Effects of neonatal maternal deprivation and postweaning environmental complexity on dendritic morphology of prefrontal pyramidal neurons in the rat
Open accessAbstract
It has been reported that periodic maternal separation in rats leads to a variety of endure behavioral, neurochemical and microstructural sequelae associated with the pathophysiology of anxiety disorders. Since it has been proposed that these changes might be permanent, we examined whether environmental complexity aid to recover the structural dendritic impairment induced by neonatal maternal deprivation in the medial prefrontal cortex of the rat. In addition, the anxiety-like behavior was assessed in the elevated plus-maze. Repeated maternal separation between postnatal days 6–21 (3 hours daily) significantly reduced the dendritic material in layer II/III pyramidal neurons and induced anxiety-like behaviors in the elevated plus maze. Furthermore, environmental stimulation (twice a day, 1 h each) during 12 consecutive days (postnatal days 23–35) failed to recover the neuronal and behavioral disorders induced by neonatal maternal separation. The results demonstrated that (i) neonatal maternal separation severely altered pyramidal dendritic outgrowth in close association with anxiety-like behavior assessed in the elevated plus maze, and (ii) postweaning environmental complexity was unable to recover neither the prefrontocortical neuronal impairment nor the novelty-induced anxiety-like behavior triggered by early maternal deprivation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Rat pups exposed to extensive maternal deprivation have enduring dendritic retraction in the PFC and increased anxiety-like behaviours.
“For example, rat pups exposed to extensive maternal deprivation have enduring dendritic retraction in the PFC and increased anxiety-like behaviours122.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
NEUROTROPHINS AND SYNAPTIC PLASTICITY
McAllister, A. K., Katz, L. C., & Lo, D. C. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.295 · Cited by 1,337 · see citing works
Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus
Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S., & Sapolsky, R. M. (1988) · Science · doi:10.1126/science.3340858 · Cited by 1,074 · see citing works
Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity
Francis, D. D., Diorio, J., Plotsky, P. M., & Meaney, M. J. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-18-07840.2002 · Cited by 663 · see citing works
Kalinichev, M., Easterling, K. W., Plotsky, P. M., & Holtzman, S. G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00781-5 · Cited by 484 · see citing works
Bock, J., Gruss, M., Becker, S., & Braun, K. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh181 · Cited by 175 · see citing works
On the nature and consequences of early loss
Hofer, M. A. (1996) · Psychosomatic Medicine · doi:10.1097/00006842-199611000-00005 · Cited by 152 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Paxinos G, Watson Ch (Eds) (1998) The Rat Brain in Stereotaxic Coordinates (2nd ed.) Academic Press, San Diego, Ca.
Cited by
Sorted by citations
Stress signalling pathways that impair prefrontal cortex structure and function
Arnsten, A. F. T. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2648 · Cited by 3,299 · see citing works
Edmiston, E. E. (2011) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2011.565 · Cited by 341 · see citing works
Duration of early adversity and structural brain development in post-institutionalized adolescents
Hodel, A. S., Hunt, R. H., Cowell, R. A., Van Den Heuvel, S. E., Gunnar, M. R., & Thomas, K. M. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.10.020 · Cited by 220 · see citing works
Maternal separation with early weaning: A novel mouse model of early life neglect
George, E. D., Bordner, K. A., Elwafi, H. M., & Simen, A. A. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-123 · Cited by 163 · see citing works
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153 · see citing works
Carlyle, B. C., Duque, A., Kitchen, R. R., Bordner, K. A., Coman, D., Doolittle, E., Papademetris, X., Hyder, F., Taylor, J. R., & Simen, A. A. (2012) · Development and Psychopathology · doi:10.1017/s095457941200079x · Cited by 80 · see citing works
Chocyk, A., Majcher-Maślanka, I., Dudys, D., Przyborowska, A., & Wędzony, K. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71506-8 · Cited by 55 · see citing works
Caregiver maltreatment causes altered neuronal DNA methylation in female rodents
Blaze, J., & Roth, T. L. (2017) · Development and Psychopathology · doi:10.1017/s0954579417000128 · Cited by 48 · see citing works
Neuroanatomical changes in a mouse model of early life neglect
Duque, A., Coman, D., Carlyle, B. C., Bordner, K. A., George, E. D., Papademetris, X., Hyder, F., & Simen, A. A. (2012) · Brain Structure and Function · doi:10.1007/s00429-011-0350-9 · Cited by 28 · see citing works
Kentrop, J., van der Tas, L., Loi, M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00122 · Cited by 16 · see citing works
- Authors
- Pascual, R., & Zamora-León, S.
- Affiliations
- Pontificia Universidad Católica de Valparaíso (CL)
- Catholic University of the Maule (CL)
- Venue
- Acta Neurobiologiae Experimentalis
- Published
- 2007-12-31
- Volume
- 67
- Issue
- 4
- Pages
- 471-479
- ISSN
- 0065-1400 (ISSN-L)
- 1689-0035
- OpenAlex
- W1977573454
- Cited by
- 74
- References
- 6
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 7 · 2019: 10 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 3 · 2012: 7
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Acta Neurobiologiae Experimentalis (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- neonatal maternal separation, maternal deprivation, dendritic morphology, pyramidal neurons, medial prefrontal cortex, anxiety-like behavior, elevated plus maze, dendritic outgrowth, early life stress
- MeSH terms
- Animals, Animals, Newborn, Anxiety, Dendrites, Environment, Exploratory Behavior, Female, Male, Maternal Deprivation, Pregnancy, Weaning, Rats, Sprague-Dawley, Prefrontal Cortex, Pyramidal Cells, Maze Learning, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
