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Post-diagnosis Soy Food Intake and Breast Cancer Survival: A Meta-analysis of Cohort Studies
Open accessAbstract
BACKGROUND AND OBJECTIVES: Data on associations between soy food intake after cancer diagnosis with breast cancer survival are conflicting, so we conducted this meta-analysis for more accurate evaluation. METHODS: Comprehensive searches were conducted to find cohort studies of the relationship between soy food intake after cancer diagnosis and breast cancer survival. Data were analyzed with comprehensive meta-analysis software. RESULTS: Five cohort studies (11,206 patients) were included. Pooling all comparisons, soy food intake after diagnosis was associated with reduced mortality (HR 0.85, 95%CI 0.77 0.93) and recurrence (HR 0.79, 95%CI 0.72 0.87). Pooling the comparisons of highest vs. lowest dose, soy food intake after diagnosis was again associated with reduced mortality (HR 0.84, 95%CI 0.71 0.99) and recurrence (HR 0.74, 95%CI 0.64 0.85). Subgroup analysis of ER status showed that soy food intake was associated with reduced mortality in both ER negative (highest vs. lowest: HR 0.75, 95%CI 0.64 0.88) and ER positive patients (highest vs. lowest: HR 0.72, 95%CI 0.61 0.84), and both premenopausal (highest vs. lowest: HR 0.78, 95%CI 0.69 0.88) and postmenopausal patients (highest vs. lowest: HR 0.81, 95%CI 0.73 0.91). In additioin, soy food intake was associated with reduced recurrence in ER negative (highest vs. lowest: HR 0.64, 95%CI 0.44 0.94) and ER+/PR+ (highest vs. lowest: HR 0.65, 95%CI 0.49 0.86), and postmenopausal patients (highest vs. lowest: HR 0.67, 95%CI 0.56 0.80). CONCLUSION: Our meta- analysis showed that soy food intake might be associated with better survival, especially for ER negative, ER+/ PR+, and postmenopausal patients.
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Metadata
- Authors
- Chi, F., Wu, R., Zeng, Y.-C., Xing, R., Liu, Y., & Xu, Z.-G.
- Affiliations
- Sheng Jing Hospital (CN)
- Venue
- Asian Pacific Journal of Cancer Prevention
- Published
- 2013-04-30
- Volume
- 14
- Issue
- 4
- Pages
- 2407-2412
- ISSN
- 1513-7368 (ISSN-L)
- OpenAlex
- W2160002407
- Cited by
- 108
- References
- 35
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 11 · 2022: 9 · 2021: 9 · 2020: 8 · 2019: 7 · 2018: 11 · 2017: 17 · 2016: 10 · 2015: 6 · 2014: 7 · 2013: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Asian Pacific Journal of Cancer Prevention (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Phytoestrogen effects and research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Keywords
- breast cancer survival, breast cancer recurrence, breast cancer mortality, estrogen receptor status, progesterone receptor status, menopausal status
- MeSH terms
- Breast Neoplasms, Female, Humans, Prognosis, Cohort Studies, Survival Rate, Soy Foods
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