Predictors of Insomnia Severity Index Profiles in United States Veterans With Obstructive Sleep Apnea
Open accessAbstract
The Insomnia Severity Index (ISI) has been used to define insomnia symptoms in individuals with obstructive sleep apnea (OSA). However, whether distinct ISI profiles exist in individuals with OSA is unclear. The aims of this study were to determine (1) empirically-based ISI profiles in veterans with OSA and (2) predictors of these ISI profiles. Participants were 630 veterans with a new diagnosis of OSA over a 12-month period. Individuals completed the ISI and other questionnaires on the polysomnography (PSG) night. Latent profile analysis was performed to detect ISI subgroups based on individual ISI items. Age, Charlson Comorbidity Index, apnea-hypopnea index (AHI), mood disorder, posttraumatic stress disorder, and chronic pain diagnoses were used to predict between ISI profiles. Latent profile analysis identified five ISI subgroups in veterans with OSA. The “asymptomatic” group (12% prevalence) had low scores across all ISI items. The “moderate insomnia” (30% prevalence) and “severe insomnia” (44% prevalence) groups had elevated scores for all ISI items but differing in severity. Last, the “moderate” (6% prevalence) and “severe daytime symptoms” groups (8% prevalence) were characterized by absence of nocturnal complaints but high scores on daytime impairment items. Age, AHI, mood disorder, posttraumatic stress disorder and chronic pain diagnoses discriminated between ISI profiles. We describe data-driven ISI profiles in veterans with OSA. Older age was associated with lower insomnia and daytime symptom complaints whereas psychological comorbidities were related to more severe insomnia. Caution should be used in interpreting the ISI score in individuals with OSA because a subset had elevated total scores without insomnia. Wallace DM, Wohlgemuth WK. Predictors of Insomnia Severity Index profiles in United States veterans with obstructive sleep apnea. J Clin Sleep Med. 2019;15(12):1827–1837.
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Comorbid insomnia and sleep apnea is associated with greater impairment of sleep quality, reduced quality of life, complex diagnostic decisions, and reduced acceptance and response rates to treatments that require adherence, such as PAP, mandibular advancement device, and hypoglossal nerve stimulation.
“Co-morbid insomnia and sleep apnea (COMISA) is associated with greater impairment of sleep quality, reduced QOL, complex diagnostic decisions, and reduced acceptance and response rates to treatments that require adherence (i.e., PAP, mandibular advancement device [MAD], and HNS therapy).955,957”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [955]
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Experimental — accuracy not yet measuredWallace and Wohlgemuth performed a latent profile analysis which identified that 30% of their OSA sample reported moderate insomnia, and an additional 44% reported severe insomnia.
“Wallace and Wohlgemuth performed a latent profile analysis which identified that 30% of their OSA sample reported moderate insomnia, and an additional 44% reported severe insomnia.”
From Co-morbid insomnia and sleep apnea (COMISA): Prevalence, consequences, methodological considerations, and recent randomized controlled trials (2019) · cites this paper as [62]
These 'moderate' and 'severe' COMISA patients reported elevated nocturnal and daytime ISI symptoms.
“Importantly, these ‘moderate’ and ‘severe’ COMISA patients reported elevated nocturnal and daytime ISI symptoms.”
From Co-morbid insomnia and sleep apnea (COMISA): Prevalence, consequences, methodological considerations, and recent randomized controlled trials (2019) · cites this paper as [62]
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ОПИТУВАЛЬНИКИ ЯК ОСНОВНІ ІНСТРУМЕНТИ В ДІАГНОСТИЦІ РОЗЛАДІВ СНУ
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“Additionally, participants with a combined score of 4 or more from the three nocturnal symptom items (range 0–12) are classified as having nocturnal symptoms of insomnia (Glidewell et al. 2014; Wallace and Wohlgemuth 2019).”
New definition, diagnostic criteria, and diagnostic workflows for patients with suspected COMISA
Zhang, Y., & Kushida, C. A. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108871 · Cited by 1 · see citing works
Do symptoms of sleepiness and insomnia in US veterans with obstructive sleep apnea vary by age?
Agudelo, C., Ramos, A. R., Williams, N. J., & Wallace, D. M. (2019) · Sleep And Breathing · doi:10.1007/s11325-019-01845-z · Cited by 1 · see citing works
Self-citationIn response to Impact of Insomnia on Hypoglossal Nerve Stimulation Outcomes in the ADHERE Registry
Patil, R. D., Ishman, S. L., Chang, J. L., Thaler, E. R., & Suurna, M. V. (2024) · The Laryngoscope · doi:10.1002/lary.31412 · Cited by 1 · see citing works
CBT-I in patients with obstructive sleep apnea
Crew, E. C. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822872-2.00001-3
Ryczkowski, A., Rudnicka-Drożak, E., & Karakuła, K. (2023) · Current Problems of Psychiatry · doi:10.12923/2353-8627/2023-0008
Cao, Y., Hu, S., Chen, C., Wang, J., Yu, Z., Li, H., & Zhong, F. (2023) · Journal of Acupuncture and Tuina Science · doi:10.1007/s11726-023-1386-0
Ich finde keinen Schlaf, das kann doch keine Schlafapnoe sein – COMISA
Frohnhofen, H. (2023) · Springer eBooks · doi:10.1007/978-3-662-60290-4_20
Diagnosis and Management of OSA Comorbid with Insomnia (COMISA)
Gupta, R. M., & Saini, L. K. (2023) · Progress in Sleep Research · doi:10.1007/978-981-99-7901-1_8
Schleef, J., Quijada-Mateluna, N., Olivera, M. P., Marilicán-Contreras, M. F., & Castellanos-Alvarenga, L. M. (2024) · Revista Latinoamericana de Psicología · doi:10.14349/rlp.2024.v56.18
Sweetman, A. (2025) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.11680
Clinical and subthreshold insomnia in U.S. veterans: increasing prevalence and mental health burden
Pietrzak, R. H., Fischer, I. C., McCarthy, E., DeViva, J. C., & Na, P. J. (2026) · Journal of Clinical Sleep Medicine · doi:10.1007/s44470-026-00143-2
“This overlap, referred to as comorbid insomnia and sleep apnea (COMISA), is associated with poorer mental health outcomes and greater cardiovascular morbidity than either condition alone [12, 13].”
Wallace, D. M., Liang, J., Razjouyan, J., Sweetman, A., Buenaver, L. F., Crew, E. C., & Sharafkhaneh, A. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.109320
Self-citation
- Authors
- Wallace, D. M., & Wohlgemuth, W. K.
- Affiliations
- University of Miami (US)
- Bruce W. Carter VA Medical Center (US)
- Corresponding author
- Wallace, Douglas M.
- ORCID
- Wallace, Douglas M.
- Venue
- Journal of Clinical Sleep Medicine
- Published
- 2019-12-15
- Volume
- 15
- Issue
- 12
- Pages
- 1827-1837
- ISSN
- 1550-9389 (ISSN-L)
- 1550-9397
- PMC
- PMC7099195
- OpenAlex
- W2982599625
- Semantic Scholar
- 14b57edc2cca3012f95b77e299af77fee21ce629
- Cited by
- 51
- References
- 43
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 10 · 2023: 6 · 2022: 9 · 2021: 11 · 2020: 3 · 2019: 3
- FWCI
- 7.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Sleep Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- obstructive sleep apnea, insomnia, Insomnia Severity Index, veterans, latent profile analysis, daytime dysfunction, post-traumatic stress disorder, mood disorders, chronic pain, apnea-hypopnea index, age, comorbidities
- MeSH terms
- Female, Humans, Sleep Initiation and Maintenance Disorders, Male, Middle Aged, Surveys and Questionnaires, Severity of Illness Index, United States, Veterans, Polysomnography, Sleep Apnea, Obstructive
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