Sexually dimorphic neuronal responses to social isolation
Open accessAbstract
Many species use social networks to buffer the effects of stress. The mere absence of a social network, however, may also be stressful. We examined neuroendocrine, PVN CRH neurons and report that social isolation alters the intrinsic properties of these cells in sexually dimorphic fashion. Specifically, isolating preadolescent female mice from littermates for <24 hr increased first spike latency (FSL) and decreased excitability of CRH neurons. These changes were not evident in age-matched males. By contrast, subjecting either males (isolated or grouped) or group housed females to acute physical stress (swim), increased FSL. The increase in FSL following either social isolation or acute physical stress was blocked by the glucocorticoid synthesis inhibitor, metyrapone and mimicked by exogenous corticosterone. The increase in FSL results in a decrease in the excitability of CRH neurons. Our observations demonstrate that social isolation, but not acute physical stress has sex-specific effects on PVN CRH neurons.
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Isolation of preadolescent female but not male mice for less than 24 hours reduced PVN CRF neuron excitability in a glucocorticoid-dependent way.
“Isolation of preadolescent female (but not male) mice for <24 h decreased the excitability of PVN CRF neurons in a glucocorticoid-dependent manner80.”
From Neural mechanisms of social homeostasis (2019) · cites this paper as [80]
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Neural mechanisms of social homeostasis
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- Authors
- Senst, L., Baimoukhametova, D., Sterley, T.-L., & Bains, J. S.
- Affiliations
- University of Calgary (CA)
- Corresponding author
- Bains, Jaideep Singh
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-10-11
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC5059136
- OpenAlex
- W2528191300
- Cited by
- 101
- References
- 32
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 15 · 2023: 7 · 2022: 15 · 2021: 15 · 2020: 12 · 2019: 9 · 2018: 2 · 2017: 5
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Leaders in Medicine, Cumming School of Medicine
- Alberta Innovates - Health Solutions (Postdoctoral Fellowship)
- University of Calgary Eyes High Postdoctoral Fellowship
- Canadian Institutes of Health Research (86501)
- Fondation Brain Canada
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- social isolation, sexually dimorphic neurons, paraventricular nucleus, corticotropin-releasing hormone neurons, neuronal excitability, first-spike latency, glucocorticoids, corticosterone, metyrapone, neuroendocrine stress response
- MeSH terms
- Action Potentials, Animals, Corticotropin-Releasing Hormone, Neurons, Paraventricular Hypothalamic Nucleus, Sex Factors, Social Isolation, Mice
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