Cited by 284Nanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryNanotechnology research and applications

Nanomaterials for Photo-Based Diagnostic and Therapeutic Applications

Open access
Menon, Jyothi U., Jadeja, Parth, Tambe, Pranjali, Vu, Khanh, Yuan, Baohong, Nguyen, Kytai T.·2013·Theranostics

Abstract

Photo-based diagnosis and treatment methods are gaining prominence due to increased spatial imaging resolution, minimally invasive modalities involved as well as localized treatment. Recently, nanoparticles (NPs) have been developed and used in photo-based therapeutic applications. While some nanomaterials have inherent photo-based imaging capabilities, others including polymeric NPs act as nanocarriers to deliver various fluorescent dyes or photosensitizers for photoimaging and therapeutic applications. These applications can vary from Magnetic Resonance Imaging (MRI) and optical imaging to photothermal therapy (PTT) and chemotherapy. Materials commonly used for development of photo-based NPs ranges from metal-based (gold, silver and silica) to polymer-based (chitosan, dextran, poly ethylene glycol (PEG) and poly lactic-co-glycolic acid (PLGA)). Recent research has paved the way for multi-modal 'theranostic' (a combination of therapy and diagnosis) nano-carriers capable of active targeting using cell-specific ligands and carrying multiple therapeutic and imaging agents for accurate diagnosis and controlled drug delivery. This review summarizes the different materials used today to synthesize photo-based NPs, their diagnostic and therapeutic applications as well as the current challenges faced in bringing these novel nano-carriers into clinical practices.

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  • Upon injection, gold nanoparticles bind specifically to cancer cells and scatter shine, allowing doctors to easily identify tumors and healthy cells.

    “Upon injection, gold nanoparticles bind specifically to cancer cells and scatter shine, allowing the doctors to easily identify tumors and healthy cells.85”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [85]

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Authors
Menon, J. U., Jadeja, P., Tambe, P., Vu, K., Yuan, B., & Nguyen, K. T.
Affiliations
The University of Texas at Arlington (US)
Corresponding author
Nguyen, Kytai T.
Venue
Theranostics
Published
2013
Volume
3
Issue
3
Pages
152-166
ISSN
1838-7640 (ISSN-L)
OpenAlex
W2100892270
Cited by
284
References
131
Citations by year
2026: 3 · 2025: 16 · 2024: 23 · 2023: 10 · 2022: 26 · 2021: 20 · 2020: 25 · 2019: 19 · 2018: 32 · 2017: 22 · 2016: 39 · 2015: 25 · 2014: 19 · 2013: 5
FWCI
2.75
Type
journal article
Language
en
Open access
Licence
cc-by-nc
Locations
  • Theranostics (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • UTA ResearchCommons (University of Texas Arlington) (submittedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanotechnology research and applications
Keywords
nanoparticles, photothermal therapy, nanocarriers, photosensitizers, fluorescent dyes, magnetic resonance imaging, optical imaging, chitosan, PLGA, polymeric nanoparticles, metal nanoparticles, targeted drug delivery, multimodal imaging
MeSH terms
Diagnostic Imaging, Drug Carriers, Gold, Humans, Phototherapy, Polymers, Nanostructures

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