Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
Open accessAbstract
Mutations in Pink1, a gene encoding a Ser/Thr kinase with a mitochondrial-targeting signal, are associated with Parkinson's disease (PD), the most common movement disorder characterized by selective loss of dopaminergic neurons. The mechanism by which loss of Pink1 leads to neurodegeneration is not understood. Here we show that inhibition of Drosophila Pink1 (dPink1) function results in energy depletion, shortened lifespan, and degeneration of select indirect flight muscles and dopaminergic neurons. The muscle pathology was preceded by mitochondrial enlargement and disintegration. These phenotypes could be rescued by the wild type but not the pathogenic C-terminal deleted form of human Pink1 (hPink1). The muscle and dopaminergic phenotypes associated with dPink1 inactivation show similarity to that seen in parkin mutant flies and could be suppressed by the overexpression of Parkin but not DJ-1. Consistent with the genetic rescue results, we find that, in dPink1 RNA interference (RNAi) animals, the level of Parkin protein is significantly reduced. Together, these results implicate Pink1 and Parkin in a common pathway that regulates mitochondrial physiology and cell survival in Drosophila.
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Unlike rodent PINK1 or Parkin models, Drosophila models exhibit obvious mitochondrial degeneration.
“Unlike rodent PINK1 or Parkin models, Drosophila models exhibit obvious mitochondrial degeneration (Clark et al., 2006, Park et al., 2006, Yang et al., 2006).”
From A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling (2020) · cites this paper as Yang et al., 2006
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A Cell-Based High-Throughput Screening Identified Two Compounds that Enhance PINK1-Parkin Signaling
Shiba-Fukushima, K., Inoshita, T., Sano, O., Iwata, H., Ishikawa, K.-I., Okano, H., Akamatsu, W., Imai, Y., & Hattori, N. (2020) · iScience · doi:10.1016/j.isci.2020.101048 · Cited by 37 · see citing works
“Unlike rodent PINK1 or Parkin models, Drosophila models exhibit obvious mitochondrial degeneration (Clark et al., 2006; Park et al., 2006; Yang et al., 2006).”
BackgroundSelf-citationDiaminodiphenyl sulfone–induced parkin ameliorates age-dependent dopaminergic neuronal loss
Lee, Y.-I., Kang, H., Ha, Y. W., Chang, K.-Y., Cho, S.-C., Song, S. O., Kim, H., Jo, A., Khang, R., Choi, J.-Y., et al. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2015.11.008 · Cited by 16 · see citing works
- Authors
- Yang, Y., Gehrke, S., Imai, Y., Huang, Z., Ouyang, Y., Wang, J.-W., Yang, L., Beal, M. F., Vogel, H., & Lu, B.
- Affiliations
- VA Palo Alto Health Care System (US)
- *Department of Pathology and
- Cornell University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2006-07-11
- Volume
- 103
- Issue
- 28
- Pages
- 10793-10798
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1502310
- OpenAlex
- W2137651420
- Cited by
- 798
- References
- 41
- Citations by year
- 2026: 14 · 2025: 13 · 2024: 26 · 2023: 17 · 2022: 35 · 2021: 35 · 2020: 50 · 2019: 24 · 2018: 47 · 2017: 38 · 2016: 37 · 2015: 39 · 2014: 49 · 2013: 47 · 2012: 44
- FWCI
- 38.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- McKnight Foundation
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- PINK1, Parkin, mitochondrial dysfunction, dopaminergic neuron loss, Parkinson's disease, Drosophila, mitochondrial fission, energy depletion, lifespan, genetic rescue, DJ-1, cell survival
- MeSH terms
- PTEN-Induced Putative Kinase, Animals, Drosophila melanogaster, Humans, Mitochondria, Muscles, Nerve Degeneration, Neurons, Parkinson Disease, Protein Kinases, Signal Transduction, Gene Silencing, Drosophila Proteins, Animals, Genetically Modified, RNA Interference, Ubiquitin-Protein Ligases
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