The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment
Open accessAbstract
Biological interactions between tumor-associated macrophages (TAMs), cancer cells and other cells within the tumor microenvironment contribute to tumorigenesis, tumor growth, metastasis and therapeutic resistance. TAMs can remodel the tumor microenvironment to reduce growth barriers such as the dense extracellular matrix and shift tumors towards an immunosuppressive microenvironment that protects cancer cells from targeted immune responses. Nanoparticles can interrupt these biological interactions within tumors by altering TAM phenotypes through a process called polarization. Macrophage polarization within tumors can shift TAMs from a growth-promoting phenotype towards a cancer cell-killing phenotype that predicts treatment efficacy. Because many types of nanoparticles have been shown to preferentially accumulate within macrophages following systemic administration, there is considerable interest in identifying nanoparticle effects on TAM polarization, evaluating nanoparticle-induced TAM polarization effects on cancer treatment using drug-loaded nanoparticles and identifying beneficial types of nanoparticles for effective cancer treatment. In this review, the macrophage polarization effects of nanoparticles will be described based on their primary chemical composition. Because of their strong macrophage-polarizing and antitumor effects compared to other types of nanoparticles, the effects of iron oxide nanoparticles on macrophages will be discussed in detail. By comparing the macrophage polarization effects of various nanoparticle treatments reported in the literature, this review aims to both elucidate nanoparticle material effects on macrophage polarization and to provide insight into engineering nanoparticles with more beneficial immunological responses for cancer treatment.
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Cites
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Cited by
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Sousa de Almeida, M., Susnik, E., Drasler, B., Taladriz-Blanco, P., Petri-Fink, A., & Rothen-Rutishauser, B. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01127d · Cited by 1,079
Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting
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The Multifaceted Role of Heme in Cancer
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Harnessing and Enhancing Macrophage Phagocytosis for Cancer Therapy
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“Therefore, nanoparticles can be packed with drugs or contents designed to induce macrophage polarization toward a more phagocytic phenotype to reprogram them with an affinity for phagocytosis, thus making them an attractive vehicle for therapy delivery (Figure 1B) (101, 103, 104).”
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Metadata
- Authors
- Reichel, D., Tripathi, M., & Perez, J. M.
- Venue
- Nanotheranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2019
- Volume
- 3
- Issue
- 1
- Pages
- 66-88
- ISSN
- 2206-7418 (ISSN-L)
- OpenAlex
- W2905076856
- Cited by
- 173
- References
- 27
- FWCI
- 6.10
- Type
- journal article
- Language
- en
- Open access
- gold
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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
