Microenvironmental regulation of cancer development

Hu, Min; Polyak, Kornelia

doi:10.1016/j.gde.2007.12.006

Cited by 332Cancer Cells and MetastasisTGF-β signaling in diseasesAngiogenesis and VEGF in Cancer

Microenvironmental regulation of cancer development

Open access

Hu, Min, Polyak, Kornelia·2008·Current Opinion in Genetics & Development

DOI 10.1016/j.gde.2007.12.006PMC PMC2467152

Open this paper in CoChat — free account

Abstract

Numerous studies have demonstrated that the tumor microenvironment not only responds to and supports carcinogenesis, but also actively contributes to tumor initiation, progression, and metastasis. During tumor progression all cells composing the tumor undergo phenotypic and epigenetic changes. Paracrine signaling between epithelial and stromal cells is important for the regulation of the proliferation, invasive, angiogenic, and metastatic behavior of cancer cells. Better understanding the molecular mechanisms by which stromal cells exert these effects may open up new venues for cancer therapeutic and preventative interventions.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.gde.2007.12.006

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Tumor-associated stroma actively facilitates tumor initiation, invasion, and therapeutic resistance through biochemical and biomechanical means.
“While stroma in normal tissues may possess anti-tumor properties, tumor-associated stroma—comprising cancer-associated fibroblasts, ECM, endothelial cells, and immune cells—actively facilitates tumor initiation, invasion, and therapeutic resistance [139,140,141,142].”
From Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis (2025) · cites this paper as [141]
The Introduction (page unavailable) describes tumor stroma as an active contributor to initiation and invasion, and identifies stromal cells, ECM, and biochemical signaling. It also reports increased chemotherapy uptake after targeting tumor-associated fibroblasts, but does not establish the broader claim that stroma facilitates therapeutic resistance through biochemical and biomechanical means; its explicit drug-resistance discussion says stromal cells are less likely than tumor cells to acquire resistance. (LLM, conf=0.84)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular portraits of human breast tumours
Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551 · see citing works
Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536 · see citing works
Involvement of chemokine receptors in breast cancer metastasis
Müller, A., Homey, B., Soto, H., Ge, N., Catron, D., Buchanan, M. E., McClanahan, T., Murphy, E., Yuan, W., Wagner, S. N., et al. (2001) · Nature · doi:10.1038/35065016 · Cited by 5,340 · see citing works
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277 · see citing works
Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391 · cited 1× · see citing works
“The tumor stroma in many aspects resembles wound healing and chronic inflammatory conditions, except that normal physiologic controls are not maintained [11].”
Background
Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion
Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288 · see citing works
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Karnoub, A. E., Dash, A. B., Vo, A. P., Sullivan, A., Brooks, M. W., Bell, G. W., Richardson, A. L., Polyak, K., Tubo, R., & Weinberg, R. A. (2007) · Nature · doi:10.1038/nature06188 · Cited by 3,206 · see citing works
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,562 · see citing works
Putting tumours in context
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180 · see citing works
Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies
Weaver, V. M., Petersen, O. W., Wang, F., Larabell, C. A., Briand, P., Damsky, C., & Bissell, M. J. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.231 · Cited by 1,483 · see citing works
TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Bhowmick, N. A., Chytil, A., Plieth, D., Gorska, A. E., Dumont, N., Shappell, S., Washington, M. K., Neilson, E. G., & Moses, H. L. (2004) · Science · doi:10.1126/science.1090922 · Cited by 1,401 · see citing works
Molecular characterization of the tumor microenvironment in breast cancer
Allinen, M., Beroukhim, R., Cai, L., Brennan, C., Lahti-Domenici, J., Huang, H., Porter, D., Hu, M., Chin, L., Richardson, A., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.06.010 · Cited by 1,299 · see citing works
Self-citation
Pathology of tumours
Willis, R. A. (1948) · Butterworths eBooks · Cited by 1,254 · see citing works
Gene expression profiles of human breast cancer progression
Ma, X., Salunga, R. C., Tuggle, J. T., Gaudet, J., Enright, E., McQuary, P., Payette, T., Pistone, M., Stecker, K., Zhang, B. M., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0931261100 · Cited by 878 · see citing works
Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction
Rønnov‐Jessen, L., PETERSEN, O. W., & Bissell, M. J. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.1.69 · Cited by 797 · see citing works
Genetic determinants of cancer metastasis
Nguyen, D. X., & Massagué, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2101 · Cited by 796 · see citing works
Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity.
Streuli, C. H., Bailey, N., & Bissell, M. J. (1991) · The Journal of Cell Biology · doi:10.1083/jcb.115.5.1383 · Cited by 678 · see citing works
Preparing the “Soil”: The Premetastatic Niche
Kaplan, R. N., Rafii, S., & Lyden, D. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2407 · Cited by 665 · see citing works
Targeting tumor‐associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
Loeffler, M. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26532 · Cited by 633 · see citing works
Axis of evil: molecular mechanisms of cancer metastasis
Bogenrieder, T., & Herlyn, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206757 · Cited by 594 · see citing works
Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation
Elenbaas, B., & Weinberg, R. A. (2001) · Experimental Cell Research · doi:10.1006/excr.2000.5133 · Cited by 557 · see citing works
Targeting tumor-associated macrophages as a novel strategy against breast cancer
Luo, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27648 · Cited by 554 · see citing works
Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts
Direkze, N. C., Hodivala-Dilke, K., Jeffery, R., Hunt, T., Poulsom, R., Oukrif, D., Alison, M. R., & Wright, N. A. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1708 · Cited by 530 · see citing works
Distinct epigenetic changes in the stromal cells of breast cancers
Hu, M., Yao, J., Cai, L., Bachman, K., van den Brûle, F., Velculescu, V. E., & Polyák, K. (2005) · Nature Genetics · doi:10.1038/ng1596 · Cited by 520 · see citing works
Self-citation
Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition
Guðjónsson, Þ., Rønnov‐Jessen, L., Villadsen, R., Rank, F. E., Bissell, M. J., & PETERSEN, O. W. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.1.39 · Cited by 518 · see citing works
Gene expression profiles of primary breast tumors maintained in distant metastases
Weigelt, B., Glas, A. M., Wessels, L. F. A., Witteveen, A. T., Peterse, J. L., & Veer, L. J. V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634067100 · Cited by 431 · see citing works
Know thy neighbor: stromal cells can contribute oncogenic signals
Tlsty, T. D., & Hein, P. W. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00156-8 · Cited by 425 · see citing works
Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas
黒瀬, 圭., Gilley, K., Matsumoto, S., Watson, P. H., Zhou, X.-P., & Eng, C. (2002) · Nature Genetics · doi:10.1038/ng1013 · Cited by 418 · see citing works
Humoral immunity, inflammation and cancer
Tan, T. T., & Coussens, L. M. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.01.001 · Cited by 418 · see citing works
The stroma as a crucial target in rat mammary gland carcinogenesis
Maffini, M. V., Soto, A. M., Calabro, J. M., Ucci, A. A., & Sonnenschein, C. (2004) · Journal of Cell Science · doi:10.1242/jcs.01000 · Cited by 417 · see citing works
Fibroblast-mediated acceleration of human epithelial tumor growth in vivo.
Camps, J. L., Chang, S. M., Hsu, T., Freeman, M. R., Hong, S. J., Zhau, H. E., von Eschenbach, A. C., & Chung, L. W. K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.75 · Cited by 416 · see citing works
Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis.
Moinfar, F., Man, Y., Arnould, L., Bratthauer, G. L., Ratschek, M., & Tavassoli, F. A. (2000) · PubMed · Cited by 402 · see citing works
In situ analyses of genome instability in breast cancer
Chin, K., de Solorzano, C. O., Knowles, D., Jones, A., Chou, W., Rodriguez, E. G., Kuo, W.-L., Ljung, B.-M., Chew, K., Myambo, K., et al. (2004) · Nature Genetics · doi:10.1038/ng1409 · Cited by 361 · see citing works
Bone marrow cells in the ‘pre-metastatic niche’: within bone and beyond
Kaplan, R. N., Psaila, B., & Lyden, D. C. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9036-9 · Cited by 335 · see citing works
Myoepithelial Cells: Their Origin and Function in Breast Morphogenesis and Neoplasia
Guðjónsson, Þ., Adriance, M. C., Sternlicht, M. D., PETERSEN, O. W., & Bissell, M. J. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-9586-4 · Cited by 282 · see citing works
Loss of TGF-β type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-α-, MSP- and HGF-mediated signaling networks
Cheng, N., Bhowmick, N. A., Chytil, A. M., Gorksa, A. E., Brown, K. A., Muraoka, R. S., Arteaga, C. L., Neilson, E. G., Hayward, S. W., & Moses, H. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208685 · Cited by 268 · see citing works
Molecular markers in ductal carcinoma in situ of the breast.
PORTER, D. A., Lahti‐Domenici, J., Keshaviah, A. P., Bae, Y. K., Argani, P., Marks, J. R., Richardson, A. L., Cooper, A. G., Strausberg, R. L., Riggins, G. J., et al. (2003) · PubMed · Cited by 265 · see citing works
Re-expression of the alpha 2 beta 1 integrin abrogates the malignant phenotype of breast carcinoma cells.
Zutter, M. M., Santoro, S. A., Staatz, W. D., & Tsung, Y. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7411 · Cited by 232 · see citing works
Stromal Involvement In Malignant Growth
van den Hooff, A. (1988) · Advances in cancer research · doi:10.1016/s0065-230x(08)60437-6 · Cited by 227 · see citing works
Niche-to-niche migration of bone-marrow-derived cells
Kaplan, R. N., Psaila, B., & Lyden, D. C. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2006.12.003 · Cited by 213 · see citing works
Inability of Rous sarcoma virus to cause sarcomas in the avian embryo
Dolberg, D. S., & Bissell, M. J. (1984) · Nature · doi:10.1038/309552a0 · Cited by 206 · see citing works
Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions
Kurose, K. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1907 · Cited by 191 · see citing works
The influence of tissue microenvironment (stroma and extracellular matrix) on the development and function of mammary epithelium.
Howlett, A. R., & Bissell, M. J. (1993) · PubMed · Cited by 184 · see citing works
Do Myoepithelial Cells Hold the Key for Breast Tumor Progression?
Polyák, K., & Hu, M. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-9584-6 · Cited by 181 · see citing works
Self-citation
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo
Jessani, N., Humphrey, M., McDonald, W. H., Niessen, S., Masuda, K. R., Gangadharan, B., Yates, J. R., Mueller, B. M., & Cravatt, B. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0404727101 · Cited by 181 · see citing works
Tumors are unique organs defined by abnormal signaling and context
Radisky, D. C., Hagios, C., & Bissell, M. J. (2001) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0360 · Cited by 177 · see citing works
Combined cDNA Array Comparative Genomic Hybridization and Serial Analysis of Gene Expression Analysis of Breast Tumor Progression
Yao, J., Weremowicz, S., Feng, B., Gentleman, R. C., Marks, J. R., Gelman, R. S., Brennan, C. W., & Polyák, K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4083 · Cited by 177 · see citing works
Gene Promoter Methylation in Prostate Tumor–Associated Stromal Cells
Hanson, J., Gillespie, J. W., Grover, A. C., Tangrea, M. A., Chuaqui, R. F., Emmert‐Buck, M. R., Tangrea, J. A., Libutti, S. K., Linehan, W. M., & Woodson, K. G. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj051 · Cited by 175 · see citing works
Breast Cancer DNA Methylation Profiles in Cancer Cells and Tumor Stroma: Association with HER-2/neu Status in Primary Breast Cancer
Fiegl, H., Millinger, S., Goebel, G., Müller‐Holzner, E., Marth, C., Laird, P. W., & Widschwendter, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2508 · Cited by 172 · see citing works
Breast fibroblasts modulate epithelial cell proliferation in three-dimensional in vitro co-culture
Sadlonova, A., Novák, Z., Johnson, M. R., Bowe, D. B., Gault, S. R., Page, G. P., Thottassery, J. V., Welch, D. R., & Frost, A. R. (2004) · Breast Cancer Research · doi:10.1186/bcr949 · Cited by 158 · see citing works
Enhancement of tumorigenicity of human breast adenocarcinoma cells in nude mice by matrigel and fibroblasts
Noël, A., Pauw-Gillet, M. C. D., Purnell, G., Nusgens, B., LAPIERE, C. H. M., & Foidart, J. M. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.453 · Cited by 142 · see citing works
Combined Total Genome Loss of Heterozygosity Scan of Breast Cancer Stroma and Epithelium Reveals Multiplicity of Stromal Targets
Fukino, K., Shen, L., Matsumoto, S., Morris, Q., Mutter, G. L., & Eng, C. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-2866 · Cited by 140 · see citing works
Priming the ‘Soil’ for Breast Cancer Metastasis: The Pre-Metastatic Niche
Psaila, B., Kaplan, R. N., Port, E. R., & Lyden, D. C. (2007) · Breast Disease · doi:10.3233/bd-2007-26106 · Cited by 133 · see citing works
Myoepithelial Cells: Autocrine and Paracrine Suppressors of Breast Cancer Progression
Barsky, S. H., & Karlin, N. J. (2005) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-005-9585-5 · Cited by 132 · see citing works
Genomic Instability Within Tumor Stroma and Clinicopathological Characteristics of Sporadic Primary Invasive Breast Carcinoma
Fukino, K., Shen, L., Patócs, A., Mutter, G. L., & Eng, C. (2007) · JAMA · doi:10.1001/jama.297.19.2103 · Cited by 110 · see citing works
Total-Genome Analysis of BRCA1/2-Related Invasive Carcinomas of the Breast Identifies Tumor Stroma as Potential Landscaper for Neoplastic Initiation
Weber, F., Shen, L., Fukino, K., Patócs, A., Mutter, G. L., Caldés, T., & Eng, C. (2006) · The American Journal of Human Genetics · doi:10.1086/504090 · Cited by 94 · see citing works
Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion
Man, Y.-G., Tai, L. H., Barner, R., VANG, R. S., Saenger, J. S., Shekitka, K. M., Bratthauer, G. L., Wheeler, D. T., Liang, C. Y., Vinh, T. N., et al. (2003) · Breast Cancer Research · doi:10.1186/bcr653 · Cited by 85 · see citing works
Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
Weber, F., Fukino, K., Sawada, T., Williams, N., Sweet, K. M., Brena, R. M., Plass, C., Caldés, T., Mutter, G. L., Villalona-Calero, M. A., et al. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602557 · Cited by 75 · see citing works
Fibroblasts from cancer patients display a mixture of both foetal and adult-like phenotypic characteristics
Schor, S. L., Schor, A. M., & Rushton, G. (1988) · Journal of Cell Science · doi:10.1242/jcs.90.3.401 · Cited by 72 · see citing works
Enhanced Hepatocyte Growth Factor Signaling by Type II Transforming Growth Factor-β Receptor Knockout Fibroblasts Promotes Mammary Tumorigenesis
Cheng, N., Chytil, A. M., Shyr, Y., Joly, A. H., & Moses, H. L. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3381 · Cited by 64 · see citing works
Tumor–stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis
Montel, V., Mose, E. S., & Tarin, D. (2006) · International Journal of Cancer · doi:10.1002/ijc.21757 · Cited by 63 · see citing works
Analysis of Tumor-Host Interactions by Gene Expression Profiling of Lung Adenocarcinoma Xenografts Identifies Genes Involved in Tumor Formation
Creighton, C. J., Bromberg-White, J. L., Misek, D. E., Monsma, D. J., Brichory, F., Kuick, R. D., Giordano, T. J., Gao, W., Omenn, G. S., Webb, C. P., et al. (2005) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-04-0189 · Cited by 62 · see citing works
cDNA expression profiling reveals elevated gene expression in cell clusters overlying focally disrupted myoepithelial cell layers: implications for breast tumor invasion
Man, Y.-G., Zhang, Y., Shen, T., Zeng, X., Tauler, J., Mulshine, J. L., & Strauss, B. L. (2005) · Breast Cancer Research and Treatment · doi:10.1007/s10549-004-2049-6 · Cited by 39 · see citing works
Mammary Ducts With and Without Focal Myoepithelial Cell Layer Disruptions Show a Different Frequency of White Blood Cell Infiltration and Growth Pattern: Implications for Tumor Progression and Invasion
Yousefi, M., Mattu, R., Gao, C., & Man, Y. (2005) · Applied immunohistochemistry & molecular morphology · doi:10.1097/00129039-200503000-00006 · Cited by 37 · see citing works
Protein and mRNA expression of uPAR and PAI-1 in myoepithelial cells of early breast cancer lesions and normal breast tissue
Hildenbrand, R., & Arens, N. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6601990 · Cited by 24 · see citing works
A subset of in situ breast tumor cell clusters lacks expression of proliferation and progression related markers but shows signs of stromal and vascular invasion
Man, Y.-G., Shen, T., Weisz, J., Berg, P. E., Schwartz, A. M., Mulshine, J. L., Sang, Q. A., & Nieburgs, H. E. (2005) · Cancer Detection and Prevention · doi:10.1016/j.cdp.2005.06.010 · Cited by 22 · see citing works
Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia
Medina, D. J., & Kittrell, F. S. (2004) · Journal of Cell Science · doi:10.1242/jcs.01597 · Cited by 20 · see citing works
Eighteenth Annual Pezcoller Symposium: Tumor Microenvironment and Heterotypic Interactions
Weinberg, R. A., & Mihich, E. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-3149 · Cited by 19 · see citing works
Angiogenesis as a new target for cancer treatment
Ono, M., Izumi, H., Yoshida, S., Goto, D., Jimi, S., Kawahara, N., Shono, T., Ushiro, S., Ryuto, M., Kohno, K., et al. (1996) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s002800051044 · Cited by 7 · see citing works
Mechanisms of progression of ductal carcinoma in situ of the breast to invasive cancer
Cocker, R. S., Oktay, M. H., Sunkara, J. L., & Koss, L. G. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2006.11.042 · Cited by 7 · see citing works

Flagged first, then by citations

1 of the 73 references couldn’t be matched to a known paper.

Sorted by citations

Principles of cancer therapy: oncogene and non-oncogene addiction
Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.024 · Cited by 1,765 · see citing works
Co-evolution of tumor cells and their microenvironment
Polyák, K., Haviv, I., & Campbell, I. (2008) · Trends in Genetics · doi:10.1016/j.tig.2008.10.012 · Cited by 622 · see citing works
Induction of myeloid‐derived suppressor cells by tumor exosomes
Xiang, X., Poliakov, A., Liu, C., Liu, Y., Deng, Z., Wang, J., Cheng, Z., Shah, S. V., Wang, G., Zhang, L., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.24249 · Cited by 597 · see citing works
LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis
Cox, T. R., Bird, D., Baker, A.-M., Barker, H. E., Ho, M. W.-Y., Lang, G., & Erler, J. T. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2233 · Cited by 571 · see citing works
Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective
Huang, S., Ernberg, I. T., & Kauffman, S. A. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.07.003 · Cited by 556 · see citing works
Cancer-associated fibroblasts and tumor growth – bystanders turning into key players
Östman, A., & Augsten, M. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.01.003 · Cited by 542 · see citing works
Role of the Tumor Microenvironment in Breast Cancer
Soysal, S. D., Tzankov, A., & Muenst, S. E. (2015) · Pathobiology · doi:10.1159/000430499 · Cited by 511 · see citing works
Metastatic Growth from Dormant Cells Induced by a Col-I–Enriched Fibrotic Environment
Barkan, D., Touny, L. H. E., Michalowski, A. M., Smith, J. A., Chu, I. M., Davis, A. S., Webster, J. D., Hoover, S. B., Simpson, R. M., Gauldie, J., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2356 · Cited by 395 · see citing works
Exosomes Derived from Hypoxic Leukemia Cells Enhance Tube Formation in Endothelial Cells
Tadokoro, H., Umezu, T., Ohyashiki, K., Hirano, T., & Ohyashiki, J. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.480822 · Cited by 361 · see citing works
Mesenchymal stem cells enhance growth and metastasis of colon cancer
Shinagawa, K., Kitadai, Y., Tanaka, M., Sumida, T., Kodama, M., Higashi, Y., Tanaka, S., Yasui, W., & Chayama, K. (2010) · International Journal of Cancer · doi:10.1002/ijc.25440 · Cited by 308 · see citing works
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
Becker, L. M., O’Connell, J. T., Vo, A. P., Cain, M. P., Tampe, D., Bizarro, L., Sugimoto, H., McGow, A. K., Asara, J. M., Lovisa, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107701 · Cited by 293 · see citing works
Tumor Microenvironment in Head and Neck Squamous Cell Carcinoma
Curry, J., Sprandio, J. D., Cognetti, D. M., Luginbuhl, A., Bar‐Ad, V., Pribitkin, E. A., & Tuluc, M. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.03.003 · Cited by 291 · see citing works
STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells
Liu, Y., Luo, F., Wang, B., Li, H., Xu, Y., Liu, X., Shi, L., Lü, X., Xu, W., Lu, L., et al. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.10.011 · Cited by 275 · see citing works
Roles of circRNAs in the tumour microenvironment
Zhang, Q., Wang, W., Zhou, Q., Chen, C., Yuan, W., Liu, J., Li, X., & Sun, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-019-1125-9 · Cited by 260 · see citing works
Hypoxia-inducible factor 1 and breast cancer metastasis
Liu, Z.-J., Semenza, G. L., & Zhang, H.-F. (2015) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400221 · Cited by 257 · see citing works
Gastric Cancer Exosomes Trigger Differentiation of Umbilical Cord Derived Mesenchymal Stem Cells to Carcinoma-Associated Fibroblasts through TGF-β/Smad Pathway
Gu, J., Qian, H., Shen, L., Zhang, X., Zhu, W., Huang, L., Yan, Y., Mao, F., Zhao, C., Shi, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052465 · Cited by 220 · see citing works
Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence
Páez, D., LaBonte, M. J., Bohanes, P. O., Zhang, W., Benhanim, L., Ning, Y., Wakatsuki, T., Loupakis, F., & Lenz, H. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-2186 · Cited by 215 · see citing works
3D tumor models: History, advances and future perspectives
Benien, P., & Swami, A. (2014) · Future Oncology · doi:10.2217/fon.13.274 · Cited by 208 · see citing works
Role of COX-2 in epithelial–stromal cell interactions and progression of ductal carcinoma in situ of the breast
Hu, M. S., Peluffo, G., Chen, H., Gelman, R. S., Schnitt, S. J., & Polyák, K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813306106 · Cited by 205 · see citing works
Self-citation
Tumor-Infiltrating Immune Cells Promoting Tumor Invasion and Metastasis: Existing Theories
Man, Y., Stojadinovic, A., Mason, J. T., Avital, I., Bilchik, A., Bruecher, B., Protić, M., Nissan, A., Izadjoo, M. J., Zhang, X., et al. (2013) · Journal of Cancer · doi:10.7150/jca.5482 · Cited by 192 · see citing works
Cancer‐associated fibroblasts predict poor outcome and promote periostin‐dependent invasion in oesophageal adenocarcinoma
Underwood, T., Hayden, A. L., Derouet, M. F., Garcia, E., Noble, F., White, M. J., Thirdborough, S., Mead, A., Clemons, N. J., Mellone, M., et al. (2014) · The Journal of Pathology · doi:10.1002/path.4467 · Cited by 186 · see citing works
Stromal-derived interleukin 6 drives epithelial-to-mesenchymal transition and therapy resistance in esophageal adenocarcinoma
Ebbing, E. A., van der Zalm, A. P., Steins, A., Creemers, A., Hermsen, S., Rentenaar, R., Klein, M., Waasdorp, C., Hooijer, G. K. J., Meijer, S. L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820459116 · Cited by 183 · see citing works
Mesenchymal Stem Cells Promote Formation of Colorectal Tumors in Mice
Tsai, K., Yang, S., Lei, Y., Tsai, C., Chen, H., Hsu, C., Chen, L., Wang, H., Miller, S. A., Chiou, S., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.05.045 · Cited by 175 · see citing works
Transforming Growth Factor-Beta and Matrix Metalloproteinases: Functional Interactions in Tumor Stroma-Infiltrating Myeloid Cells
Krstić, J., & Santibanez, J. F. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/521754 · Cited by 174 · see citing works
The origins of cancer robustness and evolvability
Tian, T., Olson, S., Whitacre, J. M., & Harding, A. S. (2010) · Integrative Biology · doi:10.1039/c0ib00046a · Cited by 168 · see citing works
Breast Cancer Cells Induce Cancer-Associated Fibroblasts to Secrete Hepatocyte Growth Factor to Enhance Breast Tumorigenesis
Tyan, S., Kuo, W., Huang, C.-K., Pan, C.-C., Shew, J., Chang, K., Lee, E. Y.-H. P., & Lee, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015313 · Cited by 167 · see citing works
Ecological Therapy for Cancer: Defining Tumors Using an Ecosystem Paradigm Suggests New Opportunities for Novel Cancer Treatments
Pienta, K. J., McGregor, N., Axelrod, R., & Axelrod, D. E. (2008) · Translational Oncology · doi:10.1593/tlo.08178 · Cited by 161 · see citing works
p38MAPK plays a crucial role in stromal-mediated tumorigenesis
Alspach, E., Flanagan, K. C., Luo, X., Ruhland, M. K., Huang, H., Pazolli, E., Donlin, M. J., Marsh, T., Piwnica-Worms, D., Monahan, J., et al. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0743 · Cited by 167 · see citing works
Astrocytes promote glioma invasion via the gap junction protein connexin43
Sin, W. C., Aftab, Q., Bechberger, J. F., Leung, J., Chen, H., & Naus, C. C. G. (2015) · Oncogene · doi:10.1038/onc.2015.210 · Cited by 163 · see citing works
Tertiary lymphoid structures: prognostic significance and relationship with tumour-infiltrating lymphocytes in triple-negative breast cancer
Lee, H. J., Park, I. A., Song, I. H., Shin, S., Kim, J. Y., Yu, J. H., & Gong, G. (2015) · Journal of Clinical Pathology · doi:10.1136/jclinpath-2015-203089 · Cited by 162 · see citing works
Evaluation of cell-cell interaction methods by integrating single-cell RNA sequencing data with spatial information
Liu, Z., Sun, D., & Wang, C. (2022) · Genome biology · doi:10.1186/s13059-022-02783-y · Cited by 162 · see citing works
Retracted: M2 Macrophage–Derived Exosomes Facilitate HCC Metastasis by Transferring αMβ2 Integrin to Tumor Cells
Wu, J., Gao, W., Tang, Q., Yu, Y., You, W., Wu, Z., Fan, Y., Zhang, L., Wu, C., Han, G., et al. (2020) · Hepatology · doi:10.1002/hep.31432 · Cited by 160 · see citing works
Retracted
Molecular aspects of tumour hypoxia
Rademakers, S. E., Span, P. N., Kaanders, J. H. A. M., Sweep, F. C. G. J., van der Kogel, A. J., & Bussink, J. (2008) · Molecular Oncology · doi:10.1016/j.molonc.2008.03.006 · Cited by 157 · see citing works
Cancer-Associated Fibroblasts and Their Putative Role in Potentiating the Initiation and Development of Epithelial Ovarian Cancer
Schauer, I. G., Sood, A. K., Mok, S. C., & Liu, J. (2011) · Neoplasia · doi:10.1593/neo.101720 · Cited by 155 · see citing works
Nanoprobes for biomedical imaging in living systems
Koo, H., Huh, M. S., Ryu, J. H., Lee, D., Sun, I., Choi, K., Kim, K., & Kwon, I. C. (2011) · Nano Today · doi:10.1016/j.nantod.2011.02.007 · Cited by 152 · see citing works
The paracrine effect of cancer‐associated fibroblast‐induced interleukin‐33 regulates the invasiveness of head and neck squamous cell carcinoma
Chen, S.-F., Nieh, S., Jao, S., Wu, M.-Z., Liu, C., Chang, Y., & Lin, Y. (2013) · The Journal of Pathology · doi:10.1002/path.4226 · Cited by 152 · see citing works
Multifocal epithelial tumors and field cancerization: stroma as a primary determinant
Dotto, G. P. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72589 · Cited by 169 · see citing works
M2 macrophage-secreted exosomes promote metastasis and increase vascular permeability in hepatocellular carcinoma
Lu, Y., Han, G., Zhang, Y., Zhang, L., Li, Z., Wang, Q., Chen, Z., Wang, X., & Wu, J. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-00872-w · Cited by 150 · see citing works
Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions
Alexander, J. I., & Cukierman, E. (2016) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2016.05.002 · Cited by 144 · see citing works
The harsh microenvironment in early breast cancer selects for a Warburg phenotype
Damaghi, M., West, J., Robertson‐Tessi, M., Xu, L., Ferrall‐Fairbanks, M. C., Stewart, P. A., Persi, E., Fridley, B. L., Altrock, P. M., Gatenby, R. A., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011342118 · Cited by 143 · see citing works
Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy?
Gonda, T. A., Varró, A., Wang, T. C., & Tycko, B. (2009) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2009.10.001 · Cited by 145 · see citing works
Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer
Muggerud, A. A., Hallett, M. T., Johnsen, H., Sahlberg, K. K., Zhou, W., Tahmasebpoor, S., Amini, R., Botling, J., Børresen‐Dale, A., Sørlie, T., et al. (2010) · Molecular Oncology · doi:10.1016/j.molonc.2010.06.007 · Cited by 132 · see citing works
The prognostic value of tumour-stroma ratio in triple-negative breast cancer
Moorman, A. M., Vink, R., Heijmans, H. J., van der Palen, J. A. M., & Kouwenhoven, E. A. (2012) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2012.01.002 · Cited by 132 · see citing works
Beyond the tumour microenvironment
Laplane, L., Duluc, D., Bikfalvi, A., Larmonier, N., & Pradeu, T. (2019) · International Journal of Cancer · doi:10.1002/ijc.32343 · Cited by 123 · see citing works
NF-kB-regulated exosomal miR-155 promotes the inflammation associated with arsenite carcinogenesis
Chen, C., Luo, F., Liu, X., Lu, L., Xu, H., Yang, Q., Xue, J., Shi, L., Li, J., Zhang, A., et al. (2016) · Cancer Letters · doi:10.1016/j.canlet.2016.11.027 · Cited by 115 · see citing works
The relationship between the tumour stroma percentage, clinicopathological characteristics and outcome in patients with operable ductal breast cancer
Gujam, F. J. A., Edwards, J., Mohammed, Z. M. A., Going, J. J., & McMillan, D. C. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.279 · Cited by 115 · see citing works
Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs OXPHOS and prostate cancer metastatic spread
Giannoni, E., Taddei, M. L., Morandi, A., Comito, G., Calvani, M., Bianchini, F., Richichi, B., Raugei, G., Wong, N., Tang, D., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4448 · Cited by 113 · see citing works
Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells
Ouyang, G., Wang, Z., Fang, X., Liu, J., & Yang, C. J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0338-2 · Cited by 113 · see citing works
Stroma–epithelium crosstalk in prostate cancer
Niu, Y.-N., & Xia, S. (2008) · Asian Journal of Andrology · doi:10.1038/aja.2008.39 · Cited by 111 · see citing works
Cancer-Associated Fibroblasts Enhance the Gland-Forming Capability of Prostate Cancer Stem Cells
Liao, C., Adisetiyo, H., Liang, M., & Roy‐Burman, P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3982 · Cited by 110 · see citing works
Tumor Hypoxia Imaging
Sun, X., Niu, G., Chan, N., Shen, B., & Chen, X. S. (2010) · Molecular Imaging and Biology · doi:10.1007/s11307-010-0420-z · Cited by 109 · see citing works
Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer
Kim, M., Zhang, Y., & Lozano, G. (2015) · Frontiers in Oncology · doi:10.3389/fonc.2015.00249 · Cited by 108 · see citing works
The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination
Beck, J. N., Singh, A., Rothenberg, A. R., Elisseeff, J. H., & Ewald, A. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.08.077 · Cited by 108 · see citing works
IFN-γ, IL-17 and TGF-β involvement in shaping the tumor microenvironment: The significance of modulating such cytokines in treating malignant solid tumors
Alshaker, H. A., & Matalka, K. Z. (2011) · Cancer Cell International · doi:10.1186/1475-2867-11-33 · Cited by 106 · see citing works
COX-2 and PGE2-dependent immunomodulation in breast cancer
Chen, E. P., & Smyth, E. M. (2011) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2011.08.005 · Cited by 107 · see citing works
Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway
Ouyang, G., Liu, M., Ruan, K., Song, G., Mao, Y., & Bao, S. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.030 · Cited by 108 · see citing works
Illuminating breast cancer invasion: diverse roles for cell–cell interactions
Cheung, K. J., & Ewald, A. J. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.07.003 · Cited by 98 · see citing works
Human breast cancer associated fibroblasts exhibit subtype specific gene expression profiles
Tchou, J. C., Kossenkov, A. V., Chang, L., Satija, C., Herlyn, M., Showe, L. C., & Puré, E. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-39 · Cited by 101 · see citing works
Targeted Methylation of Two Tumor Suppressor Genes Is Sufficient to Transform Mesenchymal Stem Cells into Cancer Stem/Initiating Cells
Teng, I.-W., Hou, P., Lee, K., Chu, P., Yeh, K., Jin, V. X., Tseng, M., Tsai, S., Chang, Y., Wu, C., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3418 · Cited by 96 · see citing works
Patterns of cancer invasion revealed by QDs-based quantitative multiplexed imaging of tumor microenvironment
Peng, C., Liu, X., Chen, C., Liu, X., Yang, X., Pang, D., Zhu, X., & Li, Y. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.053 · Cited by 97 · see citing works
Exosomal miRNAs in hepatocellular carcinoma development and clinical responses
Li, S., Yao, J., Xie, M., Liu, Y., & Zheng, M. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0579-3 · Cited by 93 · see citing works
TNFα-exposed Bone Marrow-derived Mesenchymal Stem Cells Promote Locomotion of MDA-MB-231 Breast Cancer Cells through Transcriptional Activation of CXCR3 Ligand Chemokines
Shin, S. Y., Nam, J., Lim, Y., & Lee, Y. H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.128124 · Cited by 96 · see citing works
Mesenchymal stem cells inhibit breast cancer cell migration and invasion through secretion of tissue inhibitor of metalloproteinase‐1 and ‐2
Clarke, M. R., Imhoff, F. M., & Baird, S. K. (2014) · Molecular Carcinogenesis · doi:10.1002/mc.22178 · Cited by 93 · see citing works
MULTIMERIN2 impairs tumor angiogenesis and growth by interfering with VEGF-A/VEGFR2 pathway
Lorenzon, E., Colladel, R., Andreuzzi, E., Marastoni, S., Todaro, F., Schiappacassi, M., Ligresti, G., Colombatti, A., & Mongiat, M. (2011) · Oncogene · doi:10.1038/onc.2011.487 · Cited by 88 · see citing works
NF-κB inhibition is associated with OPN/MMP-9 downregulation in cutaneous melanoma
Guarneri, C., Bevelacqua, V., Polesel, J., Falzone, L., Cannavó, P. S., Spandidos, D. A., Malaponte, G., & Libra, M. (2017) · Oncology Reports · doi:10.3892/or.2017.5362 · Cited by 88 · see citing works
Pan-Cancer Analysis of the Genomic Alterations and Mutations of the Matrisome
Izzi, V., Davis, M. N., & Naba, A. (2020) · Cancers · doi:10.3390/cancers12082046 · Cited by 87 · see citing works
Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis
Jia, Y., Shi, L., Zhou, J., Fu, C., Chen, L., Yuan, H., Wang, Y., Yan, X., Xu, Y., Zeng, Q., et al. (2011) · Hepatology · doi:10.1002/hep.24562 · Cited by 87 · see citing works
Ex-Vivo Dynamic 3-D Culture of Human Tissues in the RCCS™ Bioreactor Allows the Study of Multiple Myeloma Biology and Response to Therapy
Ferrarini, M., Steimberg, N., Ponzoni, M., Belloni, D., Berenzi, A., Girlanda, S., Caligaris‐Cappio, F., Mazzoleni, G., & Ferrero, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071613 · Cited by 85 · see citing works
Cancer Associated Fibroblasts and Tumor Growth: Focus on Multiple Myeloma
Veirman, K. D., Rao, L., Bruyne, E. D., Menu, E., Valckenborgh, E. V., Riet, I. V., Frassanito, M. A., Marzo, L. D., Vacca, A., & Vanderkerken, K. (2014) · Cancers · doi:10.3390/cancers6031363 · Cited by 84 · see citing works
Regulation of invadopodia by the tumor microenvironment
Gould, C. M., & Courtneidge, S. A. (2014) · Cell Adhesion & Migration · doi:10.4161/cam.28346 · Cited by 81 · see citing works
Breast Cancer Cells Induce Stromal Fibroblasts to Secrete ADAMTS1 for Cancer Invasion through an Epigenetic Change
Tyan, S., Hsu, C.-H., Peng, K.-L., Chen, C.-C., Kuo, W., Lee, E. Y.-H. P., Shew, J., Chang, K., Juan, L., & Lee, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035128 · Cited by 80 · see citing works
Optimization of the formation of embedded multicellular spheroids of MCF-7 cells: How to reliably produce a biomimetic 3D model
Zhang, W., Li, C., Baguley, B. C., Zhou, F., Zhou, W., Shaw, J., Wang, Z., Wu, Z., & Liu, J. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.10.004 · Cited by 78 · see citing works
Loss of Cell-Surface Laminin Anchoring Promotes Tumor Growth and Is Associated with Poor Clinical Outcomes
Akhavan, A., Griffith, O. L., Soroceanu, L., Leonoudakis, D., Luciani-Torres, M. G., Daemen, A., Gray, J. W., & Muschler, J. L. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3732 · Cited by 76 · see citing works
The metastatic microenvironment of breast cancer: Clinical implications
Coleman, R. E., Gregory, W. M., Marshall, H. C., Wilson, C., & Holen, I. (2013) · The Breast · doi:10.1016/j.breast.2013.07.010 · Cited by 76 · see citing works
CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans
Martínez‐Torres, A. C., Quiney, C., Attout, T., Boullet, H., Herbi, L., Vela, L., Barbier, S., Château, D., Chapiro, É., Nguyen‐Khac, F., et al. (2015) · PLoS Medicine · doi:10.1371/journal.pmed.1001796 · Cited by 76 · see citing works
Lack of an Endogenous Anti-inflammatory Protein in Mice Enhances Colonization of B16F10 Melanoma Cells in the Lungs
Saha, A., Lee, Y., Zhang, Z., Chandra, G., Su, S. B., & Mukherjee, A. B. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083550 · Cited by 75 · see citing works
HGF/c-MET Axis in Tumor Microenvironment and Metastasis Formation
Spina, A., Pasquale, V. D., Cerulo, G., Cocchiaro, P., Morte, R. D., Avallone, L., & Pavone, L. M. (2015) · Biomedicines · doi:10.3390/biomedicines3010071 · Cited by 75 · see citing works
Tumor progression: Chance and necessity in Darwinian and Lamarckian somatic (mutationless) evolution
Huang, S. (2012) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2012.05.001 · Cited by 76 · see citing works
Microenvironment of Tumor-Draining Lymph Nodes: Opportunities for Liposome-Based Targeted Therapy
Chandrasekaran, S., & King, M. R. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151120209 · Cited by 74 · see citing works
Tumor Microenvironment and Metabolism in Prostate Cancer
Chiarugi, P., Paoli, P., & Cirri, P. (2014) · Seminars in Oncology · doi:10.1053/j.seminoncol.2014.03.004 · Cited by 74 · see citing works
Relationships between cancer and aging: a multilevel approach
Anisimov, V. N., Sikora, E., & Pawelec, G. (2009) · Biogerontology · doi:10.1007/s10522-008-9209-8 · Cited by 70 · see citing works
The Multiple Layers of the Tumor Environment
Laplane, L., Duluc, D., Larmonier, N., Pradeu, T., & Bikfalvi, A. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.10.002 · Cited by 74 · see citing works
Clonal Mutations in the Cancer-Associated Fibroblasts: The Case against Genetic Coevolution
Campbell, I., Polyák, K., & Haviv, I. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4253 · Cited by 70 · see citing works
Breast Cancer Subtype-Specific Interactions with the Microenvironment Dictate Mechanisms of Invasion
Dang, T. T., Prechtl, A. M., & Pearson, G. W. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1818 · Cited by 70 · see citing works
FGFs/FGFRs-dependent signalling in regulation of steroid hormone receptors – implications for therapy of luminal breast cancer
Piasecka, D., Braun, M., Kitowska, K., Mieczkowski, K., Kordek, R., Sądej, R., & Romańska, H. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1236-6 · Cited by 69 · see citing works
Modeling Tumor Microenvironment Complexity In Vitro: Spheroids as Physiologically Relevant Tumor Models and Strategies for Their Analysis
Shah, S., & D’Souza, G. G. M. (2025) · Cells · doi:10.3390/cells14100732 · Cited by 66 · see citing works
Optimizing a 3D Culture System to Study the Interaction between Epithelial Breast Cancer and Its Surrounding Fibroblasts
Li, L., & Lu, Y. (2011) · Journal of Cancer · doi:10.7150/jca.2.458 · Cited by 66 · see citing works
Exosomal miR-21 derived from arsenite-transformed human bronchial epithelial cells promotes cell proliferation associated with arsenite carcinogenesis
Xu, Y., Luo, F., Liu, Y., Shi, L., Lü, X., Xu, W., & Liu, Q. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1291-x · Cited by 68 · see citing works
The Emerging Role of Exosomes in Oral Squamous Cell Carcinoma
Lu, Y., Zheng, Z., Yuan, Y., Pathak, J. L., Yang, X., Wang, L., Ye, Z., Cho, W. C. S., Zeng, M., & Wu, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628103 · Cited by 64 · see citing works
Adhesion-mediated apoptosis resistance in cancer
Westhoff, M., & Fulda, S. (2009) · Drug Resistance Updates · doi:10.1016/j.drup.2009.08.001 · Cited by 64 · see citing works
Tumour stromal cells derived from paediatric malignancies display MSC-like properties and impair NK cell cytotoxicity
Johann, P.-D., Vaegler, M., Gieseke, F., Mang, P., Armeanu–Ebinger, S., Kluba, T., Handgretinger, R., & Müller, I. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-501 · Cited by 64 · see citing works
High density of IL-17-producing cells is associated with improved prognosis for advanced epithelial ovarian cancer
Lan, C., Huang, X., Lin, S., Huang, H., Cai, Q.-C., Lu, J., & Liu, J. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1567-0 · Cited by 62 · see citing works
The role played by the microenvironment in site-specific metastasis
Klein-Goldberg, A., Maman, S., & Witz, I. P. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.08.029 · Cited by 64 · see citing works
Modeling multiple myeloma-bone marrow interactions and response to drugs in a 3D surrogate microenvironment
Belloni, D., Heltai, S., Ponzoni, M., Villa, A., Vergani, B., Pecciarini, L., Marcatti, M., Girlanda, S., Tonon, G., Ciceri, F., et al. (2018) · Haematologica · doi:10.3324/haematol.2017.167486 · Cited by 63 · see citing works
Prognostic value of tumor–stroma ratio combined with the immune status of tumors in invasive breast carcinoma
Vangangelt, K. M. H., van Pelt, G. W., Engels, C. C., Putter, H., Liefers, G., Smit, V. T. H. B. M., Tollenaar, R. A. �. �., Kuppen, P. J. K., & Mesker, W. E. (2017) · Breast Cancer Research and Treatment · doi:10.1007/s10549-017-4617-6 · Cited by 62 · see citing works
Long Non-Coding RNA H19 Acts as an Estrogen Receptor Modulator that is Required for Endocrine Therapy Resistance in ER+ Breast Cancer Cells
Basak, P., Chatterjee, S., Bhat, V., Su, A., Jin, H., Lee-Wing, V., Liu, Q., Hu, P., Murphy, L. C., & Raouf, A. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000495643 · Cited by 62 · see citing works
Targeting the Tumor Stroma as a Novel Treatment Strategy for Breast Cancer
Tchou, J. C., & Conejo-Garcia, J. R. (2012) · Advances in pharmacology · doi:10.1016/b978-0-12-397927-8.00003-8 · Cited by 62 · see citing works
Antitumor Activity of Targeting Src Kinases in Endothelial and Myeloid Cell Compartments of the Tumor Microenvironment
Liang, W. P., Kujawski, M., Wu, J., Lu, J., Herrmann, A., Loera, S., Yen, Y., Lee, F., Yu, H., Wen, W. X., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1486 · Cited by 60 · see citing works
The invasive potential of human melanoma cell lines correlates with their ability to alter fibroblast gene expression in vitro and the stromal microenvironment in vivo
Li, L., Dragulev, B. P., Zigrino, P., Mauch, C., & Fox, J. W. (2009) · International Journal of Cancer · doi:10.1002/ijc.24463 · Cited by 60 · see citing works
The role of genetic diversity in cancer
Merlo, L. M. F., & Maley, C. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42088 · Cited by 60 · see citing works

Is carcinoma a mesenchymal disease? The role of the stromal microenvironment in carcinogenesis
Hemmings, C. (2013) · Pathology · doi:10.1097/pat.0b013e328360b600 · Cited by 20 · see citing works
Adapt or Dye: Tumor Microenvironment, A Powerful Regulator of Cancer Progression
Apellániz-Ruiz, M., & Castaño, Z. (2013) · Postdoc Journal · doi:10.14304/surya.jpr.v1n5.1 · Cited by 3 · see citing works
Stromal contributions to the carcinogenic process
Spaw, M. C., Anant, S., & Thomas, S. M. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22583 · Cited by 52 · see citing works
Role of the tumor microenvironment in tumor progression and the clinical applications (Review)
YUAN, Y., JIANG, Y.-C., SUN, C.-K., & CHEN, Q.-M. (2016) · Oncology Reports · doi:10.3892/or.2016.4660 · Cited by 320 · see citing works
Interaction between tumour and microenvironment - molecular mechanisms of cell migration in canine tumours
Aricò, A. (2013) · Padua@research (University of Padova)

Authors: Hu, M., & Polyak, K.
Affiliations: Dana-Farber Cancer Institute (US)
ORCID: Hu, Min
Venue: Current Opinion in Genetics & Development
Publisher: Elsevier BV
Published: 2008-02
Volume: 18
Issue: 1
Pages: 27-34
ISSN: 0959-437X (ISSN-L)
DOI: 10.1016/j.gde.2007.12.006
PMC: PMC2467152
OpenAlex: W2049391622
Cited by: 330
References: 73
Citations by year: 2026: 2 · 2025: 5 · 2024: 6 · 2023: 15 · 2022: 9 · 2021: 10 · 2020: 20 · 2019: 11 · 2018: 15 · 2017: 20 · 2016: 23 · 2015: 21 · 2014: 31 · 2013: 32 · 2012: 24
FWCI: 2.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Genetics & Development (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Avon Foundation for Women
Susan G. Komen for the Cure
Biogen
Novartis Foundation
Susan G. Komen
IC Design Education Center
National Cancer Institute (CA 89393, CA94074, CA116235, R01CA094074, P50CA089393, R01CA116235)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: tumor microenvironment, carcinogenesis, tumor initiation, tumor progression, metastasis, paracrine signaling, stromal cells, stromal-epithelial interactions, angiogenesis, tumor invasion, epigenetic modifications
MeSH terms: Carcinoma in Situ, Epithelial Cells, Humans, Neoplasms, Phenotype, Signal Transduction, Stromal Cells, Disease Progression, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Microenvironmental regulation of cancer development

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks