The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Cardiac fibrosis: new insights into the pathogenesis
Open accessAbstract
Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic conditions. This review discusses specific markers and origin of cardiac fibroblasts (CFs), and the underlying mechanism involved in the development of cardiac fibrosis. Currently, there are no CFs-specific molecular markers. Most studies use co-labelling with panels of antibodies that can recognize CFs. Origin of fibroblasts is heterogeneous. After fibrotic stimuli, the levels of myocardial pro-fibrotic growth factors and cytokines are increased. These pro-fibrotic growth factors and cytokines bind to its receptors and then trigger the activation of signaling pathway and transcriptional factors via Smad-dependent or Smad independent-manners. These fibrosis-related transcriptional factors regulate gene expression that are involved in the fibrosis to amplify the fibrotic response. Understanding the mechanisms responsible for initiation, progression, and amplification of cardiac fibrosis are of great clinical significance to find drugs that can prevent the progression of cardiac fibrosis.
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Cites
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Shumliakivska, M., Luxán, G., Hemmerling, I., Scheller, M., Li, X., Müller-Tidow, C., Schuhmacher, B., Sun, Z., Dendorfer, A., Debes, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-43003-w · Cited by 76
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Candidate rejuvenating factor GDF11 and tissue fibrosis: friend or foe?
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Mechanotransductive receptor Piezo1 as a promising target in the treatment of fibrosis diseases
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Metadata
- Authors
- Ma, Z.-G., Yuan, Y.-P., Wu, H.-M., Zhang, X., & Tang, Q.-Z.
- Venue
- International Journal of Biological Sciences
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 14
- Issue
- 12
- Pages
- 1645-1657
- ISSN
- 1449-2288 (ISSN-L)
- OpenAlex
- W2889685209
- Cited by
- 331
- References
- 178
- FWCI
- 18.06
- Type
- journal article
- Language
- en
- Open access
- gold
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- Ma, Z.-G., Yuan, Y.-P., Wu, H.-M., Zhang, X., & Tang, Q.-Z. (2018). Cardiac fibrosis: new insights into the pathogenesis. International Journal of Biological Sciences. https://doi.org/10.7150/ijbs.28103
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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