CoChat
Sign Up
Cited by 163Sexual function and dysfunction studiesHormonal and reproductive studiesUrological Disorders and Treatments

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Effect of Testosterone Replacement on Response to Sildenafil Citrate in Men With Erectile Dysfunction: A Parallel, Randomized Trial

Spitzer, Matthew, Basaria, Shehzad, Travison, Thomas G., Davda, Maithili N., Paley, Amanda, Cohen, Beth, Mazer, Norman A., Knapp, Philip E., Hanka, Samson, Lakshman, Kishore M., Ulloor, Jagadish, Zhang, Anqi, Orwoll, Katie, Eder, Richard, Collins, Lauren, Mohammed, Nurahmed, Rosen, Raymond C., DeRogatis, Leonard, Bhasin, Shalender·2012·Annals of Internal Medicine
DOI 10.7326/0003-4819-157-10-201211200-00004
Open this paper in CoChat — free account

Abstract

BACKGROUND: Erectile dysfunction and low testosterone levels frequently occur together. OBJECTIVE: To determine whether addition of testosterone to sildenafil therapy improves erectile response in men with erectile dysfunction and low testosterone levels. DESIGN: Randomized, double-blind, parallel, placebo-controlled trial. (ClinicalTrials.gov registration number: NCT00512707) SETTING: Outpatient academic research center. PARTICIPANTS: Men aged 40 to 70 years with scores of 25 or less for the erectile function domain (EFD) of the International Index of Erectile Function, total testosterone levels less than 11.45 nmol/L (<330 ng/dL), or free testosterone levels less than 173.35 pmol/L (<50 pg/mL). INTERVENTION: Sildenafil dose was optimized, and 140 participants were then randomly assigned to 14 weeks of daily transdermal gel that contained 10-g testosterone for 70 participants and placebo for the remaining 70 participants. All participants were included in the primary analysis, although 10 in the testosterone group and 12 in the placebo group did not complete the study. RESULTS: At baseline, the 2 groups had similar EFD scores. Administration of sildenafil alone was associated with a substantial increase in EFD score (mean, 7.7 [95% CI, 6.5 to 8.8]), but change in EFD score after randomization did not differ between the groups (difference, 2.2 [CI, -0.8 to 5.1]; P = 0.150). The findings were similar for other domains of sexual function in younger men, more obese men, and men with lower baseline testosterone levels or an inadequate response to sildenafil alone. Frequency of adverse events was similar for testosterone and placebo groups. LIMITATION: Whether testosterone could improve erectile function without sildenafil was not studied. CONCLUSION: Sildenafil plus testosterone was not superior to sildenafil plus placebo in improving erectile function in men with erectile dysfunction and low testosterone levels. PRIMARY FUNDING SOURCE: National Institute of Child Health and Human Development.

Overview

Integrity signals

Registry

Crossref · 10.7326/0003-4819-157-10-201211200-00004

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 51 references

Research works printed but not linked: 2

  1. Sinha-Hikim I, 1998, J Clin Endocrinol Metab, 83, 1312
  2. Li KH, 1991, Statistica Sinica, 1, 65

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Spitzer, M., Basaria, S., Travison, T. G., Davda, M. N., Paley, A., Cohen, B., Mazer, N. A., Knapp, P. E., Hanka, S., Lakshman, K. M., Ulloor, J., Zhang, A., Orwoll, K., Eder, R., Collins, L., Mohammed, N., Rosen, R. C., DeRogatis, L., & Bhasin, S.
Affiliations
Boston University (US)
ORCID
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
2012-11-20
Volume
157
Issue
10
Pages
681-691
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-157-10-201211200-00004
OpenAlex
W2069329781
Cited by
163
References
51
Citations by year
2026: 6 · 2025: 4 · 2024: 5 · 2023: 11 · 2022: 10 · 2021: 10 · 2020: 11 · 2019: 13 · 2018: 6 · 2017: 12 · 2016: 15 · 2015: 17 · 2014: 13 · 2013: 28
FWCI
13.25
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01hd047722-03, 5p30ag031679-15)
  • National Institute on Aging (5 P30 AG031679)
  • National Center for Research Resources (UL1RR025771)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (5R01HD047722)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
erectile dysfunction, testosterone replacement therapy, sildenafil citrate, androgen deficiency, transdermal testosterone gel, erectile function, combination therapy, International Index of Erectile Function
MeSH terms
Sildenafil Citrate, Administration, Cutaneous, Adult, Aged, Androgens, Coitus, Double-Blind Method, Drug Therapy, Combination, Gels, Humans, Erectile Dysfunction, Male, Middle Aged, Orgasm, Penile Erection, Piperazines, Purines, Quality of Life, Sulfones, Testosterone, Hormone Replacement Therapy, Phosphodiesterase 5 Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review