe Drosophila hep pathway mediates Lrrk2-induced neurodegeneration
Yang, D., Thomas, J. M., Li, T., Lee, Y., Liu, Z., & Smith, W. W. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2017-0262 · Cited by 13 · see citing works
Self-citation[Pathology of familial Parkinson's disease].
Wakabayashi, K., & Takahashi, H. (2007) · PubMed · Cited by 12 · see citing works
Lehmann, S., Jardine, J., Garrido‐Maraver, J., Loh, S. H. Y., & Martins, L. M. (2017) · Matters · doi:10.19185/matters.201702000009 · Cited by 7 · see citing works
Flagged first, then by citations
1 of the 100 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [48]Clark IE Dodson MW Jiang C 2006 Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 441 1162 1166 10.1038/nature04779 16672981 · DOI · Paper page
Cited by
Sorted by citations
Teixeira, P. R., Dusi, R. G., Jimenez, P. C., Espíndola, L. S., & Costa-Lotufo, L. V. (2022) · Environmental Pollution · doi:10.1016/j.envpol.2022.118983 · Cited by 210 · see citing works
Disorders of the enteric nervous system — a holistic view
Niesler, B., Küerten, S., Demir, İ. E., & Schäfer, K. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00385-2 · Cited by 198 · see citing works
Dovonou, A., Bolduc, C., Linan, V. S., Gora, C., Peralta, M. R., & Lévesque, M. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00368-8 · Cited by 203 · see citing works
Liu, W., Wei, S., Huang, G., Liu, L.-B., Gu, C., Shen, Y., Wang, X., Xia, S., Xie, A., Hu, L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901565rr · Cited by 106 · see citing works
Gómez, X., Sanon, S., Zambrano, K., Asquel, S., Bassantes, M., Morales, J. E., Otáñez, G., Pomaquero, C., Villarroel, S., Zurita, A., et al. (2021) · npj Microgravity · doi:10.1038/s41526-021-00162-8 · Cited by 92 · see citing works
A Critical Review of Zebrafish Models of Parkinson’s Disease
Doyle, J. M., & Croll, R. P. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.835827 · Cited by 84 · see citing works
Reversing insecticide resistance with allelic-drive in Drosophila melanogaster
Kaduskar, B., Kushwah, R. B. S., Auradkar, A., Guichard, A., Li, M., Bennett, J. B., Julio, A. H. F., Marshall, J. M., Montell, C., & Bier, E. (2022) · Nature Communications · doi:10.1038/s41467-021-27654-1 · Cited by 68 · see citing works
Ortega‐Arellano, H. F., Jiménez-Del-Río, M., & Velez‐Pardo, C. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02835-z · Cited by 59 · see citing works
Musachio, E. A. S., Araújo, S. M., Bortolotto, V. C., Couto, S. D. F., Dahleh, M. M. M., Poetini, M. R., Fernandes, E. J., Meichtry, L. B., Ramborger, B. P., Roehrs, R., et al. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111128 · Cited by 59 · see citing works
Neural shutdown under stress: an evolutionary perspective on spreading depolarization
Robertson, R. M., Dawson-Scully, K. D., & Andrew, R. D. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00724.2019 · Cited by 51 · see citing works
Neuroinflammation in Parkinson’s Disease: From Gene to Clinic: A Systematic Review
Castillo-Rangel, C., Marín, G., Hernández-Contreras, K. A., Vichi-Ramírez, M. M., Zarate-Calderon, C., Torres-Pineda, O., Díaz-Chiguer, D. L., González, D. D. L. M., Apo, E. G., Teco-Cortes, J. A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065792 · Cited by 49 · see citing works
Sphingolipids in neurodegenerative diseases
Pan, X., Dutta, D., Lu, S., & Bellen, H. J. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1137893 · Cited by 49 · see citing works
Circadian clock disruption promotes the degeneration of dopaminergic neurons in male Drosophila
Dorcikova, M. M., Duret, L. C., Pottié, E., & Nagoshi, E. (2023) · Nature Communications · doi:10.1038/s41467-023-41540-y · Cited by 42 · see citing works
Sayyaed, A., Saraswat, N., Vyawahare, N. S., & Kulkarni, A. (2023) · Bulletin of the National Research Centre/Bulletin of the National Research Center · doi:10.1186/s42269-023-01047-4 · Cited by 38 · see citing works
Guo, Q., Wang, B., Wang, X., Smith, W. W., Zhu, Y., & Liu, Z. (2021) · Cells · doi:10.3390/cells10081850 · Cited by 34 · see citing works
Akinade, T. C., Babatunde, O. O., Adedara, A. O., Adeyemi, O., Otenaike, T. A., Ashaolu, O. P., Johnson, T. O., Terriente-Félix, A., Whitworth, A. J., & Abolaji, A. O. (2022) · Scientific Reports · doi:10.1038/s41598-022-08409-4 · Cited by 34 · see citing works
Drosophila as a Model for Human Disease: Insights into Rare and Ultra-Rare Diseases
Casas‐Tintó, S. (2024) · Insects · doi:10.3390/insects15110870 · Cited by 31 · see citing works
Sánchez-Giraldo, V., Monsalve, Y., Palacio, J., Mendivil‐Perez, M., Sierra, L., Velez‐Pardo, C., López, B. L., & Jiménez-Del-Río, M. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.101466 · Cited by 28 · see citing works
Metabolic Alterations in a Drosophila Model of Parkinson’s Disease Based on DJ-1 Deficiency
Solana‐Manrique, C., Sanz, F., Torregrosa, I., Palomino‐Schätzlein, M., Hernández-Oliver, C., Pineda‐Lucena, A., & Paricio, N. (2022) · Cells · doi:10.3390/cells11030331 · Cited by 27 · see citing works
Afsheen, S., Rehman, A. S., Jamal, A., Khan, N. H., & Parvez, S. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102340 · Cited by 27 · see citing works
Animal Models of Human Disease
Lange, S., & Inal, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115821 · Cited by 25 · see citing works
Rasheed, M. Z., Khatoon, R., Talat, F., Alam, M. M., Tabassum, H., & Parvez, S. (2023) · ACS Omega · doi:10.1021/acsomega.2c03992 · Cited by 25 · see citing works
Idda, T., Bonas, C., Hoffmann, J., Bertram, J., Quinete, N., Schettgen, T., Fietkau, K., Esser, A., Stope, M. B., Leijs, M. M., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78405-z · Cited by 23 · see citing works
Circadian rhythm disruption: a potential trigger in Parkinson’s disease pathogenesis
Xu, K., Zhang, Y., Shi, Y. X., Zhang, Y., Zhang, C., Wang, T., Lv, P., Bai, Y., & Wang, S. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1464595 · Cited by 22 · see citing works
Cell competition from development to neurodegeneration
RODRIGUES, M. C., Couceiro, J., & Moreno, E. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048926 · Cited by 22 · see citing works
Thane, M., Paisios, E., Stöter, T., Krüger, A.-R., Gläß, S., Dahse, A.-K., Scholz, N., Gerber, B., Lehmann, D. J., & Schleyer, M. H. (2023) · Open Biology · doi:10.1098/rsob.220308 · Cited by 20 · see citing works
Chua, S. C. J. H., Tan, H. Q., Engelberg, D., & Lim, L. H. K. (2019) · Pharmaceuticals · doi:10.3390/ph12040147 · Cited by 19 · see citing works
A new metabolic model of Drosophila melanogaster and the integrative analysis of Parkinson’s disease
Cesur, M. F., Basile, A., Patil, K. R., & Çakır, T. (2023) · Life Science Alliance · doi:10.26508/lsa.202201695 · Cited by 18 · see citing works
Ahn, Y., Han, S., Kim, M. G., Hong, K., Kim, W. J., Suh, H. J., & Jo, K. (2021) · Pharmaceutical Biology · doi:10.1080/13880209.2021.1949356 · Cited by 18 · see citing works
Narwal, S., Singh, A., & Tare, M. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1295805 · Cited by 16 · see citing works
Poetini, M. R., Musachio, E. A. S., Araújo, S. M., Bortolotto, V. C., Meichtry, L. B., Silva, N. C., Janner, D. E., Novo, D. L. R., Mesko, M. F., Roehrs, R., et al. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.02.004 · Cited by 16 · see citing works
Dithianon exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans
Lee, Y., Choi, S., & Kim, K. W. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114752 · Cited by 15 · see citing works
Self-citationNunes, R. G. D. S., de Amorim, L. C., Bezerra, I. C., da Silva, A. J., dos Santos, C. A. L., Gubert, P., de Menezes, I. R. A., Duarte, A. E., Barros, L. M., Andrade‐da‐Costa, B. L. D. S., et al. (2024) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2338431 · Cited by 13 · see citing works
Drosophila Models Reveal Properties of Mutant Lamins That Give Rise to Distinct Diseases
Walker, S. G., Langland, C. J., Viles, J., Hecker, L. A., & Wallrath, L. L. (2023) · Cells · doi:10.3390/cells12081142 · Cited by 12 · see citing works
Ramos, V., Reis, M. A., Ferreira, L., Silva, A. M., Ferraz, R., Vieira, M., Vasconcelos, V. M., & Martins, R. F. (2023) · Biomolecules · doi:10.3390/biom13101444 · Cited by 12 · see citing works
Ganesan, S., & Parvathi, V. D. (2021) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-021-00208-2 · Cited by 12 · see citing works
Solana‐Manrique, C., Moltó, M. D., Calap-Quintana, P., Sanz, F., Llorens, J. V., & Paricio, N. (2019) · Springer eBooks · doi:10.1007/978-981-13-2218-1_15 · Cited by 12 · see citing works
Sankar, S., Chandrasekaran, N., Moovendhan, M., & Parvathi, V. D. (2024) · Environmental Quality Management · doi:10.1002/tqem.70021 · Cited by 11 · see citing works
How Rearing Systems for Various Species of Flies Benefit Humanity
Pascacio‐Villafán, C., & Cohen, A. C. (2023) · Insects · doi:10.3390/insects14060553 · Cited by 12 · see citing works
Plasticity of pheromone-mediated avoidance behavior in C. elegans
Cheon, Y., Hwang, H., & Kim, K. (2020) · Journal of neurogenetics · doi:10.1080/01677063.2020.1802723 · Cited by 10 · see citing works
Quintero-Espinosa, D. A., Jiménez-Del-Río, M., & Velez‐Pardo, C. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04141-9 · Cited by 10 · see citing works
Erhardt, B., Marcora, M. S., Frenkel, L., Bochicchio, P. A., Bodín, D. H., Silva, B. A., Farías, M. I., Allo, M. Á., Höcht, C., Ferrari, C. C., et al. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15401 · Cited by 9 · see citing works
Dumitrescu, E., Copeland, J. M., & Venton, B. J. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00277 · Cited by 10 · see citing works
Progress in Parkinson's disease animal models of genetic defects: Characteristics and application
Zhang, C., Chen, S., Li, X., Xu, Q., Lin, Y., Lin, F., Yuan, M., Zi, Y., & Cai, J. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113768 · Cited by 9 · see citing works
Pedroso, A. L., Schonwald, M. K., Corte, C. L. D., Soares, F. A. A., Sperança, A., Godoi, B., & de Carvalho, N. R. (2023) · Toxicology Research · doi:10.1093/toxres/tfad081 · Cited by 9 · see citing works
Monoamine Oxidase Inhibitors in Toxic Models of Parkinsonism
Бунеева, О. А., & Medvedev, A. E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031248 · Cited by 11 · see citing works
Unrevealing the molecular mechanisms of MPTP-induced Parkinson’s in experimental animals
Mondal, S., & Firdous, S. M. (2025) · Medicinal Chemistry Research · doi:10.1007/s00044-025-03409-1 · Cited by 9 · see citing works
The international exchange of Drosophila melanogaster strains
Cook, K. R., & Parks, A. L. (2022) · Scientific and Technical Review (World Organisation for Animal Health) · doi:10.20506/rst.41.1.3305 · Cited by 9 · see citing works
Asthana, J., & Shravage, B. V. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.986849 · Cited by 10 · see citing works
Caffeine improves mitochondrial function in PINK1B9-null mutant Drosophila melanogaster
Gonçalves, D. F., Senger, L. R., Foletto, J. V. P., Michelotti, P., Soares, F. A. A., & Corte, C. L. D. (2022) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-022-09952-5 · Cited by 9 · see citing works
Bernardes, L. M. M., Malta, S. M., Rodrigues, T. S., Covizzi, L. F., Rosa, R. B., Justino, A. B., Teixeira, R. R., Espíndola, F. S., dos Santos, D. O., Ueira‐Vieira, C., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291242 · Cited by 9 · see citing works
Yang, P., Liu, Y., Tong, Z., Huang, Q., Xie, X., Mao, S.-Y., Ding, J., Lu, M., Tan, R. X., & Hu, G. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01259-y · Cited by 9 · see citing works
Okonta, C., Ogunyemi, O. M., Olabuntu, B. A., & Abolaji, A. O. (2025) · Toxicology Reports · doi:10.1016/j.toxrep.2025.102004 · Cited by 8 · see citing works
Mo, L., Li, R., He, C., Chen, Q., Xu, C., Shen, L., Chen, K., & Wu, Y. (2022) · Human Cell · doi:10.1007/s13577-022-00796-0 · Cited by 8 · see citing works
Animal Models of Human Disease
(2011) · Progress in molecular biology and translational science · doi:10.1016/c2010-0-65612-4 · Cited by 8 · see citing works
Jung, B. C., Kim, S. H., Cho, Y., & Kim, Y. S. (2023) · BMB Reports · doi:10.5483/bmbrep.2023-0134 · Cited by 7 · see citing works
In vivo and in silico models of Drosophila for Parkinson's disease
Cesur, M. F., Strazdins, R., Sarkar, S., & Çakır, T. (2025) · FEBS Journal · doi:10.1111/febs.70140 · Cited by 7 · see citing works
Sanz, F., Solana‐Manrique, C., & Paricio, N. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00026 · Cited by 7 · see citing works
The impact of Parkinson’s disease-associated gut microbiota on the transcriptome in Drosophila
Liu, X., Yang, M., Liu, R., Zhou, F., Zhu, H., & Wang, X. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00176-23 · Cited by 7 · see citing works
Use of invertebrates to model chemically induced parkinsonism-symptoms
Corrêa, C. L., Gomes, C. A. B. D. A., Mello, A. D. A., Nogueira, N. D. S., Medeiros, T. B., de Barros, C. M., & Allodi, S. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221172 · Cited by 7 · see citing works
A Comprehensive Study of miRNAs in Parkinson’s Disease: Diagnostics and Therapeutic Approaches
Siddique, Y. H., & Owais, S. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220111152756 · Cited by 6 · see citing works
Setzu, M. D., Mocci, I., Fabbri, D., Carta, P., Muroni, P., Diana, A., Dettori, M. A., & Casu, M. A. (2024) · Biomolecules · doi:10.3390/biom14030273 · Cited by 5 · see citing works
Experimental Models in Parkinson’s Disease: Advantages and Disadvantages
Altunlu, Ö., Topatan, E., Al-yaqoobi, Z., Burul, F., Bayram, C., Sezen, S., Okkay, I. F., Okkay, U., & Hacımüftüoğlu, A. (2024) · Ağrı Tıp Fakültesi Dergisi · doi:10.61845/agrimedical.1471854 · Cited by 6 · see citing works
Paraquat neurotoxicity: Oxidative stress and neuronal dysfunction in the ascidian brain
Silva, R. R. E., Portal, T. M., Nogueira, N. D. S., Nogueira, T. D. S., Mello, A. D. A., & de Barros, C. M. (2025) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2025.110128 · Cited by 6 · see citing works
Drug discovery and development for Parkinson’s disease: are preclinical models good enough?
Reinares-Sebastián, A., Esteban-García, N., Takada, M., & Trigo‐Damas, I. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1692592 · Cited by 5 · see citing works
Kasamo, Y., Kikuchi, K., Yamakuchi, M., Otsuka, S., Takada, S., Kambe, Y., Ito, T., Kawahara, K.-I., Arita, K., Yoshimoto, K., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189941 · Cited by 5 · see citing works
Jellinger, K. A. (2019) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2019.1638908 · Cited by 5 · see citing works
Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegenerationPreprint
Buck, S. A., Rubin, S. A., Kunkhyen, T., Treiber, C. D., Xue, X., Fenno, L. E., Mabry, S. J., Sundar, V. R., Yang, Z., Shah, D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.10.02.560584 · Cited by 5 · see citing works
Buck, S. A., Mabry, S. J., Kunkhyen, T., Yang, Z., Rubin, S. A., Yang, J., Cheetham, C. E. J., & Freyberg, Z. (2025) · Aging Cell · doi:10.1111/acel.70096 · Cited by 4 · see citing works
Zhang, W., Ju, Y., Ren, Y., Miao, Y., & Wang, Y. (2024) · Current Drug Targets · doi:10.2174/0113894501281402231218071641 · Cited by 4 · see citing works
Diana, A., Collu, M., Casu, M. A., Mocci, I., Aguilar‐Santelises, M., & Setzu, M. D. (2020) · Brain Sciences · doi:10.3390/brainsci10010045 · Cited by 4 · see citing works
Modeling of Parkinson’s disease in Drosophila based on DJ-1 deficiency
Sanz, F., Solana‐Manrique, C., & Paricio, N. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89833-1.00043-4 · Cited by 4 · see citing works
Ishola, I. O., Oloyo, A. K., Olubodun-Obadun, T. G., Godswill, O. D., Omilabu, S. A., & Adeyemi, O. O. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01120-3 · Cited by 3 · see citing works
Samson, J. S., Rajagopal, K., & Parvathi, V. D. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149505 · Cited by 3 · see citing works
Giles, H. H., Petersen, S. C., Call, G. B., & Chaston, J. M. (2021) · Microbiology Resource Announcements · doi:10.1128/mra.01372-20 · Cited by 2 · see citing works
Boosting life sciences research in Brazil: building a case for a local Drosophila stock center
Oliveira, M. T., Anhezini, L., Araujo, H. M., de Oliveira, M. F., & Lima, C. A. C. (2024) · Genetics and Molecular Biology · doi:10.1590/1678-4685-gmb-2023-0202 · Cited by 2 · see citing works
In vivo Effects of Salicornia herbacea and Calystegia soldanella Extracts for Memory Improvement
Sang, J., Poudel, S., & Lee, Y. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2312.12045 · Cited by 2 · see citing works
Self-citationLuan, H. (2025) · Immune discovery. · doi:10.70322/immune.2025.10001 · Cited by 2 · see citing works
The utility and caveat of split-GAL4s in the study of neurodegeneration
Stickley, L., Koch, R., & Nagoshi, E. (2023) · Fly · doi:10.1080/19336934.2023.2192847 · Cited by 2 · see citing works
Khvastunov, V. O., Goleva, T. N., Epremyan, K. K., & Rogov, A. G. (2024) · Nanobiotechnology Reports · doi:10.1134/s2635167624602377 · Cited by 1 · see citing works
Advancement in the animal model-based therapeutics in neurodegenerative diseases
Pal, D., Das, P., Ghosh, P., Gupta, S., Basak, P., & Nandi, S. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33877-9.00007-0 · Cited by 1 · see citing works
Idowu, O. K., Oremosu, A. A., & Dosumu, O. O. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-01795-y · Cited by 1 · see citing works
Baisgaard, A. E., Koldby, K. M., Kristensen, T., Nyegaard, M., & Rohde, P. D. (2023) · Insects · doi:10.3390/insects14020168 · Cited by 1 · see citing works
Absence of pretaporter restrains features of the parkin phenotype in Drosophila
Silvera, M. C., Cantera, R., & Ferreiro, M. J. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114997 · Cited by 1 · see citing works
Thane, M., Paisios, E., Stöter, T., Krüger, A.-R., Gläß, S., Dahse, A.-K., Scholz, N., Gerber, B., Lehmann, D. J., & Schleyer, M. H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.27.509663 · Cited by 1 · see citing works
Sanz, F., Solana‐Manrique, C., & Paricio, N. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.28.522104 · Cited by 1 · see citing works
Exhaustive benchmarking of de novo assembly methods for eukaryotic genomesPreprint
Southwood, D., Rane, R., Lee, S. F., Oakeshott, J. G., & Ranganathan, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.18.537422 · Cited by 1 · see citing works
Rai, J., Aswini, S., Paul, S., Shelke, T., & Gupta, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.04.647141 · Cited by 1 · see citing works
Modeling Mechanisms and Applications of Parkinson's Disease Animal ModelsPreprint
Cui, Y., LIANG, Y., Liu, Y., & Zhang, B. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4175871
A genome-scale metabolic model of Drosophila melanogaster for integrative analysis of brain diseasesPreprint
Cesur, M. F., Patil, K. R., & Çakır, T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.22.504778
Circadian clock disruption promotes the degeneration of dopaminergic neuronsPreprint
Dorcikova, M. M., Duret, L. C., Pottié, E., & Nagoshi, E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.15.512376
Usefulness of Drosophila in studying Parkinson's disease and role of natural plant products
(2023) · Advances in neurotoxicology · doi:10.1016/bs.ant.2023.01.007
Dhande, S. R., & Pansare, N. (2024) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2024.00491
Maintenance of Mitochondrial Dynamics for Healthy Brain Ageing
Mishra, E., & Thakur, M. K. (2024) · Healthy ageing and longevity · doi:10.1007/978-3-031-68513-2_10
Modeling of Parkinson's Disease in Different Models
Subhan, I., & Siddique, Y. H. (2024) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/0118715273326866240922193029
Ethical regulations for induction and validation of PD models
Oraby, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-16128-5.00019-0
Sayed, F. E., Mahmoud, A. K., Mohammed, O. A. M., Soliman, R. I., & Abdur-Rahman, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-16128-5.00014-1
Neuroprotective role of ranolazine in Parkinson disease: Drosophila melanogaster model
Parvesh, P., Kumar, S., Singh, G., Khatri, R., Shkula, S., Kaushik, K., Lather, A., & Hooda, T. (2025) · Scripta Medica · doi:10.5937/scriptamed56-53259
AGAKWU, M. U., OGUNMEFUN, G. S., YUSUF, H. O., ONMONYA, Y. A., & ADUNBI, J. O. (2024) · Journal of Biochemistry and molecular biology · doi:10.36108/jbmb/4202.20.0140
Anadu, V. E., Jimoh-Abdulghaffaar, H. O., Gilbert, T. T., Aneke, O. V., Arietarhire, L. O., Ichipi-Ifukor, P. C., Abdullahi, A. M., Okah, L., Sabine, A. F. Y., Oritsetimeyin, B. U., et al. (2025) · Biology Open · doi:10.1242/bio.061998
- Authors
- Aryal, B., & Lee, Y.
- Affiliations
- Kookmin University (KR)
- Venue
- BMB Reports
- Published
- 2019-04-30
- Volume
- 52
- Issue
- 4
- Pages
- 250-258
- ISSN
- 1976-6696 (ISSN-L)
- 1976-670X
- PMC
- PMC6507844
- OpenAlex
- W2942930317
- Cited by
- 111
- References
- 100
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 21 · 2023: 25 · 2022: 20 · 2021: 9 · 2020: 7 · 2019: 5
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMB Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (NRF-2016R1D1A1B03931273, NRF-2018R1A2B6004202)
- Ministry of Education
- Kookmin University
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- Parkinson's disease, Drosophila melanogaster, dopaminergic neuron loss, neurodegeneration, genetic risk factors, environmental risk factors, oxidative stress, mitochondrial dysfunction, neuroprotective compounds, Parkin, LRRK2, MPTP, rotenone, paraquat, SNCA, PINK1, DJ-1, ATP13A2, MAPT, VPS35
- MeSH terms
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Protein Deglycase DJ-1, PTEN-Induced Putative Kinase, Adenosine Triphosphatases, Animals, Disease Models, Animal, Drosophila melanogaster, Humans, Membrane Proteins, Mitochondria, Parkinson Disease, Hazardous Substances, Protein Serine-Threonine Kinases, Oxidative Stress, Neurodegenerative Diseases, Drosophila Proteins, Vesicular Transport Proteins, Ubiquitin-Protein Ligases, alpha-Synuclein, Dopaminergic Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
