Cited by 572Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeurobiology and Insect Physiology Research

Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change

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Bartsch, Dusan, Ghirardi, Mirella, Skehel, Paul A., Karl, Kevin A., Herder, Susan P., Chen, Mary, Bailey, Craig H., Kandel, Eric R.·1995·Cell

Abstract

The switch from short- to long-term facilitation induced by behavioral sensitization in Aplysia involves CREB-like proteins, as well as the immediate-early gene ApC/EBP. Using the bZIP domain of ApC/EBP in a two-hybrid system, we have cloned ApCREB2, a transcription factor constitutively expressed in sensory neurons that resembles human CREB2 and mouse ATF4. ApCREB2 represses ApCREB1-mediated transcription in F9 cells. Injection of anti-ApCREB2 antibodies into Aplysia sensory neurons causes a single pulse of serotonin (5-HT), which induces only short-term facilitation lasting minutes, to evoke facilitation lasting more than 1 day. This facilitation has the properties of long-term facilitation: it requires transcription and translation, induces the growth of new synaptic connections, and occludes further facilitation by five pulses of 5-HT.

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Crossref · 10.1016/0092-8674(95)90213-9

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62 of 62 references verified0 citation errors · 0 not checkable

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  • LTF relies on deactivation of CREB2, a transcriptional repressor.

    “LTF relies on deactivation of CREB2, a transcriptional repressor101.”
  • Both PKA and ERK are needed to phosphorylate transcription factors critical for LTF, such as CREB1.

    “These kinases are both needed to phosphorylate transcription factors critical for LTF (e.g., the transcriptional activator cAMP responsive element binding protein 1, CREB1)19,20.”

    From Computational design of enhanced learning protocols (2012) · cites this paper as [19]

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Authors
Bartsch, D., Ghirardi, M., Skehel, P. A., Karl, K. A., Herder, S. P., Chen, M., Bailey, C. H., & Kandel, E. R.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Cell
Publisher
Elsevier BV
Published
1995-12
Volume
83
Issue
6
Pages
979-992
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2044126921
Cited by
572
References
62
Citations by year
2026: 1 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 9 · 2020: 6 · 2019: 12 · 2018: 12 · 2017: 17 · 2016: 18 · 2015: 13 · 2014: 20 · 2013: 25 · 2012: 24
FWCI
11.20
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01gm032099-14)
  • National Institute of Mental Health (MH-37134, R01MH037134)
  • National Institute of General Medical Sciences (GM 32099)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
ATF4, long-term facilitation, short-term facilitation, behavioral sensitization, Aplysia, transcriptional repression, sensory neurons, serotonin, synaptic plasticity, synaptic growth, bZIP transcription factors, CREB1
MeSH terms
Amino Acid Sequence, Animals, Aplysia, Base Sequence, Cells, Cultured, DNA, DNA-Binding Proteins, Humans, Memory, Molecular Sequence Data, Nerve Tissue Proteins, Neurons, Afferent, Nuclear Proteins, Organ Specificity, Phosphorylation, Repressor Proteins, RNA, Messenger, Serotonin, Synapses, Transcription Factors, Trans-Activators, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Long-Term Potentiation, CCAAT-Enhancer-Binding Proteins, Mice, Activating Transcription Factor 2

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