The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment
Open accessAbstract
Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all multicellular organisms to control cell proliferation and maintain tissue homeostasis as well as eliminate harmful or unnecessary cells from an organism. Defects in the physiological mechanisms of apoptosis may contribute to different human diseases like cancer. Identification of the mechanisms of apoptosis and its effector proteins as well as the genes responsible for apoptosis has provided a new opportunity to discover and develop novel agents that can increase the sensitivity of cancer cells to undergo apoptosis or reset their apoptotic threshold. These novel targeted therapies include those targeting anti-apoptotic Bcl-2 family members, p53, the extrinsic pathway, FLICE-inhibitory protein (c-FLIP), inhibitor of apoptosis (IAP) proteins, and the caspases. In recent years a number of these novel agents have been assessed in preclinical and clinical trials. In this review, we introduce some of the key regulatory molecules that control the apoptotic pathways, extrinsic and intrinsic death receptors, discuss how defects in apoptotic pathways contribute to cancer, and list several agents being developed to target apoptosis.
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Cites
Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
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Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
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“MOMP is most commonly mediated via a variety of proteinmembrane and protein-protein interactions of the B-cell lymphoma 2 protein (BCL-2) family (Chipuk et al., 2004).”
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.030 · Cited by 1,218 · cited 2×
“Varfolomeev E. et al. demonstrated that a SMAC mimetic which binds to cIAPs results in c-IAP auto-ubiquitination activity and proteasomal degradation (Varfolomeev et al., 2007).”
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family
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Cited by
Apoptosis: A Target for Anticancer Therapy
Pfeffer, C., & Singh, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020448 · Cited by 1,542
Apoptosis (programmed cell death) and its signals - A review
Obeng, E. (2021) · Brazilian Journal of Biology · doi:10.1590/1519-6984.228437 · Cited by 513
Hepatocellular carcinoma in the setting of alcohol-related liver disease
Ganne-Carrié, N., & Nahon, P. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2018.10.008 · Cited by 360
Hombach-Klonisch, S., Mehrpour, M., Shojaei, S., Harlos, C., Pitz, M., Hamai, A., Siemianowicz, K., Likus, W., Wiechec, E., Toyota, B. D., et al. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.10.017 · Cited by 292
Lei, Y., Zhang, B., Zhang, Y., Zhao, Y., Sun, J., Zhang, X., & Yang, S. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3603 · Cited by 8
Metadata
- Authors
- Goldar, S., Khaniani, M. S., Derakhshan, S. M., & Baradaran, B.
- Venue
- Asian Pacific Journal of Cancer Prevention
- Published
- 2015-04-03
- Volume
- 16
- Issue
- 6
- Pages
- 2129-2144
- ISSN
- 1513-7368 (ISSN-L)
- OpenAlex
- W329007366
- Cited by
- 606
- References
- 12
- FWCI
- 15.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Goldar, S., Khaniani, M. S., Derakhshan, S. M., & Baradaran, B. (2015). Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment. Asian Pacific Journal of Cancer Prevention. https://doi.org/10.7314/apjcp.2015.16.6.2129
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