Cited by 51Sleep and related disordersObstructive Sleep Apnea ResearchSleep and Work-Related Fatigue

Predictors of Insomnia Severity Index Profiles in United States Veterans With Obstructive Sleep Apnea

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Wallace, Douglas M., Wohlgemuth, William K.·2019·Journal of Clinical Sleep Medicine

Abstract

The Insomnia Severity Index (ISI) has been used to define insomnia symptoms in individuals with obstructive sleep apnea (OSA). However, whether distinct ISI profiles exist in individuals with OSA is unclear. The aims of this study were to determine (1) empirically-based ISI profiles in veterans with OSA and (2) predictors of these ISI profiles. Participants were 630 veterans with a new diagnosis of OSA over a 12-month period. Individuals completed the ISI and other questionnaires on the polysomnography (PSG) night. Latent profile analysis was performed to detect ISI subgroups based on individual ISI items. Age, Charlson Comorbidity Index, apnea-hypopnea index (AHI), mood disorder, posttraumatic stress disorder, and chronic pain diagnoses were used to predict between ISI profiles. Latent profile analysis identified five ISI subgroups in veterans with OSA. The “asymptomatic” group (12% prevalence) had low scores across all ISI items. The “moderate insomnia” (30% prevalence) and “severe insomnia” (44% prevalence) groups had elevated scores for all ISI items but differing in severity. Last, the “moderate” (6% prevalence) and “severe daytime symptoms” groups (8% prevalence) were characterized by absence of nocturnal complaints but high scores on daytime impairment items. Age, AHI, mood disorder, posttraumatic stress disorder and chronic pain diagnoses discriminated between ISI profiles. We describe data-driven ISI profiles in veterans with OSA. Older age was associated with lower insomnia and daytime symptom complaints whereas psychological comorbidities were related to more severe insomnia. Caution should be used in interpreting the ISI score in individuals with OSA because a subset had elevated total scores without insomnia. Wallace DM, Wohlgemuth WK. Predictors of Insomnia Severity Index profiles in United States veterans with obstructive sleep apnea. J Clin Sleep Med. 2019;15(12):1827–1837.

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  • Comorbid insomnia and sleep apnea is associated with greater impairment of sleep quality, reduced quality of life, complex diagnostic decisions, and reduced acceptance and response rates to treatments that require adherence, such as PAP, mandibular advancement device, and hypoglossal nerve stimulation.

    “Co-morbid insomnia and sleep apnea (COMISA) is associated with greater impairment of sleep quality, reduced QOL, complex diagnostic decisions, and reduced acceptance and response rates to treatments that require adherence (i.e., PAP, mandibular advancement device [MAD], and HNS therapy).955,957”

    From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [955]

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  • Wallace and Wohlgemuth performed a latent profile analysis which identified that 30% of their OSA sample reported moderate insomnia, and an additional 44% reported severe insomnia.

    “Wallace and Wohlgemuth performed a latent profile analysis which identified that 30% of their OSA sample reported moderate insomnia, and an additional 44% reported severe insomnia.”
  • These 'moderate' and 'severe' COMISA patients reported elevated nocturnal and daytime ISI symptoms.

    “Importantly, these ‘moderate’ and ‘severe’ COMISA patients reported elevated nocturnal and daytime ISI symptoms.”

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Authors
Wallace, D. M., & Wohlgemuth, W. K.
Affiliations
  • University of Miami (US)
  • Bruce W. Carter VA Medical Center (US)
Corresponding author
Wallace, Douglas M.
Venue
Journal of Clinical Sleep Medicine
Published
2019-12-15
Volume
15
Issue
12
Pages
1827-1837
ISSN
  • 1550-9389 (ISSN-L)
  • 1550-9397
OpenAlex
W2982599625
Cited by
51
References
43
Citations by year
2026: 3 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 3 · 2019: 3
FWCI
7.63
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Sleep Medicine (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords
obstructive sleep apnea, insomnia, Insomnia Severity Index, veterans, latent profile analysis, daytime dysfunction, post-traumatic stress disorder, mood disorders, chronic pain, apnea-hypopnea index, age, comorbidities
MeSH terms
Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, United States, Veterans, Polysomnography, Sleep Apnea, Obstructive

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