Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy
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With good biocompatibility and targeting capability, the nanodrug delivery system may offer a promising clinical platform for the combined thermotherapy and chemotherapy. This work demonstrated the feasibility of developing multifunctional nanomedicine targeting CSCs for effective cancer treatment.
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A variety of tumor cell surface markers such as CD44, CD47, CD20, CD147, CD31 have been identified as effective targets for specific and selective anti-tumor therapy.
“In addition to the above specific ligand modifications, a variety of tumor cell surface markers such as CD44, CD47, CD20, CD147, CD31 have been identified as effective targets for specific and selective anti-tumor therapy.214–216”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [214]
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Research works printed but not linked: 1
- [53]Espinosa A Corato RD Kolosnjaj-Tabi J Flaud R Pellegrino T Wihelm C Duality of iron oxide nanoparticles in cancer therapy: amplification of heating efficiency by magnetic hyperthermia and photothermal bimodal treatment ACS Nano 2016 10 236 46 26766814
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Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
- Authors
- Liu, D., Hong, Y., Li, Y., Hu, C., Yip, T.-C., Yu, W.-K., Zhu, Y., Fong, C.-C., Wang, W., Au, S.-K., Wang, S., & Yang, M.
- Affiliations
- City University of Hong Kong (HK)
- Jinan University (CN)
- Queen Elizabeth Hospital (CN)
- Peking University Shenzhen Hospital (CN)
- Corresponding author
- Yang, Mengsu
- Venue
- Theranostics
- Publisher
- Ivyspring International Publisher
- Published
- 2020
- Volume
- 10
- Issue
- 3
- Pages
- 1181-1196
- ISSN
- 1838-7640 (ISSN-L)
- PMC
- PMC6956796
- OpenAlex
- W2997535973
- Cited by
- 125
- References
- 52
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 23 · 2023: 24 · 2022: 21 · 2021: 22 · 2020: 14
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Theranostics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CityU Scholars (submittedVersion, cc-by)
- Funders
- City University of Hong Kong
- Innovation and Technology Fund
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Keywords
- cancer stem cells, magnetic nanoparticles, hyperthermia, chemotherapy, combination therapy, nanoparticle drug delivery, targeted drug delivery, nanomedicine, heat therapy
- MeSH terms
- Animals, Antineoplastic Agents, Combined Modality Therapy, Drug Carriers, Humans, Hyperthermia, Induced, Lung Neoplasms, Mice, Inbred BALB C, Mice, Nude, Neoplasm Recurrence, Local, Neoplastic Stem Cells, Cell Line, Tumor, Mice, Small Cell Lung Carcinoma, Magnetite Nanoparticles, Mesenchymal Stem Cells
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