Medication-related factors of non adherence among patients with schizophrenia and bipolar disorder: Outcome of a cross-sectional survey in Maiduguri, North-eastern Nigeria
Open accessAbstract
Pharmacotherapy is the cornerstone in the symptomatic treatment of schizophrenia and bipolar disorder, but non-adherence to the medications constitutes major obstacles to optimal outcome in their management. This study assessed the prevalence of and exclusively x-rayed medication-related factors of non-adherence among patients with these disorders in a resource-poor setting. Three hundred and fifty eight (358) patients with schizophrenia and bipolar disorder were randomly enrolled and interviewed at the out-patient department of the Federal Neuropsychiatric Hospital, Maiduguri in North-eastern Nigeria. Data were collected using an anonymous sociodemographic questionnaire, clinical proforma and the Hausa version of the 8-item Morisky Medication Adherence Scale (MMAS-8). The overall prevalence of non-adherence was 54.2%, while the rates were 62.5% and 45.8% for subjects with schizophrenia and bipolar disorder respectively. The independent medication-related predictors of non-adherence were: multiple dosing frequency (Odds Ratio (O.R) = 7.843, 95% C.I = 4.537 to 13.557, P ≤ 0.001), presence of side effects (O.R = 6.823, 95% C.I = 3.900 - 11.937, p ≤ 0.001), cost of medications (O.R. = 4.009, 95% C.I = 2.555 to 6.921, p ≤ 0.001), and polytherapy (O.R. = 2.317, 95% C.I = 1.363 to 3.940, p = 0.002). This study therefore, recommends the use of guidelines that encourage rational pharmacotherapy based on monotherapy, consider routine lower dosing prescriptions, and integrating side effects surveillance and early intervention in clinical practice. Key words: Non-adherence, schizophrenia, bipolar disorder, North-eastern Nigeria.
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Multiple dose, frequency and drug combinations, or complex drug regimen were seriously linked with medication non-adherence in three studies.
“In three studies, multiple dose, frequency and drug combinations, or complex drug regimen were seriously linked with medication non-adherence [24, 32, 64].”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [32]
Psychiatric patients and their caregivers having financial constraints to buy medicines were factors associated with medication non-adherence in seven studies.
“In seven studies, psychiatric patients and their caregivers having financial constraints to buy medicines were factors associated with medication non-adherence.”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [32]
Lack of money for transportation, to purchase proper food, and to buy medications were factors associated with patients' adherence to their medication.
“In addition, the lack of money for transportation, to purchase proper food, and to buy medications were the factors associated with patients’ adherence to their medication.”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [32]
Psychotropic medications had an appetite stimulation that increased food demand, incurring additional economic burden and contributing to medication non-adherence.
“Psychotropic medications had an appetite stimulation that has been increasing food demand which incurs an additional economic burden [11, 24, 32, 37, 42, 45, 50] and contribute for medication non-adherence.”
From Psychotropic medication non-adherence and its associated factors among patients with major psychiatric disorders: A systematic review and meta-analysis (2020) · cites this paper as [32]
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MEN’S RECOVERY FROM SCHIZOPHRENIA IN NORTHERN NIGERIA
Utoblo, B. (2017) · Leeds Beckett Repository (Leeds Beckett University)
- Authors
- Ibrahim, W, A., Pindar, K, S., Yerima, M, M., Rabbebe, B, I., Shehu, S, Garkuwa, A, H., Bashir, Y, I., Wakil, A, M., Yahya, & J, S.
- Affiliations
- Abubakar Tafawa Balewa University (NG)
- University of Maiduguri (NG)
- Venue
- Journal of Neuroscience and Behavioral Health
- Publisher
- Academic Journals
- Published
- 2015-06-30
- Volume
- 7
- Issue
- 5
- Pages
- 31-39
- ISSN
- 2141-2286 (ISSN-L)
- OpenAlex
- W2196731914
- Cited by
- 20
- References
- 44
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1
- FWCI
- 1.96
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Journal of Neuroscience and Behavioral Health (publishedVersion, cc-by)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- medication non-adherence, schizophrenia, bipolar disorder, adverse drug reactions, polypharmacy, drug costs, dosing frequency, rational pharmacotherapy, monotherapy, resource-limited settings, North-East Nigeria
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