The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Tumor-Infiltrating Immune Cells Promoting Tumor Invasion and Metastasis: Existing Theories
Open accessAbstract
It is a commonly held belief that infiltration of immune cells into tumor tissues and direct physical contact between tumor cells and infiltrated immune cells is associated with physical destructions of the tumor cells, reduction of the tumor burden, and improved clinical prognosis. An increasing number of studies, however, have suggested that aberrant infiltration of immune cells into tumor or normal tissues may promote tumor progression, invasion, and metastasis. Neither the primary reason for these contradictory observations, nor the mechanism for the reported diverse impact of tumor-infiltrating immune cells has been elucidated, making it difficult to judge the clinical implications of infiltration of immune cells within tumor tissues. This mini-review presents several existing hypotheses and models that favor the promoting impact of tumor-infiltrating immune cells on tumor invasion and metastasis, and also analyzes their strength and weakness.
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Cites
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Of Mice and Not Men: Differences between Mouse and Human Immunology
Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822
Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer
Zhang, L., Conejo-Garcia, J. R., Katsaros, D., Gimotty, P. A., Massobrio, M., Regnani, G., Makrigiannakis, A., Gray, H., Schlienger, K., Liebman, M. N., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020177 · Cited by 3,397
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer
Pagès, F., Berger, A., Camus, M., Sanchez-Cabo, F., Costes, A., Molidor, R., Mlecnik, B., Kirilovsky, A., Nilsson, M., Damotte, D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051424 · Cited by 2,135 · cited 1×
“The main strength of this hypothesis is that it is based on both clinical and laboratory data and that Treg-cell induced immune suppression has been well documented in multiple types of human cancer and diseases [100-104].”
BackgroundTumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells
Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., et al. (2011) · Nature · doi:10.1038/nature10169 · Cited by 1,376
Granzymes in cancer and immunity
Cullen, S. P., Brunet, M., & Martin, S. J. (2010) · Cell Death & Differentiation · doi:10.1038/cdd.2009.206 · Cited by 391
Li, L., Yan, B., Shi, Y.-Q., Zhang, W.-Q., & Wen, Z.-L. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.349126 · Cited by 353
Microenvironmental regulation of cancer development
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Cited by
Liang, C., Xu, L., Song, G., & Liu, Z. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00458j · Cited by 435
HYPE or HOPE: the prognostic value of infiltrating immune cells in cancer
Barnes, T. A., & Amir, E. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.220 · Cited by 432
Nishijima, T. F., Muss, H. B., Shachar, S. S., Tamura, K., & Takamatsu, Y. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.10.003 · Cited by 324
Cell Therapy: Types, Regulation, and Clinical Benefits
El-Kadiry, A. E.-H., Rafei, M., & Shammaa, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.756029 · Cited by 256
Nilkhet, S., Mongkolpobsin, K., Sillapachaiyaporn, C., Wongsirojkul, N., Tencomnao, T., & Chuchawankul, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-58208-2 · Cited by 21
Metadata
- Authors
- Man, Y.-G., Stojadinovic, A., Mason, J., Avital, I., Bilchik, A., Bruecher, B., Protic, M., Nissan, A., Izadjoo, M., Zhang, X., & Jewett, A.
- Venue
- Journal of Cancer
- Publisher
- Ivyspring International Publisher
- Published
- 2013
- Volume
- 4
- Issue
- 1
- Pages
- 84-95
- ISSN
- 1837-9664 (ISSN-L)
- OpenAlex
- W2101076675
- Cited by
- 192
- References
- 9
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- gold
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- Man, Y.-G., Stojadinovic, A., Mason, J., Avital, I., Bilchik, A., Bruecher, B., Protic, M., Nissan, A., Izadjoo, M., Zhang, X., & Jewett, A. (2013). Tumor-Infiltrating Immune Cells Promoting Tumor Invasion and Metastasis: Existing Theories. Journal of Cancer. https://doi.org/10.7150/jca.5482
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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