The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages
Open accessAbstract
Tumor-associated macrophages (TAM) have attracted attention as they can modulate key cancer-related activities, yet TAM represent a heterogenous group of cells that remain incompletely characterized. In growing tumors, TAM are often referred to as M2-like macrophages, which are cells that display immunosuppressive and tumorigenic functions and express the enzyme arginase 1 (Arg1). Methods: Here we combined high resolution intravital imaging with single cell RNA seq to uncover the topography and molecular profiles of immunosuppressive macrophages in mice. We further assessed how immunotherapeutic interventions impact these cells directly in vivo. Results: We show that: i) Arg1+ macrophages are more abundant in tumors compared to other organs; ii) there exist two morphologically distinct subsets of Arg1 TAM defined by previously unknown markers (Gbp2b, Bst1, Sgk1, Pmepa1, Ms4a7); iii) anti-Programmed Cell Death-1 (aPD-1) therapy decreases the number of Arg1+ TAM while increasing Arg1- TAM; iv) accordingly, pharmacological inhibition of arginase 1 does not synergize with aPD-1 therapy. Conclusion: Overall, this research shows how powerful complementary single cell analytical approaches can be used to improve our understanding of drug action in vivo.
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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy
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“Meta-analyses of published RNA-seq data from the MC38 model (Arlauckas et al., 2018; Hoves et al., 2018) showed that macrophages express TREM2 (data not shown).”
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Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages
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Metadata
- Authors
- Arlauckas, S. P., Garren, S. B., Garris, C. S., Kohler, R. H., Oh, J., Pittet, M. J., & Weissleder, R.
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2018
- Volume
- 8
- Issue
- 21
- Pages
- 5842-5854
- ISSN
- 1838-7640 (ISSN-L)
- OpenAlex
- W2902292985
- Cited by
- 331
- References
- 49
- FWCI
- 8.20
- Type
- journal article
- Language
- en
- Open access
- gold
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