The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Open accessAbstract
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the adaptive starvation response. Among its effects, FGF21 induces hepatic fatty acid oxidation and ketogenesis, increases insulin sensitivity, blocks somatic growth and causes bone loss. Here we show that transgenic overexpression of FGF21 markedly extends lifespan in mice without reducing food intake or affecting markers of NAD+ metabolism or AMP kinase and mTOR signaling. Transcriptomic analysis suggests that FGF21 acts primarily by blunting the growth hormone/insulin-like growth factor-1 signaling pathway in liver. These findings raise the possibility that FGF21 can be used to extend lifespan in other species.DOI:http://dx.doi.org/10.7554/eLife.00065.001.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Interestingly, a recent report showed that mice with transgenic overexpression of fibroblast growth factor 21 (FGF21), a fasting hormone, can extend life span when maintained on an ad libitum diet (Zhang et al., 2012).”
From The Search for Antiaging Interventions: From Elixirs to Fasting Regimens (2014) · cites this paper as Zhang et al., 2012
In the citing paper
“prolonged overexpression of FGF21 in mice increases insulin sensitivity and extends lifespan64,79.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [64]
In the citing paper
“FGF21 is markedly induced in response to protein restriction (25, 73, 85) but not caloric restriction (73, 148).”
From Fibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis (2018) · cites this paper as [148]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,239
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158
In silico prediction of protein-protein interactions in human macrophages
Souiai, O., Guerfali, F. Z., Miled, S. B., Brun, C., & Benkahla, A. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-157 · Cited by 10,785
Significance analysis of microarrays applied to the ionizing radiation response
Tusher, V. G., Tibshirani, R., & Chu, G. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.091062498 · Cited by 10,568
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739
Modelling for Survival Data in Medical Research
(1995) · Technometrics · doi:10.1080/00401706.1995.10485920 · Cited by 2,159
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
Telomere dysfunction induces metabolic and mitochondrial compromise
Sahin, E., Colla, S., Liesa, M., Moslehi, J., Müller, F. L., Guo, M., Cooper, M., Kotton, D., Fabian, A. J., Walkey, C., et al. (2011) · Nature · doi:10.1038/nature09787 · Cited by 1,319
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 420
The Role of Growth Differentiation Factor 15 in Energy Metabolism
Chang, J. Y., Hong, H. J., Kang, S., Kim, J. T., Zhang, B. Y., & Shong, M. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0087 · Cited by 32
Nuclear receptors and AMPK: can exercise mimetics cure diabetes?
Wall, C. E., Yu, R. T., Atkins, A. R., Downes, M., & Evans, R. M. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0073 · Cited by 32
McCarty, M. F. (2014) · Medical Hypotheses · doi:10.1016/j.mehy.2014.06.014 · Cited by 32
Fujii, N., Uta, S., Kobayashi, M., Sato, T., Okita, N., & Higami, Y. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.001 · Cited by 32
Kobayashi, M., Uta, S., Otsubo, M., Deguchi, Y., Tagawa, R., Mizunoe, Y., Nakagawa, Y., Shimano, H., & Higami, Y. (2020) · Nutrients · doi:10.3390/nu12072054 · Cited by 32
Can Blood-Circulating Factors Unveil and Delay Your Biological Aging?
Rybtsova, N., Berezina, T. N., Kagansky, A., & Александрович, Р. С. (2020) · Biomedicines · doi:10.3390/biomedicines8120615 · Cited by 35
Effect of mitochondrial stress on systemic metabolism
Lee, M. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12822 · Cited by 32
The mitochondrial integrated stress response: A novel approach to anti-aging and pro-longevity
Wang, X., & Zhang, G. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102603 · Cited by 29
Protein-responsive gut hormone tachykinin directs food choice and impacts lifespan
Ahrentløv, N., Kubrak, O. I., Lassen, M., Malita, A., Koyama, T., Frederiksen, A. S., Sigvardsen, C. M., John, A., Madsen, P. S. M. S. M., Halberg, K. A., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01267-0 · Cited by 33
Asghari, S., Rezaei, M., Rafraf, M., Taghizadeh, M., Jafarabadi, M. A., & Ebadi, M. (2022) · Nutrients · doi:10.3390/nu14122509 · Cited by 29
Dommerholt, M. B., Blankestijn, M., Vieira‐Lara, M. A., van Dijk, T. H., Wolters, H., Koster, M. H., Gerding, A., van Os, R. P., Bloks, V. W., Bakker, B. M., et al. (2020) · FEBS Journal · doi:10.1111/febs.15604 · Cited by 28
Sex differences and aging: Is there a role of brown adipose tissue?
Hoffman, J. M., & Valencak, T. G. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111310 · Cited by 29
FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish
Blanco, A. M., Bertucci, J. I., & Unniappan, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-63726-w · Cited by 26
Finding Ponce de Leon’s Pill: Challenges in Screening for Anti-Aging Molecules
Kumar, S., & Lombard, D. B. (2016) · F1000Research · doi:10.12688/f1000research.7821.1 · Cited by 25
Barretto, S. A., Lasserre, F., Fougerat, A., Smith, L., Fougeray, T., Lukowicz, C., Polizzi, A., Smati, S., Régnier, M., Naylies, C., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153767 · Cited by 25
Almendáriz-Palacios, C., Mousseau, D. D., Eskiw, C. H., & Gillespie, Z. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239220 · Cited by 30
Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin
Thepsuwan, P., Bhattacharya, A., Song, Z., Hippleheuser, S. W., Feng, S., Wei, X., Das, N. K., Sierra, M., Wei, J., Fang, D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212644120 · Cited by 26
Development of a long acting FGF21 analogue-albumin fusion protein and its anti-diabetic effects
Watanabe, H., Miyahisa, M., Chikamatsu, M., Nishida, K., Minayoshi, Y., Takano, M., Ichimizu, S., Kobashigawa, Y., Morioka, H., Maeda, H., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.036 · Cited by 24
Endocrine Fibroblast Growth Factors in Relation to Stress Signaling
Shimizu, M., & Sato, R. (2022) · Cells · doi:10.3390/cells11030505 · Cited by 25
Fujita, Y., Makishima, M., & BHAWAL, U. K. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.045 · Cited by 23
Pérez‐Martí, A., Sandoval, V., Marrero, P. F., Haro, D., & Relat, J. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2016-0034 · Cited by 24
Bond, S. T., King, E. J., Walker, S., Yang, C., Liu, Y., Liu, K. H., Zhuang, A., Jurrjens, A. W., Fang, H., Formosa, L. E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57299-3 · Cited by 24
Love is a battlefield: programmed cell death during fertilization
Heydlauff, J., & Groß‐Hardt, R. (2014) · Journal of Experimental Botany · doi:10.1093/jxb/eru030 · Cited by 23
Growth signaling and longevity in mouse models
Kim, S.-S., & Lee, C. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.1.299 · Cited by 25
Does Diet Have a Role in the Treatment of Alzheimer's Disease?
Thelen, M., & Brown‐Borg, H. M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.617071 · Cited by 24
Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy
McCarty, M. F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042054 · Cited by 21
Reduced insulin signaling in neurons induces sex-specific health benefits
Baghdadi, M., Nespital, T., Mesaros, A., Buschbaum, S., Withers, D. J., Grönke, S., & Partridge, L. (2023) · Science Advances · doi:10.1126/sciadv.ade8137 · Cited by 24
A Serum Component Mediates Food Restriction–Induced Growth Attenuation
Pando, R., Shtaif, B., Phillip, M., & Gat‐Yablonski, G. (2014) · Endocrinology · doi:10.1210/en.2013-1610 · Cited by 21
Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARα and FXR
Lee, J. M. (2016) · Annals of Pediatric Endocrinology & Metabolism · doi:10.6065/apem.2016.21.4.193 · Cited by 21
Enhanced paracrine action of FGF21 in stromal cells delays thymic aging
Youm, Y., Gliniak, C. M., Zhang, Y., Dlugos, T., Scherer, P. E., & Dixit, V. D. (2025) · Nature Aging · doi:10.1038/s43587-025-00813-5 · Cited by 23
Playing cancer at its own game: activating mitogenic signaling as a paradoxical intervention
Dias, M. H., & Bernards, R. (2021) · Molecular Oncology · doi:10.1002/1878-0261.12979 · Cited by 22
Teng, Y., Wang, J.-Y., Chi, Y., & Tsai, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239059 · Cited by 20
Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification
Arch, J. R. S., & Trayhurn, P. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00064 · Cited by 20
Nakano, T., Shiizaki, K., Miura, Y., Matsui, M., Kosaki, K., Mori, S., Yamagata, K., Maeda, S., Kishi, T., Usui, N., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-55643-4 · Cited by 20
Mutations Affecting Mammalian Aging: GH and GHR vs IGF-1 and Insulin
Bartke, A., & Brown‐Borg, H. M. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.667355 · Cited by 18
Targeting multiple hallmarks of mammalian aging with combinations of interventions
Panchin, A. Y., Ogmen, A., Blagodatski, A. S., Egorova, A., Batin, M., & Glinin, T. S. (2024) · Aging · doi:10.18632/aging.206078 · Cited by 22
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?
Parrotta, M. E., Colangeli, L., Scipione, V., Vitale, C., Sbraccia, P., & Guglielmi, V. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00609-z · Cited by 19
Brooks, N. E., Hjortebjerg, R., Henry, B. E., List, E. O., Kopchick, J. J., & Berryman, D. E. (2016) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2016.08.003 · Cited by 18
The mysterious relationship between reproduction and longevity
Aguilaniu, H. (2015) · Worm · doi:10.1080/21624054.2015.1020276 · Cited by 18
Ageing-related receptors resolved
Kuro‐o, M. (2018) · Nature · doi:10.1038/d41586-017-09032-4 · Cited by 18
Mizumoto, T., Yoshizawa, T., Sato, Y., Ito, T., Tsuyama, T., Satoh, A., Araki, S., Tsujita, K., Tamura, M., Oike, Y., et al. (2022) · Cells · doi:10.3390/cells11223609 · Cited by 18
Peelable Microneedle Patches Deliver Fibroblast Growth Factors to Repair Skin Photoaging Damage
Yang, G.-J., Hu, S.-Q., Jiang, H.-Y., & Cheng, K. (2023) · Nanotheranostics · doi:10.7150/ntno.79187 · Cited by 16
Influence of Adipokines on Metabolic Dysfunction and Aging
Park, S., & Shimokawa, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040873 · Cited by 20
Thompson, A. C. S., Bruss, M. D., Nag, N., Kharitonenkov, A., Adams, A. C., & Hellerstein, M. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111418 · Cited by 17
Regulation of diurnal energy balance by mitokines
Klaus, S., Gil, C. I., & Ost, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03748-9 · Cited by 19
Postprandial dynamics and response of fibroblast growth factor 21 in older adults
Herpich, C., Haß, U., Kochlik, B., Franz, K., Laeger, T., Klaus, S., Bosy‐Westphal, A., & Norman, K. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.037 · Cited by 17
Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 18
High FGF21 levels are associated with altered bone homeostasis in HIV-1-infected patients
Gallego-Escuredo, J. M., Lamarca, K., Villarroya, J., Domingo, J. C., Mateo, M. G., Gutierrez, M. D. M., Vidal, F., Villarroya, F., Domingo, P., & Giralt, M. (2017) · Metabolism · doi:10.1016/j.metabol.2017.03.014 · Cited by 17
Protein-Restricted Diets and Their Impact on Metabolic Health and Aging
Kim, S. Q., Spann, R. A., Hill, C. M., Berryman, C. E., Berthoud, H., McDougal, D. H., He, Y., Münzberg, H., Yu, S., & Morrison, C. D. (2025) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-121624-114918 · Cited by 17
Mechanisms of endothelial senescence and vascular aging
Qiao, L., Qian, Z., Huang, Y., Yang, X. F., Yang, J., Xiao, N., Liang, G., Zhang, H., Fu, Y., Yan, L., et al. (2025) · Biogerontology · doi:10.1007/s10522-025-10279-y · Cited by 21
Antonellis, P. J., Kharitonenkov, A., & Adams, A. C. (2014) · Journal of Animal Science · doi:10.2527/jas.2013-7076 · Cited by 15
The Roles of White Adipose Tissue and Liver NADPH in Dietary Restriction-Induced Longevity
Jamerson, L. E., & Bradshaw, P. C. (2024) · Antioxidants · doi:10.3390/antiox13070820 · Cited by 22
Kuro‐o, M. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.013 · Cited by 16
Larsson, S. C., & Gill, D. (2021) · Nutrients · doi:10.3390/nu13051504 · Cited by 17
McCarty, M. F. (2016) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0056 · Cited by 16
A Reassessment of Genes Modulating Aging in Mice Using Demographic Measurements of the Rate of Aging
de Magalhães, J. P., Thompson, L. M., de Lima, I., Gaskill, D., Li, X., Thornton, D., Yang, C., & Palmer, D. H. (2018) · Genetics · doi:10.1534/genetics.118.300821 · Cited by 17
Kaka, N., Sethi, Y., Patel, N., Kaiwan, O., Al-Inaya, Y., Manchanda, K., & Uniyal, N. (2022) · Disease-a-Month · doi:10.1016/j.disamonth.2022.101466 · Cited by 15
Combinatorial interventions in aging
Parkhitko, A. A., Filine, E., & Tatar, M. (2023) · Nature Aging · doi:10.1038/s43587-023-00489-9 · Cited by 17
Trusz, G. J. (2024) · Differentiation · doi:10.1016/j.diff.2024.100793 · Cited by 15
Arlien-Søborg, M. C., Grøndahl, C., Bæk, A., Dal, J., Madsen, M. A., Høgild, M. L., Pedersen, S. B., Bjerre, M., & Jørgensen, J. O. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz033 · Cited by 15
Neuronal Mechanisms that Drive Organismal Aging Through the Lens of Perception
Gendron, C. M., Chakraborty, T. S., Chung, B. Y., Harvanek, Z. M., Holme, K. J., Johnson, J. C., Lyu, Y., Munneke, A. S., & Pletcher, S. D. (2019) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021119-034440 · Cited by 17
Rodent diet aids and the fallacy of caloric restriction
Wolf, A. M. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111584 · Cited by 15
Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases
Parkhitko, A. A., & Cracan, V. (2025) · Science Advances · doi:10.1126/sciadv.adu1710 · Cited by 15
Neuron-periphery mitochondrial stress communication in aging and diseases
Li, J., Cui, J., & Tian, Y. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac051 · Cited by 14
Feng, J. N., Shao, W., & Jin, T. (2023) · Physiological Reports · doi:10.14814/phy2.15620 · Cited by 13
Responses to Many Anti-Aging Interventions Are Sexually Dimorphic
Bartke, A., Hascup, E. R., & Hascup, K. N. (2023) · The World Journal of Men s Health · doi:10.5534/wjmh.230015 · Cited by 13
Li, Z., Shi, B., Li, N., Sun, J., Zeng, X., Huang, R., Bok, S., Chen, X., Han, J., Yallowitz, A. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51155-6 · Cited by 16
Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD
Song, Z., Thepsuwan, P., Hur, W. S., Torres, M., Wu, S. A., Wei, X., Tushi, N. J., Wei, J., Ferraresso, F., Paton, A. W., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53639-x · Cited by 14
Conte, M., Sevini, F., Conte, G., Tognocchi, M., Ciurca, E., Trofarello, L., Chiariello, A., Capri, M., Franceschi, C., Monti, D., et al. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112077 · Cited by 14
Thompson, K. E., Guillot, M., Graziano, M. J., Mangipudy, R. S., & Chadwick, K. D. (2021) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2021.115673 · Cited by 14
Role of circulating molecules in age-related cardiovascular and metabolic disorders
Hsiao, Y., Shimizu, I., Yoshida, Y., & Minamino, T. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-021-00187-2 · Cited by 16
Kobayashi, M., Nezu, Y., Tagawa, R., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062854 · Cited by 14
Oxidative phosphorylation and fatty acid oxidation in slow-aging mice
Elmansi, A. M., & Miller, R. A. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.08.018 · Cited by 14
The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans
Ching, T., & Hsu, A. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01188-w · Cited by 17
Long-Term Low Carbohydrate Diet Leads to Deleterious Metabolic Manifestations in Diabetic Mice
Handa, K., Inukai, K., Onuma, H., Kudo, A., Nakagawa, F., Tsugawa, K., Kitahara, A., Moriya, R., Takahashi, K., Sumitani, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104948 · Cited by 13
Sutton, E. F., Morrison, C. D., Stephens, J. M., & Redman, L. M. (2018) · Endocrine Research · doi:10.1080/07435800.2018.1473421 · Cited by 13
Long-term effects of a fat-directed FGF21 gene therapy in aged female mice
Anderson, J. M., Arnold, W. D., Huang, W., Ray, A., Owendoff, G., & Cao, L. (2023) · Gene Therapy · doi:10.1038/s41434-023-00422-0 · Cited by 13
Molecular origin and biological effects of exercise mimetics
Zhu, Y., & Song, G. (2023) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2023.12.002 · Cited by 14
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock
Sun, J., Zhang, Y., Adams, J. A., Higgins, C. B., Kelly, S. C., Zhang, H., Cho, K., Johnson, U. G., Swarts, B. M., Wada, S.-I., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114865 · Cited by 13
Targeting Mitochondrial Defects to Increase Longevity in Animal Models of Neurodegenerative Diseases
Casajús-Pelegay, E., Puzzo, F., Yılmazer, A., & Cagin, U. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_5 · Cited by 12
Dorval, L., Knapp, B. I., Majekodunmi, O. A., Eliseeva, S. I., & Bidlack, J. M. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108858 · Cited by 13
Wang, W., Ma, L., Liu, M., Zhao, T., Zhang, T., Yang, Y., Cao, H., Han, X., & Li, D. (2014) · Endocrine · doi:10.1007/s12020-014-0502-9 · Cited by 12
Zhao, T., Wang, W., Gao, K., Li, S., Jiang, Y., Yang, Z., Liu, J., Wang, Y., & Peng, S. (2022) · Experimental Eye Research · doi:10.1016/j.exer.2022.109014 · Cited by 12
Voigt, A., Katterle, Y., Kahle, M., Kluge, R., Schürmann, A., Joost, H., & Klaus, S. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0507-x · Cited by 11
Devo-Aging: Intersections Between Development and Aging
Silva-García, C. G. (2023) · GeroScience · doi:10.1007/s11357-023-00809-2 · Cited by 14
Fuentealba, M., Fabian, D. K., Dönertaş, H. M., Thornton, J. M., & Partridge, L. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111437 · Cited by 13
Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents
Davis, K., Chamseddine, D., & Harper, J. M. (2016) · Experimental Gerontology · doi:10.1016/j.exger.2016.05.001 · Cited by 12
Mishra, M., Kim, H.-H., Youm, Y.-H., Gonzalez-Hurtado, E., Zaitsev, K., Dlugos, T., Shchukina, I., Gliniak, C., Ravussin, E., Mohanty, S., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01107-0 · Cited by 10
Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21
Agius, T., Emsley, R., Lyon, A., MacArthur, M. R., Kiesworo, K., Faivre, A., Stavart, L., Lambelet, M., Legouis, D., de Seigneux, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-44866-3 · Cited by 10
Therapeutic Role of Fibroblast Growth Factor 21 (FGF21) in the Amelioration of Chronic Diseases
Opoku, Y. K., Liu, Z., Afrifa, J., Khoso, M. H., Ren, G., & Li, D. (2019) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-019-09820-8 · Cited by 10
Evolution, mechanism and limits of dietary restriction induced health benefits & longevity
Becker, F. R., Behrends, M., & Rudolph, K. L. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102725 · Cited by 12
Practical prospects for boosting hepatic production of the “pro-longevity” hormone FGF21
McCarty, M. F. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0057 · Cited by 10
Psychology and Pathophysiological Outcomes of Eating
Takada, A., & Himmerich, H. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.92917 · Cited by 10
Bass, J. T. (2013) · Nature Medicine · doi:10.1038/nm.3334 · Cited by 10
Ozlu Karahan, T., Yilmaz Akyuz, E., Yilmaz Karadag, D., Yilmaz, Y., & Eren, F. (2025) · Life · doi:10.3390/life15050696 · Cited by 9
FGF21 negatively affects long-term female fertility in mice
Moeckli, B., Pham, T.-V., Slits, F., Latrille, S., Peloso, A., Delaune, V., Oldani, G., Lacotte, S., & Toso, C. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e11490 · Cited by 9
Rouskas, K., Bocher, O., Simistiras, A., Emmanouil, C., Mantas, P., Skoulakis, A., Park, Y., Dimopoulos, A. C., Glentis, S., Kastenmüller, G., et al. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00057-2 · Cited by 7
Jafarnezhad, F., Nazarzadeh, A., Bazavar, H., Keramat, S., Ryszkiel, I., & Stanek, A. (2025) · Nutrients · doi:10.3390/nu17162656 · Cited by 15
FGF21 Normalizes Plasma Glucose in Mouse Models of Type 1 Diabetes and Insulin Receptor Dysfunction
Diener, J. L., Mowbray, S. F., Huang, W.-J., Yowe, D. L., Xu, J., Caplan, S. L., Misra, A., Kapur, A., Shapiro, J., Ke, X., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab092 · Cited by 9
Biology of Stress Responses in Aging
Calubag, M. F., Ademi, I., Yeh, C., Babygirija, R., Bhoopat, A. M., Kasza, I., Sonsalla, M. M., Green, C. L., Pak, H. H., & Lamming, D. W. (2023) · doi:10.59368/agingbio.20230002 · Cited by 10
Metadata
- Authors
- Zhang, Y., Xie, Y., Berglund, E. D., Coate, K. C., He, T. T., Katafuchi, T., Xiao, G., Potthoff, M. J., Wei, W., Wan, Y., Yu, R. T., Evans, R. M., Kliewer, S. A., & Mangelsdorf, D. J.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Howard Hughes Medical Institute (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Kliewer, Steven A
- ORCID
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2012-10-15
- Volume
- 1
- Pages
- e00065-e00065
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC3466591
- OpenAlex
- W2165852917
- Cited by
- 420
- References
- 42
- Citations by year
- 2026: 27 · 2025: 31 · 2024: 27 · 2023: 27 · 2022: 27 · 2021: 41 · 2020: 33 · 2019: 38 · 2018: 30 · 2017: 22 · 2016: 40 · 2015: 38 · 2014: 25 · 2013: 13 · 2012: 1
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Howard Hughes Medical Institute
- Leona M and Harry B Helmsley Charitable Trust
- UTSW Endowed Scholar Startup Fund
- National Institutes of Health (CA152301, DK057978, DK062434, DK089113, DK092083, RL1GM084436)
- Robert A Welch Foundation (I-1275, I-1558, I-1751)
- CPRIT (RP100841)
- Glenn Foundation
- Leona M. and Harry B. Helmsley Charitable Trust
- Welch Foundation (I-1275, I-1558, I-1751)
- Cancer Prevention and Research Institute of Texas (RP100841)
- Glenn Foundation for Medical Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- FGF21, lifespan extension, aging, fasting response, liver, transgenic overexpression, insulin sensitivity, ketogenesis, hepatic fatty acid oxidation, bone loss, physical growth
- MeSH terms
- Adaptation, Physiological, Adenylate Kinase, Animals, Bone Resorption, Fasting, Fatty Acids, Female, Fibroblast Growth Factors, Gene Expression Regulation, Insulin Resistance, Insulin-Like Growth Factor I, Ketone Bodies, Liver, Longevity, Male, Mice, Transgenic, NAD, Oxidation-Reduction, Growth Hormone, Signal Transduction, Transgenes, Caloric Restriction, Lipid Metabolism, Mice, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review