Cited by 37Gut microbiota and healthGenetic factors in colorectal cancerDNA Repair Mechanisms

Gut microbiota imbalance and base excision repair dynamics in colon cancer

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Ray, Debolina, Kidane, Dawit·2016·Journal of Cancer

Abstract

Gut microbiota are required for host nutrition, energy balance, and regulating immune homeostasis, however, in some cases, this mutually beneficial relationship becomes twisted (dysbiosis), and the gut flora can incite pathological disorders including colon cancer. Microbial dysbiosis promotes the release of bacterial genotoxins, metabolites, and causes chronic inflammation, which promote oxidative DNA damage. Oxidized DNA base lesions are removed by base excision repair (BER), however, the role of this altered function of BER, as well as microbiota-mediated genomic instability and colon cancer development, is still poorly understood. In this review article, we will discuss how dysbiotic microbiota induce DNA damage, its impact on base excision repair capacity, the potential link of host BER gene polymorphism, and the risk of dysbiotic microbiota mediated genomic instability and colon cancer.

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Crossref · 10.7150/jca.15480

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  • Persistent oxidatively generated DNA damage and BER activity have been implicated in several human diseases, particularly cancer, inherited and acquired neurological disorders, and aging.

    “However, persistent oxidatively generated DNA damage and BER activity have been implicated in several other human diseases, in particular cancer and inherited and acquired neurological disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis as well as in aging [194][195][196][197].”

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Authors
Ray, D., & Kidane, D.
Affiliations
The University of Texas at Austin (US)
Corresponding author
Kidane, Dawit
Venue
Journal of Cancer
Published
2016
Volume
7
Issue
11
Pages
1421-1430
ISSN
1837-9664 (ISSN-L)
OpenAlex
W2475036271
Cited by
37
References
162
Citations by year
2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5
FWCI
0.39
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Journal of Cancer (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Texas at Austin
  • National Institutes of Health (CA15485401)
  • National Cancer Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords
gut microbiota, dysbiosis, colon cancer, base excision repair, oxidative DNA damage, bacterial genotoxins, chronic inflammation, genomic instability, DNA base lesions

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