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Cited by 931

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Genital Herpes Simplex Virus Infections: Clinical Manifestations, Course, and Complications

COREY, LAWRENCE, ADAMS, HARRY G., BROWN, ZANE A., HOLMES, KING K.·1983·Annals of Internal Medicine
DOI 10.7326/0003-4819-98-6-958
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Abstract

The clinical course and complications of 268 patients with first episodes and 362 with recurrent episodes of genital herpes infection were reviewed. Symptoms of genital herpes were more severe in women than in men. Primary first-episode genital herpes was accompanied by systemic symptoms (67%), local pain and itching (98%), dysuria (63%), and tender adenopathy (80%). Patients presented with several bilaterally distributed postular ulcerative lesions that lasted a mean of 19.0 days. Herpes simplex virus was isolated from the urethra, cervix, and pharynx of 82%, 88%, and 13% of women with first-episode primary genital herpes, and the urethra and pharynx of 28% and 7% of men. Complications included aseptic meningitis (8%), sacral autonomic nervous system dysfunction (2%), development of extragenital lesions (20%), and secondary yeast infections (11%). Recurrent episodes were characterized by small vesicular or ulcerative unilaterally distributed lesions that lasted a mean of 10.1 days. Systemic symptoms were uncommon and 25% of recurrent episodes were asymptomatic. The major concerns of patients were the frequency of recurrences and fear of transmitting infection to partners or infants.

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Metadata

Authors
COREY, L., ADAMS, H. G., BROWN, Z. A., & HOLMES, K. K.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1983-06-01
Volume
98
Issue
6
Pages
958-972
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-98-6-958
OpenAlex
W1964522214
Cited by
931
References
1
FWCI
37.65
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)

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CoChat. (2026). Citation check: Genital Herpes Simplex Virus Infections: Clinical Manifestations, Course, and Complications. https://app.cochat.ai/papers/10.7326/0003-4819-98-6-958
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COREY, L., ADAMS, H. G., BROWN, Z. A., & HOLMES, K. K. (1983). Genital Herpes Simplex Virus Infections: Clinical Manifestations, Course, and Complications. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-98-6-958

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