Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works

Cellular and Molecular Mechanisms of Pain

Basbaum, A. I., Bautista, D. M., Scherrer, G., & Julius, D. (2009) · Cell · doi:10.1016/j.cell.2009.09.028 · Cited by 4,344 · see citing works

Functional neurogenesis in the adult hippocampus

van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853 · see citing works

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations

Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works

Partitioning of Lipid-Modified Monomeric GFPs into Membrane Microdomains of Live Cells

Zacharias, D. A., Violin, J. D., Newton, A. C., & Tsien, R. Y. (2002) · Science · doi:10.1126/science.1068539 · Cited by 2,242 · see citing works

A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex

Taniguchi, H., He, M., Wu, P., Kim, S., Paik, R., Sugino, K., Kvitsani, D., Fu, Y., Lu, J., Lin, Y., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.07.026 · Cited by 1,828 · see citing works

Shared and distinct transcriptomic cell types across neocortical areas

Tasic, B., Yao, Z., Graybuck, L. T., Smith, K. A., Nguyen, T. N., Bertagnolli, D., Goldy, J., Garren, E., Economo, M. N., Viswanathan, S., et al. (2018) · Nature · doi:10.1038/s41586-018-0654-5 · Cited by 1,746 · see citing works

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688 · see citing works

The Sensory Neurons of Touch

Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648 · see citing works

REVIEW ON CPP: Measuring reward with the conditioned place preference (CPP) paradigm: update of the last decade

Tzschentke, T. M. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00070.x · Cited by 1,336 · see citing works

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

Vong, L., Ye, C., Yang, Z., Choi, B. J., Chua, S. C., & Lowell, B. B. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.028 · Cited by 1,238 · see citing works

A Comparison of the Social Postures of Some Common Laboratory Rodents

Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167 · see citing works

Coding of pleasant touch by unmyelinated afferents in humans

Löken, L. S., Wessberg, J., Morrison, I., McGlone, F., & Olausson, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2312 · Cited by 1,120 · see citing works

Discriminative and affective touch: Sensing and feeling.

McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112 · see citing works

Evoked axonal oxytocin release in the central amygdala attenuates fear response

Knobloch, H. S., Charlet, A., Hoffmann, L. C., Eliava, M., Khrulev, S., Cetin, A. H., Osten, P., Schwarz, M. K., Seeburg, P. H., Stoop, R., et al. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.030 · Cited by 1,049 · see citing works

The Challenge of Translation in Social Neuroscience: A Review of Oxytocin, Vasopressin, and Affiliative Behavior

Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044 · see citing works

Oxytocin: The Great Facilitator of Life

Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037 · see citing works

Variations in maternal care in the rat as a mediating influence for the effects of environment on development

Champagne, F. A., Francis, D. D., Mar, A., & Meaney, M. J. (2003) · Physiology & Behavior · doi:10.1016/s0031-9384(03)00149-5 · Cited by 1,021 · see citing works

The oxytocin receptor: from intracellular signaling to behavior

Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999 · see citing works

OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS1The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions.1

Uvnäs-Moberg, K. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00056-0 · Cited by 966 · see citing works

Dendritic peptide release and peptide-dependent behaviours

Ludwig, M., & Leng, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1845 · Cited by 945 · see citing works

The Neurobiology of Human Attachments

Feldman, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2016.11.007 · Cited by 839 · see citing works

Oxytocin enables maternal behaviour by balancing cortical inhibition

Marlin, B. J., Mitre, M., D’amour, J. A., Chao, M. V., & Froemke, R. C. (2015) · Nature · doi:10.1038/nature14402 · Cited by 744 · see citing works

Neurophysiological Correlates of Affiliative Behaviour between Humans and Dogs

Odendaal, J. S. J., & Meintjes, R. A. (2003) · The Veterinary Journal · doi:10.1016/s1090-0233(02)00237-x · Cited by 742 · see citing works

Evolutionary optimization of fluorescent proteins for intracellular FRET

Nguyen, A. W., & Daugherty, P. S. (2005) · Nature Biotechnology · doi:10.1038/nbt1066 · Cited by 687 · see citing works

Sexually Dimorphic Neurons in the Ventromedial Hypothalamus Govern Mating in Both Sexes and Aggression in Males

Yang, C. F., Chiang, M. C., Gray, D. C., Prabhakaran, M., Alvarado, M., Juntti, S. A., Unger, E. K., Wells, J. A., & Shah, N. M. (2013) · Cell · doi:10.1016/j.cell.2013.04.017 · Cited by 674 · see citing works

Genetic Causes and Modifiers of Autism Spectrum Disorder

Rylaarsdam, L. E., & Guemez‐Gamboa, A. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00385 · Cited by 575 · see citing works

The skin as a social organ

Morrison, I., Löken, L. S., & Olausson, H. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-2007-y · Cited by 549 · see citing works

Social touch and human development

Cascio, C. J., Moore, D., & McGlone, F. P. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.04.009 · Cited by 513 · see citing works

Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation

Harris, J. A., Hirokawa, K. E., Sorensen, S. A., Gu, H., Mills, M., Ng, L. L., Bohn, P., Mortrud, M., Ouellette, B., Kidney, J., et al. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00076 · Cited by 485 · see citing works

The biology of mammalian parenting and its effect on offspring social development

Rilling, J. K., & Young, L. J. (2014) · Science · doi:10.1126/science.1252723 · Cited by 452 · see citing works

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

Mei, Y., Monteiro, P., Zhou, Y., Kim, J.-A., Gao, X., Fu, Z., & Feng, G. (2016) · Nature · doi:10.1038/nature16971 · Cited by 392 · see citing works

A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK?

Knapska, E., & Kaczmarek, L. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.007 · Cited by 371 · see citing works

Hypothalamic Oxytocin Mediates Social Buffering of the Stress Response

Smith, A. S., & Wang, Z. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.09.017 · Cited by 359 · see citing works

Oxytocin enhances social recognition by modulating cortical control of early olfactory processing

Oettl, L.-L., Ravi, N., Schneider, M., Scheller, M. F., Schneider, P., Mitre, M., da Silva Gouveia, M., Froemke, R. C., Chao, M. V., Young, W. S., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.03.033 · Cited by 359 · see citing works

Brain mechanisms for processing affective touch

Gordon, I., Voos, A. C., Bennett, R. H., Bolling, D. Z., Pelphrey, K. A., & Kaiser, M. D. (2011) · Human Brain Mapping · doi:10.1002/hbm.21480 · Cited by 356 · see citing works

The neural mechanisms and circuitry of the pair bond

Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353 · see citing works

Self-soothing behaviors with particular reference to oxytocin release induced by non-noxious sensory stimulation

Uvnäs-Moberg, K., Handlin, L., & Petersson, M. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01529 · Cited by 351 · see citing works

Localization of preproenkephalin mRNA in the rat brain and spinal cord by in situ hybridization

Harlan, R. E., Shivers, B. D., Romano, G. J., Pfaff, D. W., & Howells, R. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902580202 · Cited by 346 · see citing works

Intracellular calcium stores regulate activity-dependent neuropeptide release from dendrites

Ludwig, M., Sabatier, N., Bull, P. M., Landgraf, R., Dayanithi, G., & Leng, G. (2002) · Nature · doi:10.1038/nature00822 · Cited by 346 · see citing works

Quantitative assessment of pleasant touch

Essick, G. K., McGlone, F. P., Dancer, C., Fabricant, D., Ragin, Y., Phillips, N., Jones, T., & Guest, S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.02.003 · Cited by 328 · see citing works

Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition

Young III, W. S., Shepard, E., Amico, J., Hennighausen, L., Wagner, K., LaMarca, M. E., McKinney, C., & Ginns, E. I. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.05266.x · Cited by 308 · see citing works

Early-life experience, epigenetics, and the developing brain

Kundakovic, M., & Champagne, F. A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.140 · Cited by 304 · see citing works

Massage for promoting growth and development of preterm and/or low birth-weight infants

Vickers, A., Ohlsson, A., Lacy, J., & Horsley, A. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000390.pub2 · Cited by 293 · see citing works

Genetic identification of C fibres that detect massage-like stroking of hairy skin in vivo

Vrontou, S., Wong, A. M., Rau, K. K., Koerber, H. R., & Anderson, D. J. (2013) · Nature · doi:10.1038/nature11810 · Cited by 289 · see citing works

Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain

He, M., Liu, Y., Wang, X., Zhang, M. Q., Hannon, G. J., & Huang, Z. J. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.010 · Cited by 277 · see citing works

Intergenerational effects of complete maternal deprivation and replacement stimulation on maternal behavior and emotionality in female rats

González, A., Lovic, V., Ward, G. R., Wainwright, P. E., & Fleming, A. S. (2000) · Developmental Psychobiology · doi:10.1002/1098-2302(2001)38:1 · Cited by 273 · see citing works

Identifying the pathways required for coping behaviours associated with sustained pain

Huang, T., Lin, S.-H., Malewicz, N. M., Zhang, Y., Zhang, Y., Goulding, M., LaMotte, R. H., & Ma, Q. (2019) · Nature · doi:10.1038/s41586-018-0793-8 · Cited by 264 · see citing works

The cross-generation transmission of oxytocin in humans

Feldman, R., Gordon, I., & Zagoory-Sharon, O. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.06.005 · Cited by 256 · see citing works

Parallel ascending spinal pathways for affective touch and pain

Choi, S., Hachisuka, J., Brett, M. A., Magee, A. R., Omori, Y., Iqbal, N.-U.-A., Zhang, D., DeLisle, M. M., Wolfson, R. L., Bai, L., et al. (2020) · Nature · doi:10.1038/s41586-020-2860-1 · Cited by 255 · see citing works

Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons

Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0674-y · Cited by 249 · see citing works

Breif Report: Sensory Abnormalities as Distinguishing Symptoms of Autism Spectrum Disorders in Young Children

Wiggins, L. D., Robins, D. L., Bakeman, R., & Adamson, L. B. (2009) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-009-0711-x · Cited by 248 · see citing works

Social reward among juvenile mice

Panksepp, J. B., & Lahvis, G. P. (2007) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2006.00295.x · Cited by 248 · see citing works

Massage Accelerates Brain Development and the Maturation of Visual Function

Guzzetta, A., Baldini, S., Bancale, A., Baroncelli, L., Ciucci, F., Ghirri, P., Putignano, E., Sale, A., Viegi, A., Berardi, N., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5548-08.2009 · Cited by 244 · see citing works

Somatosensory projection to the mesencephalon: An anatomical study in the monkey

Wiberg, M., Westman, J., & Blomqvist, A. G. (1987) · The Journal of Comparative Neurology · doi:10.1002/cne.902640108 · Cited by 231 · see citing works

Increased plasma levels of oxytocin in response to afferent electrical stimulation of the sciatic and vagal nerves and in response to touch and pinch in anaesthetized rats

STOCK, S., & UVNÄS‐MOBERG, K. (1988) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1988.tb08294.x · Cited by 230 · see citing works

Oxytocin treatment, circuitry and autism: a critical review of the literature placing oxytocin into the autism context

Guastella, A. J., & Hickie, I. B. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.06.028 · Cited by 223 · see citing works

Periaqueductal gray

Benarroch, E. E. (2012) · Neurology · doi:10.1212/wnl.0b013e31823fcdee · Cited by 223 · see citing works

Massage increases oxytocin and reduces adrenocorticotropin hormone in humans.

(2012) · PubMed · Cited by 215 · see citing works

Mapping the face in the somatosensory brainstem

Erzurumlu, R., Murakami, Y., & Rijli, F. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2804 · Cited by 213 · see citing works

PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2

Duan, L., Zhang, X., Miao, W., Sun, Y., Xiong, G., Wu, Q.-Z., Li, G., Yang, P., Yu, H., Li, H., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.08.030 · Cited by 210 · see citing works

Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices

Zheng, J.-J., Li, S.-J., Zhang, X.-D., Miao, W.-Y., Zhang, D., Yao, H., & Yu, X. (2014) · Nature Neuroscience · doi:10.1038/nn.3634 · Cited by 206 · see citing works

Autistic traits are associated with diminished neural response to affective touch

Voos, A. C., Pelphrey, K. A., & Kaiser, M. D. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss009 · Cited by 205 · see citing works

Brain Mechanisms for Processing Affective (and Nonaffective) Touch Are Atypical in Autism

Kaiser, M. D., Yang, D. Y. ‐., Voos, A. C., Bennett, R. H., Gordon, I., Pretzsch, C. M., Beam, D. E., Keifer, C. M., Eilbott, J. A., McGlone, F. P., et al. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv125 · Cited by 204 · see citing works

Oxytocin and early parent-infant interactions: A systematic review

Scatliffe, N., Casavant, S. G., Vittner, D. J., & Cong, X. S. (2019) · International Journal of Nursing Sciences · doi:10.1016/j.ijnss.2019.09.009 · Cited by 202 · see citing works

C-tactile afferents: Cutaneous mediators of oxytocin release during affiliative tactile interactions?

Walker, S. C., Trotter, P. D., Swaney, W. T., Marshall, A. G., & McGlone, F. P. (2017) · Neuropeptides · doi:10.1016/j.npep.2017.01.001 · Cited by 193 · see citing works

Massage therapy research

Field, T. M., Diego, M., & Hernandez‐Reif, M. (2006) · Developmental Review · doi:10.1016/j.dr.2005.12.002 · Cited by 184 · see citing works

An obligate role of oxytocin neurons in diet induced energy expenditure

Wu, Z., Xu, Y., Zhu, Y., Sutton, A. K., Zhao, R., Lowell, B. B., Olson, D. P., & Tong, Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045167 · Cited by 181 · see citing works

Social transmission and buffering of synaptic changes after stress

Sterley, T.-L., Baimoukhametova, D., Füzesi, T., Zurek, A. A., Daviu, N., Rasiah, N. P., Rosenegger, D., & Bains, J. S. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0044-6 · Cited by 179 · see citing works

Artificially-reared female rats show reduced prepulse inhibition and deficits in the attentional set shifting task—reversal of effects with maternal-like licking stimulation

Lovic, V., & Fleming, A. S. (2003) · Behavioural Brain Research · doi:10.1016/s0166-4328(03)00206-7 · Cited by 170 · see citing works

The periaqueductal gray and primal emotional processing critical to influence complex defensive responses, fear learning and reward seeking

Motta, S. C., Carobrez, A. P., & Canteras, N. S. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.10.012 · Cited by 167 · see citing works

Are periaqueductal gray and dorsal raphe the foundation of appetitive and aversive control? A comprehensive review

Silva, C., & McNaughton, N. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.02.001 · Cited by 156 · see citing works

Neuropsychopathology of Autism Spectrum Disorder: Complex Interplay of Genetic, Epigenetic, and Environmental Factors

Bhandari, R., Paliwal, J. K., & Kuhad, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_4 · Cited by 156 · see citing works

Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings

Moehring, F., Halder, P., Seal, R. P., & Stucky, C. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.019 · Cited by 155 · see citing works

Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropic

Nässel, D. R., Zandawala, M., Kawada, T., & Satake, H. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01262 · Cited by 153 · see citing works

Sensory Processing in Children with Autism Spectrum Disorders and Impact on Functioning

Suarez, M. A. (2012) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.10.012 · Cited by 152 · see citing works

Integrative Approaches Utilizing Oxytocin to Enhance Prosocial Behavior: From Animal and Human Social Behavior to Autistic Social Dysfunction

Yamasue, H., Yee, J. R., Hurlemann, R., Rilling, J. K., Chen, F. S., Meyer-Lindenberg, A., & Tost, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3327-12.2012 · Cited by 149 · see citing works

The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris‐leucoagglutinin study. I. Ascending projections

Cameron, A. A., Khan, I. A., Westlund, K. N., Cliffer, K. D., & Willis, W. D. (1995) · The Journal of Comparative Neurology · doi:10.1002/cne.903510407 · Cited by 149 · see citing works

Interplay between Oxytocin and Sensory Systems in the Orchestration of Socio-Emotional Behaviors

Grinevich, V., & Stoop, R. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.016 · Cited by 139 · see citing works

Neural correlates of gentle skin stroking in early infancy

Tuulari, J. J., Scheinin, N. M., Lehtola, S. J., Merisaari, H., Saunavaara, J. P., Parkkola, R. K., Sehlstedt, I., Karlsson, L., Karlsson, H., & Björnsdotter, M. (2017) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2017.10.004 · Cited by 135 · see citing works

Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation

Gao, Z., Chen, W., Liu, M., Chen, X., Wan, L., Zhang, X., Yuan, L., Lin, J.-K., Wang, M., Zhou, L., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.010 · Cited by 135 · see citing works

The ascending input to the midbrain periaqueductal gray of the primate

Mantyh, P. W. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902110106 · Cited by 134 · see citing works

The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals

Moss, M., Glazer, E. J., & Basbaum, A. I. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-03-00603.1983 · Cited by 132 · see citing works

<scp>O</scp>xytocin modulation of neural circuits for social behavior

Marlin, B. J., & Froemke, R. C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22452 · Cited by 130 · see citing works

Role of Massage Therapy in Cancer Care

Russell, N. C., Sumler, S.-S., Beinhorn, C. M., & Frenkel, M. A. (2008) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2007.7176 · Cited by 129 · see citing works

Autism and Oxytocin: New Developments in Translational Approaches to Therapeutics

Green, J. J., & Hollander, E. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.006 · Cited by 124 · see citing works

Oxytocin as an Indicator of Psychological and Social Well-Being in Domesticated Animals: A Critical Review

Rault, J., van den Munkhof, M. H., & Buisman‐Pijlman, F. T. A. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01521 · Cited by 118 · see citing works

The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles

Barrett, C. E., Arambula, S. E., & Young, L. J. (2015) · Translational Psychiatry · doi:10.1038/tp.2015.73 · Cited by 115 · see citing works

Interactions between the lateral hypothalamus and the periaqueductal gray

Behbehani, M., Park, M., & Clement, M. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-08-02780.1988 · Cited by 115 · see citing works

Distribution of messenger RNAs encoding enkephalin, substance P, somatostatin, galanin, vasoactive intestinal polypeptide, neuropeptide Y, and calcitonin gene‐related peptide in the midbrain periaqueductal grey in the rat

Smith, G. S. J., Savery, D., Marden, C. M., Costa, J. J. L., Averill, S., Priestley, J. V., & Rattray, M. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903500103 · Cited by 114 · see citing works

Innate and plastic mechanisms for maternal behaviour in auditory cortex

Schiavo, J. K., Valtcheva, S., Bair-Marshall, C. J., Song, S. C., Martin, K. A., & Froemke, R. C. (2020) · Nature · doi:10.1038/s41586-020-2807-6 · Cited by 113 · see citing works

Social and affective touch in primates and its role in the evolution of social cohesion

Jablonski, N. G. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.024 · Cited by 111 · see citing works

The development of whisker control in rats in relation to locomotion

Grant, R. A., Mitchinson, B., & Prescott, T. J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20591 · Cited by 106 · see citing works

Periaqueductal Gray Sheds Light on Dark Areas of Psychopathology

George, D. T., Ameli, R., & Koob, G. F. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.03.004 · Cited by 103 · see citing works

Sexually dimorphic neuronal responses to social isolation

Senst, L., Baimoukhametova, D., Sterley, T.-L., & Bains, J. S. (2016) · eLife · doi:10.7554/elife.18726 · Cited by 101 · see citing works

Role of whiskers in sensorimotor development of C57BL/6 mice

Arakawa, H., & Erzurumlu, R. S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.03.040 · Cited by 91 · see citing works

Neonatal handling: An overview of the positive and negative effects

Raineki, C., Lucion, A. B., & Weinberg, J. (2014) · Developmental Psychobiology · doi:10.1002/dev.21241 · Cited by 90 · see citing works

The peptidergic organization of the cat periaqueductal gray. II. The distribution of immunoreactive substance P and vasoactive intestinal polypeptide

Moss, M., & Basbaum, A. I. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-07-01437.1983 · Cited by 87 · see citing works

Periaqueductal gray afferents synapse onto dopamine and GABA neurons in the rat ventral tegmental area

Omelchenko, N., & Sesack, S. R. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22265 · Cited by 87 · see citing works

Activation of hypothalamic oxytocin neurons following tactile stimuli in rats

Okabe, S., Yoshida, M., Takayanagi, Y., & Onaka, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.055 · Cited by 82 · see citing works

Allatostatin‐like‐immunoreactive neurons of the tobacco hornworm, Manduca sexta , and isolation and identification of a new neuropeptide related to cockroach allatostatins

Davis, N. T., Veenstra, J. A., Feyereisen, R., & Hildebrand, J. G. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970825)385:2 · Cited by 82 · see citing works

Oxytocin and behavior: lessons from knockout mice

Caldwell, H. K., Aulino, E. A., Freeman, A. R., Miller, T. V., & Witchey, S. K. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22431 · Cited by 79 · see citing works

The Promise and Perils of Oxytocin

Miller, G. (2013) · Science · doi:10.1126/science.339.6117.267 · Cited by 76 · see citing works

Neuropathology and Animal Models of Autism: Genetic and Environmental Factors

Gadad, B. S., Hewitson, L. C., Young, K. A., & German, D. C. (2013) · Autism Research and Treatment · doi:10.1155/2013/731935 · Cited by 69 · see citing works

L-733,060, a novel tachykinin NK1 receptor antagonist; effects in [Ca2+]i mobilisation, cardiovascular and dural extravasation assays

Seabrook, G. R., Shepheard, S. L., Williamson, D. J., Tyrer, P. J., Rigby, M., Cascieri, M. A., Harrison, T., Hargreaves, R. J., & Hill, R. G. (1996) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00706-6 · Cited by 65 · see citing works

INFANT AVOIDANCE DURING A TACTILE TASK PREDICTS AUTISM SPECTRUM BEHAVIORS IN TODDLERHOOD

Mammen, M. A., Moore, G. A., Scaramella, L. V., Reiss, D., Ganiban, J. M., Shaw, D. S., Leve, L. D., & Neiderhiser, J. M. (2015) · Infant Mental Health Journal · doi:10.1002/imhj.21539 · Cited by 64 · see citing works

A Systematic Look at Environmental Modulation and Its Impact in Brain Development

Sale, A. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.004 · Cited by 62 · see citing works

A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals.

Cui, Y., Lv, G., Jin, S., Peng, J., Yuan, J., He, X.-B., Gong, H., Xu, F.-Q., Xu, T.-H., & Li, H. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.062 · Cited by 59 · see citing works

Social touch during development: Long-term effects on brain and behavior

Bales, K. L., Witczak, L. R., Simmons, T. C., Savidge, L. E., Rothwell, E. S., Rogers, F. D., Manning, R., Heise, M. J., Englund, M., & Razo, R. A. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.019 · Cited by 54 · see citing works

Tachykinin: recent developments and novel roles in health and disease

Onaga, T. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0008 · Cited by 53 · see citing works

Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences

Grund, T., Tang, Y., Benusiglio, D., Althammer, F., Probst, S., Oppenländer, L., Neumann, I. D., & Grinevich, V. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.03.019 · Cited by 53 · see citing works

The periaqueductal gray as a critical site to mediate reward seeking during predatory hunting

Ortiz, S. R. M., Sukikara, M. H., Bittencourt, J. C., Baldo, M. V. C., Elias, C. F., Felício, L. F., & Canteras, N. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.034 · Cited by 49 · see citing works

Substance P decreases a potassium conductance of spinal cord neurons in cell culture

Nowak, L. M., & Macdonald, R. L. (1981) · Brain Research · doi:10.1016/0006-8993(81)91205-1 · Cited by 48 · see citing works

Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation

Lénárd, L., László, K., Kertes, E., Ollmann, T., Péczely, L., Kovács, A., Kállai, V., Zagorácz, O., Gálosi, R., & Karádi, Z. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.003 · Cited by 47 · see citing works

Effects of Stroking on Salivary Oxytocin and Cortisol in Guide Dogs: Preliminary Results

Ogi, A., Mariti, C., Baragli, P., Sergi, V., & Gazzano, A. (2020) · Animals · doi:10.3390/ani10040708 · Cited by 43 · see citing works

Periaqueductal efferents to dopamine and GABA neurons of the VTA

Ntamati, N. R., Creed, M. C., Achargui, R., & Lüscher, C. (2018) · PLoS ONE · doi:10.1371/journal.pone.0190297 · Cited by 38 · see citing works

Substance P Modulates Sensory Action Potentials in the Lamprey Via a Protein Kinase C‐Mediated Reduction of a 4‐Aminopyridine‐Sensitive Potassium Conductance

Parker, D., Svensson, E., & Grillner, S. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01374.x · Cited by 26 · see citing works

Three times as many lamina I neurons project to the periaqueductal gray than to the thalamus: a retrograde tracing study in the cat

Mouton, L. J., & Holstege, G. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00723-x · Cited by 26 · see citing works

An increased extrasynaptic NMDA tone inhibits A‐type K+ current and increases excitability of hypothalamic neurosecretory neurons in hypertensive rats

Zhang, M., Biancardi, V. C., & Stern, J. E. (2017) · The Journal of Physiology · doi:10.1113/jp274327 · Cited by 25 · see citing works

Experience Salience Gates Endocannabinoid Signaling at Hypothalamic Synapses

Cusulin, J. I. W., Senst, L., Teskey, G. C., & Bains, J. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0163-14.2014 · Cited by 21 · see citing works

Periaqueductal gray and emotions: the complexity of the problem and the light at the end of the tunnel, the magnetic resonance imaging

Zelena, D., Menant, O., Andersson, F., & Chaillou, É. (2018) · Endocrine Regulations · doi:10.2478/enr-2018-0027 · Cited by 16 · see citing works

Post-weaning stroking stimuli induce affiliative behavior toward humans and influence brain activity in female rats

Okabe, S., Takayanagi, Y., Yoshida, M., & Onaka, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-83314-w · Cited by 15 · see citing works

Can Male Mice Develop Preference Towards Gentle Stroking by an Experimenter?

Cho, C., Chan, C., & Martin, L. J. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.017 · Cited by 13 · see citing works

Connections from the rat dorsal column nuclei (DCN) to the periaqueductal gray matter (PAG)

Barbaresi, P., & Mensa’, E. (2016) · Neuroscience Research · doi:10.1016/j.neures.2016.02.003 · Cited by 9 · see citing works

An Invitation to Neurobiology

Luo, L. (2020) · Garland Science eBooks · doi:10.1201/9781003053972-1 · Cited by 1 · see citing works

Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities

Rigney, N., de Vries, G. J., Petrulis, A., & Young, L. J. (2022) · Endocrinology · doi:10.1210/endocr/bqac111 · Cited by 191 · see citing works

The brain-body disconnect: A somatic sensory basis for trauma-related disorders

Kearney, B. E., & Lanius, R. A. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1015749 · Cited by 154 · see citing works

A systematic review and multivariate meta-analysis of the physical and mental health benefits of touch interventions

Packheiser, J., Hartmann, H., Fredriksen, K., Gazzola, V., Keysers, C., & Michon, F. (2024) · Nature Human Behaviour · doi:10.1038/s41562-024-01841-8 · Cited by 152 · see citing works

Social isolation and the brain: effects and mechanisms

Xiong, Y., Hong, H., Liu, C., & Zhang, Y. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01835-w · Cited by 127 · see citing works

Detection, processing and reinforcement of social cues: regulation by the oxytocin system

Menon, R., & Neumann, I. D. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00759-w · Cited by 100 · see citing works

Adolescent sleep shapes social novelty preference in mice

Bian, W.-J., Brewer, C. L., Kauer, J. A., & de Lecea, L. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01076-8 · Cited by 96 · see citing works

Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity

Elias, L. J., Succi, I. K., Schaffler, M. D., Foster, W., Gradwell, M. A., Bohic, M., Fushiki, A., Upadhyay, A., Ejoh, L. L., Schwark, R., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.034 · Cited by 85 · see citing works

A neural circuit for male sexual behavior and reward

Bayless, D. W., Davis, C.-H. O., Yang, R., Wei, Y., Carvalho, V. M. D. A., Knoedler, J. R., Yang, T., Livingston, O., Lomvardas, A., Martins, G. J., et al. (2023) · Cell · doi:10.1016/j.cell.2023.07.021 · Cited by 82 · see citing works

A hypothalamic circuit underlying the dynamic control of social homeostasis

Liu, D., Rahman, M., Johnson, A., Amo, R., Tsutsui‐Kimura, I., Sullivan, Z. A., Pena, N., Talay, M., Logeman, B. L., Finkbeiner, S., et al. (2025) · Nature · doi:10.1038/s41586-025-08617-8 · Cited by 83 · see citing works

Molecular and neural basis of pleasant touch sensation

Liu, B., Qiao, L., Liu, K., Liu, J., Piccinni-Ash, T. J., & Chen, Z. (2022) · Science · doi:10.1126/science.abn2479 · Cited by 81 · see citing works

A dedicated hypothalamic oxytocin circuit controls aversive social learning

Osakada, T., Yan, R., Jiang, Y., Wei, D., Tabuchi, R. A., Dai, B., Wang, X., Zhao, G., Wang, C. X., Liu, J., et al. (2024) · Nature · doi:10.1038/s41586-023-06958-w · Cited by 65 · see citing works

The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives

Blumenthal, S. A., & Young, L. J. (2023) · Biology · doi:10.3390/biology12060844 · Cited by 59 · see citing works

The Current View on the Paradox of Pain in Autism Spectrum Disorders

Bogdanova, O. V., Bogdanov, V. B., Pizano, A., Bouvard, M. P., Cazalets, J., Mellen, N. M., & Amestoy, A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.910824 · Cited by 60 · see citing works

Sensory input, sex and function shape hypothalamic cell type development

Kaplan, H. S., Logeman, B. L., Zhang, K., Yawitz, T. A., Santiago, C., Sohail, N., Talay, M., Seo, C., Naumenko, S., Sui, S. J. H., et al. (2025) · Nature · doi:10.1038/s41586-025-08603-0 · Cited by 51 · see citing works

Bridging skin, brain, and behavior to understand pleasurable social touch

Elias, L. J., & Abdus-Saboor, I. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102527 · Cited by 48 · see citing works

Brain circuits that regulate social behavior

Li, H., Zhao, Z., Jiang, S., & Wu, H. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03037-6 · Cited by 57 · see citing works

Ginsenoside Rg1 enriches gut microbial indole-3-acetic acid to alleviate depression-like behavior in mice via oxytocin signaling

Yu, S., Yin, Z., Ling, M., Chen, Z., Zhang, Y., Pan, Y., Zhang, Y., Cai, X., Chen, Z., Hao, H., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156186 · Cited by 36 · see citing works

SORI: A softness-rendering interface to unravel the nature of softness perception

Mete, M., Jeong, H., Wang, W., & Paik, J. K. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314901121 · Cited by 31 · see citing works

Sleep dysfunction mediates the relationship between hypothalamic-insula connectivity and anxiety-depression symptom severity bidirectionally in young adults

Li, G., Chen, Y. S., Chaudhary, S., Li, C. S.-P., Hao, D., Yang, L., & Li, C.-S. R. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120340 · Cited by 31 · see citing works

Prosocial Helping Behavior: Conceptual Issues and Neural Mechanisms

Rigney, N., & Hong, W. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.03.003 · Cited by 31 · see citing works

Neurophysiological and behavioral synchronization in group-living and sleeping mice

Sotelo, M. I., Markunas, C., Kudlak, T., Kohtz, C., Vyssotski, A. L., Rothschild, G., & Eban-Rothschild, A. (2023) · Current Biology · doi:10.1016/j.cub.2023.11.065 · Cited by 36 · see citing works

Human endogenous oxytocin and its neural correlates show adaptive responses to social touch based on recent social context

Handlin, L., Novembre, G., Lindholm, H., Kämpe, R., Paul, E. R., & Morrison, I. (2022) · bioRxiv · doi:10.7554/elife.81197 · Cited by 27 · see citing works

The thalamic reticular nucleus orchestrates social memory

Wang, F., Sun, H., Chen, M., Feng, B., Lu, Y., Lyu, M., Cui, D., Zhai, Y., Zhang, Y., Zhu, Y., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.04.013 · Cited by 28 · see citing works

Neural mechanisms of comforting: Prosocial touch and stress buffering

Lim, K. Y., & Hong, W. (2023) · Hormones and Behavior · doi:10.1016/j.yhbeh.2023.105391 · Cited by 29 · see citing works

Interconnected neural circuits mediating social reward

Isaac, J., & Murugan, M. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.10.004 · Cited by 25 · see citing works

Affective touch in the context of development, oxytocin signaling, and autism

Li, Q., Zhao, W., & Kendrick, K. M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.967791 · Cited by 24 · see citing works

Social Touch Reduces Pain Perception—An fMRI Study of Cortical Mechanisms

Savallampi, M., Maallo, A. M. S., Shaikh, S. M., McGlone, F. P., Revel, F. B., Olausson, H., & Boehme, R. (2023) · Brain Sciences · doi:10.3390/brainsci13030393 · Cited by 23 · see citing works

Adaptation of Coping Strategies to Reduce the Impact of Stress and Lonelines on the Psychological Well-Being of Adults

Бондарчук, О. І., Balakhtar, V., Pinchuk, N. I., Пустовалов, І. В., & Pavlenok, K. S. (2023) · Journal of Law and Sustainable Development · doi:10.55908/sdgs.v11i10.1852 · Cited by 24 · see citing works

Whole‐brain monosynaptic inputs to lateral periaqueductal gray glutamatergic neurons in mice

Ma, W., Li, L., Kong, L., Zhang, H., Yuan, P., Huang, Z., & Wang, Y. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14338 · Cited by 20 · see citing works

Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP‐Induced Parkinson's Disease Model

Wang, Y., Xu, H., Chen, S., Chen, J., Zheng, Q., Ma, Y., Zhao, X., Shi, Y., & Xiao, L. (2024) · Advanced Science · doi:10.1002/advs.202310244 · Cited by 17 · see citing works

Social Bonds Retain Oxytocin-Mediated Brain-Liver Axis to Retard Atherosclerosis

Ko, S., Anzai, A., Liu, X., Kinouchi, K., Yamanoi, K., Torimitsu, T., Ichihara, G., Kitakata, H., Shirakawa, K., Katsumata, Y., et al. (2024) · Circulation Research · doi:10.1161/circresaha.124.324638 · Cited by 19 · see citing works

Neonatal oxytocin gives the tempo of social and feeding behaviors

Muscatelli, F., Matarazzo, V. A., & Chini, B. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1071719 · Cited by 17 · see citing works

Oxytocin Receptor in Cerebellar Purkinje Cells Does Not Engage in Autism-Related Behaviors

Shen, L.-P., Li, W., Pei, L.-Z., Yin, J., Xie, S.-T., Li, H.-Z., Yan, C., Wang, J., Zhang, Q., Zhang, X., et al. (2022) · The Cerebellum · doi:10.1007/s12311-022-01466-5 · Cited by 16 · see citing works

Projections from anteromedial thalamus nucleus to the midcingulate cortex mediate pain and anxiety-like behaviors in mice

Hong, J., Li, J., Wu, F.-L., Bao, S.-Y., Sun, H.-X., Zhu, K.-H., Cai, Z.-P., Li, F., & Li, Y.-Q. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105640 · Cited by 16 · see citing works

Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases

Cui, X., & Xiao, L. (2025) · Neuroscience Bulletin · doi:10.1007/s12264-025-01424-1 · Cited by 16 · see citing works

Light disrupts social memory via a retina‐to‐supraoptic nucleus circuit

Huang, Y., Liao, P., Yu, J., & Chen, S. (2023) · EMBO Reports · doi:10.15252/embr.202356839 · Cited by 14 · see citing works

A Novel Head-Fixed Assay for Social Touch in Mice Uncovers Aversive Responses in Two Autism Models

Chari, T., Hernandez, A., & Portera‐Cailliau, C. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.0226-23.2023 · Cited by 14 · see citing works

Physical exercise activates a PVN–NAc oxytocin circuit to relieve stress-induced depressive-like behaviors

Xia, J., Zou, Y., Cui, Y., Zhang, S., Huo, K., Liu, W., Huang, Z., Zhang, Q., Qi, Z., & Liu, W. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2503675122 · Cited by 14 · see citing works

Survival, Attachment, and Healing: An Evolutionary Lens on Interventions for Trauma-Related Dissociation

Burback, L., Forner, C. C., Winkler, O., Al-Shamali, H. F., Ayoub, Y., Paquet, J., & Verghese, M. (2024) · Psychology Research and Behavior Management · doi:10.2147/prbm.s402456 · Cited by 13 · see citing works

A prefrontal–habenular circuitry regulates social fear behaviour

Tian, Y., Zheng, J., Zhu, X., Liu, X., Li, H., Wang, J., Yang, Q., Zeng, L., Shi, Z., Gong, M., et al. (2024) · Brain · doi:10.1093/brain/awae209 · Cited by 12 · see citing works

Oxytocin signaling regulates maternally directed behavior during early life

Zelmanoff, D. D., Bornstein, R., Kaufman, M., Dine, J., Wietek, J., Litvin, A., Abraham, S., Cohen, S., Atzmon, A., Porat, I., et al. (2025) · Science · doi:10.1126/science.ado5609 · Cited by 12 · see citing works

Autonomic Modulations to Cardiac Dynamics in Response to Affective Touch: Differences Between Social Touch and Self-Touch

Candia‐Rivera, D., Boehme, R., & Salamone, P. (2025) · IEEE Transactions on Affective Computing · doi:10.1109/taffc.2025.3548778 · Cited by 11 · see citing works

Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling

Hu, S., Wang, Y., Han, X., Dai, M., Zhang, Y., Ma, Y., Weng, S.-J., & Xiao, L. (2022) · BMC Biology · doi:10.1186/s12915-022-01405-0 · Cited by 11 · see citing works

Oxytocin and autism: Insights from clinical trials and animal models

Xing, C., & Yu, X. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103015 · Cited by 11 · see citing works

From pathology to pleasure: Reframing mechanistic studies on same-sex sexual behavior in primates

Cunningham, E., & Benítez, M. E. (2024) · Hormones and Behavior · doi:10.1016/j.yhbeh.2024.105476 · Cited by 10 · see citing works

Neuropeptides and Their Roles in the Cerebellum

Li, Z.-H., Li, B., Zhang, X., & Zhu, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042332 · Cited by 10 · see citing works

Touch in Human Social Robot Interaction: Systematic Literature Review with PRISMA Method

Tsirka, C., Velentza, A.-M., & Fachantidis, N. (2025) · International Journal of Social Robotics · doi:10.1007/s12369-025-01319-1 · Cited by 10 · see citing works

Pain perception and physiological responses are modulated by active support from a romantic partner

Mazza, A., Ciorli, T., Mirlisenna, I., D'Onofrio, I., Mantellino, S., Zaccaria, M., Pia, L., & Monte, O. D. (2023) · Psychophysiology · doi:10.1111/psyp.14299 · Cited by 10 · see citing works

Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study

Zhong, X., Wang, L., Xu, L., Lian, J., Chen, J., Gong, X., & Shao, Y. (2023) · Brain and Behavior · doi:10.1002/brb3.3238 · Cited by 9 · see citing works

A narrative review of mechanisms linking romantic relationship experiences to sleep quality

Xie, Y., & Feeney, B. C. (2024) · SLEEP Advances · doi:10.1093/sleepadvances/zpae049 · Cited by 10 · see citing works

The impact of daily affective touch on cortisol levels in institutionalized & fostered children

Nikolaeva, E. I., Александровна, Д. Е., Mayorova, L. A., & Portnova, G. V. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114479 · Cited by 12 · see citing works

Making developmental sense of the senses, their origin and function

Edens, B. M., & Bronner-Fraser, M. E. (2024) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2024.01.015 · Cited by 8 · see citing works

Insecure Attachment, Oxytocinergic System and C-Tactile Fibers: An Integrative and Translational Pathophysiological Model of Fibromyalgia and Central Sensitivity Syndromes

Bruti, G., & Foggetti, P. (2024) · Biomedicines · doi:10.3390/biomedicines12081744 · Cited by 8 · see citing works

Primary sensory neuron dysfunction underlying mechanical itch hypersensitivity in a Shank3 mouse model of autism

Huzard, D., Oliva, G., Marias, M., Granat, C., Soubeyre, V., Pereira, G. A. N., Negm, A., Grellier, G., Devaux, J. J., Bourinet, E., et al. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03461-w · Cited by 7 · see citing works

Robotic Actuation‐Mediated Quantitative Mechanogenetics for Noninvasive and On‐Demand Cancer Therapy

Liu, Y., Li, J., Zhang, Y., Wang, F., Su, J., Ma, C., Zhang, S., Du, Y., Fan, C., Zhang, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202401611 · Cited by 7 · see citing works

Oxytocin Modulation of Spinal Circuits Drives Therapeutic Benefits of MassagePreprint

Bohic, M., Salamone, P., Zuo, W., Negm, A., Fulton, S. L., Du, S., Jayakumar, S., Keating, J., Soubeyre, V., Gradwell, M. A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.11.698886 · Cited by 11 · see citing works

Oxytocin facilitates human touch-induced play behavior in rats

Hayashi, H., Tateishi, S., Inutsuka, A., Maejima, S., Hagiwara, D., Sakuma, Y., Onaka, T., Grinevich, V., & Sakamoto, H. (2025) · Current Biology · doi:10.1016/j.cub.2025.05.034 · Cited by 6 · see citing works

Corticotropin-releasing hormone signaling from piriform cortex to amygdala mediates social homophily in opioid addiction

Huo, Y., Wang, X., Lin, X., Yu, J., Li, B., Liu, Z., Guo, S., Wang, Y., Tang, R.-C., Li, B., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.08.012 · Cited by 7 · see citing works

From fundamental research to clinical translation: The neural modulation of social behavior by oxytocin and vasopressin

Zhao, W., Zhang, X., & Kendrick, K. M. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106624 · Cited by 7 · see citing works

Why help others? Insights from rodent to human early childhood research

Chen, Y., Han, S., & Yin, B. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1058352 · Cited by 6 · see citing works

From Parental Behavior to Sexual Function: Recent Advances in Oxytocin Research

Dale, J. K., Harberson, M. T., & Hill, J. W. (2024) · Current Sexual Health Reports · doi:10.1007/s11930-024-00386-1 · Cited by 7 · see citing works

Tactile Stimulation Early in Life and During Adulthood: A Natural Strategy to Prevent or Ameliorate Health Disturbances

Melo, Á. I., & Hoffman, K. L. (2024) · Integrated science · doi:10.1007/978-3-031-73061-0_7 · Cited by 6 · see citing works

Neural control of sex differences in affiliative and prosocial behaviors

Mikulovic, S., & Lenschow, C. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106039 · Cited by 5 · see citing works

The effect of modulation Piezo2 by IGF-1 on tactile hypersensitivity in BTBR model mice

Zhai, J., Hao, H., Xu, Z., Tomoda, A., Zhang, X., Wang, X., Liu, Y., Cao, X., Li, D., Zhang, Y., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123449 · Cited by 5 · see citing works

A bench-to-bedside narrative review of the sleep-social-oxytocin nexus

Raymond, J. S., Troxel, W., & Bowen, M. T. (2025) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2025.102077 · Cited by 6 · see citing works

Tactile stimulation reverses painful stimuli outcomes via PVN-VTA oxytocin circuitry and dopaminergic regulation

Sun, Y., Qian, W., Zhang, L., Niu, H., Li, L., Li, L., Zhu, Y., Xiao, J., Liu, J., Han, X., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-09208-z · Cited by 5 · see citing works

MASSAG model: Towards an integrative neuroscience framework linking emotional trauma, pain, and mechanisms of force-based manipulations

Jinich‐Diamant, A., Albinni, B., Fishbein, J. N., Jacobson, E., Abraira, V. E., Hong, S., Korgan, A. C., Mazzieri, A. M., & Case, L. K. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106517 · Cited by 5 · see citing works

Positive effects of tactile massage for adolescents with Attention Deficit/Hyperactivity Disorder (ADHD) - A small scale study.

Robertz, A., Törnhage, C.-J., Nilsson, S., Nyman, V., & Kantzer, A.-K. (2024) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2024.101909 · Cited by 5 · see citing works

Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective

Edens, B. M., & Bronner-Fraser, M. E. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2024.12.008 · Cited by 5 · see citing works

PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice

Liu, S., Liu, X., Duan, Y., Huang, L., Ye, T., Gu, N., Tan, T., Zhang, Z., & Sun, J. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03557-x · Cited by 5 · see citing works

Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder

Portnova, G. V., Proskurnina, E. V., Skorokhodov, I. V., Sokolova, S. V., Semirechenko, A., & Алексеевич, В. А. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512322 · Cited by 5 · see citing works

Oxytocin increases during fur‐rubbing regardless of level of social contact in tufted capuchin monkeys

Sosnowski, M. J., Reilly, O. T., Brosnan, S. F., & Benítez, M. E. (2023) · American Journal of Primatology · doi:10.1002/ajp.23490 · Cited by 5 · see citing works

A reappraisal of attachment theory: The role of affective touch

McGlone, F., & Rankin, L. (2025) · Infant Behavior and Development · doi:10.1016/j.infbeh.2025.102053 · Cited by 5 · see citing works

Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs

Lyu, W., Li, Y., Yao, A., Tan, Q.-Q., Zhang, R., Zhao, J., Guo, K., Jiang, Y., Tian, R., & Zhang, Y. (2025) · Translational Psychiatry · doi:10.1038/s41398-025-03296-5 · Cited by 4 · see citing works

SST neurons in the periaqueductal gray regulate urination and bladder function

Yan, J., Gao, Z., Li, X., Li, J., Yuan, C., Liang, S., Li, J., Deng, G., Yin, L., Pang, S., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08069-w · Cited by 4 · see citing works

Differential brain activation and network connectivity in social interactions presence and absence of physical contact

Zhai, J., Zhang, X., Wang, X., Xu, Z., Yao, X., Zhang, Y., Fan, L., Wu, L., & Wang, J. (2025) · Communications Biology · doi:10.1038/s42003-025-08417-w · Cited by 4 · see citing works

Social stress and affiliative touch: A tale of two affective states

Papantoniou, L. P., Vityk, O., & Tzanoulinou, S. (2026) · iScience · doi:10.1016/j.isci.2026.114833 · Cited by 4 · see citing works

Challenges and prospects in the autism spectrum disorder field

Zhao, W., Kendrick, K. M., & Duan, X. (2024) · Medicine Plus · doi:10.1016/j.medp.2024.100045 · Cited by 4 · see citing works

A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism

Chari, T., Hernandez, A., Couto, J., & Portera‐Cailliau, C. (2025) · Nature Communications · doi:10.1038/s41467-025-59852-6 · Cited by 4 · see citing works

The Potential of Biophilic Design and Nature to Improve Health, Creativity and Well-Being

Sjövall, I. A. K., & Spiers, H. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-64699-7_11 · Cited by 4 · see citing works

Neural Correlates of Social Touch Processing: An fMRI Study on Brain Functional Connectivity

Khorev, V. S., Kurkin, S., Mayorova, L. A., Portnova, G. V., Кушнир, А. Б., & Hramov, A. E. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin26280 · Cited by 4 · see citing works

Pleasant touch: Behavioural and hemodynamic responses to a protocol for systematic assessment of tactile stimulation

Abagnale, S., Panico, F., Sagliano, L., Gosseries, O., & Trojano, L. (2025) · Cortex · doi:10.1016/j.cortex.2025.01.003 · Cited by 4 · see citing works

Neural mechanisms underlying strain preference behaviour and plasticity in mice

Peng, K., Tan, L.-L., You, S., Li, J., Xu, Y., Chen, J.-Y., Wu, M. H., Qin, L., & Zhang, X. (2025) · Scientific Reports · doi:10.1038/s41598-025-90885-5 · Cited by 4 · see citing works

The Touched Body and the Experience of Self

Böhme, R. (2025) · Current topics in behavioral neurosciences · doi:10.1007/7854_2025_577 · Cited by 4 · see citing works

Peripheral and central innervation pattern of mechanosensory neurons in the trigeminal ganglion

Su, Y., Zhang, X., & Sun, Y.-G. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.12.005 · Cited by 3 · see citing works

Repetitive unidirectional spinal tactile stimulation engages microglial Bmal1 pathways to promote synaptic remodeling in the mPFC of adolescent VPA-exposed mice

Chen, Y.-N., Zhao, S.-T., Hu, M., Li, W., Yu, J., Ma, M.-J., Tang, L.-Y., Feng, X., Li, J., & Zhang, Y. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03627-9 · Cited by 3 · see citing works

Role of Mast Cells and Neuroinflammation in Neuropsychiatric Disorders of the Developmental Period

Aitella, E., Neri, L., Azzellino, G., Romano, C. P., Martinis, M. D., Roncone, R., & Ginaldi, L. (2026) · Biomolecules · doi:10.3390/biom16040530 · Cited by 3 · see citing works

Fmri study of changes in large-scale brain networks during affective touch

Khorev, V. S., Portnova, G. V., Кушнир, А. Б., & Mayorova, L. A. (2024) · The European Physical Journal Special Topics · doi:10.1140/epjs/s11734-024-01330-z · Cited by 3 · see citing works

The petting factor: Oxytocin and social touch

Tang, Y., & Stoop, R. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.021 · Cited by 3 · see citing works

Distinct roles of amylin and oxytocin signaling in intrafamilial social behaviors at the medial preoptic area of common marmosets

Kurachi, T., Shinozuka, K., Yoshihara, C., Yano‐Nashimoto, S., Murayama, A. Y., Hata, J., Haga, Y., Okano, H., & Kuroda, K. O. (2023) · Communications Biology · doi:10.1038/s42003-023-05593-5 · Cited by 3 · see citing works

PROK2–PROKR2 Signaling: New Contributor to Pleasant Touch

Chen, F., Yin, H., & Tang, Y. (2022) · Neuroscience Bulletin · doi:10.1007/s12264-022-00940-8 · Cited by 2 · see citing works

The effects of different sensory functions on depression and its neuromechanism

Wenbin, L. I. U., Zhengtang, Q. I., & Weina, L. I. U. (2022) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.00641 · Cited by 2 · see citing works

Huddling promotes adult neurogenesis in the brain regions related to social behavior in cold-exposed Brandt’s voles

Sukhchuluun, G., Wang, Z., Wang, D., & Zhang, X.-Y. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.04.020 · Cited by 2 · see citing works

Fatherhood is life changing: Uncovering structural and functional changes in the dad brain

Dickson, R. G., Jacobs, M. W., & Kim, E. J. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.023 · Cited by 2 · see citing works

L’ocytocine, dès la naissance, conditionne le comportement alimentaire et social d’un individu

Muscatelli, F. (2022) · Biologie Aujourd hui · doi:10.1051/jbio/2022017 · Cited by 2 · see citing works

Social dysfunction in autism spectrum disorder: Tactility and oxytocin

Yujie, H., Rong, Z., Libinuer·aierken, K., Jingjing, L., Junqi, W., Haiping, P., & Jun, G. (2023) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2023.00800 · Cited by 2 · see citing works

Labeling of the serotonergic neuronal circuits emerging from the raphe nuclei via some retrograde tracers

Hussein, M. N. A. (2024) · Microscopy Research and Technique · doi:10.1002/jemt.24662 · Cited by 2 · see citing works

Genetic variability in the oxytocin system is linked to individual differences in cuddliness among human infants

Großmann, T., & Fairhurst, M. T. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106419 · Cited by 1 · see citing works

Impact of the Type of Playful Massage Movements on the Perception of Tactile Stimulation in Children: An EEG Study

Александровна, Д. Е., Zhukova, E. V., Khairulina, G. М., Mayorova, L. A., & Portnova, G. V. (2025) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-025-01766-3 · Cited by 1 · see citing works

Oxytocin in periaqueductal gray plasticly regulates strain-dependent social recognition memory in mice, modeling social identity

Peng, K., Li, J., You, S., Xu, Y., Qin, L., Bao, W., Tan, L., & Zhang, X. (2025) · Communications Biology · doi:10.1038/s42003-025-08307-1 · Cited by 1 · see citing works

The petting factor: Oxytocin and social touch

Tang, Y., & Stoop, R. (2022) · Neuron · doi:10.1016/j.neuron.2022.02.021 · Cited by 3 · see citing works

Somatosensory stimuli trigger coordinated oxytocin neurons activity during social interaction

Benusiglio, D. (2019) · heiDOK (Heidelberg University) · doi:10.11588/heidok.00027080

Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons

Tang, Y., Benusiglio, D., Lefevre, A., Hilfiger, L., Althammer, F., Bludau, A., Hagiwara, D., Baudon, A., Darbon, P., Schimmer, J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0674-y · Cited by 249 · see citing works

Activation of hypothalamic oxytocin neurons following tactile stimuli in rats

Okabe, S., Yoshida, M., Takayanagi, Y., & Onaka, T. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.05.055 · Cited by 82 · see citing works

Oxytocin release patterns and effects, with a focus on touch, social interaction, and closeness

Uvnäs‐Moberg, K., & Petersson, M. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2026.1771799