Gene expression in learning processes

The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation

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Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun.

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Synaptic tagging and long-term potentiation

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The long and the short of long–term memory—a molecular framework

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Induction of a dominant negative CREB transgene specifically blocks long-term memory in Drosophila

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Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

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Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites.

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Synapse-specific, long-term facilitation of aplysia sensory to motor synapses: a function for local protein synthesis in memory storage.

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Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

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Induction of immediate-early genes and the control of neurotransmitter-regulated gene expression within the nervous system.

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CREB as a Memory Modulator: induced expression of a dCREB2 activator isoform enhances long-term memory in drosophila

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Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

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Involvement of Hormonal and Neuromodulatory Systems in the Regulation of Memory Storage

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Memory in Mice as Affected by Intracerebral Puromycin

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A Transient, Neuron-Wide Form of CREB-Mediated Long-Term Facilitation Can Be Stabilized at Specific Synapses by Local Protein Synthesis

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Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines.

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CREB: A mediator of long-term memory from mollusks to mammals

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Activation of cAMP-Responsive genes by stimuli that produce long-term facilitation in aplysia sensory neurons

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Psychobiology of memory: Towards a model of memory formation

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Sensory regulation of immediate–early gene expression in mammalian visual cortex: implications for functional mapping and neural plasticity

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cAMP Response Element-Binding Protein in the Amygdala Is Required for Long- but not Short-Term Conditioned Taste Aversion Memory

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How chicks make memories: the cellular cascade from c-fos to dendritic remodelling

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Regulation of synapsin I gene expression by the zinc finger transcription factor zif268/egr-1.

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Molecular Enhancement of Memory Formation

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Transcription factor AP-1 activity is required for initiation of DNA synthesis and is lost during cellular aging.

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The mnemon and its juices: neuromodulation of memory processes

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Stimulus-Transcription Coupling In The Nervous System: Involvement Of The Inducible Proto-oncogenes fos And jun

Morgan, J. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.14.1.421 · Cited by 160 · see citing works

Transient expression of c-Fos in rat amygdala during training is required for encoding conditioned taste aversion memory.Preprint

Lamprecht, R., & Dudai, Y. (1996) · Learning & Memory · doi:10.1101/lm.3.1.31 · Cited by 149 · see citing works

Cell-adhesion molecules, glucocorticoids and long-term-memory formation

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Protooncogene expression during the cell cycle.

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Immediate-early genes, neuronal plasticity, and memory

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Neurobiological Aspects of Learning and Memory

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Molecular biology of cell activation

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Synaptic Regulation of Immediate Early Gene Expression in Primary Cultures of Cortical Neurons

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Role of RNA and protein synthesis in memory formation

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Involvement Of Hormonal And Neuromodulatory Systems In The Regulation Of Memory Storage

McGaugh, J. L. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.12.1.255 · Cited by 24 · see citing works

Isolation and characterization of the rat gene encoding glutamate dehydrogenase

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Towards understanding of the role of transcription factors in learning processes.

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Neurobiological Aspects Of Learning And Memory

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Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches

Guzowski, J. F. (2002) · Hippocampus · doi:10.1002/hipo.10010 · Cited by 392 · see citing works

A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?

Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 371 · see citing works

Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc

Gallo, F. T., Katche, C., Morici, J. F., Medina, J. H., & Weisstaub, N. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00079 · Cited by 339 · see citing works

Networks of neurons, networks of genes: An integrated view of memory consolidation

Miyashita, T., Kubík, Š., Lewandowski, G. A., & Guzowski, J. F. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.08.012 · Cited by 158 · see citing works

Functional internal complexity of amygdala: focus on gene activity mapping after behavioral training and drugs of abuse.

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Developmental change and the nature of learning in childhood

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MAPK Establishes a Molecular Context That Defines Effective Training Patterns for Long-Term Memory Formation

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Olfactory discrimination ability and brain expression of c-fos, Gir and Glut1 mRNA are altered in n−3 fatty acid-depleted rats

Hichami, A., Datiche, F., ULLAH, S., Liénard, F., Chardigny, J., Cattarelli, M., & Khan, N. A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.06.010 · Cited by 56 · see citing works

Different pattern of brain c-Fos expression following re-exposure to ethanol or sucrose self-administration environment

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Gene expression during memory formation

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Retrosplenial cortex in spatial memory: focus on immediate early genes mapping

Balcerek, E., Włodkowska, U., & Czajkowski, R. (2021) · Molecular Brain · doi:10.1186/s13041-021-00880-w · Cited by 36 · see citing works

Cell death and neuronal arborization upon quercetin treatment in rat neurons

Jakubowicz-Gil, J., Rzeski, W., Zdzisińska, B., Dobrowolski, P., & Gawron, A. (2008) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2008-1683 · Cited by 28 · see citing works

Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior

Filipkowski, R. K., Rydz, M., & Kaczmarek, L. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00310-4 · Cited by 26 · see citing works

Chapter VIII c-Fos in learning: beyond the mapping of neuronal activity

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Distinct functional brain regional integration of Casp3, Ascl1 and S100a6 gene expression in spatial memory

Алексеевна, Г. М., Storozheva, Z. I., Sewell, R. D. E., Викторович, К. В., & Sherstnev, V. V. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.06.024 · Cited by 16 · see citing works

Dissociation of ethanol and saccharin preference in fosB knockout mice

Korkosz, A., Kołomańska, P., Kowalska, K., Rogowski, A., Radwańska, K., Kaczmarek, L., Mierzejewski, P., Ścińska, A., Kostowski, W., & Bieńkowski, P. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.04.054 · Cited by 15 · see citing works

Expression of the immediate-early gene egr-1 and substance P in the spinal cord following locomotor training in adult rats

Nunes, A. C. L., Duarte, R. B., de Sousa, T. B., dos Santos, J. R., Freire, M. A. M., & Costa, M. S. M. O. (2010) · Brain Research · doi:10.1016/j.brainres.2010.05.041 · Cited by 14 · see citing works

Fos protein expression in olfactory-related brain areas after learning and after reactivation of a slowly acquired olfactory discrimination task in the ratPreprint

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Cue valence representation studied by Fos immunocytochemistry after acquisition of a discrimination learning task

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Spatial memory formation differentially affects c-Fos expression in retrosplenial areas during place avoidance training in rats

Malinowska, M., Niewiadomska, M., & Wesierska, M. (2016) · Acta Neurobiologiae Experimentalis · doi:10.21307/ane-2017-024 · Cited by 11 · see citing works

N-(2-hydroxy phenyl) acetamide produces profound inhibition of c-Fos protein and mRNA expression in the brain of adjuvant-induced arthritic rats

Jawed, H., Jamall, S., Shah, S. U. A., Perveen, K., Hanif, F., & Sımjee, S. U. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1873-6 · Cited by 9 · see citing works

Does the olfactory cue activate the same brain network during aging in the rat after taste potentiated odor aversion retrieval?

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Transcription Control Pathways Decode Patterned Synaptic Inputs into Diverse mRNA Expression Profiles

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c-Fos and Zif268 in Learning and Memory—Studies on Expression and Function

Filipkowski, R. K., Knapska, E., & Kaczmarek, L. (2006) · Springer eBooks · doi:10.1007/978-0-387-33604-6_8 · Cited by 5 · see citing works

New Tools in Cognitive Neurobiology: Biotin-Digoxigenin Detection of Overlapping Active Neuronal Populations by Two-Color c-fos Compartment Analysis of Temporal Activity by Fluorescent in situ Hybridization (catFISH) and c-Fos Immunohistochemistry

Saidov, K., Тиунова, А. А., Subach, O. M., Subach, F. V., & Anokhin, K. V. (2019) · OBM Genetics · doi:10.21926/obm.genet.1901065 · Cited by 4 · see citing works

Chronic morphine treatment enhances sciatic nerve stimulation-induced immediate early gene expression in the rat dorsal horn

Bojović, O., Bramham, C. R., & Tjølsen, A. (2015) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2015-2036 · Cited by 4 · see citing works

Timescales of Change in Connectionist and Dynamical Systems Approaches to Learning and Development

Newell, K. M., Liu, Y.-T., & Mayer‐Kress, G. (2009) · doi:10.1093/acprof:oso/9780195300598.003.0006 · Cited by 4 · see citing works

HEXIM1/P–TEFb complex controls RNA polymerase II pause release and immediate early gene induction following neuronal depolarization

Htet, M., Estay-Olmos, C., Hu, L., Wu, Y., Powers, B. E., Campbell, C. D., Rameshwar, A., Ahmed, M. R., Hohman, T. J., Wang, Y., et al. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111325 · Cited by 4 · see citing works

New Approaches in Cognitive Neurobiology: Methods of Molecular Marking and Ex Vivo Imaging of Cognitively Active Neurons

Saidov, K., & Анохин, К. В. (2018) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-018-0633-1 · Cited by 2 · see citing works

FOS mapping reveals two complementary circuits for spatial navigation in mouse

Balcerek, E., Włodkowska, U., & Czajkowski, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-72272-8 · Cited by 1 · see citing works

A Survey on Computational Intelligence Techniques in Learning and Memory

Singh, A. K., & Tiwari, A. K. (2022) · Communications in computer and information science · doi:10.1007/978-3-031-10766-5_11 · Cited by 1 · see citing works

Amygdala electrical stimulation for operant conditioning in rat navigation

Lee, Y., Kim, S., Cho, Y. K., Kong, C., Chang, J. W., & Jun, S. B. (2023) · Biomedical Engineering Letters · doi:10.1007/s13534-023-00336-1 · Cited by 1 · see citing works

Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex

Pereira, C. M., Freire, M. A. M., dos Santos, J. R., Guimarães, J. S., Dias-Florencio, G., Santos, S., Pereira, A., & Ribeiro, S. T. G. (2018) · PeerJ · doi:10.7717/peerj.5678 · Cited by 1 · see citing works

Moderate to high ethanol and acetaldehyde administration decreases c-fos protein expression in the hippocampus of Aldh2-knockout and C57BL/6N mice

Jamal, M., Ito, A., Tanaka, N., Ameno, K., Miki, T., & Kinoshita, H. (2019) · Bangladesh Journal of Medical Science · doi:10.3329/bjms.v19i1.43876 · Cited by 1 · see citing works

Expressão dos genes de ativação imediata c-fos e egr-1 em encéfalos de ratos submetidos ao modelo do desamparo aprendido

Yochiy, A. (2010) · doi:10.11606/t.47.2010.tde-26072010-143609

Sensibilidade diferencial aos efeitos comportamentais induzidos por etanol e sobre a expressão de c-Fos e Egr-1, entre camundongos adultos e adolescentes.

Faria, R. R. (2007) · doi:10.11606/d.42.2007.tde-04012008-160519

(Poli)geny na język. Prolegomena do lingwistyki genetycznej

Krysiak, A. P. (2010) · Investigationes Linguisticae · doi:10.14746/il.2010.20.4

Preventive Role of Gabapentin in Transmission of Inflammatory Nociception in Acute and Sub-chronic Inflammatory Models of Rat

Jawed, H., & Sımjee, S. U. (2018) · Molecular Biology · doi:10.4172/2168-9547.1000218

Peer Review #2 of "Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.5678v0.1/reviews/2

Peer Review #1 of "Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex (v0.1)"

(2018) · PeerJ · doi:10.7287/peerj.5678v0.1/reviews/1

Peer Review #2 of "Non-visual exploration of novel objects increases the levels of plasticity factors in the rat primary visual cortex (v0.2)"

(2018) · PeerJ · doi:10.7287/peerj.5678v0.2/reviews/2

Immediate-Early Genes Detection in the CNS of Terrestrial Snail

Ierusalimsky, V. N., Roshchin, M. V., & Balaban, P. M. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00825-2

A Survey on Computational Models for Learning and Memory in Artificial IntelligencePreprint

Singh, A. K., & Tiwari, A. K. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3350991

MotivationWe thank A. E. Fink for producing the Predatory Imminence Continuum artwork in Figure . We would like to thank M. Tinsley for his contribution to the first edition of this chapter. We would like to thank Polar Bears Alive, Baton Rouge, Louisiana, for the use of the polar bear photo, M. Domjan for the quail photo, K. Hollis for the pictures of the fish, and S. Crowley for the pictures of the rats.

Godsil, B. P., & Fanselow, M. S. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop204002

Regulation of Neuronal Gene Expression and Protein Synthesis

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Activity-dependent Gene Transcription in Neurons: Defining the Plasticity Transcriptome

Barth, A. L., & Yassin, L. (2007) · Springer eBooks · doi:10.1007/978-0-387-73609-9_15 · Cited by 2 · see citing works

Role of Gene Transcription in Long-Term Memory Storage

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Activity-Dependent Neuronal Gene Expression: A Potential Memory Mechanism?

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Studies of Neuronal Gene Regulation Controlling the Molecular Mechanisms Underlying Neural Plasticity

Fukuchi, M. (2017) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.17-00107 · Cited by 1 · see citing works