The DOI matches its Crossref record; 76 of the 76 references it cites were found in a registry or an index.
The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function
Open accessAbstract
Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions. Proliferative mesoderm-derived nestin− MSCs participate in fetal skeletogenesis and lose MSC activity soon after birth. In contrast, quiescent neural crest-derived nestin+ cells preserve MSC activity, but do not generate fetal chondrocytes. Instead, they differentiate into HSC niche-forming MSCs, helping to establish the HSC niche by secreting Cxcl12. Perineural migration of these cells to the bone marrow requires the ErbB3 receptor. The neonatal Nestin-GFP+ Pdgfrα− cell population also contains Schwann cell precursors, but does not comprise mature Schwann cells. Thus, in the developing bone marrow HSC niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells, and ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC niche formation.
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BackgroundOsteoblastic cells regulate the haematopoietic stem cell niche
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Cited by
Haematopoietic stem cell activity and interactions with the niche
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Metadata
- Authors
- Isern, J., García-García, A., Martín, A. M., Arranz, L., Martín-Pérez, D., Torroja, C., Sánchez-Cabo, F., & Méndez-Ferrer, S.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2014-09-25
- Volume
- 3
- Pages
- e03696-e03696
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2123954788
- Cited by
- 310
- References
- 76
- FWCI
- 19.80
- Type
- journal article
- Language
- en
- Open access
- gold
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