Gut microbiota imbalance and base excision repair dynamics in colon cancer
Open accessAbstract
Gut microbiota are required for host nutrition, energy balance, and regulating immune homeostasis, however, in some cases, this mutually beneficial relationship becomes twisted (dysbiosis), and the gut flora can incite pathological disorders including colon cancer. Microbial dysbiosis promotes the release of bacterial genotoxins, metabolites, and causes chronic inflammation, which promote oxidative DNA damage. Oxidized DNA base lesions are removed by base excision repair (BER), however, the role of this altered function of BER, as well as microbiota-mediated genomic instability and colon cancer development, is still poorly understood. In this review article, we will discuss how dysbiotic microbiota induce DNA damage, its impact on base excision repair capacity, the potential link of host BER gene polymorphism, and the risk of dysbiotic microbiota mediated genomic instability and colon cancer.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Persistent oxidatively generated DNA damage and BER activity have been implicated in several human diseases, particularly cancer, inherited and acquired neurological disorders, and aging.
“However, persistent oxidatively generated DNA damage and BER activity have been implicated in several other human diseases, in particular cancer and inherited and acquired neurological disorders including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis as well as in aging [194][195][196][197].”
From Sunlight damage to cellular DNA: focus on oxidatively generated lesions (2017) · cites this paper as [196]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Proceedings of the National Academy of Sciences of the United States of America
Dowling, J. E., & Wald, G. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1981.tb06752.x · Cited by 17,937 · see citing works
Changes of Intestinal Functions in Liver Cirrhosis
Fukui, H., & Wiest, R. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000444436 · Cited by 6,820 · see citing works
Host-Bacterial Mutualism in the Human Intestine
Bäckhed, F., Ley, R. E., Sonnenburg, J. L., Peterson, D. A., & Gordon, J. I. (2005) · Science · doi:10.1126/science.1104816 · Cited by 5,277 · see citing works
Metagenomic Analysis of the Human Distal Gut Microbiome
Gill, S. R., Pop, M., DeBoy, R. T., Eckburg, P. B., Turnbaugh, P. J., Samuel, B. S., Gordon, J. I., Relman, D. A., Fraser-Liggett, C. M., & Nelson, K. E. (2006) · Science · doi:10.1126/science.1124234 · Cited by 4,699 · see citing works
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182 · see citing works
Oxidative DNA damage: mechanisms, mutation, and disease
Cooke, M. S., Evans, M. D., Dizdaroglu, M., & Lunec, J. (2003) · The FASEB Journal · doi:10.1096/fj.02-0752rev · Cited by 3,245 · see citing works
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718 · see citing works
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476 · see citing works
Intestinal inflammation targets cancer-inducing activity of the microbiota
Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works
Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms
Elinav, E., Nowarski, R., Thaiss, C. A., Hu, B., Jin, C., & Flavell, R. A. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3611 · Cited by 2,000 · see citing works
Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works
Chronic inflammation and cytokines in the tumor microenvironment
Landskron, G., De la Fuente, M., Thuwajit, P., Thuwajit, C., & Hermoso, M. A. (2014) · Journal of Immunology Research · doi:10.1155/2014/149185 · Cited by 1,765 · see citing works
Schwabe, R. F., & Jobin, C. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3610 · Cited by 1,689 · see citing works
DNA damage by oxygen‐derived species Its mechanism and measurement in mammalian systems
Halliwell, B. B., & Aruoma, O. I. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80347-6 · Cited by 1,526 · see citing works
REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology
Demple, B., & Harrison, L. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.004411 · Cited by 1,495 · see citing works
Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors
Tassan, N. A. A., Chmiel, N. H., Maynard, J. H., Fleming, N. I., Livingston, A. L., Williams, G. T., Hodges, A., Davies, D. R., David, S. S., Sampson, J. R., et al. (2002) · Nature Genetics · doi:10.1038/ng828 · Cited by 1,392 · see citing works
Benson, A. K., Kelly, S. A., Legge, R., Ma, F., Low, S. J., Kim, J., Zhang, M., Oh, P. L., Nehrenberg, D., Hua, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007028107 · Cited by 1,314 · see citing works
Base-excision repair of oxidative DNA damage
David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238 · see citing works
Polymorphisms in DNA repair genes and associations with cancer risk.
Goode, E. L., Ulrich, C. M., & Potter, J. D. (2002) · PubMed · Cited by 1,199 · see citing works
The core gut microbiome, energy balance and obesity
Turnbaugh, P. J., & Gordon, J. I. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.174136 · Cited by 993 · see citing works
MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES
Loeb, L. A., & Preston, B. D. (1986) · Annual Review of Genetics · doi:10.1146/annurev.ge.20.120186.001221 · Cited by 901 · see citing works
Multiple Colorectal Adenomas, Classic Adenomatous Polyposis, and Germ-Line Mutations inMYH
Sieber, O. M., Lipton, L. R., Crabtree, M., Heinimann, K., Fidalgo, P. O., Phillips, R. K. S., Bisgaard, M.-L., Orntoft, T. F., Aaltonen, L. A., Hodgson, S. V., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa025283 · Cited by 859 · see citing works
Cuevas-Ramos, G., Petit, C. R., Marcq, I., Boury, M., Oswald, E., & Nougayrède, J.-P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001261107 · Cited by 855 · see citing works
Microbes, Microbiota, and Colon Cancer
Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 820 · see citing works
Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809 · see citing works
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753 · see citing works
The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites
Hendrich, B., Hardeland, U., Ng, H., Jiricny, J., & Bird, A. P. (1999) · Nature · doi:10.1038/45843 · Cited by 637 · see citing works
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
Jackson, A. L., & Loeb, L. A. (2001) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(01)00091-4 · Cited by 630 · see citing works
Cloning and characterization of hOGG1 , a human homolog of the OGG1 gene of Saccharomyces cerevisiae
Radicella, J. P., Dhérin, C., Desmaze, C., Fox, M. S., & Boiteux, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8010 · Cited by 595 · see citing works
Inflammation and colorectal cancer: colitis-associated neoplasia
Grivennikov, S. I. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0352-6 · Cited by 555 · see citing works
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice
Meira, L. B., Bugni, J. M., Green, S. L., Lee, C., Pang, B., Borenshtein, D., Rickman, B. H., Rogers, A. B., Moroski-Erkul, C. A., McFaline‐Figueroa, J. L., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci35073 · Cited by 548 · see citing works
Esteller, M., Toyota, M., Sánchez‐Céspedes, M., Capellá, G., Peinado, M. A., Watkins, D. N., Issa, J. J., Sidransky, D., Baylin, S. B., & Herman, J. G. (2000) · PubMed · Cited by 542 · see citing works
MGMT Promoter Methylation and Field Defect in Sporadic Colorectal Cancer
Shen, L., Kondo, Y., Rosner, G. L., Xiao, L., Hernandez, N., Vilaythong, J. N., Houlihan, P., Krouse, R. S., Prasad, A. R., Einspahr, J. G., et al. (2005) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dji275 · Cited by 492 · see citing works
Emerging patterns of somatic mutations in cancer
Watson, I. R., Takahashi, K., Futreal, P. A., & Chin, L. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3539 · Cited by 481 · see citing works
Agus, A., Denizot, J., Thévenot, J., Martinez-Medina, M., Massier, S., Sauvanet, P., Bernalier-Donadille, A., Denis, S., Hofman, P., Bonnet, R., et al. (2016) · Scientific Reports · doi:10.1038/srep19032 · Cited by 477 · see citing works
Colonization of the Human Gut by <i>E. coli</i> and Colorectal Cancer Risk
Bonnet, M., Buc, E., Sauvanet, P., Darcha, C., Dubois, D., Pereira, B., Déchelotte, P., Bonnet, R., Pezet, D., & Darfeuille-Michaud, A. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1343 · Cited by 475 · see citing works
Dysbiosis Signature of Fecal Microbiota in Colorectal Cancer Patients
Wu, N., Yang, X., Zhang, R., Li, J., Xiao, X., Hu, Y., Chen, Y., Yang, F., Lu, N., Wang, Z., et al. (2013) · Microbial Ecology · doi:10.1007/s00248-013-0245-9 · Cited by 454 · see citing works
Kawanishi, S., Hiraku, Y., Pinlaor, S., & Ma, N. (2006) · Biological Chemistry · doi:10.1515/bc.2006.049 · Cited by 450 · see citing works
Base excision repair of DNA in mammalian cells
Krokan, H. E., Nilsen, H. L., Skorpen, F., Otterlei, M., & Slupphaug, G. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01674-4 · Cited by 371 · see citing works
Bjørås, M., Luna, L., Johnsen, B., Hoff, E., Haug, T., Rognes, T., & Seeberg, E. C. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6314 · Cited by 351 · see citing works
HIF-1α Induces Genetic Instability by Transcriptionally Downregulating MutSα Expression
Koshiji, M., To, K. K.-W., Hammer, S., Kumamoto, K., Harris, A. L., Modrich, P., & Huang, L. E. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.02.015 · Cited by 346 · see citing works
Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2
Hong, D., MITRA, S. P., & Hazra, T. K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308658200 · Cited by 344 · see citing works
Assembly and function of a bacterial genotoxin
Nes̆ić, D., Hsu, Y., & Stebbins, C. E. (2004) · Nature · doi:10.1038/nature02532 · Cited by 344 · see citing works
Genetic susceptibility to lung cancer: the role of DNA damage and repair.
Spitz, M. R., Wei, Q., Dong, Q., Amos, C. I., & Wu, X. (2003) · PubMed · Cited by 343 · see citing works
Aburatani, H., Hippo, Y., Ishida, T., Takashima, R., Matsuba, C., Kodama, T., Takao, M., Yasui, A., Yamamoto, K., & Asano, M. (1997) · PubMed · Cited by 333 · see citing works
Structural basis for removal of adenine mispaired with 8-oxoguanine by MutY adenine DNA glycosylase
Fromme, J. C., Banerjee, A., Huang, S. J., & Verdine, G. L. (2004) · Nature · doi:10.1038/nature02306 · Cited by 331 · see citing works
Bandaru, V. (2002) · DNA repair · doi:10.1016/s1568-7864(02)00036-8 · Cited by 329 · see citing works
Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice
Millar, C. B., Guy, J., Sansom, O. J., Selfridge, J., MacDougall, E., Hendrich, B., Keightley, P. D., Bishop, S. M., Clarke, A. R., & Bird, A. P. (2002) · Science · doi:10.1126/science.1073354 · Cited by 328 · see citing works
The dynamics of gut‐associated microbial communities during inflammation
Winter, S., Lopez, C. A., & Bäumler, A. J. (2013) · EMBO Reports · doi:10.1038/embor.2013.27 · Cited by 328 · see citing works
Esteller, M., & Herman, J. G. (2004) · Oncogene · doi:10.1038/sj.onc.1207316 · Cited by 326 · see citing works
Guan, Y., Manuel, R. C., Arvai, A. S., Parikh, S. S., Mol, C. D., Miller, J. H., Lloyd, R. S., & Tainer, J. A. (1998) · Nature Structural Biology · doi:10.1038/4168 · Cited by 325 · see citing works
Gäbele, E., Dostert, K., Hofmann, C., Wiest, R., Schölmerich, J., Hellerbrand, C., & Obermeier, F. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.035 · Cited by 324 · see citing works
Association of CBP/p300 Acetylase and Thymine DNA Glycosylase Links DNA Repair and Transcription
Tini, M., Benecke, A., Um, S.-J., Torchia, J., Evans, R. M., & Chambon, P. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00453-7 · Cited by 285 · see citing works
High expression of DNA repair pathways is associated with metastasis in melanoma patients
Kauffmann, A., Rosselli, F., Lazar, V, Winnepenninckx, V, Mansuet-Lupo, A., Dessen, P., van den Oord, J. J., Spatz, A., & Sarasin, A. (2008) · Oncogene · doi:10.1038/sj.onc.1210700 · Cited by 274 · see citing works
Dhérin, C. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.20.4001 · Cited by 260 · see citing works
Human AP endonuclease 1 (APE1): From mechanistic insights to druggable target in cancer
Abbotts, R., & Madhusudan, S. (2010) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2009.12.006 · Cited by 250 · see citing works
The Type of DNA Glycosylase Determines the Base Excision Repair Pathway in Mammalian Cells
Fortini, P., Parlanti, E., Sidorkina, O. M., Laval, J., & Eugenia Dogliotti, Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15230 · Cited by 249 · see citing works
Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase
Engelward, B. P., Weeda, G., Wyatt, M. D., Broekhof, J. L. M., de Wit, J., Donker, I., Allan, J. M., Gold, B. I., Hoeijmakers, J. H. J., & Samson, L. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.13087 · Cited by 235 · see citing works
The cytolethal distending toxin family
Pickett, C. L., & Whitehouse, C. A. (1999) · Trends in Microbiology · doi:10.1016/s0966-842x(99)01537-1 · Cited by 233 · see citing works
The base excision repair: mechanisms and its relevance for cancer susceptibility
Fortini, P. (2003) · Biochimie · doi:10.1016/j.biochi.2003.11.003 · Cited by 224 · see citing works
Host genetic and environmental effects on mouse intestinal microbiota
Campbell, J. H., Foster, C. M., Vishnivetskaya, T. A., Campbell, A. G., Yang, Z. K., Wymore, A. M., Palumbo, A. V., Chesler, E. J., & Podar, M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.54 · Cited by 216 · see citing works
Hofseth, L. J., Ma, K., Ambrose, M., Nikolayeva, O., Xu‐Welliver, M., Kartalou, M., Hussain, S. P., Roth, R. B., Zhou, X., Mechanic, L. E., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci19757 · Cited by 206 · see citing works
Gut microbiota accelerate tumor growth via c-jun and STAT3 phosphorylation in APC Min/+ mice
Li, Y., Kundu, P., Seow, S. W., de Matos, C. T., Aronsson, L., Chin, K. C., Kärre, K., Pettersson, S., & Greicius, G. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs137 · Cited by 206 · see citing works
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo
Liu, M., Bandaru, V., Bond, J. P., Jaruga, P., Zhao, X., Christov, P. P., Burrows, C. J., Rizzo, C. J., Dizdaroğlu, M., & Wallace, S. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908307107 · Cited by 203 · see citing works
Fan, X., Crowe, S. E., Behar, S., Gunasena, H., Ye, G., Haeberle, H. A., Houten, N. V., Gourley, W. K., Ernst, P. B., & Reyes, V. E. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.10.1659 · Cited by 200 · see citing works
The enigmatic thymine DNA glycosylase
Cortázar, D., Kunz, C., Saito, Y., Steinacher, R., & Schär, P. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.10.013 · Cited by 199 · see citing works
Robertson, K. A., Bullock, H. A., Xu, Y., Tritt, R., Zimmerman, E., Ulbright, T. M., Foster, R. S., Einhorn, L. H., & Kelley, M. R. (2001) · PubMed · Cited by 194 · see citing works
Canitrot, Y., Cazaux, C., Fréchet, M., Bouayadi, K., Lesca, C., Salles, B., & Hoffmann, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12586 · Cited by 193 · see citing works
Kelley, M. R., Cheng, L., Foster, R. S., Tritt, R., Jiang, J., Broshears, J. R., & Koch, M. O. (2001) · PubMed · Cited by 193 · see citing works
Biphasic Kinetics of the Human DNA Repair Protein MED1 (MBD4), a Mismatch-specific DNA N-Glycosylase
Petronzelli, F., Riccio, A., Markham, G. D., Seeholzer, S. H., Stoerker, J., Genuardi, M., Yeung, A. T., Matsumoto, Y., & Bellacosa, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004535200 · Cited by 179 · see citing works
Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells
Kim, J. J., Tao, H., Carloni, E., Leung, W. K., Graham, D. Y., & Sepulveda, A. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34751 · Cited by 178 · see citing works
Touati, E., Michel, V., Thiberge, J.-M., Wuscher, N., Huerre, M., & Labigne-Roussel, A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00266-x · Cited by 176 · see citing works
Anti-infective properties of bacteriocins: an update
Hammami, R., Fernandez, B., Lacroix, C., & Fliss, I. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1202-3 · Cited by 165 · see citing works
Krishnamurthy, N., Zhao, X., Burrows, C. J., & David, S. S. (2008) · Biochemistry · doi:10.1021/bi800160s · Cited by 148 · see citing works
Preferential Repair of Oxidized Base Damage in the Transcribed Genes of Mammalian Cells
Banerjee, D., Mandal, S. M., Das, A., Hegde, M. L., Das, S., Bhakat, K. K., Boldogh, I. R., Sarkar, P. S., MITRA, S. P., & Hazra, T. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.198796 · Cited by 143 · see citing works
MUTYH-Null Mice Are Susceptible to Spontaneous and Oxidative Stress–Induced Intestinal Tumorigenesis
Sakamoto, K., Tominaga, Y., Yamauchi, K., Nakatsu, Y., Sakumi, K., Yoshiyama, K., Egashira, A., Kura, S., Yao, T., Tsuneyoshi, M., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4802 · Cited by 141 · see citing works
The α/β fold uracil DNA glycosylases: a common origin with diverse fates
Aravind, L., & Koonin, E. V. (2000) · Genome biology · doi:10.1186/gb-2000-1-4-research0007 · Cited by 141 · see citing works
Identification of 127 amino acid substitution variants in screening 37 DNA repair genes in humans.
Mohrenweiser, H. W., Xi, T., Vázquez‐Matías, J., & Jones, I. M. (2002) · PubMed · Cited by 140 · see citing works
Redox Regulation of DNA Repair: Implications for Human Health and Cancer Therapeutic Development
Luo, M., He, H., Kelley, M. R., & Georgiadis, M. M. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2698 · Cited by 136 · see citing works
Cytolethal distending toxin: limited damage as a strategy to modulate cellular functions
Lara-Tejero, M., & Galán, J. E. (2002) · Trends in Microbiology · doi:10.1016/s0966-842x(02)02316-8 · Cited by 135 · see citing works
Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas.
Bobola, M. S., Blank, A., Berger, M. S., Stevens, B. A., & Silber, J. R. (2001) · PubMed · Cited by 134 · see citing works
Zhou, J., Liu, M., Fleming, A. M., Burrows, C. J., & Wallace, S. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.479055 · Cited by 130 · see citing works
Boldogh, I. R., Hajas, G., Aguilera-Aguirre, L., Hegde, M. L., Radak, Z. O., Bácsi, A., Sur, S. A., Hazra, T. K., & MITRA, S. P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.c112.364620 · Cited by 130 · see citing works
Dimerization and opposite base-dependent catalytic impairment of polymorphic S326C OGG1 glycosylase
Hill, J. W. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl060 · Cited by 130 · see citing works
Cortellino, S., Turner, D. P., Masciullo, V., Schepis, F., Albino, D., Daniel, R., Skalka, A. M., Meropol, N. J., Alberti, C., Larue, L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2334585100 · Cited by 127 · see citing works
Cancer and inflammation: A complex relationship
Mantovani, A., & Pierotti, M. A. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.003 · Cited by 125 · see citing works
Deregulated DNA polymerase beta induces chromosome instability and tumorigenesis.
Bergoglio, V., Pillaire, M., Lacroix‐Triki, M., Raynaud‐Messina, B., Canitrot, Y., Bieth, A., Garès, M., Wright, M., Delsol, G., Loeb, L. A., et al. (2002) · PubMed · Cited by 121 · see citing works
Variation in base excision repair capacity
Wilson, D. M., Kim, D., Berquist, B. R., & Sigurdson, A. J. (2010) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2010.12.004 · Cited by 121 · see citing works
Potential role for 8‐oxoguanine DNA glycosylase in regulating inflammation
Mabley, J. G., Pacher, P., Deb, A., Wallace, R., Elder, R. H., & Szabó, C. (2004) · The FASEB Journal · doi:10.1096/fj.04-2278fje · Cited by 117 · see citing works
Jelonek, K., Gdowicz‐Kłosok, A., Pietrowska, M., Borkowska, M., Korfanty, J., Rzeszowska‐Wolny, J., & Widłak, P. (2010) · Journal of Applied Genetics · doi:10.1007/bf03208865 · Cited by 115 · see citing works
MBD4 and TDG: Multifaceted DNA glycosylases with ever expanding biological roles
Sjolund, A. B., Senejani, A. G., & Sweasy, J. B. (2012) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2012.11.001 · Cited by 113 · see citing works
Cytolethal distending toxin (CDT): a bacterial weapon to control host cell proliferation?
de Rycke, J., & Oswald, É. (2001) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(01)00344-5 · Cited by 112 · see citing works
Hegde, M. L., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G., Boldogh, I. R., Tomkinson, A. E., & MITRA, S. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1304231110 · Cited by 105 · see citing works
Park, J., Chen, L., Tockman, M. S., Elahi, A. H., & Lazarus, P. J. (2004) · Pharmacogenetics · doi:10.1097/00008571-200402000-00004 · Cited by 104 · see citing works
Mutagenicity of a unique apurinic/apyrimidinic site in mammalian cells
Gentil, A., Cabral-Neto, J. B., Mariage, R., Margot, A., Imbach, J. L., Rayner, B., & Sarasin, A. R. (1992) · Journal of Molecular Biology · doi:10.1016/0022-2836(92)90513-j · Cited by 102 · see citing works
Innate Inflammation Induced by the 8-Oxoguanine DNA Glycosylase-1–KRAS–NF-κB Pathway
Aguilera-Aguirre, L., Bácsi, A., Radak, Z. O., Hazra, T. K., MITRA, S. P., Sur, S., Brasier, A. R., Ba, X., & Boldogh, I. R. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401625 · Cited by 101 · see citing works
Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors
Donigan, K. A., Sun, K.-W., Nemec, A. A., Murphy, D. L., Cong, X., Northrup, V. S., Zelterman, D. A., & Sweasy, J. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324947 · Cited by 101 · see citing works
Origin of Endogenous DNA Abasic Sites in Saccharomyces cerevisiae
Guillet, M., & Boiteux, S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8386-8394.2003 · Cited by 98 · see citing works
Nishimura, S. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00778-5 · Cited by 96 · see citing works
Repair of Oxidative Damage to DNA: Enzymology and Biology
Demple, B. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.63.1.915 · Cited by 96 · see citing works
Bergoglio, V., Canitrot, Y., Hogarth, L., Minto, L., Howell, S. B., Cazaux, C., & Hoffmann, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204743 · Cited by 92 · see citing works
MUTYH Associated Polyposis (MAP)
Poulsen, M. H., & Bisgaard, M. L. (2008) · Current Genomics · doi:10.2174/138920208785699562 · Cited by 87 · see citing works
Expression patterns of Neil3 during embryonic brain development and neoplasia
Hildrestrand, G. A., Neurauter, C. G., Diep, D. B., Castellanos, C. G., Krauss, S. J. K., Bjørås, M., & Luna, L. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-45 · Cited by 85 · see citing works
Human Polymorphic Variants of the NEIL1 DNA Glycosylase
Roy, L. M., Jaruga, P., Wood, T. G., McCullough, A. K., Dizdaroğlu, M., & Lloyd, R. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610626200 · Cited by 83 · see citing works
El‐Andaloussi, N., Valovka, T., Toueille, M., Hassa, P. O., Gehrig, P., Covic, M., Hübscher, U., & Hottiger, M. O. (2006) · The FASEB Journal · doi:10.1096/fj.06-6194com · Cited by 83 · see citing works
Broderick, P., Bagratuni, T., Vijayakrishnan, J., Lubbe, S. J., Chandler, I. P., & Houlston, R. S. (2006) · BMC Cancer · doi:10.1186/1471-2407-6-243 · Cited by 82 · see citing works
Chmiel, N. H. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.2.553 · Cited by 82 · see citing works
Yamtich, J., Nemec, A. A., Keh, A., & Sweasy, J. B. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003052 · Cited by 80 · see citing works
Association of APE1 and hOGG1 polymorphisms with colorectal cancer risk in a Turkish population
Canbay, E., Çakmakoğlu, B., Zeybek, Ü., Sozen, S., Cacına, C., GULLUOGLU, M. G., Balık, E., Bulut, T., Yamaner, S., & Buğra, D. (2011) · Current Medical Research and Opinion · doi:10.1185/03007995.2011.573544 · Cited by 80 · see citing works
Roukos, D. H., Katsios, C. G., & Liakakos, T. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.49 · Cited by 80 · see citing works
Kidane, D., Murphy, D. L., & Sweasy, J. B. (2014) · Oncogenesis · doi:10.1038/oncsis.2014.42 · Cited by 79 · see citing works
Self-citationIs Base Excision Repair a Tumor Suppressor Mechanism?
Sweasy, J. B., Lang, T., & DiMaio, D. (2006) · Cell Cycle · doi:10.4161/cc.5.3.2414 · Cited by 77 · see citing works
Brevik, A., Joshi, A. D., Corral, R., Onland‐Moret, N. C., Siegmund, K. D., Marchand, L. L., Baron, J. A., Martı́nez, M. E., Haile, R. W., Ahnen, D. J., et al. (2010) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0606 · Cited by 77 · see citing works
Human MutY: gene structure, protein functions and interactions, and role in carcinogenesis
Parker, A. R., & Eshleman, J. R. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3053-4 · Cited by 70 · see citing works
Haploinsufficiency in DNA Polymerase β Increases Cancer Risk with Age and Alters Mortality Rate
Cabelof, D. C., Ikeno, Y., Nyska, A., Busuttil, R. A., Anyangwe, N., Vijg, J., Matherly, L. H., Tucker, J. D., Wilson, S. H., Richardson, A., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1177 · Cited by 70 · see citing works
Intestinal Inflammation Targets Cancer-Inducing Activity of the Microbiota
Jobin, C., Perez-Chanona, E., Abujamel, T., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/d6zy-hr28 · Cited by 68 · see citing works
Edara, S., Kanugula, S., Goodtzova, K., & Pegg, A. E. (1996) · PubMed · Cited by 66 · see citing works
Barnes, D. E., Lindahl, T. L., & Sedgwick, B. (1993) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(93)90007-d · Cited by 66 · see citing works
Gu, D., Wang, M., Wang, M., Zhang, Z., & Chen, J. (2009) · Mutagenesis · doi:10.1093/mutage/gep036 · Cited by 63 · see citing works
Active DNA demethylation by oxidation and repair
Gong, Z., & Zhu, J. (2011) · Cell Research · doi:10.1038/cr.2011.140 · Cited by 62 · see citing works
Common variants in human CRC genes as low-risk alleles
Picelli, S., Zając, P., Zhou, X., Edler, D., Lenander, C., Dalén, J., Hjern, F., Lundqvist, N., Lindforss, U., Påhlman, L., et al. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.01.013 · Cited by 61 · see citing works
Structural Similarities between MutT and the C-Terminal Domain of MutY
Volk, D. E., House, P. G., Thiviyanathan, V., Luxon, B. A., Zhang, S., Lloyd, R. S., & Gorenstein, D. G. (2000) · Biochemistry · doi:10.1021/bi000416p · Cited by 60 · see citing works
Effect of Helicobacter pylori Infection on the Expression of DNA Mismatch Repair Protein
Park, D. I., Park, S. H., Kim, S. H., Kim, J. W., Cho, Y. K., Kim, H. J., Sohn, C. I., Jeon, W. K., Kim, B. I., Cho, E. Y., et al. (2005) · Helicobacter · doi:10.1111/j.1523-5378.2005.00309.x · Cited by 60 · see citing works
Pope, M. A., Chmiel, N. H., & David, S. S. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.10.003 · Cited by 56 · see citing works
Liao, J., Seril, D. N., Lu, G. G., Zhang, M., Toyokuni, S., Yang, A. L., & Yang, G. (2008) · Molecular Carcinogenesis · doi:10.1002/mc.20427 · Cited by 54 · see citing works
Apurinic/Apyrimidinic endonuclease 1 regulates inflammatory response in macrophages.
Jedinak, A., Dudhgaonkar, S. P., Kelley, M. R., & Slíva, D. (2011) · PubMed · Cited by 53 · see citing works
Qian, X. C., von Wronski, M. A., & Brent, T. P. (1995) · Carcinogenesis · doi:10.1093/carcin/16.6.1385 · Cited by 53 · see citing works
Guo, Z., Zheng, L., Dai, H., Zhou, M., Xu, H., & Shen, B. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp201 · Cited by 53 · see citing works
Margison, G. P., Heighway, J., Pearson, S. J., McGown, G., Thorncroft, M. R., Watson, A. J., Harrison, K., Lewis, S. J., Rohde, K., Barber, P. V., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi087 · Cited by 53 · see citing works
Characterization of human polymorphic DNA repair methyltransferase
Inoüe, R., Abe, M., Nakabeppu, Y., Sekiguchi, M., Mori, T., & Suzuki, T. (2000) · Pharmacogenetics · doi:10.1097/00008571-200002000-00008 · Cited by 49 · see citing works
Repair of O6-G-Alkyl-O6-G Interstrand Cross-Links by Human O6-Alkylguanine-DNA Alkyltransferase
Fang, Q., Noronha, A. M., Murphy, S. P., Wilds, C. J., Tubbs, J. L., Tainer, J. A., Chowdhury, G., Guengerich, F. P., & Pegg, A. E. (2008) · Biochemistry · doi:10.1021/bi8008664 · Cited by 49 · see citing works
Coulter, R., Blandino, M., Tomlinson, J. M., Pauly, G. T., Krajewska, M., Moschel, R. C., Peterson, L. A., Pegg, A. E., & Spratt, T. E. (2007) · Chemical Research in Toxicology · doi:10.1021/tx700271j · Cited by 44 · see citing works
Nemec, A. A., Donigan, K. A., Murphy, D. L., Jäger, J., & Sweasy, J. B. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.362111 · Cited by 43 · see citing works
Mutagenesis by Apurinic/Apyrimidinic Sites
Loeb, L. (1986) · Annual Review of Genetics · doi:10.1146/annurev.genet.20.1.201 · Cited by 43 · see citing works
Cytolethal distending toxins and activation of DNA damage-dependent checkpoint responses
Frisan, T., Cortes-Bratti, X., & Thelestam, M. (2001) · International Journal of Medical Microbiology · doi:10.1078/1438-4221-00158 · Cited by 42 · see citing works
Organ and cell specificity of base excision repair mutants in mice
Larsen, E., Meza, T. J., Kleppa, L., & Klungland, A. (2006) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.01.023 · Cited by 41 · see citing works
Vasovčák, P., Křepelová, A., Menigatti, M., Puchmajerová, A., Škapa, P., Augustinakova, A., Amann, G., Wernstedt, A., Jiricny, J., Marra, G., et al. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.04.004 · Cited by 39 · see citing works
Inactivation of a common OGG1 variant by TNF-alpha in mammalian cells
Morreall, J., Limpose, K. L., Sheppard, C. L., Kow, Y. W., Werner, E., & Doetsch, P. W. (2014) · DNA repair · doi:10.1016/j.dnarep.2014.11.007 · Cited by 38 · see citing works
No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk
Gsur, A., Bernhart, K., Baierl, A., Feik, E., Führlinger, G., Hofer, P., Leeb, G., Mach, K., & Micksche, M. (2011) · Cancer Epidemiology · doi:10.1016/j.canep.2011.03.005 · Cited by 36 · see citing works
Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk
AlMutairi, F., Pathan, A. A. K., Alanazi, M., Shalaby, M. A., Alabdulkarim, H. A., Alamri, A. M., Naeem, A. A., Elrobh, M., Shaik, J. P., Khan, W., et al. (2015) · Disease Markers · doi:10.1155/2015/869512 · Cited by 34 · see citing works
New genes emerging for colorectal cancer predisposition
Esteban-Jurado, C. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i8.1961 · Cited by 34 · see citing works
Futagami, S., Hiratsuka, T., Shindo, T., Horie, A., Hamamoto, T., Suzuki, K., Kusunoki, M., Miyake, K., Gudis, K., Crowe, S. E., et al. (2008) · Helicobacter · doi:10.1111/j.1523-5378.2008.00605.x · Cited by 31 · see citing works
Association of OGG1 Ser326Cys polymorphism with colorectal cancer risk: a meta-analysis
Zhang, Y., He, B., Pan, Y., Xu, Y., & Wang, S. (2011) · International Journal of Colorectal Disease · doi:10.1007/s00384-011-1258-9 · Cited by 31 · see citing works
Investigation of the effects of DNA repair gene polymorphisms on the risk of colorectal cancer
Tomlinson, I. P. M., Houlston, R. S., Montgomery, G. W., Sieber, O. M., & Dunlop, M. G. (2012) · Mutagenesis · doi:10.1093/mutage/ger070 · Cited by 31 · see citing works
Agus, A., Denizot, J., Thévenot, J., Massier, S., Sauvanet, P., Bonnet, R., Billard, E., & Barnich, N. (2016) · Gastroenterology · doi:10.1016/s0016-5085(16)30201-3 · Cited by 31 · see citing works
Activation of the abundant nuclear factor poly(ADP-ribose) polymerase-1 by Helicobacter pylori
Nossa, C. W., Jain, P., Tamilselvam, B., Gupta, V. R., Chen, L., Schreiber, V., Desnoyers, S., & Blanke, S. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906753106 · Cited by 27 · see citing works
The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads
Hofseth, L. J. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh196 · Cited by 27 · see citing works
Enhanced expression and activity of DNA polymerase beta in chronic myelogenous leukemia.
Canitrot, Y., Laurent, G., Astarie‐Dequeker, C., Bordier, C., Cazaux, C., & Hoffmann, J. (2006) · PubMed · Cited by 27 · see citing works
APE1polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans
Zhang, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8700 · Cited by 26 · see citing works
Loh, Y. H., Mitrou, P. N., Bowman, R., Wood, A., Jeffery, H., Luben, R., Lentjes, M. A. H., Khaw, K., & Rodwell, S. A. (2010) · DNA repair · doi:10.1016/j.dnarep.2010.01.002 · Cited by 25 · see citing works
Sjolund, A. B., Nemec, A. A., Paquet, N., Prakash, A., Sung, P., Doublié, S., & Sweasy, J. B. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004753 · Cited by 20 · see citing works
Population-specific variation in haplotype composition and heterozygosity at the POLB locus
Yamtich, J., Speed, W. C., Straka, E., Kidd, J. R., Sweasy, J. B., & Kídd, K. K. (2009) · DNA repair · doi:10.1016/j.dnarep.2008.12.005 · Cited by 20 · see citing works
Levi, L., Toyooka, T., Patarroyo, M. E., & Frisan, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124119 · Cited by 16 · see citing works
Su, Y., Xu, A., & Zhu, J. (2013) · Tumor Biology · doi:10.1007/s13277-013-1072-9 · Cited by 12 · see citing works
SONG, J., Maeng, E. J., Cao, Z., Kim, S. Y., NAM, S., Lee, J., & PARK, W. (2009) · Neoplasma · doi:10.4149/neo_2009_04_343 · Cited by 11 · see citing works
Hofseth, L. J., Khan, M. A. Q., Ambrose, M., Nikolayeva, O., Xu‐Welliver, M., Kartalou, M., Hussain, S. P., Roth, R. B., Zhou, X., Mechanic, L. E., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19757e1 · Cited by 10 · see citing works
Adhikari, S., Chetram, M. A., Woodrick, J., Mitra, P. S., Manthena, P. V., Khatkar, P., Dakshanamurthy, S., Dixon, M., Karmahapatra, S. K., Nuthalapati, N. K., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.627000 · Cited by 9 · see citing works
Effect of Helicobacter pylori infection on the expression of DNA Mismatch Repair Protein
Mirzaee, V., Molaee, M., Shalmani, H. M., Zojaji, H., Mashayekhi, R., & Zali, M. R. (2008) · Gastroenterology and hepatology from bed to bench. · doi:10.22037/ghfbb.v1i1.16 · Cited by 9 · see citing works
APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans
Shi-Heng, Zhang, Lin-Ang, Wang, Zheng, Li, Yu, Peng, Yan, Ping, P., et al. (2014) · Acta Scientiarum Naturalium Universitatis Sunyatseni · Cited by 7 · see citing works
Immediate early genes induced by H-Ras in thyroid cells
Cobellis, G., Missero, C., Simionati, B., Valle, G., & Lauro, R. D. (2001) · Oncogene · doi:10.1038/sj.onc.1204320 · Cited by 5 · see citing works
Margison, G. P., Heighway, J., Pearson, S. J., Harrison, K., Rhode, K., Barber, P. V., O’Donnell, E., Povey, A. C., & Santibanez‐Koref, M. (2004) · European Journal of Cancer Supplements · doi:10.1016/s1359-6349(04)80490-7 · Cited by 4 · see citing works
The alpha/beta fold uracil DNA glycosylases: a common origin with diverse fates
Aravind, L., & Koonin, E. V. (2000) · Europe PMC (PubMed Central) · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Human Gut Microbiota and Gastrointestinal Cancer
Meng, C., Bai, C., Brown, T. D., Hood, L., & Tian, Q. (2018) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.06.002 · Cited by 472 · see citing works
Sunlight damage to cellular DNA: focus on oxidatively generated lesions
Schuch, A. P., Moreno, N. C., Schuch, N. J., Menck, C. F. M., & Garcia, C. C. M. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.01.029 · Cited by 436 · see citing works
Alhasson, F. A., Das, S., Seth, R. K., Dattaroy, D., Chandrashekaran, V., Ryan, C. N., Chan, L. S., Testerman, T. L., Burch, J. B., Hofseth, L. J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172914 · Cited by 152 · see citing works
Human Gut Microbiota: Toward an Ecology of Disease
Selber‐Hnatiw, S., Rukundo, B., Ahmadi, M., Akoubi, H., Al-Bizri, H., Aliu, A. F., Ambeaghen, T. U., Avetisyan, L., Bahar, I., Baird, A., et al. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01265 · Cited by 145 · see citing works
Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota
Loke, Y. L., Chew, M. T., Ngeow, Y. F., Lim, W. W.-D., & Peh, S. C. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.603086 · Cited by 129 · see citing works
Yuan, Y., Lü, L., Nan, B., Yang, C., & Yan, H. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05014 · Cited by 107 · see citing works
Remely, M., Ferk, F., Sterneder, S., Setayesh, T., Roth, S., Kepčija, T., Noorizadeh, R., Rebhan, I., Greunz, M., Beckmann, J., et al. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3079148 · Cited by 104 · see citing works
Interplay and cooperation of Helicobacter pylori and gut microbiota in gastric carcinogenesis
Bakhti, S. Z., & Latifi‐Navid, S. (2021) · BMC Microbiology · doi:10.1186/s12866-021-02315-x · Cited by 59 · see citing works
Xiao, T., Wu, S., Yan, C., Zhao, C., Jin, H., Yan, N., Xu, J., Wu, Y., Li, C., Shao, Q., et al. (2018) · Oncology Letters · doi:10.3892/ol.2018.9201 · Cited by 54 · see citing works
Sun, Y., Cheng, L., Zeng, X., Zhang, X., Liu, Y., Wu, Z., & Weng, P. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.12.164 · Cited by 50 · see citing works
Codrich, M., Comelli, M., Malfatti, M. C., Mio, C., Ayyildiz, D., Zhang, C., Kelley, M. R., Terrosu, G., Pucillo, C. E. M., & Tell, G. (2019) · DNA repair · doi:10.1016/j.dnarep.2019.102675 · Cited by 44 · see citing works
Maintaining the Balance of Intestinal Flora through the Diet: Effective Prevention of Illness
Zhang, L., Zhang, Z., Xu, L., & Zhang, X. (2021) · Foods · doi:10.3390/foods10102312 · Cited by 45 · see citing works
Espinoza, J. L., & Minami, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00052 · Cited by 42 · see citing works
Tang, M., Cheng, L., Liu, Y., Wu, Z., Zhang, X., & Luo, S. (2022) · Molecules · doi:10.3390/molecules27092773 · Cited by 33 · see citing works
Heidarian, F., Alebouyeh, M., Shahrokh, S., Balaii, H., & Zali, M. R. (2019) · Current Research in Translational Medicine · doi:10.1016/j.retram.2019.01.002 · Cited by 33 · see citing works
Why do insects evolve immune priming? A search for crossroads
Prakash, A., & Khan, I. (2021) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2021.104246 · Cited by 31 · see citing works
Microbiota as the unifying factor behind the hallmarks of cancer
Benešová, I., Křížová, Ľ., & Kverka, M. (2023) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-023-05244-6 · Cited by 34 · see citing works
Malfatti, M. C., Antoniali, G., Codrich, M., Burra, S., Mangiapane, G., Dalla, E., & Tell, G. (2019) · Mutagenesis · doi:10.1093/mutage/gez051 · Cited by 26 · see citing works
Induction and modulation of genotoxicity by the bacteriome in mammals
Druzhinin, V. G., Matskova, L. V., & Fucic, A. (2018) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2018.04.002 · Cited by 24 · see citing works
Gut dysbiosis in cancer immunotherapy: microbiota-mediated resistance and emerging treatments
Eiman, L., Moazzam, K., Anjum, S., Kausar, H., Sharif, E. A. M., & Ibrahim, W. N. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1575452 · Cited by 25 · see citing works
Chen, L.-H., Lin, C.-H., Siao, R.-F., & Wang, L. (2022) · mSphere · doi:10.1128/msphere.00194-22 · Cited by 23 · see citing works
Cui, X., Hu, S.-Y., Zhu, C., & Qin, X. (2020) · BMC Cancer · doi:10.1186/s12885-020-07590-x · Cited by 19 · see citing works
Zhang, W., Zhang, J., Liu, T., Xing, J., Zhang, H., Wang, D., & Tang, D. (2022) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-022-04081-3 · Cited by 14 · see citing works
Sonowal, R., Swimm, A. I., Cingolani, F., Parulekar, N., Cleverley, T. L., Sahoo, A., Ranawade, A., Chaudhuri, D., Mocarski, E. S., Koehler, H. S., et al. (2023) · Science Advances · doi:10.1126/sciadv.ade8653 · Cited by 13 · see citing works
Gasser, M., Lissner, R., Nawalaniec, K., Hsiao, L., & Waaga-Gasser, A. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00684 · Cited by 11 · see citing works
Jauvain, M., Lepied, G., Bénéjat, L., Roudier, N., Dussert, C., Lehours, P., Varon, C., & Bessède, E. (2024) · Helicobacter · doi:10.1111/hel.13108 · Cited by 10 · see citing works
Blanco, J. R., del Campo, R., Ortiz, J. A., Olmos, M. L., & Carnero, A. (2025) · Cells · doi:10.3390/cells14221813 · Cited by 9 · see citing works
Campillo-Gimenez, L., Ríos-Covián, D., Rivera–Nieves, J., Kiyono, H., Chu, H., & Ernst, P. B. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.752304 · Cited by 6 · see citing works
Obesity and cancer: Relevance of DNA damage response
Deshmukh, B., Ajay, A. K., & Bhat, M. K. (2026) · Translational Oncology · doi:10.1016/j.tranon.2025.102657 · Cited by 5 · see citing works
The Effect of H. pylori Infection on the Gastric Microbiota
Kim, N., & Jo, H. J. (2023) · Springer eBooks · doi:10.1007/978-981-97-0013-4_59 · Cited by 4 · see citing works
Yang, W., Li, T., An, S., Chen, R., Zhao, Y.-X., Cui, J., Zhang, M., Lu, J., Tian, Y., Bao, L., et al. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.01861-24 · Cited by 4 · see citing works
Prebiotics and Probiotics in Altering Microbiota
Purama, R. K., Raman, M., Ambalam, P. S., Pithva, S. P., Kothari, C., & Doble, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805417-8.00030-5 · Cited by 4 · see citing works
Detecting a Probiotic Product Within the Gut of Broiler Chickens
Pisula, A. (2018) · doi:10.15368/theses.2018.113 · Cited by 2 · see citing works
Chen, L.-H., Lin, C.-H., Siao, R.-F., & Wang, L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.27.478127
Cui, X.-H., Hu, S.-Y., 朱春富, & Qin, X. (2020) · Figshare · doi:10.6084/m9.figshare.13297006
Metabolic crossroads: Integrating ROS, SCF, and gut microbiota in cancer
Parihar, B. O., Kumar, A., & Yadav, A. K. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33459-7.00011-9
- Authors
- Ray, D., & Kidane, D.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Kidane, Dawit
- ORCID
- Kidane, Dawit
- Venue
- Journal of Cancer
- Publisher
- Ivyspring International Publisher
- Published
- 2016
- Volume
- 7
- Issue
- 11
- Pages
- 1421-1430
- ISSN
- 1837-9664 (ISSN-L)
- PMC
- PMC4964126
- OpenAlex
- W2475036271
- Cited by
- 37
- References
- 162
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 5 · 2017: 5
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Journal of Cancer (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Texas at Austin
- National Institutes of Health (CA15485401)
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- gut microbiota, dysbiosis, colon cancer, base excision repair, oxidative DNA damage, bacterial genotoxins, chronic inflammation, genomic instability, DNA base lesions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review