Western diet induces a shift in microbiota composition enhancing susceptibility to adherent-invasive E. coli infection and intestinal inflammation
Open accessAbstract
Recent advances have shown that the abnormal inflammatory response observed in CD involves an interplay among intestinal microbiota, host genetics and environmental factors. The escalating consumption of fat and sugar in Western countries parallels an increased incidence of CD during the latter 20(th) century. The impact of a HF/HS diet in mice was evaluated for the gut micro-inflammation, intestinal microbiota composition, function and selection of an E. coli population. The HF/HS diet created a specific inflammatory environment in the gut, correlated with intestinal mucosa dysbiosis characterized by an overgrowth of pro-inflammatory Proteobacteria such as E. coli, a decrease in protective bacteria, and a significantly decreased of SCFA concentrations. The expression of GPR43, a SCFA receptor was reduced in mice treated with a HF/HS diet and reduced in CD patients compared with controls. Interestingly, mice treated with an agonist of GPR43 were protected against DSS-induced colitis. Finally, the transplantation of feces from HF/HS treated mice to GF mice increased susceptibility to AIEC infection. Together, our results demonstrate that a Western diet could aggravate the inflammatory process and that the activation of the GPR43 receptor pathway could be used as a new strategy to treat CD patients.
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An increased Firmicutes:Bacteroidetes ratio and decreases in protective SCFA-producing bacteria such as F. prausnitzii are often observed.
“Likewise, an increased Firmicutes:Bacteroidetes ratio (41) and decreases in protective SCFA-producing bacteria (e.g., F. prausnitzii) (89, 204) are often observed.”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [89]
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- Authors
- Agus, A., Denizot, J., Thévenot, J., Martinez-Medina, M., Massier, S., Sauvanet, P., Bernalier-Donadille, A., Denis, S., Hofman, P., Bonnet, R., Billard, E., & Barnich, N.
- Affiliations
- Inserm (FR)
- Université Clermont Auvergne (FR)
- Centre National de la Recherche Scientifique (FR)
- Corresponding author
- Barnich, Nicolas
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-01-08
- Volume
- 6
- Issue
- 1
- Pages
- 19032-19032
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4705701
- OpenAlex
- W2400773242
- Cited by
- 477
- References
- 42
- Citations by year
- 2026: 35 · 2025: 50 · 2024: 47 · 2023: 51 · 2022: 59 · 2021: 56 · 2020: 58 · 2019: 42 · 2018: 49 · 2017: 14 · 2016: 15
- FWCI
- 20.80
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale (UMR 1071, USC-2018)
- Institut National de la Recherche Agronomique (USC-2018)
- Société Française de Nutrition
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- Western diet, high-fat high-sugar diet, gut microbiota, Crohn's disease, intestinal inflammation, short-chain fatty acids, GPR43, DSS-induced colitis, fecal microbiota transplantation, Proteobacteria, gut dysbiosis, dietary fat and sugar
- MeSH terms
- Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Animals, Bacterial Adhesion, Colitis, Crohn Disease, Disease Susceptibility, Escherichia coli, Fatty Acids, Volatile, Female, Gene Expression Regulation, Humans, Intestinal Mucosa, Male, Sodium Dodecyl Sulfate, Dietary Sucrose, Receptors, G-Protein-Coupled, Benzeneacetamides, Mice, Diet, High-Fat, Gene-Environment Interaction, Dysbiosis, Diet, Western
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