Effects of 7-MEGATM500 on Oxidative Stress, Inflammation, and Skin Regeneration in H2O2-Treated Skin Cells
Open accessAbstract
Environmental stimuli can lead to the excessive accumulation of reactive oxygen species (ROS), which is one of the risk factors for premature skin aging.Here, we investigated the protective effects of 7-MEGA TM 500 (50% palmitoleic acid, 7-MEGA) against oxidative stress-induced cellular damage and its underlying therapeutic mechanisms in the HaCaT human skin keratinocyte cell line (HaCaT cells).Our results showed that treatment with 7-MEGA prior to hydrogen peroxide (H 2 O 2 )-induced damage significantly increased the viability of HaCaT cells.7-MEGA effectively attenuated generation of H 2 O 2 -induced reactive oxygen species (ROS), and inhibited H 2 O 2induced inflammatory factors, such as prostaglandin E 2 (PGE 2 ), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β).In addition, cells treated with 7-MEGA exhibited significantly decreased expression of matrix metalloproteinase-1 (MMP-1) and increased expression of procollagen type 1 (PCOL1) and Elastin against oxidative stress by H 2 O 2 .Interestingly, these protective activities of 7-MEGA were similar in scope and of a higher magnitude than those seen with 98.5% palmitoleic acid (PA) obtained from Sigma when given at the same concentration (100 nL/mL).According to our data, 7-MEGA is able to protect HaCaT cells from H 2 O 2 -induced damage through inhibiting cellular oxidative stress and inflammation.Moreover, 7-MEGA may affect skin elasticity maintenance and improve skin wrinkles.These findings indicate that 7-MEGA may be useful as a food supplement for skin health.
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Oral 7-MEGATM 500 (a product containing more than 50% palmitoleic acid containing fish oil, omega-7) relieves UV-B and H2O2-induced skin oxidative stress, inflammation, aging, and promotes skin regeneration in mice.
“Oral 7-MEGATM 500 (a product containing more than 50% palmitoleic acid containing fish oil, omega-7) has been shown to relieve UV-B and H2O2-induced skin oxidative stress, inflammation, aging, and promotes skin regeneration in mice [126,127].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [127]
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Diet and Skin Aging—From the Perspective of Food Nutrition
Cao, C., Xiao, Z., Wu, Y., & Ge, C. (2020) · Nutrients · doi:10.3390/nu12030870 · Cited by 231 · see citing works
Alleviation of Ultraviolet B-Induced Photoaging by 7-MEGATM 500 in Hairless Mouse Skin
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Self-citation
- Authors
- Song, I.-B., Gu, H., Han, H.-J., Lee, N.-Y., Cha, J.-Y., Son, Y.-K., & Kwon, J.
- Affiliations
- Jeonbuk National University (KR)
- R&D Team, Food & Supplement Health Claims, Vitech, Jeonju, Korea
- Corresponding author
- Kwon, Jungkee
- Venue
- Toxicological Research
- Published
- 2018-04-15
- Volume
- 34
- Issue
- 2
- Pages
- 103-110
- ISSN
- 1976-8257 (ISSN-L)
- 2234-2753
- PMC
- PMC5903135
- OpenAlex
- W2797689987
- Cited by
- 28
- References
- 28
- Citations by year
- 2026: 3 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 2
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Toxicological Research (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- palmitoleic acid, oxidative stress, inflammation, skin regeneration, hydrogen peroxide, reactive oxygen species, keratinocytes, HaCaT keratinocytes, prostaglandin E2, TNF-α, IL-1β, MMP-1, elastin, skin aging, dietary supplements, skin health
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