Effectiveness of digital psychotherapeutic intervention among perinatal women: a systematic review and meta-analysis of randomized controlled trials
Open accessAbstract
BACKGROUND: The perinatal period is a challenging time of substantial emotional, physiological, social, and relational changes. Depression, anxiety, and stress symptoms are common, and co-exist in the perinatal period. Digital technology continues to grow at an unprecedented pace with wide application, including psychotherapeutic intervention. A growing number of meta-analyses supported the application of digital psychotherapeutic intervention across different populations, but relatively few meta- and meta-regression analyses have concentrated on perinatal women. AIM: To evaluate the effectiveness of digital psychotherapeutic intervention on improving psychological outcomes among perinatal women and identify its essential features. METHODS: Randomized controlled trials (RCTs) were obtained from eight databases, including Cumulative Index to Nursing and Allied Health Literature, Cochrane Library, Embase, Scopus, PsycINFO, PubMed, Web of Science, and ProQuest Dissertation and Theses from inception up until November 24, 2020. Comprehensive Meta-analysis 3.0 software was used to conduct meta- and meta-regression analyses. The Cochrane risk-of-bias tool and the Grading of the Recommendation, Assessment, Development, and Evaluation system were adopted to assess the individual and overall qualities of the evidence, respectively. RESULTS: = 0.47) symptoms compared to the control. Subgroup analyses demonstrated that a website platform with ≥ eight therapist-guided sessions using the theoretical principle of cognitive behavioral therapy was more effective than other treatments in improving depression symptoms in postnatal women. Meta-regression analyses observed that the age of perinatal women and the type of psychotherapy also had statistically significant effects on depression symptoms. Egger's regression asymmetry tests suggested that no publication biases occurred, but the overall quality of the evidence was very low. CONCLUSION: This review suggests that digital psychotherapeutic intervention may be a potential solution to reduce psychological problems in perinatal women. Further high-quality RCTs with large sample sizes are needed.
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Larger effects were observed among postpartum women compared to antepartum women.
“and among postpartum women compared to antepartum women (Lau et al., 2021)”
From PandaMom – Feasibility and acceptability of an internet- and mobile-based intervention to enhance peripartum mental well-being and to prevent postpartum depression (2024) · cites this paper as Lau et al., 2021
IMIs have shown efficacy in significantly improving depressive symptoms in peripartum women.
“IMIs have also shown efficacy in significantly improving depressive symptoms in peripartum women (e.g., Duffecy et al., 2022; Hanach et al., 2021; Lau et al., 2021; Loughnan et al., 2019; Mu et al., 2021).”
From PandaMom – Feasibility and acceptability of an internet- and mobile-based intervention to enhance peripartum mental well-being and to prevent postpartum depression (2024) · cites this paper as Lau et al., 2021
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Psychotherapeutic nursing as Advanced Clinical Practice for the promotion of mental health in Spain
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Current treatment options for perinatal depression
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- Authors
- Lau, Y., Cheng, J.-Y., Wong, S.-H., Yen, K.-Y., & Cheng, L.-J.
- Affiliations
- National University of Singapore (SG)
- Khoo Teck Puat Hospital (SG)
- Venue
- World Journal of Psychiatry
- Publisher
- Baishideng Publishing Group Inc.
- Published
- 2021-04-19
- Volume
- 11
- Issue
- 4
- Pages
- 133-152
- ISSN
- 2220-3206 (ISSN-L)
- PMC
- PMC8040152
- OpenAlex
- W3155774879
- Cited by
- 68
- References
- 92
- Citations by year
- 2026: 17 · 2025: 7 · 2024: 26 · 2023: 9 · 2022: 8 · 2021: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by-nc
- Locations
- World Journal of Psychiatry (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- digital psychotherapy, perinatal depression, postpartum depression, perinatal anxiety, perinatal stress, perinatal women, cognitive behavioral therapy, psychological outcomes, treatment effectiveness
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