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Reduction of Serum Testosterone Levels During Chronic Glucocorticoid Therapy
Abstract
The effect of chronic glucocorticoid therapy on serum testosterone levels was studied in men aged 67 +/- 4 (SD) years with chronic pulmonary disease. The serum testosterone level was reduced in 14 of 16 patients to a mean value of 211 +/- 93 ng/dL, compared with 449 +/- 111 ng/dL in 11 age- and disease-matched control patients (p less than 0.001). The corticosteroid dosage and the serum testosterone level were inversely related (r = -0.78). Testosterone binding to serum proteins was not significantly affected. Basal gonadotrophin levels were not elevated while their secretory responses to exogenous gonadotrophin-releasing hormone (GnRH) were intact. We conclude that glucocorticoid therapy commonly reduces serum testosterone levels in older men due to alteration of hypothalamic GnRH secretion.
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Cites
Low serum testosterone and sex-hormone-binding-globulin in massively obese men
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Reversible gonadotropin Deficiency in Male Cushing's Dusease
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Endocrinology of the stress response
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The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Stress, the Stress System and the Role of Glucocorticoids
Nicolaides, N. C., Kyratzi, E., Lamprokostopoulou, A., Chrousos, G. P., & Charmandari, E. (2015) · Neuroimmunomodulation · doi:10.1159/000362736 · Cited by 477
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Basaria, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61126-5 · Cited by 328
The hypothalamic-pituitary-adrenal axis and the female reproductive system
MAGIAKOU, M. A., MASTORAKOS, G., WEBSTER, E., & CHROUSOS, G. P. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb52128.x · Cited by 320
Declining gonadal function in elderly men
Kaufman, J. M., & Vermeulen, A. (1997) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(97)80302-3 · Cited by 181
High serum cortisol levels in exercise-associated amenorrhea
DING, J.-H., SHECKTER, C. B., DRINKWATER, B. L., SOULES, M. R., & BREMNER, W. J. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-108-4-530 · Cited by 131
Zumoff, B., Miller, L. K., & Strain, G. W. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00186-0 · Cited by 118
Spratt, D. I., Bigos, S. T., Beitins, I., Cox, P., Longcope, C., & Orav, J. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.6.1464665 · Cited by 118
Jasuja, G. K., Bhasin, S., Reisman, J. I., Hanlon, J. T., Miller, D. R., Morreale, A. P., Pogach, L. M., Cunningham, F. E., Park, A., Berlowitz, D. R., et al. (2017) · Journal of General Internal Medicine · doi:10.1007/s11606-016-3940-7 · Cited by 44
Proposals for prevention and management of steroid-induced osteoporosis in children and adolescents
Brown, J., & Zacharin, M. (2005) · Journal of Paediatrics and Child Health · doi:10.1111/j.1440-1754.2005.00718.x · Cited by 36
Matsumoto, A. M., & Bremner, W. J. (2011) · Williams Textbook of Endocrinology · doi:10.1016/b978-1-4377-0324-5.00019-5 · Cited by 18
Metadata
- Authors
- MacADAMS, M. R., WHITE, R. H., & CHIPPS, B. E.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1986-05-01
- Volume
- 104
- Issue
- 5
- Pages
- 648-651
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2004352733
- Cited by
- 391
- References
- 3
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
